PMC:7417788 / 35526-36837 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7417788","sourcedb":"PMC","sourceid":"7417788","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7417788","text":"Figure 5 Abnormal TCR and BCR repertoire during aging. (A) Pie plots showing TCR clone differences across YA and AA groups. (B) Pie plots showing BCR clone differences across YA and AA groups. (C) Percentage of maximum clones between YA (n = 8) and AA groups (n = 8). (D) Diversity of TCR and BCR between YA (n = 8) and AA groups (n = 8). (E) Diversity of TCR in T cell subsets between YA (n = 8) and AA groups (n = 8). (F) Diversity of BCR in B cell subsets between YA (n = 8) and AA groups (n = 8). (G) Volcano plot showing DEGs of clonal T cells between the YA and AA groups. P values were calculated using a paired, two-sided Wilcoxon test and FDR was corrected using the Benjamini-Hochberg procedure. (H) Volcano plot showing DEGs of clonal B cells between the YA and AA groups. P values were calculated using a paired, two-sided Wilcoxon test and FDR was corrected using the Benjamini-Hochberg procedure. (I) Chord diagram showing pairing of V and J segments within the TRB subset from the AA group. Chord widths represent the proportion of sequences with a given V (colored) and J (gray) segment pairing. (J) Chord diagram showing pairing of V and J segments within the IGH subset from the AA group. Chord widths represent the proportion of sequences with a given V (colored) and J (gray) segment pairing","divisions":[{"label":"label","span":{"begin":0,"end":8}}],"tracks":[{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T803","span":{"begin":48,"end":53},"obj":"GO:0007568"},{"id":"T804","span":{"begin":363,"end":369},"obj":"CL:0000084"},{"id":"T805","span":{"begin":444,"end":450},"obj":"CL:0000236"},{"id":"T806","span":{"begin":534,"end":548},"obj":"CL:0000084"},{"id":"T807","span":{"begin":746,"end":753},"obj":"CL:0000236"}],"attributes":[{"subj":"T803","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T804","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T805","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T806","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T807","pred":"source","obj":"LitCovid-PMC-OGER-BB"}]},{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T300","span":{"begin":365,"end":369},"obj":"Body_part"},{"id":"T301","span":{"begin":446,"end":450},"obj":"Body_part"},{"id":"T302","span":{"begin":543,"end":548},"obj":"Body_part"},{"id":"T303","span":{"begin":748,"end":753},"obj":"Body_part"}],"attributes":[{"id":"A300","pred":"fma_id","subj":"T300","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A301","pred":"fma_id","subj":"T301","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A302","pred":"fma_id","subj":"T302","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A303","pred":"fma_id","subj":"T303","obj":"http://purl.org/sig/ont/fma/fma68646"},{"subj":"T300","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T301","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T302","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T303","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T664","span":{"begin":56,"end":57},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T665","span":{"begin":113,"end":115},"obj":"http://purl.obolibrary.org/obo/CLO_0001627"},{"id":"T666","span":{"begin":125,"end":126},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T667","span":{"begin":182,"end":184},"obj":"http://purl.obolibrary.org/obo/CLO_0001627"},{"id":"T668","span":{"begin":249,"end":251},"obj":"http://purl.obolibrary.org/obo/CLO_0001627"},{"id":"T669","span":{"begin":320,"end":322},"obj":"http://purl.obolibrary.org/obo/CLO_0001627"},{"id":"T670","span":{"begin":363,"end":369},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T671","span":{"begin":401,"end":403},"obj":"http://purl.obolibrary