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PMC:7441788 / 12085-12955 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T74 19-23 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T75 91-98 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T76 148-160 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T77 148-152 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T78 304-308 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T79 309-325 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T80 320-325 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T5 304-308 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T83 192-201 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T84 231-239 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T85 682-688 Disease denotes dengue http://purl.obolibrary.org/obo/MONDO_0005502

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T132 19-23 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T133 24-33 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T134 81-90 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T135 131-138 http://purl.obolibrary.org/obo/SO_0000418 denotes signals
T136 148-152 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T137 223-225 http://purl.obolibrary.org/obo/CLO_0001313 denotes 36
T138 288-293 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T139 304-325 http://purl.obolibrary.org/obo/CL_0000082 denotes lung epithelial cells
T140 327-331 http://purl.obolibrary.org/obo/CLO_0007158 denotes L132
T141 357-367 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T142 516-526 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T143 638-647 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T144 689-694 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T145 695-703 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T146 759-767 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T147 787-797 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T155 73-80 Chemical denotes mitogen http://purl.obolibrary.org/obo/CHEBI_52290
T156 91-98 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T157 168-175 Chemical denotes nucleus http://purl.obolibrary.org/obo/CHEBI_33252
T158 246-248 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T159 449-472 Chemical denotes reactive oxygen species http://purl.obolibrary.org/obo/CHEBI_26523
T160 458-464 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T161 474-477 Chemical denotes ROS http://purl.obolibrary.org/obo/CHEBI_26523
T162 628-637 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T163 721-723 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T164 749-758 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587

LitCovid-sample-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T104 91-98 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T105 246-248 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T106 449-472 Chemical denotes reactive oxygen species http://purl.obolibrary.org/obo/CHEBI_26523
T107 474-477 Chemical denotes ROS http://purl.obolibrary.org/obo/CHEBI_26523
T108 721-723 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638

LitCovid-sample-PD-NCBITaxon

Id Subject Object Predicate Lexical cue ncbi_taxonomy_id
T90 218-221 Species denotes MHV NCBItxid:11138
T91 231-239 Species denotes SARS-CoV NCBItxid:694009
T92 263-272 Species denotes HCoV-229E NCBItxid:11137
T93 288-293 Species denotes human NCBItxid:9606
T94 682-694 Species denotes dengue virus NCBItxid:12637

LitCovid-sample-sentences

Id Subject Object Predicate Lexical cue
T86 0-6 Sentence denotes 4.1.3.
T87 8-68 Sentence denotes Effects on cell signaling pathway and host defense machinery
T88 69-245 Sentence denotes The mitogen-activated protein kinase (MAPK) pathway transmits signals from the cell surface to the nucleus involved in the infection of CoVs such as MHV [36] and SARS-CoV [37].
T89 246-385 Sentence denotes CQ could inhibit HCoV-229E replication in human embryonic lung epithelial cells (L132) through suppressing the activation of p38 MAPK [38].
T90 386-551 Sentence denotes Moreover, HCQ could markedly induce the production of cellular reactive oxygen species (ROS), which play an important role in the activation of innate immunity [39].
T91 552-709 Sentence denotes HCQ also could trigger the host defense mechanism through the mitochondrial antiviral signaling (MAVS) pathway, resulting in anti-dengue virus activity [39].
T92 710-870 Sentence denotes Therefore, CQ/HCQ may also exert their antiviral activity by suppressing the activation of p38 MAPK pathway and affecting the host defense machinery (Figure 1).

LitCovid-sample-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T5 304-308 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048

LitCovid-sample-Pubtator

Id Subject Object Predicate Lexical cue pubann:denotes
478 614-647 Gene denotes mitochondrial antiviral signaling Gene:57506
479 649-653 Gene denotes MAVS Gene:57506
480 205-209 Species denotes CoVs Tax:11118
482 263-272 Species denotes HCoV-229E Tax:11137
483 288-293 Species denotes human Tax:9606
484 396-399 Chemical denotes HCQ MESH:D006886
485 449-472 Chemical denotes reactive oxygen species MESH:D017382
486 474-477 Chemical denotes ROS MESH:D017382
487 552-555 Chemical denotes HCQ MESH:D006886
488 721-727 Chemical denotes CQ/HCQ
489 192-201 Disease denotes infection MESH:D007239

