PMC:7435837 / 45828-46830
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7435837","sourcedb":"PMC","sourceid":"7435837","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7435837","text":"Figure 1 Two simplified routes of the fate of an encapsulated virus are shown. Either route (A–D) or route (A–I) can be followed. (A). The virus with spike proteins comprising of N-glycan moieties on the protein (red and green) is presented. (B). A potential host cell presents glycan-recognizing lectins on its bilipid membrane surface. (C). The virus glycan array binds to the host cell lectins and membrane fusion is initiated and after phagocytosis, virus replication follows. (D). Host cell destruction takes place with the subsequent release of new virus particles. (E). The virus is intercepted by dendritic cells before it can interact with the host cell membrane. The dendritic cells label the virus with cytokines CD4+/CD8+ (green and orange symbols), and (G). presents the cytokine-labeled virus to T-cells. (H). T-cells recognize the CD4+/CD8+ labels and phagocytose the virus that is destroyed in the T-cell lysosomes. (I). Only inactive, non-pathogenic viral degradation products remain.","divisions":[{"label":"label","span":{"begin":0,"end":8}}],"tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T294","span":{"begin":157,"end":165},"obj":"Body_part"},{"id":"T295","span":{"begin":205,"end":212},"obj":"Body_part"},{"id":"T296","span":{"begin":265,"end":269},"obj":"Body_part"},{"id":"T297","span":{"begin":385,"end":389},"obj":"Body_part"},{"id":"T298","span":{"begin":492,"end":496},"obj":"Body_part"},{"id":"T299","span":{"begin":606,"end":621},"obj":"Body_part"},{"id":"T300","span":{"begin":616,"end":621},"obj":"Body_part"},{"id":"T301","span":{"begin":659,"end":672},"obj":"Body_part"},{"id":"T302","span":{"begin":659,"end":663},"obj":"Body_part"},{"id":"T303","span":{"begin":678,"end":693},"obj":"Body_part"},{"id":"T304","span":{"begin":688,"end":693},"obj":"Body_part"},{"id":"T305","span":{"begin":715,"end":724},"obj":"Body_part"},{"id":"T306","span":{"begin":785,"end":793},"obj":"Body_part"},{"id":"T307","span":{"begin":813,"end":818},"obj":"Body_part"},{"id":"T308","span":{"begin":827,"end":832},"obj":"Body_part"},{"id":"T309","span":{"begin":917,"end":921},"obj":"Body_part"},{"id":"T310","span":{"begin":922,"end":931},"obj":"Body_part"}],"attributes":[{"id":"A294","pred":"fma_id","subj":"T294","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A295","pred":"fma_id","subj":"T295","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A296","pred":"fma_id","subj":"T296","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A297","pred":"fma_id","subj":"T297","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A298","pred":"fma_id","subj":"T298","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A299","pred":"fma_id","subj":"T299","obj":"http://purl.org/sig/ont/fma/fma273565"},{"id":"A300","pred":"fma_id","subj":"T300","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A301","pred":"fma_id","subj":"T301","obj":"http://purl.org/sig/ont/fma/fma63841"},{"id":"A302","pred":"fma_id","subj":"T302","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A303","pred":"fma_id","subj":"T303","obj":"http://purl.org/sig/ont/fma/fma273565"},{"id":"A304","pred":"fma_id","subj":"T304","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A305","pred":"fma_id","subj":"T305","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A306","pred":"fma_id","subj":"T306","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A307","pred":"fma_id","subj":"T307","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A308","pred":"fma_id","subj":"T308","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A309","pred":"fma_id","subj":"T309","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A310","pred":"fma_id","subj":"T310","obj":"http://purl.org/sig/ont/fma/fma63836"},{"subj":"T294","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T295","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T296","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T297","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T298","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T299","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T300","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T301","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T302","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T303","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T304","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T305","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T306","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T307","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T308","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T309","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T310","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T422","span":{"begin":63,"end":68},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T423","span":{"begin":94,"end":95},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T424","span":{"begin":109,"end":110},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T425","span":{"begin":132,"end":133},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T426","span":{"begin":140,"end":145},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T427","span":{"begin":244,"end":245},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T428","span":{"begin":248,"end":249},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T429","span":{"begin":265,"end":269},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T430","span":{"begin":321,"end":329},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T431","span":{"begin":348,"end":353},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T432","span":{"begin":385,"end":389},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T433","span":{"begin":402,"end":410},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T434","span":{"begin":455,"end":460},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T435","span":{"begin":492,"end":496},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T436","span":{"begin":556,"end":561},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T437","span":{"begin":582,"end":587},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T438","span":{"begin":606,"end":621},"obj":"http://purl.obolibrary.org/obo/CL_0000451"},{"id":"T439","span":{"begin":659,"end":663},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T440","span":{"begin":664,"end":672},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T441","span":{"begin":678,"end":693},"obj":"http://purl.obolibrary.org/obo/CL_0000451"},{"id":"T442","span":{"begin":694,"end":699},"obj":"http://purl.obolibrary.org/obo/CLO_0007225"},{"id":"T443","span":{"begin":704,"end":709},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T444","span":{"begin":725,"end":728},"obj":"http://purl.obolibrary.org/obo/PR_000001004"},{"id":"T445","span":{"begin":730,"end":733},"obj":"http://purl.obolibrary.org/obo/CLO_0053438"},{"id":"T446","span":{"begin":794,"end":801},"obj":"http://purl.obolibrary.org/obo/CLO_0007225"},{"id":"T447","span":{"begin":802,"end":807},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T448","span":{"begin":811,"end":818},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T449","span":{"begin":820,"end":826},"obj":"http://purl.obolibrary.org/obo/CLO_0004265"},{"id":"T450","span":{"begin":827,"end":832},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T451","span":{"begin":847,"end":850},"obj":"http://purl.obolibrary.org/obo/PR_000001004"},{"id":"T452","span":{"begin":852,"end":855},"obj":"http://purl.obolibrary.org/obo/CLO_0053438"},{"id":"T453","span":{"begin":857,"end":863},"obj":"http://purl.obolibrary.org/obo/CLO_0007225"},{"id":"T454","span":{"begin":884,"end":889},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T455","span":{"begin":915,"end":921},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T456","span":{"begin":922,"end":931},"obj":"http://purl.obolibrary.org/obo/GO_0005764"}],"attributes":[{"subj":"T422","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T423","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T424","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T425","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T426","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T427","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T428","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T429","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T430","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T431","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T432","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T433","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T434","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T435","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T436","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T437","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T438","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T439","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T440","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T441","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T442","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T443","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T444","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T445","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T446","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T447","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T448","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T449","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T450","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T451","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T452","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T453","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T454","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T455","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T456","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T554","span":{"begin":157,"end":165},"obj":"Chemical"},{"id":"T555","span":{"begin":180,"end":188},"obj":"Chemical"},{"id":"T556","span":{"begin":205,"end":212},"obj":"Chemical"},{"id":"T557","span":{"begin":694,"end":699},"obj":"Chemical"}],"attributes":[{"id":"A554","pred":"chebi_id","subj":"T554","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A555","pred":"chebi_id","subj":"T555","obj":"http://purl.obolibrary.org/obo/CHEBI_59520"},{"id":"A556","pred":"chebi_id","subj":"T556","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A557","pred":"chebi_id","subj":"T557","obj":"http://purl.obolibrary.org/obo/CHEBI_35209"},{"subj":"T554","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T555","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T556","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T557","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T35","span":{"begin":402,"end":417},"obj":"http://purl.obolibrary.org/obo/GO_0061025"},{"id":"T36","span":{"begin":441,"end":453},"obj":"http://purl.obolibrary.org/obo/GO_0006909"},{"id":"T37","span":{"begin":974,"end":985},"obj":"http://purl.obolibrary.org/obo/GO_0009056"}],"attributes":[{"subj":"T35","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T36","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T37","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"1419","span":{"begin":151,"end":156},"obj":"Gene"},{"id":"1420","span":{"begin":180,"end":188},"obj":"Chemical"},{"id":"1421","span":{"begin":279,"end":285},"obj":"Chemical"},{"id":"1422","span":{"begin":313,"end":320},"obj":"Chemical"},{"id":"1423","span":{"begin":354,"end":360},"obj":"Chemical"}],"attributes":[{"id":"A1419","pred":"tao:has_database_id","subj":"1419","obj":"Gene:43740568"},{"id":"A1421","pred":"tao:has_database_id","subj":"1421","obj":"MESH:D011134"},{"id":"A1423","pred":"tao:has_database_id","subj":"1423","obj":"MESH:D011134"},{"subj":"1419","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1420","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1421","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1422","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1423","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T353","span":{"begin":0,"end":79},"obj":"Sentence"},{"id":"T354","span":{"begin":80,"end":135},"obj":"Sentence"},{"id":"T355","span":{"begin":136,"end":247},"obj":"Sentence"},{"id":"T356","span":{"begin":248,"end":343},"obj":"Sentence"},{"id":"T357","span":{"begin":344,"end":486},"obj":"Sentence"},{"id":"T358","span":{"begin":487,"end":577},"obj":"Sentence"},{"id":"T359","span":{"begin":578,"end":673},"obj":"Sentence"},{"id":"T360","span":{"begin":674,"end":824},"obj":"Sentence"},{"id":"T361","span":{"begin":825,"end":937},"obj":"Sentence"},{"id":"T362","span":{"begin":938,"end":1002},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T353","pred":"source","obj":"LitCovid-sentences"},{"subj":"T354","pred":"source","obj":"LitCovid-sentences"},{"subj":"T355","pred":"source","obj":"LitCovid-sentences"},{"subj":"T356","pred":"source","obj":"LitCovid-sentences"},{"subj":"T357","pred":"source","obj":"LitCovid-sentences"},{"subj":"T358","pred":"source","obj":"LitCovid-sentences"},{"subj":"T359","pred":"source","obj":"LitCovid-sentences"},{"subj":"T360","pred":"source","obj":"LitCovid-sentences"},{"subj":"T361","pred":"source","obj":"LitCovid-sentences"},{"subj":"T362","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#9593ec","default":true},{"id":"LitCovid-PD-CLO","color":"#aaec93"},{"id":"LitCovid-PD-CHEBI","color":"#ec93c4"},{"id":"LitCovid-PD-GO-BP","color":"#93deec"},{"id":"LitCovid-PubTator","color":"#ece093"},{"id":"LitCovid-sentences","color":"#c693ec"}]}]}}