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PMC:7441788 / 9600-10485 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T48 15-22 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T49 23-41 Body_part denotes membrane receptors http://purl.org/sig/ont/fma/fma0326969
T50 61-66 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T51 114-127 Body_part denotes glycoproteins http://purl.org/sig/ont/fma/fma62925
T52 132-144 Body_part denotes gangliosides http://purl.org/sig/ont/fma/fma82816
T53 418-430 Body_part denotes gangliosides http://purl.org/sig/ont/fma/fma82816
T54 443-455 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T55 443-447 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T56 515-527 Body_part denotes gangliosides http://purl.org/sig/ont/fma/fma82816
T57 596-603 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T58 607-619 Body_part denotes gangliosides http://purl.org/sig/ont/fma/fma82816
T59 862-873 Body_part denotes ganglioside http://purl.org/sig/ont/fma/fma82816

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T72 43-52 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T73 211-220 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T74 246-254 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T75 336-344 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T97 23-31 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T98 61-66 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T99 164-165 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T100 181-188 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T101 286-287 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T102 369-370 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T103 443-447 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T104 767-775 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T119 15-22 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T120 91-102 Chemical denotes sialic acid http://purl.obolibrary.org/obo/CHEBI_26667
T121 98-102 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T122 114-127 Chemical denotes glycoproteins http://purl.obolibrary.org/obo/CHEBI_17089
T123 132-144 Chemical denotes gangliosides http://purl.obolibrary.org/obo/CHEBI_28892
T124 418-430 Chemical denotes gangliosides http://purl.obolibrary.org/obo/CHEBI_28892
T125 464-475 Chemical denotes sialic acid http://purl.obolibrary.org/obo/CHEBI_26667
T126 471-475 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T127 485-487 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T128 498-510 Chemical denotes sialic acids http://purl.obolibrary.org/obo/CHEBI_26667
T129 505-510 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T130 515-527 Chemical denotes gangliosides http://purl.obolibrary.org/obo/CHEBI_28892
T131 596-603 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T132 607-619 Chemical denotes gangliosides http://purl.obolibrary.org/obo/CHEBI_28892
T133 626-628 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T134 654-661 Chemical denotes quinone http://purl.obolibrary.org/obo/CHEBI_36141
T135 712-724 Chemical denotes sialic acids http://purl.obolibrary.org/obo/CHEBI_26667
T136 719-724 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T137 779-781 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T138 846-857 Chemical denotes sialic acid http://purl.obolibrary.org/obo/CHEBI_26667
T139 853-857 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T140 862-873 Chemical denotes ganglioside http://purl.obolibrary.org/obo/CHEBI_28892

LitCovid-sample-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T78 15-22 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T79 91-102 Chemical denotes sialic acid http://purl.obolibrary.org/obo/CHEBI_26667
T80 114-127 Chemical denotes glycoproteins http://purl.obolibrary.org/obo/CHEBI_17089
T81 132-144 Chemical denotes gangliosides http://purl.obolibrary.org/obo/CHEBI_28892
T82 418-430 Chemical denotes gangliosides http://purl.obolibrary.org/obo/CHEBI_28892
T83 464-475 Chemical denotes sialic acid http://purl.obolibrary.org/obo/CHEBI_26667
T84 485-487 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T85 498-510 Chemical denotes sialic acids http://purl.obolibrary.org/obo/CHEBI_26667
T86 515-527 Chemical denotes gangliosides http://purl.obolibrary.org/obo/CHEBI_28892
T87 596-603 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T88 607-619 Chemical denotes gangliosides http://purl.obolibrary.org/obo/CHEBI_28892
T89 626-628 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T90 654-661 Chemical denotes quinone http://purl.obolibrary.org/obo/CHEBI_36141
T91 712-724 Chemical denotes sialic acids http://purl.obolibrary.org/obo/CHEBI_26667
T92 779-781 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T93 846-857 Chemical denotes sialic acid http://purl.obolibrary.org/obo/CHEBI_26667
T94 862-873 Chemical denotes ganglioside http://purl.obolibrary.org/obo/CHEBI_28892

LitCovid-sample-PD-NCBITaxon

Id Subject Object Predicate Lexical cue ncbi_taxonomy_id
T75 181-188 Species denotes viruses NCBItxid:10239
T76 246-254 Species denotes SARS-CoV NCBItxid:694009
T77 264-273 Species denotes HCoV-OC43 NCBItxid:31631
T78 336-346 Species denotes SARS-CoV-2 NCBItxid:2697049

