PMC:7402624 / 29832-31625 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7402624","sourcedb":"PMC","sourceid":"7402624","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7402624","text":"During acute viral infections or vaccination, PB responses are transiently detectable in the blood and correlate with cTfh responses (40). Comparing the frequency of PB to the frequency of total cTfh or activated cTfh, however, revealed a weak correlation only with activated cTfh (Fig. 4F and fig. S5, B and C). Furthermore, some patients had robust activated cTfh responses but PB frequencies similar to controls, whereas other patients with robust PB responses had relatively low frequencies of activated cTfh (Fig. 4F and fig. S5, B and C). However, there was also an association between PB frequency and CD38+HLA-DR+ or KI67+ CD4 T cells that might reflect a role for non-CXCR5+ CD4 T cell help (fig. S5D), but such a relationship did not exist for the equivalent CD8 T cell populations (fig. S5E). Although ~70% of COVID-19 patients analyzed made antibodies against SARS-CoV2 spike protein (79/111 IgG; 77/115 IgM (44)), antibody levels did not correlate with PB frequencies (Fig. 4G and fig. S5F). The occasional lack of antibody did not appear to be related to immunosuppression in a small number of patients (fig. S5G). The lack of PB correlation with antibody suggests that a proportion of these large PB responses were: i) generated against SARS-CoV2 antigens other than the spike protein or ii) inflammation-driven and perhaps non-specific or low affinity. Notably, anti-SARS-CoV2 IgG and IgM levels correlated with the activated, but not total, cTfh response, suggesting that at least a proportion of cTfh were providing SARS-CoV2-specific help to B cells (Fig. 4, H and I, and fig. S5, H and I). Although defining the precise specificity of the robust PB populations will require future studies, these data suggest that at least some of the PB response is specific for SARS-CoV2.","tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T254","span":{"begin":46,"end":48},"obj":"Body_part"},{"id":"T255","span":{"begin":93,"end":98},"obj":"Body_part"},{"id":"T256","span":{"begin":166,"end":168},"obj":"Body_part"},{"id":"T257","span":{"begin":380,"end":382},"obj":"Body_part"},{"id":"T258","span":{"begin":451,"end":453},"obj":"Body_part"},{"id":"T259","span":{"begin":592,"end":594},"obj":"Body_part"},{"id":"T260","span":{"begin":614,"end":617},"obj":"Body_part"},{"id":"T261","span":{"begin":637,"end":642},"obj":"Body_part"},{"id":"T262","span":{"begin":690,"end":694},"obj":"Body_part"},{"id":"T263","span":{"begin":775,"end":779},"obj":"Body_part"},{"id":"T264","span":{"begin":888,"end":895},"obj":"Body_part"},{"id":"T265","span":{"begin":904,"end":907},"obj":"Body_part"},{"id":"T266","span":{"begin":916,"end":919},"obj":"Body_part"},{"id":"T267","span":{"begin":927,"end":935},"obj":"Body_part"},{"id":"T268","span":{"begin":966,"end":968},"obj":"Body_part"},{"id":"T269","span":{"begin":1028,"end":1036},"obj":"Body_part"},{"id":"T270","span":{"begin":1141,"end":1143},"obj":"Body_part"},{"id":"T271","span":{"begin":1161,"end":1169},"obj":"Body_part"},{"id":"T272","span":{"begin":1212,"end":1214},"obj":"Body_part"},{"id":"T273","span":{"begin":1292,"end":1299},"obj":"Body_part"},{"id":"T274","span":{"begin":1393,"end":1396},"obj":"Body_part"},{"id":"T275","span":{"begin":1401,"end":1404},"obj":"Body_part"},{"id":"T276","span":{"begin":1563,"end":1568},"obj":"Body_part"},{"id":"T277","span":{"begin":1666,"end":1668},"obj":"Body_part"},{"id":"T278","span":{"begin":1755,"end":1757},"obj":"Body_part"}],"attributes":[{"id":"A254","pred":"fma_id","subj":"T254","obj":"http://purl.org/sig/ont/fma/fma84371"},{"id":"A255","pred":"fma_id","subj":"T255","obj":"http://purl.org/sig/ont/fma/fma9670"},{"id":"A256","pred":"fma_id","subj":"T256","obj":"http://purl.org/sig/ont/fma/fma84371"},{"id":"A257","pred":"fma_id","subj":"T257","obj":"http://purl.org/sig/ont/fma/fma84371"},{"id":"A258","pred":"fma_id","subj":"T258","obj":"http://purl.org/sig/ont/fma/fma84371"},{"id":"A259","pred":"fma_id","subj":"T259","obj":"http://purl.org/sig/ont/fma/fma84371"},{"id":"A260","pred":"fma_id","subj":"T260","obj":"http://purl.org/sig/ont/fma/fma84795"},{"id":"A261","pred":"fma_id","subj":"T261","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A262","pred":"fma_id","subj":"T262","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A263","pred":"fma_id","subj":"T263","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A264","pred":"fma_id","subj":"T264","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A265","pred":"fma_id","subj":"T265","obj":"http://purl.org/sig/ont/fma/fma62872"},{"id":"A266","pred":"fma_id","subj":"T266","obj":"http://purl.org/sig/ont/fma/fma62873"},{"id":"A267","pred":"fma_id","subj":"T267","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A268","pred":"fma_id","subj":"T268","obj":"http://purl.org/sig/ont/fma/fma84371"},{"id":"A269","pred":"fma_id","subj":"T269","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A270","pred":"fma_id","subj":"T270","obj":"http://purl.org/sig/