.org/obo/CLO_0001627"},{"id":"T672","span":{"begin":444,"end":450},"obj":"http://purl.obolibrary.org/obo/CL_0000236"},{"id":"T673","span":{"begin":482,"end":484},"obj":"http://purl.obolibrary.org/obo/CLO_0001627"},{"id":"T674","span":{"begin":541,"end":548},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T675","span":{"begin":568,"end":570},"obj":"http://purl.obolibrary.org/obo/CLO_0001627"},{"id":"T676","span":{"begin":610,"end":611},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T677","span":{"begin":639,"end":643},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T678","span":{"begin":746,"end":753},"obj":"http://purl.obolibrary.org/obo/CL_0000236"},{"id":"T679","span":{"begin":773,"end":775},"obj":"http://purl.obolibrary.org/obo/CLO_0001627"},{"id":"T680","span":{"begin":815,"end":816},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T681","span":{"begin":844,"end":848},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T682","span":{"begin":915,"end":920},"obj":"http://purl.obolibrary.org/obo/CLO_0050421"},{"id":"T683","span":{"begin":996,"end":998},"obj":"http://purl.obolibrary.org/obo/CLO_0001627"},{"id":"T684","span":{"begin":1006,"end":1011},"obj":"http://purl.obolibrary.org/obo/CLO_0050421"},{"id":"T685","span":{"begin":1062,"end":1063},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T686","span":{"begin":1116,"end":1121},"obj":"http://purl.obolibrary.org/obo/CLO_0050421"},{"id":"T687","span":{"begin":1197,"end":1199},"obj":"http://purl.obolibrary.org/obo/CLO_0001627"},{"id":"T688","span":{"begin":1207,"end":1212},"obj":"http://purl.obolibrary.org/obo/CLO_0050421"},{"id":"T689","span":{"begin":1263,"end":1264},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"attributes":[{"subj":"T664","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T665","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T666","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T667","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T668","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T669","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T670","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T671","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T672","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T673","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T674","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T675","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T676","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T677","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T678","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T679","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T680","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T681","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T682","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T683","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T684","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T685","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T686","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T687","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T688","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T689","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T274","span":{"begin":106,"end":108},"obj":"Chemical"},{"id":"T275","span":{"begin":113,"end":115},"obj":"Chemical"},{"id":"T277","span":{"begin":175,"end":177},"obj":"Chemical"},{"id":"T278","span":{"begin":182,"end":184},"obj":"Chemical"},{"id":"T280","span":{"begin":234,"end":236},"obj":"Chemical"},{"id":"T281","span":{"begin":249,"end":251},"obj":"Chemical"},{"id":"T283","span":{"begin":305,"end":307},"obj":"Chemical"},{"id":"T284","span":{"begin":320,"end":322},"obj":"Chemical"},{"id":"T286","span":{"begin":386,"end":388},"obj":"Chemical"},{"id":"T287","span":{"begin":401,"end":403