PMC:7417788 / 7733-8655 JSONTXT

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T160","span":{"begin":165,"end":171},"obj":"UBERON:0007023"},{"id":"T161","span":{"begin":184,"end":189},"obj":"SO:0002031"},{"id":"T162","span":{"begin":330,"end":336},"obj":"UBERON:0007023"},{"id":"T163","span":{"begin":371,"end":382},"obj":"NCBITaxon:1"},{"id":"T164","span":{"begin":399,"end":405},"obj":"UBERON:0007023"},{"id":"T165","span":{"begin":411,"end":419},"obj":"SP_7"},{"id":"T166","span":{"begin":460,"end":471},"obj":"NCBITaxon:1"},{"id":"T167","span":{"begin":488,"end":494},"obj":"UBERON:0007023"},{"id":"T168","span":{"begin":510,"end":518},"obj":"SP_7"},{"id":"T169","span":{"begin":603,"end":607},"obj":"SO:0000704;GO:0010467"},{"id":"T170","span":{"begin":608,"end":618},"obj":"GO:0010467"},{"id":"T171","span":{"begin":629,"end":634},"obj":"SO:0002031"},{"id":"T172","span":{"begin":758,"end":769},"obj":"GO:0042995"},{"id":"T173","span":{"begin":848,"end":858},"obj":"GO:0010467"},{"id":"T174","span":{"begin":877,"end":881},"obj":"SO:0000704"},{"id":"T91068","span":{"begin":165,"end":171},"obj":"UBERON:0007023"},{"id":"T93824","span":{"begin":184,"end":189},"obj":"SO:0002031"},{"id":"T43880","span":{"begin":330,"end":336},"obj":"UBERON:0007023"},{"id":"T88710","span":{"begin":371,"end":382},"obj":"NCBITaxon:1"},{"id":"T77600","span":{"begin":399,"end":405},"obj":"UBERON:0007023"},{"id":"T75290","span":{"begin":411,"end":419},"obj":"SP_7"},{"id":"T20843","span":{"begin":460,"end":471},"obj":"NCBITaxon:1"},{"id":"T1753","span":{"begin":488,"end":494},"obj":"UBERON:0007023"},{"id":"T77198","span":{"begin":510,"end":518},"obj":"SP_7"},{"id":"T82106","span":{"begin":603,"end":607},"obj":"SO:0000704;GO:0010467"},{"id":"T85334","span":{"begin":608,"end":618},"obj":"GO:0010467"},{"id":"T20103","span":{"begin":629,"end":634},"obj":"SO:0002031"},{"id":"T2266","span":{"begin":758,"end":769},"obj":"GO:0042995"},{"id":"T35696","span":{"begin":848,"end":858},"obj":"GO:0010467"},{"id":"T94423","span":{"begin":877,"end":881},"obj":"SO:0000704"}],"text":"Figure 1 Schematic illustration of the collection and data processing of PBMC from young and aged group. (A) Flowchart overview of PBMC collection in young and aged adults followed by scRNA-seq, mass cytometry, scATAC-seq and scTCR/BCR-seq experiments. (B) Schematic illustration of experimental cohorts; cohort-1: young and aged adults, cohort-2: young and aged healthy individuals, young and aged adults with COVID-19 onset, cohort-3: young and aged healthy individuals, young and aged adults recovered from COVID-19, matched with analysis as indicated: single-cell proteomic data from CyTOF studies, gene expression data from scRNA-seq studies, chromosomal accessibility data from scATAC-seq, and TCR and BCR repertoire data from scTCR/BCR-seq. (C) t-SNE projections of PBMCs derived from scRNA-seq data in cohort-1. (D) Heatmaps showing scaled expression of discriminative gene sets for each cell type and cell subset."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T78","span":{"begin":563,"end":567},"obj":"Body_part"},{"id":"T79","span":{"begin":603,"end":607},"obj":"Body_part"},{"id":"T80","span":{"begin":648,"end":659},"obj":"Body_part"},{"id":"T81","span":{"begin":877,"end":881},"obj":"Body_part"},{"id":"T82","span":{"begin":896,"end":900},"obj":"Body_part"},{"id":"T83","span":{"begin":910,"end":914},"obj":"Body_part"}],"attributes":[{"id":"A78","pred":"fma_id","subj":"T78","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A79","pred":"fma_id","subj":"T79","obj":"http://purl.org/sig/ont/fma/fma74402"},{"id":"A80","pred":"fma_id","subj":"T80","obj":"http://purl.org/sig/ont/fma/fma67093"},{"id":"A81","pred":"fma_id","subj":"T81","obj":"http://purl.org/sig/ont/fma/fma74402"},{"id":"A82","pred":"fma_id","subj":"T82","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A83","pred":"fma_id","subj":"T83","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"Figure 1 Schematic illustration of the collection and data processing of PBMC from young and aged group. (A) Flowchart overview of PBMC collection in young and aged adults followed by scRNA-seq, mass cytometry, scATAC-seq and scTCR/BCR-seq experiments. (B) Schematic illustration of experimental cohorts; cohort-1: young and aged adults, cohort-2: young and aged healthy individuals, young and aged adults with COVID-19 onset, cohort-3: young and aged healthy individuals, young and aged adults recovered from COVID-19, matched with analysis as indicated: single-cell proteomic data from CyTOF studies, gene expression data from scRNA-seq studies, chromosomal accessibility data from scATAC-seq, and TCR and BCR repertoire data from scTCR/BCR-seq. (C) t-SNE projections of PBMCs derived from scRNA-seq data in cohort-1. (D) Heatmaps showing scaled expression of discriminative gene sets for each cell type and cell subset."