PMC:7417788 / 35526-36837 JSON TXT

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LitCovid-PMC-OGER-BB

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T803","span":{"begin":48,"end":53},"obj":"GO:0007568"},{"id":"T804","span":{"begin":363,"end":369},"obj":"CL:0000084"},{"id":"T805","span":{"begin":444,"end":450},"obj":"CL:0000236"},{"id":"T806","span":{"begin":534,"end":548},"obj":"CL:0000084"},{"id":"T807","span":{"begin":746,"end":753},"obj":"CL:0000236"}],"text":"Figure 5 Abnormal TCR and BCR repertoire during aging. (A) Pie plots showing TCR clone differences across YA and AA groups. (B) Pie plots showing BCR clone differences across YA and AA groups. (C) Percentage of maximum clones between YA (n = 8) and AA groups (n = 8). (D) Diversity of TCR and BCR between YA (n = 8) and AA groups (n = 8). (E) Diversity of TCR in T cell subsets between YA (n = 8) and AA groups (n = 8). (F) Diversity of BCR in B cell subsets between YA (n = 8) and AA groups (n = 8). (G) Volcano plot showing DEGs of clonal T cells between the YA and AA groups. P values were calculated using a paired, two-sided Wilcoxon test and FDR was corrected using the Benjamini-Hochberg procedure. (H) Volcano plot showing DEGs of clonal B cells between the YA and AA groups. P values were calculated using a paired, two-sided Wilcoxon test and FDR was corrected using the Benjamini-Hochberg procedure. (I) Chord diagram showing pairing of V and J segments within the TRB subset from the AA group. Chord widths represent the proportion of sequences with a given V (colored) and J (gray) segment pairing. (J) Chord diagram showing pairing of V and J segments within the IGH subset from the AA group. Chord widths represent the proportion of sequences with a given V (colored) and J (gray) segment pairing"}

LitCovid-PD-FMA-UBERON

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T300","span":{"begin":365,"end":369},"obj":"Body_part"},{"id":"T301","span":{"begin":446,"end":450},"obj":"Body_part"},{"id":"T302","span":{"begin":543,"end":548},"obj":"Body_part"},{"id":"T303","span":{"begin":748,"end":753},"obj":"Body_part"}],"attributes":[{"id":"A300","pred":"fma_id","subj":"T300","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A301","pred":"fma_id","subj":"T301","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A302","pred":"fma_id","subj":"T302","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A303","pred":"fma_id","subj":"T303","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"Figure 5 Abnormal TCR and BCR repertoire during aging. (A) Pie plots showing TCR clone differences across YA and AA groups. (B) Pie plots showing BCR clone differences across YA and AA groups. (C) Percentage of maximum clones between YA (n = 8) and AA groups (n = 8). (D) Diversity of TCR and BCR between YA (n = 8) and AA groups (n = 8). (E) Diversity of TCR in T cell subsets between YA (n = 8) and AA groups (n = 8). (F) Diversity of BCR in B cell subsets between YA (n = 8) and AA groups (n = 8). (G) Volcano plot showing DEGs of clonal T cells between the YA and AA groups. P values were calculated using a paired, two-sided Wilcoxon test and FDR was corrected using the Benjamini-Hochberg procedure. (H) Volcano plot showing DEGs of clonal B cells between the YA and AA groups. P values were calculated using a paired, two-sided Wilcoxon test and FDR was corrected using the Benjamini-Hochberg procedure. (I) Chord diagram showing pairing of V and J segments within the TRB subset from the AA group. Chord widths represent the proportion of sequences with a given V (colored) and J (gray) segment pairing. (J) Chord diagram showing pairing of V and J segments within the IGH subset from the AA group. Chord widths represent the proportion of sequences with a given V (colored) and J (gray) segment pairing"}