ont/fma/fma84371"},{"id":"A271","pred":"fma_id","subj":"T271","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A272","pred":"fma_id","subj":"T272","obj":"http://purl.org/sig/ont/fma/fma84371"},{"id":"A273","pred":"fma_id","subj":"T273","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A274","pred":"fma_id","subj":"T274","obj":"http://purl.org/sig/ont/fma/fma62872"},{"id":"A275","pred":"fma_id","subj":"T275","obj":"http://purl.org/sig/ont/fma/fma62873"},{"id":"A276","pred":"fma_id","subj":"T276","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A277","pred":"fma_id","subj":"T277","obj":"http://purl.org/sig/ont/fma/fma84371"},{"id":"A278","pred":"fma_id","subj":"T278","obj":"http://purl.org/sig/ont/fma/fma84371"},{"subj":"T254","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T255","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T256","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T257","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T258","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T259","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T260","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T261","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T262","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T263","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T264","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T265","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T266","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T267","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T268","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T269","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T270","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T271","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T272","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T273","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T274","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T275","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T276","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T277","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T278","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T14","span":{"begin":93,"end":98},"obj":"Body_part"}],"attributes":[{"id":"A14","pred":"uberon_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"subj":"T14","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"1100","span":{"begin":531,"end":542},"obj":"Gene"},{"id":"1101","span":{"begin":609,"end":613},"obj":"Gene"},{"id":"1102","span":{"begin":631,"end":634},"obj":"Gene"},{"id":"1103","span":{"begin":677,"end":682},"obj":"Gene"},{"id":"1104","span":{"begin":684,"end":687},"obj":"Gene"},{"id":"1105","span":{"begin":769,"end":772},"obj":"Gene"},{"id":"1106","span":{"begin":299,"end":310},"obj":"Gene"},{"id":"1107","span":{"begin":331,"end":339},"obj":"Species"},{"id":"1108","span":{"begin":430,"end":438},"obj":"Species"},{"id":"1109","span":{"begin":830,"end":838},"obj":"Species"},{"id":"1110","span":{"begin":872,"end":881},"obj":"Species"},{"id":"1111","span":{"begin":1108,"end":1116},"obj":"Species"},{"id":"1112","span":{"begin":1534,"end":1543},"obj":"Species"},{"id":"1113","span":{"begin":1783,"end":1792},"obj":"Species"},{"id":"1114","span":{"begin":1252,"end":1261},"obj":"Species"},{"id":"1115","span":{"begin":1383,"end":1392},"obj":"Species"},{"id":"1116","span":{"begin":46,"end":48},"obj":"Chemical"},{"id":"1117","span":{"begin":118,"end":122},"obj":"Chemical"},{"id":"1118","span":{"begin":166,"end":168},"obj":"Chemical"},{"id":"1119","span":{"begin":195,"end":199},"obj":"Chemical"},{"id":"1120","span":{"begin":213,"end":217},"obj":"Chemical"},{"id":"1121","span":{"begin":276,"end":280},"obj":"Chemical"},{"id":"1122","span":{"begin":361,"end":365},"obj":"Chemical"},{"id":"1123","span":{"begin":380,"end":382},"obj":"Chemical"},{"id":"1124","span":{"begin":451,"end":453},"obj":"Chemical"},{"id":"1125","span":{"begin":508,"end":512},"obj":"Chemical"},{"id":"1126","span":{"begin":1458,"end":1462},"obj":"Chemical"},{"id":"1127","span":{"begin":1514,"end":1518},"obj":"Chemical"},{"id":"1128","span":{"begin":1755,"end":1757},"obj":"Chemical"},{"id":"1129","span":{"begin":13,"end":29},"obj":"Disease"},{"id":"1130","span":{"begin":821,"end":829},"obj":"Disease"},{"id":"1131","span":{"begin":1307,"end":1319},"obj":"Disease"}],"attributes":[{"id":"A1100","pred":"tao:has_database_id","subj":"1100","obj":"Gene:6193"},{"id":"A1101","pred":"tao:has_database_id","subj":"1101","obj":"Gene:952"},{"id":"A1102","pred":"tao:has_database_id","subj":"1102","obj":"Gene:920"},{"id":"A1103","pred":"tao:has_database_id","subj":"1103","obj":"Gene:643"},{"id":"A1104","pred":"tao:has_database_id","subj":"1104","obj":"Gene:920"},{"id":"A1105","pred":"tao:has_database_id","subj":"1105","obj":"Gene:925"},{"id":"A1106","pred":"tao:has_database_id","subj":"1106","obj":"Gene:6193"},{"id":"A1107","pred":"tao:has_database_id","subj":"1107","obj":"Tax:9606"},{"id":"A1108","pred":"tao:has_database_id","subj":"1108","obj":"Tax:9606"},{"id":"A1109","pred":"tao:has_database_id","