2012)
Synaptic transmission Tat1–86 No Morphine ex vivo (1 μM) to the bath ↓ mIPSC frequency Mouse, male and female, PFC slices, ex vivo (Xu and Fitting 2016)
SIVmacR71/17E
Tat No info • Morphine (escalating doses of 1–3 mg/kg i.m., q.i.d., 12 months)
• Morphine in vitro • SIV ↑ Synaptic protein HSPA5
• Tat ↑ HSPA5 mRNA (in vitro) Rhesus macaques;
Human,
SH-SY5Y neuroblastoma cells in vitro (Pendyala et al. 2015)
White matter effects SIVmacR71/17E No Mor