LitCovid-sample-sentences

Id Subject Object Predicate Lexical cue
T72 0-285 Sentence denotes In addition to protein membrane receptors, infection of host cells by HCoVs also relies on sialic acid-containing glycoproteins and gangliosides, which are used by a broad range of viruses as receptors, such as influenza [20] and HCoVs including SARS-CoV [21] and HCoV-OC43 [13,22,23].
T73 286-484 Sentence denotes A recent molecular structure analysis showed that SARS-CoV-2 not only uses ACE2 as a receptor, but also recognizes highly conserved gangliosides on the host cell surface through sialic acid [24,25].
T74 485-625 Sentence denotes CQ/HCQ binds sialic acids and gangliosides with high affinity, which can prevent the attachment of SARSCoV-2 S protein to gangliosides [25].
T75 626-733 Sentence denotes CQ had inhibitory effect on quinone reductase 2 (QR2) involved in the biosynthesis of sialic acids [26,27].
T76 734-885 Sentence denotes Hence, the mechanism of anti-CoV activity of CQ/HCQ may also be related to hindering the recognition process of sialic acid and ganglioside (Figure 1).

LitCovid-sample-Pubtator

Id Subject Object Predicate Lexical cue pubann:denotes
394 361-365 Gene denotes ACE2 Gene:59272
395 654-673 Gene denotes quinone reductase 2 Gene:4835
396 675-678 Gene denotes QR2 Gene:4835
397 485-491 Gene denotes CQ/HCQ
398 246-254 Species denotes SARS-CoV Tax:694009
400 336-346 Species denotes SARS-CoV-2 Tax:2697049
401 211-220 Species denotes influenza Tax:11320
402 584-591 Species denotes SARSCoV Tax:694009
403 763-766 Species denotes CoV Tax:11118
404 91-102 Chemical denotes sialic acid MESH:D019158
405 132-144 Chemical denotes gangliosides MESH:D005732
406 418-430 Chemical denotes gangliosides MESH:D005732
407 464-475 Chemical denotes sialic acid MESH:D019158
408 498-510 Chemical denotes sialic acids MESH:D012794
409 515-527 Chemical denotes gangliosides MESH:D005732
410 607-619 Chemical denotes gangliosides MESH:D005732
411 626-628 Chemical denotes CQ MESH:D002738
412 712-724 Chemical denotes sialic acids MESH:D012794
413 779-781 Chemical denotes CQ MESH:D002738
414 782-785 Chemical denotes HCQ MESH:D006886
415 846-857 Chemical denotes sialic acid MESH:D019158
416 862-873 Chemical denotes ganglioside MESH:D005732
417 43-52 Disease denotes infection MESH:D007239