subj":"1109","obj":"Tax:9606"},{"id":"A1110","pred":"tao:has_database_id","subj":"1110","obj":"Tax:2697049"},{"id":"A1111","pred":"tao:has_database_id","subj":"1111","obj":"Tax:9606"},{"id":"A1112","pred":"tao:has_database_id","subj":"1112","obj":"Tax:2697049"},{"id":"A1113","pred":"tao:has_database_id","subj":"1113","obj":"Tax:2697049"},{"id":"A1114","pred":"tao:has_database_id","subj":"1114","obj":"Tax:2697049"},{"id":"A1115","pred":"tao:has_database_id","subj":"1115","obj":"Tax:2697049"},{"id":"A1129","pred":"tao:has_database_id","subj":"1129","obj":"MESH:D001102"},{"id":"A1130","pred":"tao:has_database_id","subj":"1130","obj":"MESH:C000657245"},{"id":"A1131","pred":"tao:has_database_id","subj":"1131","obj":"MESH:D007249"},{"subj":"1100","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1101","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1102","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1103","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1104","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1105","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1106","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1107","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1108","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1109","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1110","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1111","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1112","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1113","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1114","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1115","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1116","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1117","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1118","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1119","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1120","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1121","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1122","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1123","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1124","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1125","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1126","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1127","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1128","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1129","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1130","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1131","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T231","span":{"begin":13,"end":29},"obj":"Disease"},{"id":"T232","span":{"begin":46,"end":48},"obj":"Disease"},{"id":"T233","span":{"begin":166,"end":168},"obj":"Disease"},{"id":"T234","span":{"begin":380,"end":382},"obj":"Disease"},{"id":"T235","span":{"begin":451,"end":453},"obj":"Disease"},{"id":"T236","span":{"begin":592,"end":594},"obj":"Disease"},{"id":"T237","span":{"begin":821,"end":829},"obj":"Disease"},{"id":"T238","span":{"begin":872,"end":876},"obj":"Disease"},{"id":"T239","span":{"begin":966,"end":968},"obj":"Disease"},{"id":"T240","span":{"begin":1141,"end":1143},"obj":"Disease"},{"id":"T241","span":{"begin":1212,"end":1214},"obj":"Disease"},{"id":"T242","span":{"begin":1252,"end":1256},"obj":"Disease"},{"id":"T243","span":{"begin":1307,"end":1319},"obj":"Disease"},{"id":"T244","span":{"begin":1383,"end":1387},"obj":"Disease"},{"id":"T245","span":{"begin":1534,"end":1538},"obj":"Disease"},{"id":"T246","span":{"begin":1666,"end":1668},"obj":"Disease"},{"id":"T247","span":{"begin":1755,"end":1757},"obj":"Disease"},{"id":"T248","span":{"begin":1783,"end":1787},"obj":"Disease"}],"attributes":[{"id":"A231","pred":"mondo_id","subj":"T231","obj":"http://purl.obolibrary.org/obo/MONDO_0005108"},{"id":"A232","pred":"mondo_id","subj":"T232","obj":"http://purl.obolibrary.org/obo/MONDO_0019035"},{"id":"A233","pred":"mondo_id","subj":"T233","obj":"http://purl.obolibrary.org/obo/MONDO_0019035"},{"id":"A234","pred":"mondo_id","subj":"T234","obj":"http://purl.obolibrary.org/obo/MONDO_0019035"},{"id":"A235","pred":"mondo_id","subj":"T235","obj":"http://purl.obolibrary.org/obo/MONDO_0019035"},{"id":"A236","pred":"mondo_id","subj":"T236","obj":"http://purl.obolibrary.org/obo/MONDO_0019035"},{"id":"A237","pred":"mondo_id","subj":"T237","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A238","pred":"mondo_id","subj":"T238","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A239","pred":"mondo_id","subj":"T239","obj":"http://purl.obolibrary.org/obo/MONDO_0019035"},{"id":"A240","pred":"mondo_id","subj":"T240","obj":"http://purl.obolibrary.org/obo/MONDO_0019035"},{"id":"A241","pred":"mondo_id","subj":"T241","obj":"http://purl.obolibrary.org/obo/MONDO_0019035"},{"id":"A242","pred":"mondo_id","subj":"T242","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A243","pred":"mondo_id","subj":"T243","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"},{"id":"A244","pred":"mondo_id","subj":"T244","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