LitCovid-PD-CLO

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T664","span":{"begin":56,"end":57},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T665","span":{"begin":113,"end":115},"obj":"http://purl.obolibrary.org/obo/CLO_0001627"},{"id":"T666","span":{"begin":125,"end":126},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T667","span":{"begin":182,"end":184},"obj":"http://purl.obolibrary.org/obo/CLO_0001627"},{"id":"T668","span":{"begin":249,"end":251},"obj":"http://purl.obolibrary.org/obo/CLO_0001627"},{"id":"T669","span":{"begin":320,"end":322},"obj":"http://purl.obolibrary.org/obo/CLO_0001627"},{"id":"T670","span":{"begin":363,"end":369},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T671","span":{"begin":401,"end":403},"obj":"http://purl.obolibrary.org/obo/CLO_0001627"},{"id":"T672","span":{"begin":444,"end":450},"obj":"http://purl.obolibrary.org/obo/CL_0000236"},{"id":"T673","span":{"begin":482,"end":484},"obj":"http://purl.obolibrary.org/obo/CLO_0001627"},{"id":"T674","span":{"begin":541,"end":548},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T675","span":{"begin":568,"end":570},"obj":"http://purl.obolibrary.org/obo/CLO_0001627"},{"id":"T676","span":{"begin":610,"end":611},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T677","span":{"begin":639,"end":643},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T678","span":{"begin":746,"end":753},"obj":"http://purl.obolibrary.org/obo/CL_0000236"},{"id":"T679","span":{"begin":773,"end":775},"obj":"http://purl.obolibrary.org/obo/CLO_0001627"},{"id":"T680","span":{"begin":815,"end":816},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T681","span":{"begin":844,"end":848},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T682","span":{"begin":915,"end":920},"obj":"http://purl.obolibrary.org/obo/CLO_0050421"},{"id":"T683","span":{"begin":996,"end":998},"obj":"http://purl.obolibrary.org/obo/CLO_0001627"},{"id":"T684","span":{"begin":1006,"end":1011},"obj":"http://purl.obolibrary.org/obo/CLO_0050421"},{"id":"T685","span":{"begin":1062,"end":1063},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T686","span":{"begin":1116,"end":1121},"obj":"http://purl.obolibrary.org/obo/CLO_0050421"},{"id":"T687","span":{"begin":1197,"end":1199},"obj":"http://purl.obolibrary.org/obo/CLO_0001627"},{"id":"T688","span":{"begin":1207,"end":1212},"obj":"http://purl.obolibrary.org/obo/CLO_0050421"},{"id":"T689","span":{"begin":1263,"end":1264},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"Figure 5 Abnormal TCR and BCR repertoire during aging. (A) Pie plots showing TCR clone differences across YA and AA groups. (B) Pie plots showing BCR clone differences across YA and AA groups. (C) Percentage of maximum clones between YA (n = 8) and AA groups (n = 8). (D) Diversity of TCR and BCR between YA (n = 8) and AA groups (n = 8). (E) Diversity of TCR in T cell subsets between YA (n = 8) and AA groups (n = 8). (F) Diversity of BCR in B cell subsets between YA (n = 8) and AA groups (n = 8). (G) Volcano plot showing DEGs of clonal T cells between the YA and AA groups. P values were calculated using a paired, two-sided Wilcoxon test and FDR was corrected using the Benjamini-Hochberg procedure. (H) Volcano plot showing DEGs of clonal B cells between the YA and AA groups. P values were calculated using a paired, two-sided Wilcoxon test and FDR was corrected using the Benjamini-Hochberg procedure. (I) Chord diagram showing pairing of V and J segments within the TRB subset from the AA group. Chord widths represent the proportion of sequences with a given V (colored) and J (gray) segment pairing. (J) Chord diagram showing pairing of V and J segments within the IGH subset from the AA group. Chord widths represent the proportion of sequences with a given V (colored) and J (gray) segment pairing"}

LitCovid-PD-CHEBI

LitCovid-PD-GO-BP

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T194","span":{"begin":48,"end":53},"obj":"http://purl.obolibrary.org/obo/GO_0007568"}],"text":"Figure 5 Abnormal TCR and BCR repertoire during aging. (A) Pie plots showing TCR clone differences across YA and AA groups. (B) Pie plots showing BCR clone differences across YA and AA groups. (C) Percentage of maximum clones between YA (n = 8) and AA groups (n = 8). (D) Diversity of TCR and BCR between YA (n = 8) and AA groups (n = 8). (E) Diversity of TCR in T cell subsets between YA (n = 8) and AA groups (n = 8). (F) Diversity of BCR in B cell subsets between YA (n = 8) and AA groups (n = 8). (G) Volcano plot showing DEGs of clonal T cells between the YA and AA groups. P values were calculated using a paired, two-sided Wilcoxon test and FDR was corrected using the Benjamini-Hochberg procedure. (H) Volcano plot showing DEGs of clonal B cells between the YA and AA groups. P values were calculated using a paired, two-sided Wilcoxon test and FDR was corrected using the Benjamini-Hochberg procedure. (I) Chord diagram showing pairing of V and J segments within the TRB subset from the AA group. Chord widths represent the proportion of sequences with a given V (colored) and J (gray) segment pairing. (J) Chord diagram showing pairing of V and J segments within the IGH subset from the AA group. Chord widths represent the proportion of sequences with a given V (colored) and J (gray) segment pairing"}

