PMC:7454539 / 2821-3812 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T12","span":{"begin":588,"end":592},"obj":"Body_part"}],"attributes":[{"id":"A12","pred":"fma_id","subj":"T12","obj":"http://purl.org/sig/ont/fma/fma7155"}],"text":"A 68-year-old male with a past medical history of hypertension and hypercholesterolaemia, was admitted with a history of dyspnoea, myalgia and cough. He was similarly found to have type-1 respiratory failure, CPAP was instituted (PEEP of 8 FiO2 0.4), and Co-Amoxiclav and Doxycycline administered. The diagnosis of COVID-19 was confirmed by RT-PCR. Over a period of 13 days, despite increased CPAP support, he continued to deteriorate and required intubation and mechanical ventilation. Post-intubation CXR demonstrated bilateral pulmonary infiltrates and subcutaneous emphysema into the neck. A subsequent CT scan demonstrated widespread pneumomediastinum with significant subcutaneous, retrocrural and retroperitoneal extensions, with no evidence of visceral perforation. His oxygen requirements increased the following day and CXR demonstrated a new right-sided pneumothorax requiring drainage. The patient clinically improved and serial CXR confirmed resolution of the pneumomediastinum."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T12","span":{"begin":588,"end":592},"obj":"Body_part"},{"id":"T13","span":{"begin":720,"end":730},"obj":"Body_part"}],"attributes":[{"id":"A12","pred":"uberon_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/UBERON_0000974"},{"id":"A13","pred":"uberon_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/UBERON_2000106"}],"text":"A 68-year-old male with a past medical history of hypertension and hypercholesterolaemia, was admitted with a history of dyspnoea, myalgia and cough. He was similarly found to have type-1 respiratory failure, CPAP was instituted (PEEP of 8 FiO2 0.4), and Co-Amoxiclav and Doxycycline administered. The diagnosis of COVID-19 was confirmed by RT-PCR. Over a period of 13 days, despite increased CPAP support, he continued to deteriorate and required intubation and mechanical ventilation. Post-intubation CXR demonstrated bilateral pulmonary infiltrates and subcutaneous emphysema into the neck. A subsequent CT scan demonstrated widespread pneumomediastinum with significant subcutaneous, retrocrural and retroperitoneal extensions, with no evidence of visceral perforation. His oxygen requirements increased the following day and CXR demonstrated a new right-sided pneumothorax requiring drainage. The patient clinically improved and serial CXR confirmed resolution of the pneumomediastinum."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T19","span":{"begin":50,"end":62},"obj":"Disease"},{"id":"T20","span":{"begin":188,"end":207},"obj":"Disease"},{"id":"T21","span":{"begin":315,"end":323},"obj":"Disease"},{"id":"T22","span":{"begin":407,"end":409},"obj":"Disease"},{"id":"T23","span":{"begin":569,"end":578},"obj":"Disease"},{"id":"T24","span":{"begin":865,"end":877},"obj":"Disease"}],"attributes":[{"id":"A19","pred":"mondo_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/MONDO_0005044"},{"id":"A20","pred":"mondo_id","subj":"T20","obj":"http://purl.obolibrary.org/obo/MONDO_0021113"},{"id":"A21","pred":"mondo_id","subj":"T21","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A22","pred":"mondo_id","subj":"T22","obj":"http://purl.obolibrary.org/obo/MONDO_0017319"},{"id":"A23","pred":"mondo_id","subj":"T23","obj":"http://purl.obolibrary.org/obo/MONDO_0004849"},{"id":"A24","pred":"mondo_id","subj":"T24","obj":"http://purl.obolibrary.org/obo/MONDO_0002076"}],"text":"A 68-year-old male with a past medical history of hypertension and hypercholesterolaemia, was admitted with a history of dyspnoea, myalgia and cough. He was similarly found to have type-1 respiratory failure, CPAP was instituted (PEEP of 8 FiO2 0.4), and Co-Amoxiclav and Doxycycline administered. The diagnosis of COVID-19 was confirmed by RT-PCR. Over a period of 13 days, despite increased CPAP support, he continued to deteriorate and required intubation and mechanical ventilation. Post-intubation CXR demonstrated bilateral pulmonary infiltrates and subcutaneous emphysema into the neck. A subsequent CT scan demonstrated widespread pneumomediastinum with significant subcutaneous, retrocrural and retroperitoneal extensions, with no evidence of visceral perforation. His oxygen requirements increased the following day and CXR demonstrated a new right-sided pneumothorax requiring drainage. The patient clinically improved and serial CXR confirmed resolution of the pneumomediastinum."