A245","pred":"mondo_id","subj":"T245","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A246","pred":"mondo_id","subj":"T246","obj":"http://purl.obolibrary.org/obo/MONDO_0019035"},{"id":"A247","pred":"mondo_id","subj":"T247","obj":"http://purl.obolibrary.org/obo/MONDO_0019035"},{"id":"A248","pred":"mondo_id","subj":"T248","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"subj":"T231","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T232","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T233","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T234","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T235","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T236","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T237","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T238","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T239","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T240","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T241","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T242","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T243","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T244","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T245","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T246","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T247","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T248","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T508","span":{"begin":93,"end":98},"obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"T509","span":{"begin":93,"end":98},"obj":"http://www.ebi.ac.uk/efo/EFO_0000296"},{"id":"T510","span":{"begin":203,"end":212},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T511","span":{"begin":237,"end":238},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T512","span":{"begin":266,"end":275},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T513","span":{"begin":299,"end":301},"obj":"http://purl.obolibrary.org/obo/CLO_0008933"},{"id":"T514","span":{"begin":303,"end":304},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T515","span":{"begin":351,"end":360},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T516","span":{"begin":498,"end":507},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T517","span":{"begin":531,"end":533},"obj":"http://purl.obolibrary.org/obo/CLO_0008933"},{"id":"T518","span":{"begin":535,"end":536},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T519","span":{"begin":609,"end":613},"obj":"http://purl.obolibrary.org/obo/PR_000001408"},{"id":"T520","span":{"begin":631,"end":634},"obj":"http://purl.obolibrary.org/obo/PR_000001004"},{"id":"T521","span":{"begin":635,"end":642},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T522","span":{"begin":662,"end":663},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T523","span":{"begin":684,"end":687},"obj":"http://purl.obolibrary.org/obo/PR_000001004"},{"id":"T524","span":{"begin":688,"end":694},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T525","span":{"begin":721,"end":722},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T526","span":{"begin":769,"end":772},"obj":"http://purl.obolibrary.org/obo/CLO_0053438"},{"id":"T527","span":{"begin":773,"end":779},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T528","span":{"begin":1090,"end":1091},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T529","span":{"begin":1184,"end":1185},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T530","span":{"begin":1432,"end":1441},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T531","span":{"begin":1498,"end":1499},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T532","span":{"begin":1561,"end":1568},"obj":"http://purl.obolibrary.org/obo/CL_0000236"},{"id":"T533","span":{"begin":1596,"end":1598},"obj":"http://purl.obolibrary.org/obo/CLO_0008933"}],"attributes":[{"subj":"T508","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T509","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T510","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T511","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T512","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T513","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T514","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T515","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T516","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T517","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T518","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T519","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T520","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T521","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T522","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T523","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T524","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T525","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T526","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T527","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T528","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