PMC:7441777 / 35490-36221 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue	fma_id
T53	375-386	Body_part	denotes	amino acids	http://purl.org/sig/ont/fma/fma82739

Id	Subject	Object	Predicate	Lexical cue	chebi_id
T467	80-91	Chemical	denotes	polyphenols	http://purl.obolibrary.org/obo/CHEBI_26195
T468	327-338	Chemical	denotes	polyphenols	http://purl.obolibrary.org/obo/CHEBI_26195
T469	343-353	Chemical	denotes	remdesivir	http://purl.obolibrary.org/obo/CHEBI_145994
T470	375-386	Chemical	denotes	amino acids	http://purl.obolibrary.org/obo/CHEBI_33709
T471	375-380	Chemical	denotes	amino	http://purl.obolibrary.org/obo/CHEBI_46882
T472	381-386	Chemical	denotes	acids	http://purl.obolibrary.org/obo/CHEBI_37527
T473	422-432	Chemical	denotes	remdesivir	http://purl.obolibrary.org/obo/CHEBI_145994
T474	477-481	Chemical	denotes	EGCG	http://purl.obolibrary.org/obo/CHEBI_4806
T475	534-537	Chemical	denotes	TF3	http://purl.obolibrary.org/obo/CHEBI_136608

Id	Subject	Object	Predicate	Lexical cue	tao:has_database_id
863	97-101	Gene	denotes	RdRp	Gene:43740578
864	288-292	Gene	denotes	RdRp	Gene:43740578
865	417-421	Gene	denotes	RdRp	Gene:43740578
866	472-476	Gene	denotes	RdRp	Gene:43740578
867	529-533	Gene	denotes	RdRp	Gene:43740578
868	577-581	Gene	denotes	RdRp	Gene:43740578
869	582-586	Gene	denotes	TF2b	Gene:2959
870	626-630	Gene	denotes	RdRp	Gene:43740578
871	80-91	Chemical	denotes	polyphenols	MESH:D059808
872	110-116	Chemical	denotes	Asp452
873	126-132	Chemical	denotes	Arg555
874	134-140	Chemical	denotes	Val557
875	142-148	Chemical	denotes	Asp618
876	150-156	Chemical	denotes	Pro620
877	158-164	Chemical	denotes	Lys621
878	166-172	Chemical	denotes	Asp623
879	174-180	Chemical	denotes	Arg624
880	182-188	Chemical	denotes	Asp760
881	190-196	Chemical	denotes	Asp761
882	202-208	Chemical	denotes	Glu811
883	210-216	Chemical	denotes	Asp833
884	222-228	Chemical	denotes	Arg836
885	327-338	Chemical	denotes	polyphenols	MESH:D059808
886	343-353	Chemical	denotes	remdesivir	MESH:C000606551
887	422-432	Chemical	denotes	remdesivir	MESH:C000606551

Id	Subject	Object	Predicate	Lexical cue
T351	230-354	Sentence	denotes	Most of these residues are located in the binding site of RdRp and can form direct contacts with polyphenols and remdesivir.
T352	355-731	Sentence	denotes	Figure 5 shows that amino acids Pro620, Asp761 and Lys798 for RdRp/remdesivir; Asp452, Arg553, Pro620 and Lys621 for RdRp/EGCG; Ile548, Arg555, Thr556, Asp761 and Arg836 for RdRp/TF3; Glu811, His816, Asp833 and Tyr877 for RdRp/TF2b; Lys551, Arg553, Arg555 and Asp618 for RdRp/TF2a contributed more favorably towards the binding by contributing more than −1.0 kcal/mol in size.