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T31","span":{"begin":0,"end":1},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T32","span":{"begin":14,"end":18},"obj":"http://purl.obolibrary.org/obo/UBERON_0003101"},{"id":"T33","span":{"begin":14,"end":18},"obj":"http://www.ebi.ac.uk/efo/EFO_0000970"},{"id":"T34","span":{"begin":24,"end":25},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T35","span":{"begin":108,"end":109},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T36","span":{"begin":354,"end":355},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T37","span":{"begin":588,"end":592},"obj":"http://www.ebi.ac.uk/efo/EFO_0000967"},{"id":"T38","span":{"begin":594,"end":595},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T39","span":{"begin":847,"end":848},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"A 68-year-old male with a past medical history of hypertension and hypercholesterolaemia, was admitted with a history of dyspnoea, myalgia and cough. He was similarly found to have type-1 respiratory failure, CPAP was instituted (PEEP of 8 FiO2 0.4), and Co-Amoxiclav and Doxycycline administered. The diagnosis of COVID-19 was confirmed by RT-PCR. Over a period of 13 days, despite increased CPAP support, he continued to deteriorate and required intubation and mechanical ventilation. Post-intubation CXR demonstrated bilateral pulmonary infiltrates and subcutaneous emphysema into the neck. A subsequent CT scan demonstrated widespread pneumomediastinum with significant subcutaneous, retrocrural and retroperitoneal extensions, with no evidence of visceral perforation. His oxygen requirements increased the following day and CXR demonstrated a new right-sided pneumothorax requiring drainage. The patient clinically improved and serial CXR confirmed resolution of the pneumomediastinum."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T11","span":{"begin":14,"end":18},"obj":"Chemical"},{"id":"T12","span":{"begin":230,"end":234},"obj":"Chemical"},{"id":"T14","span":{"begin":255,"end":257},"obj":"Chemical"},{"id":"T15","span":{"begin":272,"end":283},"obj":"Chemical"},{"id":"T16","span":{"begin":778,"end":784},"obj":"Chemical"}],"attributes":[{"id":"A11","pred":"chebi_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/CHEBI_30780"},{"id":"A12","pred":"chebi_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/CHEBI_53359"},{"id":"A13","pred":"chebi_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/CHEBI_60683"},{"id":"A14","pred":"chebi_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/CHEBI_27638"},{"id":"A15","pred":"chebi_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/CHEBI_50845"},{"id":"A16","pred":"chebi_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/CHEBI_25805"}],"text":"A 68-year-old male with a past medical history of hypertension and hypercholesterolaemia, was admitted with a history of dyspnoea, myalgia and cough. He was similarly found to have type-1 respiratory failure, CPAP was instituted (PEEP of 8 FiO2 0.4), and Co-Amoxiclav and Doxycycline administered. The diagnosis of COVID-19 was confirmed by RT-PCR. Over a period of 13 days, despite increased CPAP support, he continued to deteriorate and required intubation and mechanical ventilation. Post-intubation CXR demonstrated bilateral pulmonary infiltrates and subcutaneous emphysema into the neck. A subsequent CT scan demonstrated widespread pneumomediastinum with significant subcutaneous, retrocrural and retroperitoneal extensions, with no evidence of visceral perforation. His oxygen requirements increased the following day and CXR demonstrated a new right-sided pneumothorax requiring drainage. The patient clinically improved and serial CXR confirmed resolution of the pneumomediastinum."}