},"obj":"Chemical"},{"id":"T289","span":{"begin":467,"end":469},"obj":"Chemical"},{"id":"T290","span":{"begin":482,"end":484},"obj":"Chemical"},{"id":"T292","span":{"begin":561,"end":563},"obj":"Chemical"},{"id":"T293","span":{"begin":568,"end":570},"obj":"Chemical"},{"id":"T295","span":{"begin":766,"end":768},"obj":"Chemical"},{"id":"T296","span":{"begin":773,"end":775},"obj":"Chemical"},{"id":"T298","span":{"begin":996,"end":998},"obj":"Chemical"},{"id":"T300","span":{"begin":999,"end":1004},"obj":"Chemical"},{"id":"T301","span":{"begin":1197,"end":1199},"obj":"Chemical"},{"id":"T303","span":{"begin":1200,"end":1205},"obj":"Chemical"}],"attributes":[{"id":"A274","pred":"chebi_id","subj":"T274","obj":"http://purl.obolibrary.org/obo/CHEBI_74879"},{"id":"A275","pred":"chebi_id","subj":"T275","obj":"http://purl.obolibrary.org/obo/CHEBI_15843"},{"id":"A276","pred":"chebi_id","subj":"T275","obj":"http://purl.obolibrary.org/obo/CHEBI_72816"},{"id":"A277","pred":"chebi_id","subj":"T277","obj":"http://purl.obolibrary.org/obo/CHEBI_74879"},{"id":"A278","pred":"chebi_id","subj":"T278","obj":"http://purl.obolibrary.org/obo/CHEBI_15843"},{"id":"A279","pred":"chebi_id","subj":"T278","obj":"http://purl.obolibrary.org/obo/CHEBI_72816"},{"id":"A280","pred":"chebi_id","subj":"T280","obj":"http://purl.obolibrary.org/obo/CHEBI_74879"},{"id":"A281","pred":"chebi_id","subj":"T281","obj":"http://purl.obolibrary.org/obo/CHEBI_15843"},{"id":"A282","pred":"chebi_id","subj":"T281","obj":"http://purl.obolibrary.org/obo/CHEBI_72816"},{"id":"A283","pred":"chebi_id","subj":"T283","obj":"http://purl.obolibrary.org/obo/CHEBI_74879"},{"id":"A284","pred":"chebi_id","subj":"T284","obj":"http://purl.obolibrary.org/obo/CHEBI_15843"},{"id":"A285","pred":"chebi_id","subj":"T284","obj":"http://purl.obolibrary.org/obo/CHEBI_72816"},{"id":"A286","pred":"chebi_id","subj":"T286","obj":"http://purl.obolibrary.org/obo/CHEBI_74879"},{"id":"A287","pred":"chebi_id","subj":"T287","obj":"http://purl.obolibrary.org/obo/CHEBI_15843"},{"id":"A288","pred":"chebi_id","subj":"T287","obj":"http://purl.obolibrary.org/obo/CHEBI_72816"},{"id":"A289","pred":"chebi_id","subj":"T289","obj":"http://purl.obolibrary.org/obo/CHEBI_74879"},{"id":"A290","pred":"chebi_id","subj":"T290","obj":"http://purl.obolibrary.org/obo/CHEBI_15843"},{"id":"A291","pred":"chebi_id","subj":"T290","obj":"http://purl.obolibrary.org/obo/CHEBI_72816"},{"id":"A292","pred":"chebi_id","subj":"T292","obj":"http://purl.obolibrary.org/obo/CHEBI_74879"},{"id":"A293","pred":"chebi_id","subj":"T293","obj":"http://purl.obolibrary.org/obo/CHEBI_15843"},{"id":"A294","pred":"chebi_id","subj":"T293","obj":"http://purl.obolibrary.org/obo/CHEBI_72816"},{"id":"A295","pred":"chebi_id","subj":"T295","obj":"http://purl.obolibrary.org/obo/CHEBI_74879"},{"id":"A296","pred":"chebi_id","subj":"T296","obj":"http://purl.obolibrary.org/obo/CHEBI_15843"},{"id":"A297","pred":"chebi_id","subj":"T296","obj":"http://purl.obolibrary.org/obo/CHEBI_72816"},{"id":"A298","pred":"chebi_id","subj":"T298","obj":"http://purl.obolibrary.org/obo/CHEBI_15843"},{"id":"A299","pred":"chebi_id","subj":"T298","obj":"http://purl.obolibrary.org/obo/CHEBI_72816"},{"id":"A300","pred":"chebi_id","subj":"T300","obj":"http://purl.obolibrary.org/obo/CHEBI_24433"},{"id":"A301","pred":"chebi_id","subj":"T301","obj":"http://purl.obolibrary.org/obo/CHEBI_15843"},{"id":"A302","pred":"chebi_id","subj":"T301","obj":"http://purl.obolibrary.org/obo/CHEBI_72816"},{"id":"A303","pred":"chebi_id","subj":"T303","obj":"http://purl.obolibrary.org/obo/CHEBI_24433"},{"subj":"T274","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T275","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T277","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T278","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T280","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T281","