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PMC:7461420 / 69854-70195 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T269 335-340 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T332 144-148 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T333 307-311 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T845 163-164 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T846 203-204 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T847 267-275 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T848 327-340 http://purl.obolibrary.org/obo/CLO_0051719 denotes Vero E6 cells

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T81382 257-266 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
2179 155-159 Gene denotes Mpro Gene:8673700
2180 45-49 Gene denotes Mpro Gene:8673700
2185 144-152 Species denotes SARS‐CoV Tax:694009
2186 13-20 Chemical denotes (R)‐123
2187 126-133 Chemical denotes (R)‐123
2188 237-244 Chemical denotes (R)‐123
2189 294-302 Disease denotes infected MESH:D007239
2190 307-331 Disease denotes SARS‐CoV‐1 infected Vero MESH:C000657245
2191 332-334 CellLine denotes E6 CVCL:4582

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T606 0-341 Sentence denotes Indeed, only (R)‐123 was able to inhibit the Mpro enzyme with an IC50 value of 1.5 µM, while the (S)‐enantiomer was inactive. (R)‐123 inhibited SARS‐CoV‐1 Mpro in a competitive manner (K i, 1.6 µM) with a noncovalent mode of inhibition. (R)‐123 also showed antiviral activity (12.9 µM) in mock infected and SARS‐CoV‐1 infected Vero E6 cells.