{"project":"LitCovid-sentences","denotations":[{"id":"T28","span":{"begin":0,"end":149},"obj":"Sentence"},{"id":"T29","span":{"begin":150,"end":297},"obj":"Sentence"},{"id":"T30","span":{"begin":298,"end":348},"obj":"Sentence"},{"id":"T31","span":{"begin":349,"end":486},"obj":"Sentence"},{"id":"T32","span":{"begin":487,"end":593},"obj":"Sentence"},{"id":"T33","span":{"begin":594,"end":773},"obj":"Sentence"},{"id":"T34","span":{"begin":774,"end":897},"obj":"Sentence"},{"id":"T35","span":{"begin":898,"end":991},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"A 68-year-old male with a past medical history of hypertension and hypercholesterolaemia, was admitted with a history of dyspnoea, myalgia and cough. He was similarly found to have type-1 respiratory failure, CPAP was instituted (PEEP of 8 FiO2 0.4), and Co-Amoxiclav and Doxycycline administered. The diagnosis of COVID-19 was confirmed by RT-PCR. Over a period of 13 days, despite increased CPAP support, he continued to deteriorate and required intubation and mechanical ventilation. Post-intubation CXR demonstrated bilateral pulmonary infiltrates and subcutaneous emphysema into the neck. A subsequent CT scan demonstrated widespread pneumomediastinum with significant subcutaneous, retrocrural and retroperitoneal extensions, with no evidence of visceral perforation. His oxygen requirements increased the following day and CXR demonstrated a new right-sided pneumothorax requiring drainage. The patient clinically improved and serial CXR confirmed resolution of the pneumomediastinum."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T18","span":{"begin":50,"end":62},"obj":"Phenotype"},{"id":"T19","span":{"begin":121,"end":129},"obj":"Phenotype"},{"id":"T20","span":{"begin":131,"end":138},"obj":"Phenotype"},{"id":"T21","span":{"begin":143,"end":148},"obj":"Phenotype"},{"id":"T22","span":{"begin":188,"end":207},"obj":"Phenotype"},{"id":"T23","span":{"begin":530,"end":551},"obj":"Phenotype"},{"id":"T24","span":{"begin":569,"end":578},"obj":"Phenotype"},{"id":"T25","span":{"begin":639,"end":656},"obj":"Phenotype"},{"id":"T26","span":{"begin":865,"end":877},"obj":"Phenotype"},{"id":"T27","span":{"begin":973,"end":990},"obj":"Phenotype"}],"attributes":[{"id":"A18","pred":"hp_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/HP_0000822"},{"id":"A19","pred":"hp_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/HP_0002094"},{"id":"A20","pred":"hp_id","subj":"T20","obj":"http://purl.obolibrary.org/obo/HP_0003326"},{"id":"A21","pred":"hp_id","subj":"T21","obj":"http://purl.obolibrary.org/obo/HP_0012735"},{"id":"A22","pred":"hp_id","subj":"T22","obj":"http://purl.obolibrary.org/obo/HP_0002878"},{"id":"A23","pred":"hp_id","subj":"T23","obj":"http://purl.obolibrary.org/obo/HP_0002113"},{"id":"A24","pred":"hp_id","subj":"T24","obj":"http://purl.obolibrary.org/obo/HP_0002097"},{"id":"A25","pred":"hp_id","subj":"T25","obj":"http://purl.obolibrary.org/obo/HP_0025421"},{"id":"A26","pred":"hp_id","subj":"T26","obj":"http://purl.obolibrary.org/obo/HP_0002107"},{"id":"A27","pred":"hp_id","subj":"T27","obj":"http://purl.obolibrary.org/obo/HP_0025421"}],"text":"A 68-year-old male with a past medical history of hypertension and hypercholesterolaemia, was admitted with a history of dyspnoea, myalgia and cough. He was similarly found to have type-1 respiratory failure, CPAP was instituted (PEEP of 8 FiO2 0.4), and Co-Amoxiclav and Doxycycline administered. The diagnosis of COVID-19 was confirmed by RT-PCR. Over a period of 13 days, despite increased CPAP support, he continued to deteriorate and required intubation and mechanical ventilation. Post-intubation CXR demonstrated bilateral pulmonary infiltrates and subcutaneous emphysema into the neck. A subsequent CT scan demonstrated widespread pneumomediastinum with significant subcutaneous, retrocrural and retroperitoneal extensions, with no evidence of visceral perforation. His oxygen requirements increased the following day and CXR demonstrated a new right-sided pneumothorax requiring drainage. The patient clinically improved and serial CXR confirmed resolution of the pneumomediastinum."}