LitCovid-sample-UniProt

Id Subject Object Predicate Lexical cue uniprot_id
T872 294-303 Protein denotes embryonic https://www.uniprot.org/uniprot/P02301
T873 371-379 Protein denotes p38 MAPK https://www.uniprot.org/uniprot/Q9TXB4|https://www.uniprot.org/uniprot/O62618|https://www.uniprot.org/uniprot/O46216|https://www.uniprot.org/uniprot/A4V3C0
T877 649-653 Protein denotes MAVS https://www.uniprot.org/uniprot/Q9ULE9|https://www.uniprot.org/uniprot/Q9H8D3|https://www.uniprot.org/uniprot/Q9H4Y1|https://www.uniprot.org/uniprot/Q9H1H3|https://www.uniprot.org/uniprot/Q8VCF0|https://www.uniprot.org/uniprot/Q86VY7|https://www.uniprot.org/uniprot/Q7Z434|https://www.uniprot.org/uniprot/Q66HG9|https://www.uniprot.org/uniprot/Q5T7I6|https://www.uniprot.org/uniprot/Q3I0Y2|https://www.uniprot.org/uniprot/Q2HWT5|https://www.uniprot.org/uniprot/M1P2Z0|https://www.uniprot.org/uniprot/F5H6C8|https://www.uniprot.org/uniprot/B2BD34|https://www.uniprot.org/uniprot/B2BD33|https://www.uniprot.org/uniprot/A8K6X0
T893 801-809 Protein denotes p38 MAPK https://www.uniprot.org/uniprot/Q9TXB4|https://www.uniprot.org/uniprot/O62618|https://www.uniprot.org/uniprot/O46216|https://www.uniprot.org/uniprot/A4V3C0

LitCovid-sample-PD-IDO

Id Subject Object Predicate Lexical cue
T90 19-23 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T91 46-50 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T92 148-152 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T93 192-201 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T94 273-284 http://purl.obolibrary.org/obo/IDO_0000608 denotes replication
T95 320-325 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T96 426-436 http://purl.obolibrary.org/obo/IDO_0000607 denotes production
T97 579-583 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T98 628-637 http://purl.obolibrary.org/obo/IDO_0000559 denotes antiviral
T99 689-694 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T100 749-758 http://purl.obolibrary.org/obo/IDO_0000559 denotes antiviral
T101 836-840 http://purl.obolibrary.org/obo/IDO_0000531 denotes host

LitCovid-sample-PD-FMA

Id Subject Object Predicate Lexical cue fma_id
T74 19-23 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T75 91-98 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T76 148-160 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T77 148-152 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T78 304-308 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T79 309-325 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T80 320-325 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646

LitCovid-sample-PD-MAT

Id Subject Object Predicate Lexical cue
T3 304-308 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung

LitCovid-sample-PD-GO-BP-0

Id Subject Object Predicate Lexical cue
T35 24-41 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T36 24-33 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T37 107-111 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T38 371-374 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T39 375-379 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T40 530-545 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immunity
T41 638-647 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T42 801-804 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T43 805-809 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK

LitCovid-sample-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T76 192-201 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T77 231-239 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T78 682-688 Disease denotes dengue http://purl.obolibrary.org/obo/MONDO_0005502

LitCovid-sample-GO-BP

Id Subject Object Predicate Lexical cue
T34 24-41 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T35 24-33 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T36 107-111 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T37 375-379 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T38 530-545 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immunity
T39 638-647 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T40 805-809 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T34 24-41 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T35 24-33 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T36 107-111 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T37 375-379 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T38 530-545 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immunity
T39 638-647 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T40 805-809 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
478 614-647 Gene denotes mitochondrial antiviral signaling Gene:57506
479 649-653 Gene denotes MAVS Gene:57506
480 205-209 Species denotes CoVs Tax:11118
481 231-239 Species denotes SARS-CoV Tax:694009
482 263-272 Species denotes HCoV-229E Tax:11137
483 288-293 Species denotes human Tax:9606
484 396-399 Chemical denotes HCQ MESH:D006886
485 449-472 Chemical denotes reactive oxygen species MESH:D017382
486 474-477 Chemical denotes ROS MESH:D017382
487 552-555 Chemical denotes HCQ MESH:D006886
488 721-727 Chemical denotes CQ/HCQ
489 192-201 Disease denotes infection MESH:D007239

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T86 0-6 Sentence denotes 4.1.3.
T87 8-68 Sentence denotes Effects on cell signaling pathway and host defense machinery
T88 69-245 Sentence denotes The mitogen-activated protein kinase (MAPK) pathway transmits signals from the cell surface to the nucleus involved in the infection of CoVs such as MHV [36] and SARS-CoV [37].
T89 246-385 Sentence denotes CQ could inhibit HCoV-229E replication in human embryonic lung epithelial cells (L132) through suppressing the activation of p38 MAPK [38].
T90 386-551 Sentence denotes Moreover, HCQ could markedly induce the production of cellular reactive oxygen species (ROS), which play an important role in the activation of innate immunity [39].
T91 552-709 Sentence denotes HCQ also could trigger the host defense mechanism through the mitochondrial antiviral signaling (MAVS) pathway, resulting in anti-dengue virus activity [39].
T92 710-870 Sentence denotes Therefore, CQ/HCQ may also exert their antiviral activity by suppressing the activation of p38 MAPK pathway and affecting the host defense machinery (Figure 1).

2_test

Id Subject Object Predicate Lexical cue
32496926-12021326-132195688 223-225 12021326 denotes 36
32496926-16378980-132195689 241-243 16378980 denotes 37
32496926-18055026-132195690 381-383 18055026 denotes 38
32496926-25321315-132195691 547-549 25321315 denotes 39
32496926-25321315-132195692 705-707 25321315 denotes 39