LitCovid-sample-UniProt

Id Subject Object Predicate Lexical cue uniprot_id
T332 114-127 Protein denotes glycoproteins https://www.uniprot.org/uniprot/Q9QSP1|https://www.uniprot.org/uniprot/Q9QJT6|https://www.uniprot.org/uniprot/Q9JGT4|https://www.uniprot.org/uniprot/Q9IPJ6|https://www.uniprot.org/uniprot/Q9DIC6|https://www.uniprot.org/uniprot/Q91DS0|https://www.uniprot.org/uniprot/Q91C28|https://www.uniprot.org/uniprot/Q8QQA2|https://www.uniprot.org/uniprot/Q8QPE5|https://www.uniprot.org/uniprot/Q8QPE4|https://www.uniprot.org/uniprot/Q8QPE3|https://www.uniprot.org/uniprot/Q8JTH0|https://www.uniprot.org/uniprot/Q8BDV6|https://www.uniprot.org/uniprot/Q8B6J6|https://www.uniprot.org/uniprot/Q8B0I1|https://www.uniprot.org/uniprot/Q8B0H6|https://www.uniprot.org/uniprot/Q8B0H1|https://www.uniprot.org/uniprot/Q89669|https://www.uniprot.org/uniprot/Q85213|https://www.uniprot.org/uniprot/Q82706|https://www.uniprot.org/uniprot/Q82683|https://www.uniprot.org/uniprot/Q82020|https://www.uniprot.org/uniprot/Q787B5|https://www.uniprot.org/uniprot/Q77SK0|https://www.uniprot.org/uniprot/Q77N36|https://www.uniprot.org/uniprot/Q76G52|https://www.uniprot.org/uniprot/Q75T09|https://www.uniprot.org/uniprot/Q6X1D5|https://www.uniprot.org/uniprot/Q6X1D1|https://www.uniprot.org/uniprot/Q6TYA0|https://www.uniprot.org/uniprot/Q6E0W7|https://www.uniprot.org/uniprot/Q66T62|https://www.uniprot.org/uniprot/Q5VKP3|https://www.uniprot.org/uniprot/Q5VKN9|https://www.uniprot.org/uniprot/Q5K2K4|https://www.uniprot.org/uniprot/Q5IX93|https://www.uniprot.org/uniprot/Q5IX92|https://www.uniprot.org/uniprot/Q5IX91|https://www.uniprot.org/uniprot/Q5IX90|https://www.uniprot.org/uniprot/Q5IX89|https://www.uniprot.org/uniprot/Q5IX88|https://www.uniprot.org/uniprot/Q5IX87|https://www.uniprot.org/uniprot/Q5GA86|https://www.uniprot.org/uniprot/Q58FH1|https://www.uniprot.org/uniprot/Q4VKV3|https://www.uniprot.org/uniprot/Q4F900|https://www.uniprot.org/uniprot/Q49LL3|https://www.uniprot.org/uniprot/Q49IU2|https://www.uniprot.org/uniprot/Q49IU1|https://www.uniprot.org/uniprot/Q49IT9|https://www.uniprot.org/uniprot/Q49IT8|https://www.uniprot.org/uniprot/Q49AV0|https://www.uniprot.org/uniprot/Q0GBY1|https://www.uniprot.org/uniprot/Q0GBX6|https://www.uniprot.org/uniprot/Q08089|https://www.uniprot.org/uniprot/P32595|https://www.uniprot.org/uniprot/P32550|https://www.uniprot.org/uniprot/P19462|https://www.uniprot.org/uniprot/P16288|https://www.uniprot.org/uniprot/P15199|https://www.uniprot.org/uniprot/P13180|https://www.uniprot.org/uniprot/P0C572|https://www.uniprot.org/uniprot/P08667|https://www.uniprot.org/uniprot/P08163|https://www.uniprot.org/uniprot/P07923|https://www.uniprot.org/uniprot/P04884|https://www.uniprot.org/uniprot/P04883|https://www.uniprot.org/uniprot/P04882|https://www.uniprot.org/uniprot/P03524|https://www.uniprot.org/uniprot/P03522|https://www.uniprot.org/uniprot/O92284|https://www.uniprot.org/uniprot/O56677|https://www.uniprot.org/uniprot/O10236|https://www.uniprot.org/uniprot/J7HBH4|https://www.uniprot.org/uniprot/D8V075|https://www.uniprot.org/uniprot/A7WNB3|https://www.uniprot.org/uniprot/A4UHQ6|https://www.uniprot.org/uniprot/A4UHQ1|https://www.uniprot.org/uniprot/A3RM22|https://www.uniprot.org/uniprot/A3F5R8|https://www.uniprot.org/uniprot/A3F5R3|https://www.uniprot.org/uniprot/A3F5Q8|https://www.uniprot.org/uniprot/A3F5N3|https://www.uniprot.org/uniprot/A3F5M3|https://www.uniprot.org/uniprot/A3F5L8
T417 361-365 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T418 594-603 Protein denotes S protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T451 654-673 Protein denotes quinone reductase 2 https://www.uniprot.org/uniprot/Q9JI75|https://www.uniprot.org/uniprot/Q6AY80|https://www.uniprot.org/uniprot/Q5TD04|https://www.uniprot.org/uniprot/Q5RBB9|https://www.uniprot.org/uniprot/P16083|https://www.uniprot.org/uniprot/B2R492
T457 675-678 Protein denotes QR2 https://www.uniprot.org/uniprot/Q9JI75|https://www.uniprot.org/uniprot/Q6AY80|https://www.uniprot.org/uniprot/Q5TD04|https://www.uniprot.org/uniprot/Q5RBB9|https://www.uniprot.org/uniprot/P16083|https://www.uniprot.org/uniprot/B2R492

LitCovid-sample-PD-IDO

Id Subject Object Predicate Lexical cue
T77 43-52 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T78 56-60 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T79 61-66 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T80 181-188 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T81 438-442 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T82 443-447 http://purl.obolibrary.org/obo/CL_0000000 denotes cell