{"project":"LitCovid-PubTator","denotations":[{"id":"70","span":{"begin":902,"end":909},"obj":"Species"},{"id":"71","span":{"begin":255,"end":267},"obj":"Chemical"},{"id":"72","span":{"begin":272,"end":283},"obj":"Chemical"},{"id":"73","span":{"begin":778,"end":784},"obj":"Chemical"},{"id":"74","span":{"begin":50,"end":62},"obj":"Disease"},{"id":"75","span":{"begin":67,"end":88},"obj":"Disease"},{"id":"76","span":{"begin":121,"end":129},"obj":"Disease"},{"id":"77","span":{"begin":131,"end":138},"obj":"Disease"},{"id":"78","span":{"begin":143,"end":148},"obj":"Disease"},{"id":"79","span":{"begin":188,"end":207},"obj":"Disease"},{"id":"80","span":{"begin":315,"end":323},"obj":"Disease"},{"id":"81","span":{"begin":530,"end":551},"obj":"Disease"},{"id":"82","span":{"begin":569,"end":578},"obj":"Disease"},{"id":"83","span":{"begin":865,"end":877},"obj":"Disease"}],"attributes":[{"id":"A70","pred":"tao:has_database_id","subj":"70","obj":"Tax:9606"},{"id":"A71","pred":"tao:has_database_id","subj":"71","obj":"MESH:D019980"},{"id":"A72","pred":"tao:has_database_id","subj":"72","obj":"MESH:D004318"},{"id":"A73","pred":"tao:has_database_id","subj":"73","obj":"MESH:D010100"},{"id":"A74","pred":"tao:has_database_id","subj":"74","obj":"MESH:D006973"},{"id":"A76","pred":"tao:has_database_id","subj":"76","obj":"MESH:D004417"},{"id":"A77","pred":"tao:has_database_id","subj":"77","obj":"MESH:D063806"},{"id":"A78","pred":"tao:has_database_id","subj":"78","obj":"MESH:D003371"},{"id":"A79","pred":"tao:has_database_id","subj":"79","obj":"MESH:D012131"},{"id":"A80","pred":"tao:has_database_id","subj":"80","obj":"MESH:C000657245"},{"id":"A81","pred":"tao:has_database_id","subj":"81","obj":"MESH:D017254"},{"id":"A82","pred":"tao:has_database_id","subj":"82","obj":"MESH:D004646"},{"id":"A83","pred":"tao:has_database_id","subj":"83","obj":"MESH:D011030"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"A 68-year-old male with a past medical history of hypertension and hypercholesterolaemia, was admitted with a history of dyspnoea, myalgia and cough. He was similarly found to have type-1 respiratory failure, CPAP was instituted (PEEP of 8 FiO2 0.4), and Co-Amoxiclav and Doxycycline administered. The diagnosis of COVID-19 was confirmed by RT-PCR. Over a period of 13 days, despite increased CPAP support, he continued to deteriorate and required intubation and mechanical ventilation. Post-intubation CXR demonstrated bilateral pulmonary infiltrates and subcutaneous emphysema into the neck. A subsequent CT scan demonstrated widespread pneumomediastinum with significant subcutaneous, retrocrural and retroperitoneal extensions, with no evidence of visceral perforation. His oxygen requirements increased the following day and CXR demonstrated a new right-sided pneumothorax requiring drainage. The patient clinically improved and serial CXR confirmed resolution of the pneumomediastinum."}

{"project":"testtesttest","denotations":[{"id":"T16","span":{"begin":14,"end":18},"obj":"Body_part"},{"id":"T17","span":{"begin":588,"end":592},"obj":"Body_part"},{"id":"T18","span":{"begin":720,"end":730},"obj":"Body_part"}],"attributes":[{"id":"A16","pred":"uberon_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/UBERON_0003101"},{"id":"A17","pred":"uberon_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/UBERON_0000974"},{"id":"A18","pred":"uberon_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/UBERON_2000106"}],"text":"A 68-year-old male with a past medical history of hypertension and hypercholesterolaemia, was admitted with a history of dyspnoea, myalgia and cough. He was similarly found to have type-1 respiratory failure, CPAP was instituted (PEEP of 8 FiO2 0.4), and Co-Amoxiclav and Doxycycline administered. The diagnosis of COVID-19 was confirmed by RT-PCR. Over a period of 13 days, despite increased CPAP support, he continued to deteriorate and required intubation and mechanical ventilation. Post-intubation CXR demonstrated bilateral pulmonary infiltrates and subcutaneous emphysema into the neck. A subsequent CT scan demonstrated widespread pneumomediastinum with significant subcutaneous, retrocrural and retroperitoneal extensions, with no evidence of visceral perforation. His oxygen requirements increased the following day and CXR demonstrated a new right-sided pneumothorax requiring drainage. The patient clinically improved and serial CXR confirmed resolution of the pneumomediastinum."}