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T28","span":{"begin":411,"end":419},"obj":"Disease"},{"id":"T29","span":{"begin":510,"end":518},"obj":"Disease"},{"id":"T30","span":{"begin":754,"end":757},"obj":"Disease"}],"attributes":[{"id":"A28","pred":"mondo_id","subj":"T28","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A29","pred":"mondo_id","subj":"T29","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A30","pred":"mondo_id","subj":"T30","obj":"http://purl.obolibrary.org/obo/MONDO_0018859"}],"text":"Figure 1 Schematic illustration of the collection and data processing of PBMC from young and aged group. (A) Flowchart overview of PBMC collection in young and aged adults followed by scRNA-seq, mass cytometry, scATAC-seq and scTCR/BCR-seq experiments. (B) Schematic illustration of experimental cohorts; cohort-1: young and aged adults, cohort-2: young and aged healthy individuals, young and aged adults with COVID-19 onset, cohort-3: young and aged healthy individuals, young and aged adults recovered from COVID-19, matched with analysis as indicated: single-cell proteomic data from CyTOF studies, gene expression data from scRNA-seq studies, chromosomal accessibility data from scATAC-seq, and TCR and BCR repertoire data from scTCR/BCR-seq. (C) t-SNE projections of PBMCs derived from scRNA-seq data in cohort-1. (D) Heatmaps showing scaled expression of discriminative gene sets for each cell type and cell subset."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T119","span":{"begin":106,"end":107},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T120","span":{"begin":254,"end":255},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T121","span":{"begin":563,"end":567},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T122","span":{"begin":603,"end":607},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"},{"id":"T123","span":{"begin":877,"end":881},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"},{"id":"T124","span":{"begin":896,"end":905},"obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"T125","span":{"begin":910,"end":914},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"Figure 1 Schematic illustration of the collection and data processing of PBMC from young and aged group. (A) Flowchart overview of PBMC collection in young and aged adults followed by scRNA-seq, mass cytometry, scATAC-seq and scTCR/BCR-seq experiments. (B) Schematic illustration of experimental cohorts; cohort-1: young and aged adults, cohort-2: young and aged healthy individuals, young and aged adults with COVID-19 onset, cohort-3: young and aged healthy individuals, young and aged adults recovered from COVID-19, matched with analysis as indicated: single-cell proteomic data from CyTOF studies, gene expression data from scRNA-seq studies, chromosomal accessibility data from scATAC-seq, and TCR and BCR repertoire data from scTCR/BCR-seq. (C) t-SNE projections of PBMCs derived from scRNA-seq data in cohort-1. (D) Heatmaps showing scaled expression of discriminative gene sets for each cell type and cell subset."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T15","span":{"begin":98,"end":103},"obj":"Chemical"}],"attributes":[{"id":"A15","pred":"chebi_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/CHEBI_24433"}],"text":"Figure 1 Schematic illustration of the collection and data processing of PBMC from young and aged group. (A) Flowchart overview of PBMC collection in young and aged adults followed by scRNA-seq, mass cytometry, scATAC-seq and scTCR/BCR-seq experiments. (B) Schematic illustration of experimental cohorts; cohort-1: young and aged adults, cohort-2: young and aged healthy individuals, young and aged adults with COVID-19 onset, cohort-3: young and aged healthy individuals, young and aged adults recovered from COVID-19, matched with analysis as indicated: single-cell proteomic data from CyTOF studies, gene expression data from scRNA-seq studies, chromosomal accessibility data from scATAC-seq, and TCR and BCR repertoire data from scTCR/BCR-seq. (C) t-SNE projections of PBMCs derived from scRNA-seq data in cohort-1. (D) Heatmaps showing scaled expression of discriminative gene sets for each cell type and cell subset."