LitCovid-sentences

{"project":"LitCovid-sentences","denotations":[{"id":"T184","span":{"begin":0,"end":578},"obj":"Sentence"},{"id":"T185","span":{"begin":579,"end":783},"obj":"Sentence"},{"id":"T186","span":{"begin":784,"end":1005},"obj":"Sentence"},{"id":"T187","span":{"begin":1006,"end":1206},"obj":"Sentence"},{"id":"T188","span":{"begin":1207,"end":1311},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Figure 5 Abnormal TCR and BCR repertoire during aging. (A) Pie plots showing TCR clone differences across YA and AA groups. (B) Pie plots showing BCR clone differences across YA and AA groups. (C) Percentage of maximum clones between YA (n = 8) and AA groups (n = 8). (D) Diversity of TCR and BCR between YA (n = 8) and AA groups (n = 8). (E) Diversity of TCR in T cell subsets between YA (n = 8) and AA groups (n = 8). (F) Diversity of BCR in B cell subsets between YA (n = 8) and AA groups (n = 8). (G) Volcano plot showing DEGs of clonal T cells between the YA and AA groups. P values were calculated using a paired, two-sided Wilcoxon test and FDR was corrected using the Benjamini-Hochberg procedure. (H) Volcano plot showing DEGs of clonal B cells between the YA and AA groups. P values were calculated using a paired, two-sided Wilcoxon test and FDR was corrected using the Benjamini-Hochberg procedure. (I) Chord diagram showing pairing of V and J segments within the TRB subset from the AA group. Chord widths represent the proportion of sequences with a given V (colored) and J (gray) segment pairing. (J) Chord diagram showing pairing of V and J segments within the IGH subset from the AA group. Chord widths represent the proportion of sequences with a given V (colored) and J (gray) segment pairing"}

LitCovid-PubTator

{"project":"LitCovid-PubTator","denotations":[{"id":"746","span":{"begin":18,"end":21},"obj":"Gene"},{"id":"747","span":{"begin":26,"end":29},"obj":"Gene"},{"id":"748","span":{"begin":976,"end":979},"obj":"Gene"},{"id":"749","span":{"begin":1177,"end":1180},"obj":"Gene"},{"id":"750","span":{"begin":293,"end":296},"obj":"Gene"},{"id":"751","span":{"begin":437,"end":440},"obj":"Gene"},{"id":"752","span":{"begin":146,"end":149},"obj":"Gene"},{"id":"753","span":{"begin":356,"end":359},"obj":"Gene"},{"id":"754","span":{"begin":285,"end":288},"obj":"Gene"},{"id":"755","span":{"begin":77,"end":80},"obj":"Gene"}],"attributes":[{"id":"A746","pred":"tao:has_database_id","subj":"746","obj":"Gene:6962"},{"id":"A747","pred":"tao:has_database_id","subj":"747","obj":"Gene:613"},{"id":"A748","pred":"tao:has_database_id","subj":"748","obj":"Gene:6957"},{"id":"A749","pred":"tao:has_database_id","subj":"749","obj":"Gene:3492"},{"id":"A750","pred":"tao:has_database_id","subj":"750","obj":"Gene:613"},{"id":"A751","pred":"tao:has_database_id","subj":"751","obj":"Gene:613"},{"id":"A752","pred":"tao:has_database_id","subj":"752","obj":"Gene:613"},{"id":"A753","pred":"tao:has_database_id","subj":"753","obj":"Gene:6962"},{"id":"A754","pred":"tao:has_database_id","subj":"754","obj":"Gene:6962"},{"id":"A755","pred":"tao:has_database_id","subj":"755","obj":"Gene:6962"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Figure 5 Abnormal TCR and BCR repertoire during aging. (A) Pie plots showing TCR clone differences across YA and AA groups. (B) Pie plots showing BCR clone differences across YA and AA groups. (C) Percentage of maximum clones between YA (n = 8) and AA groups (n = 8). (D) Diversity of TCR and BCR between YA (n = 8) and AA groups (n = 8). (E) Diversity of TCR in T cell subsets between YA (n = 8) and AA groups (n = 8). (F) Diversity of BCR in B cell subsets between YA (n = 8) and AA groups (n = 8). (G) Volcano plot showing DEGs of clonal T cells between the YA and AA groups. P values were calculated using a paired, two-sided Wilcoxon test and FDR was corrected using the Benjamini-Hochberg procedure. (H) Volcano plot showing DEGs of clonal B cells between the YA and AA groups. P values were calculated using a paired, two-sided Wilcoxon test and FDR was corrected using the Benjamini-Hochberg procedure. (I) Chord diagram showing pairing of V and J segments within the TRB subset from the AA group. Chord widths represent the proportion of sequences with a given V (colored) and J (gray) segment pairing. (J) Chord diagram showing pairing of V and J segments within the IGH subset from the AA group. Chord widths represent the proportion of sequences with a given V (colored) and J (gray) segment pairing"}