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T283","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T284","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T286","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T287","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T289","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T290","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T292","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T293","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T295","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T296","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T298","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T300","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T301","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T303","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T194","span":{"begin":48,"end":53},"obj":"http://purl.obolibrary.org/obo/GO_0007568"}],"attributes":[{"subj":"T194","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T184","span":{"begin":0,"end":578},"obj":"Sentence"},{"id":"T185","span":{"begin":579,"end":783},"obj":"Sentence"},{"id":"T186","span":{"begin":784,"end":1005},"obj":"Sentence"},{"id":"T187","span":{"begin":1006,"end":1206},"obj":"Sentence"},{"id":"T188","span":{"begin":1207,"end":1311},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T184","pred":"source","obj":"LitCovid-sentences"},{"subj":"T185","pred":"source","obj":"LitCovid-sentences"},{"subj":"T186","pred":"source","obj":"LitCovid-sentences"},{"subj":"T187","pred":"source","obj":"LitCovid-sentences"},{"subj":"T188","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"746","span":{"begin":18,"end":21},"obj":"Gene"},{"id":"747","span":{"begin":26,"end":29},"obj":"Gene"},{"id":"748","span":{"begin":976,"end":979},"obj":"Gene"},{"id":"749","span":{"begin":1177,"end":1180},"obj":"Gene"},{"id":"750","span":{"begin":293,"end":296},"obj":"Gene"},{"id":"751","span":{"begin":437,"end":440},"obj":"Gene"},{"id":"752","span":{"begin":146,"end":149},"obj":"Gene"},{"id":"753","span":{"begin":356,"end":359},"obj":"Gene"},{"id":"754","span":{"begin":285,"end":288},"obj":"Gene"},{"id":"755","span":{"begin":77,"end":80},"obj":"Gene"}],"attributes":[{"id":"A746","pred":"tao:has_database_id","subj":"746","obj":"Gene:6962"},{"id":"A747","pred":"tao:has_database_id","subj":"747","obj":"Gene:613"},{"id":"A748","pred":"tao:has_database_id","subj":"748","obj":"Gene:6957"},{"id":"A749","pred":"tao:has_database_id","subj":"749","obj":"Gene:3492"},{"id":"A750","pred":"tao:has_database_id","subj":"750","obj":"Gene:613"},{"id":"A751","pred":"tao:has_database_id","subj":"751","obj":"Gene:613"},{"id":"A752","pred":"tao:has_database_id","subj":"752","obj":"Gene:613"},{"id":"A753","pred":"tao:has_database_id","subj":"753","obj":"Gene:6962"},{"id":"A754","pred":"tao:has_database_id","subj":"754","obj":"Gene:6962"},{"id":"A755","pred":"tao:has_database_id","subj":"755","obj":"Gene:6962"},{"subj":"746","pred":"source","obj":"LitCovid-PubTator"},{"subj":"747","pred":"source","obj":"LitCovid-PubTator"},{"subj":"748","pred":"source","obj":"LitCovid-PubTator"},{"subj":"749","pred":"source","obj":"LitCovid-PubTator"},{"subj":"750","pred":"source","obj":"LitCovid-PubTator"},{"subj":"751","pred":"source","obj":"LitCovid-PubTator"},{"subj":"752","pred":"source","obj":"LitCovid-PubTator"},{"subj":"753","pred":"source","obj":"LitCovid-PubTator"},{"subj":"754","pred":"source","obj":"LitCovid-PubTator"},{"subj":"755","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PMC-OGER-BB","color":"#ec93d5","default":true},{"id":"LitCovid-PD-FMA-UBERON","color":"#93ece9"},{"id":"LitCovid-PD-CLO","color":"#eccf93"},{"id":"LitCovid-PD-CHEBI","color":"#b593ec"},{"id":"LitCovid-PD-GO-BP","color":"#93ec9b"},{"id":"LitCovid-sentences","color":"#ec93a4"},{"id":"LitCovid-PubTator","color":"#93beec"}]}]}}