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T37","span":{"begin":603,"end":618},"obj":"http://purl.obolibrary.org/obo/GO_0010467"}],"text":"Figure 1 Schematic illustration of the collection and data processing of PBMC from young and aged group. (A) Flowchart overview of PBMC collection in young and aged adults followed by scRNA-seq, mass cytometry, scATAC-seq and scTCR/BCR-seq experiments. (B) Schematic illustration of experimental cohorts; cohort-1: young and aged adults, cohort-2: young and aged healthy individuals, young and aged adults with COVID-19 onset, cohort-3: young and aged healthy individuals, young and aged adults recovered from COVID-19, matched with analysis as indicated: single-cell proteomic data from CyTOF studies, gene expression data from scRNA-seq studies, chromosomal accessibility data from scATAC-seq, and TCR and BCR repertoire data from scTCR/BCR-seq. (C) t-SNE projections of PBMCs derived from scRNA-seq data in cohort-1. (D) Heatmaps showing scaled expression of discriminative gene sets for each cell type and cell subset."}

{"project":"LitCovid-sentences","denotations":[{"id":"T40","span":{"begin":0,"end":922},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Figure 1 Schematic illustration of the collection and data processing of PBMC from young and aged group. (A) Flowchart overview of PBMC collection in young and aged adults followed by scRNA-seq, mass cytometry, scATAC-seq and scTCR/BCR-seq experiments. (B) Schematic illustration of experimental cohorts; cohort-1: young and aged adults, cohort-2: young and aged healthy individuals, young and aged adults with COVID-19 onset, cohort-3: young and aged healthy individuals, young and aged adults recovered from COVID-19, matched with analysis as indicated: single-cell proteomic data from CyTOF studies, gene expression data from scRNA-seq studies, chromosomal accessibility data from scATAC-seq, and TCR and BCR repertoire data from scTCR/BCR-seq. (C) t-SNE projections of PBMCs derived from scRNA-seq data in cohort-1. (D) Heatmaps showing scaled expression of discriminative gene sets for each cell type and cell subset."}

{"project":"LitCovid-PubTator","denotations":[{"id":"80","span":{"begin":700,"end":703},"obj":"Gene"},{"id":"81","span":{"begin":708,"end":711},"obj":"Gene"},{"id":"82","span":{"begin":232,"end":235},"obj":"Gene"},{"id":"83","span":{"begin":739,"end":742},"obj":"Gene"},{"id":"84","span":{"begin":411,"end":419},"obj":"Disease"},{"id":"85","span":{"begin":510,"end":518},"obj":"Disease"}],"attributes":[{"id":"A80","pred":"tao:has_database_id","subj":"80","obj":"Gene:6962"},{"id":"A81","pred":"tao:has_database_id","subj":"81","obj":"Gene:613"},{"id":"A82","pred":"tao:has_database_id","subj":"82","obj":"Gene:613"},{"id":"A83","pred":"tao:has_database_id","subj":"83","obj":"Gene:613"},{"id":"A84","pred":"tao:has_database_id","subj":"84","obj":"MESH:C000657245"},{"id":"A85","pred":"tao:has_database_id","subj":"85","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Figure 1 Schematic illustration of the collection and data processing of PBMC from young and aged group. (A) Flowchart overview of PBMC collection in young and aged adults followed by scRNA-seq, mass cytometry, scATAC-seq and scTCR/BCR-seq experiments. (B) Schematic illustration of experimental cohorts; cohort-1: young and aged adults, cohort-2: young and aged healthy individuals, young and aged adults with COVID-19 onset, cohort-3: young and aged healthy individuals, young and aged adults recovered from COVID-19, matched with analysis as indicated: single-cell proteomic data from CyTOF studies, gene expression data from scRNA-seq studies, chromosomal accessibility data from scATAC-seq, and TCR and BCR repertoire data from scTCR/BCR-seq. (C) t-SNE projections of PBMCs derived from scRNA-seq data in cohort-1. (D) Heatmaps showing scaled expression of discriminative gene sets for each cell type and cell subset."}