PMC:7461420 / 69854-70195 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7461420","sourcedb":"PMC","sourceid":"7461420","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7461420","text":"Indeed, only (R)‐123 was able to inhibit the Mpro enzyme with an IC50 value of 1.5 µM, while the (S)‐enantiomer was inactive. (R)‐123 inhibited SARS‐CoV‐1 Mpro in a competitive manner (K i, 1.6 µM) with a noncovalent mode of inhibition. (R)‐123 also showed antiviral activity (12.9 µM) in mock infected and SARS‐CoV‐1 infected Vero E6 cells.","tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T269","span":{"begin":335,"end":340},"obj":"Body_part"}],"attributes":[{"id":"A269","pred":"fma_id","subj":"T269","obj":"http://purl.org/sig/ont/fma/fma68646"},{"subj":"T269","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T332","span":{"begin":144,"end":148},"obj":"Disease"},{"id":"T333","span":{"begin":307,"end":311},"obj":"Disease"}],"attributes":[{"id":"A332","pred":"mondo_id","subj":"T332","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A333","pred":"mondo_id","subj":"T333","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"subj":"T332","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T333","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T845","span":{"begin":163,"end":164},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T846","span":{"begin":203,"end":204},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T847","span":{"begin":267,"end":275},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T848","span":{"begin":327,"end":340},"obj":"http://purl.obolibrary.org/obo/CLO_0051719"}],"attributes":[{"subj":"T845","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T846","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T847","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T848","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T81382","span":{"begin":257,"end":266},"obj":"Chemical"}],"attributes":[{"id":"A43145","pred":"chebi_id","subj":"T81382","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"subj":"T81382","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"2179","span":{"begin":155,"end":159},"obj":"Gene"},{"id":"2180","span":{"begin":45,"end":49},"obj":"Gene"},{"id":"2185","span":{"begin":144,"end":152},"obj":"Species"},{"id":"2186","span":{"begin":13,"end":20},"obj":"Chemical"},{"id":"2187","span":{"begin":126,"end":133},"obj":"Chemical"},{"id":"2188","span":{"begin":237,"end":244},"obj":"Chemical"},{"id":"2189","span":{"begin":294,"end":302},"obj":"Disease"},{"id":"2190","span":{"begin":307,"end":331},"obj":"Disease"},{"id":"2191","span":{"begin":332,"end":334},"obj":"CellLine"}],"attributes":[{"id":"A2179","pred":"tao:has_database_id","subj":"2179","obj":"Gene:8673700"},{"id":"A2180","pred":"tao:has_database_id","subj":"2180","obj":"Gene:8673700"},{"id":"A2185","pred":"tao:has_database_id","subj":"2185","obj":"Tax:694009"},{"id":"A2189","pred":"tao:has_database_id","subj":"2189","obj":"MESH:D007239"},{"id":"A2190","pred":"tao:has_database_id","subj":"2190","obj":"MESH:C000657245"},{"id":"A2191","pred":"tao:has_database_id","subj":"2191","obj":"CVCL:4582"},{"subj":"2179","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2180","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2185","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2186","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2187","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2188","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2189","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2190","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2191","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T606","span":{"begin":0,"end":341},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T606","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#ec93b0","default":true},{"id":"LitCovid-PD-MONDO","color":"#93caec"},{"id":"LitCovid-PD-CLO","color":"#e4ec93"},{"id":"LitCovid-PD-CHEBI","color":"#da93ec"},{"id":"LitCovid-PubTator","color":"#93ecc0"},{"id":"LitCovid-sentences","color":"#eca693"}]}]}}