LitCovid-sample-PD-FMA

Id Subject Object Predicate Lexical cue fma_id
T48 15-22 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T49 23-41 Body_part denotes membrane receptors http://purl.org/sig/ont/fma/fma0326969
T50 61-66 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T51 114-127 Body_part denotes glycoproteins http://purl.org/sig/ont/fma/fma62925
T52 132-144 Body_part denotes gangliosides http://purl.org/sig/ont/fma/fma82816
T53 418-430 Body_part denotes gangliosides http://purl.org/sig/ont/fma/fma82816
T54 443-455 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T55 443-447 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T56 515-527 Body_part denotes gangliosides http://purl.org/sig/ont/fma/fma82816
T57 596-603 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T58 607-619 Body_part denotes gangliosides http://purl.org/sig/ont/fma/fma82816
T59 862-873 Body_part denotes ganglioside http://purl.org/sig/ont/fma/fma82816

LitCovid-sample-PD-GO-BP-0

Id Subject Object Predicate Lexical cue
T23 696-708 http://purl.obolibrary.org/obo/GO_0009058 denotes biosynthesis

LitCovid-sample-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T65 43-52 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T66 211-220 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T67 246-254 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T68 336-346 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-sample-GO-BP

Id Subject Object Predicate Lexical cue
T22 696-708 http://purl.obolibrary.org/obo/GO_0009058 denotes biosynthesis

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T22 696-708 http://purl.obolibrary.org/obo/GO_0009058 denotes biosynthesis

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
394 361-365 Gene denotes ACE2 Gene:59272
395 654-673 Gene denotes quinone reductase 2 Gene:4835
396 675-678 Gene denotes QR2 Gene:4835
397 485-491 Gene denotes CQ/HCQ
398 246-254 Species denotes SARS-CoV Tax:694009
399 264-273 Species denotes HCoV-OC43 Tax:31631
400 336-346 Species denotes SARS-CoV-2 Tax:2697049
401 211-220 Species denotes influenza Tax:11320
402 584-591 Species denotes SARSCoV Tax:694009
403 763-766 Species denotes CoV Tax:11118
404 91-102 Chemical denotes sialic acid MESH:D019158
405 132-144 Chemical denotes gangliosides MESH:D005732
406 418-430 Chemical denotes gangliosides MESH:D005732
407 464-475 Chemical denotes sialic acid MESH:D019158
408 498-510 Chemical denotes sialic acids MESH:D012794
409 515-527 Chemical denotes gangliosides MESH:D005732
410 607-619 Chemical denotes gangliosides MESH:D005732
411 626-628 Chemical denotes CQ MESH:D002738
412 712-724 Chemical denotes sialic acids MESH:D012794
413 779-781 Chemical denotes CQ MESH:D002738
414 782-785 Chemical denotes HCQ MESH:D006886
415 846-857 Chemical denotes sialic acid MESH:D019158
416 862-873 Chemical denotes ganglioside MESH:D005732
417 43-52 Disease denotes infection MESH:D007239

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T72 0-285 Sentence denotes In addition to protein membrane receptors, infection of host cells by HCoVs also relies on sialic acid-containing glycoproteins and gangliosides, which are used by a broad range of viruses as receptors, such as influenza [20] and HCoVs including SARS-CoV [21] and HCoV-OC43 [13,22,23].
T73 286-484 Sentence denotes A recent molecular structure analysis showed that SARS-CoV-2 not only uses ACE2 as a receptor, but also recognizes highly conserved gangliosides on the host cell surface through sialic acid [24,25].
T74 485-625 Sentence denotes CQ/HCQ binds sialic acids and gangliosides with high affinity, which can prevent the attachment of SARSCoV-2 S protein to gangliosides [25].
T75 626-733 Sentence denotes CQ had inhibitory effect on quinone reductase 2 (QR2) involved in the biosynthesis of sialic acids [26,27].
T76 734-885 Sentence denotes Hence, the mechanism of anti-CoV activity of CQ/HCQ may also be related to hindering the recognition process of sialic acid and ganglioside (Figure 1).

2_test

Id Subject Object Predicate Lexical cue
32496926-18279660-132195669 256-258 18279660 denotes 21
32496926-16115318-132195670 275-277 16115318 denotes 13
32496926-31160783-132195671 278-280 31160783 denotes 22
32496926-23873408-132195672 281-283 23873408 denotes 23
32496926-32221306-132195673 477-479 32221306 denotes 24
32496926-15078100-132195674 726-728 15078100 denotes 26
32496926-9068613-132195675 729-731 9068613 denotes 27