T529","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T530","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T531","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T532","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T533","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T202","span":{"begin":46,"end":48},"obj":"Chemical"},{"id":"T204","span":{"begin":166,"end":168},"obj":"Chemical"},{"id":"T206","span":{"begin":299,"end":301},"obj":"Chemical"},{"id":"T207","span":{"begin":380,"end":382},"obj":"Chemical"},{"id":"T209","span":{"begin":451,"end":453},"obj":"Chemical"},{"id":"T211","span":{"begin":531,"end":533},"obj":"Chemical"},{"id":"T212","span":{"begin":592,"end":594},"obj":"Chemical"},{"id":"T214","span":{"begin":618,"end":620},"obj":"Chemical"},{"id":"T215","span":{"begin":888,"end":895},"obj":"Chemical"},{"id":"T216","span":{"begin":966,"end":968},"obj":"Chemical"},{"id":"T218","span":{"begin":1141,"end":1143},"obj":"Chemical"},{"id":"T220","span":{"begin":1212,"end":1214},"obj":"Chemical"},{"id":"T222","span":{"begin":1262,"end":1270},"obj":"Chemical"},{"id":"T223","span":{"begin":1292,"end":1299},"obj":"Chemical"},{"id":"T224","span":{"begin":1596,"end":1598},"obj":"Chemical"},{"id":"T225","span":{"begin":1666,"end":1668},"obj":"Chemical"},{"id":"T227","span":{"begin":1755,"end":1757},"obj":"Chemical"}],"attributes":[{"id":"A202","pred":"chebi_id","subj":"T202","obj":"http://purl.obolibrary.org/obo/CHEBI_53319"},{"id":"A203","pred":"chebi_id","subj":"T202","obj":"http://purl.obolibrary.org/obo/CHEBI_60686"},{"id":"A204","pred":"chebi_id","subj":"T204","obj":"http://purl.obolibrary.org/obo/CHEBI_53319"},{"id":"A205","pred":"chebi_id","subj":"T204","obj":"http://purl.obolibrary.org/obo/CHEBI_60686"},{"id":"A206","pred":"chebi_id","subj":"T206","obj":"http://purl.obolibrary.org/obo/CHEBI_29386"},{"id":"A207","pred":"chebi_id","subj":"T207","obj":"http://purl.obolibrary.org/obo/CHEBI_53319"},{"id":"A208","pred":"chebi_id","subj":"T207","obj":"http://purl.obolibrary.org/obo/CHEBI_60686"},{"id":"A209","pred":"chebi_id","subj":"T209","obj":"http://purl.obolibrary.org/obo/CHEBI_53319"},{"id":"A210","pred":"chebi_id","subj":"T209","obj":"http://purl.obolibrary.org/obo/CHEBI_60686"},{"id":"A211","pred":"chebi_id","subj":"T211","obj":"http://purl.obolibrary.org/obo/CHEBI_29386"},{"id":"A212","pred":"chebi_id","subj":"T212","obj":"http://purl.obolibrary.org/obo/CHEBI_53319"},{"id":"A213","pred":"chebi_id","subj":"T212","obj":"http://purl.obolibrary.org/obo/CHEBI_60686"},{"id":"A214","pred":"chebi_id","subj":"T214","obj":"http://purl.obolibrary.org/obo/CHEBI_73445"},{"id":"A215","pred":"chebi_id","subj":"T215","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A216","pred":"chebi_id","subj":"T216","obj":"http://purl.obolibrary.org/obo/CHEBI_53319"},{"id":"A217","pred":"chebi_id","subj":"T216","obj":"http://purl.obolibrary.org/obo/CHEBI_60686"},{"id":"A218","pred":"chebi_id","subj":"T218","obj":"http://purl.obolibrary.org/obo/CHEBI_53319"},{"id":"A219","pred":"chebi_id","subj":"T218","obj":"http://purl.obolibrary.org/obo/CHEBI_60686"},{"id":"A220","pred":"chebi_id","subj":"T220","obj":"http://purl.obolibrary.org/obo/CHEBI_53319"},{"id":"A221","pred":"chebi_id","subj":"T220","obj":"http://purl.obolibrary.org/obo/CHEBI_60686"},{"id":"A222","pred":"chebi_id","subj":"T222","obj":"http://purl.obolibrary.org/obo/CHEBI_59132"},{"id":"A223","pred":"chebi_id","subj":"T223","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A224","pred":"chebi_id","subj":"T224","obj":"http://purl.obolibrary.org/obo/CHEBI_29386"},{"id":"A225","pred":"chebi_id","subj":"T225","obj":"http://purl.obolibrary.org/obo/CHEBI_53319"},{"id":"A226","pred":"chebi_id","subj":"T225","obj":"http://purl.obolibrary.org/obo/CHEBI_60686"},{"id":"A227","pred":"chebi_id","subj":"T227","obj":"http://purl.obolibrary.org/obo/CHEBI_53319"},{"id":"A228","pred":"chebi_id","subj":"T227","obj":"http://purl.obolibrary.org/obo/CHEBI_60686"},{"subj":"T202","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T204","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T206","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T207","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T209","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T211","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T212","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T214","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T215","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T216","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T218","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T220","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T222","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T223","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T224","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T225","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T227","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T66","span":{"begin":13,"end":29},"obj":"http://purl.obolibrary.org/obo/GO_0016032"},{"id":"T67","span":{"begin":1307,"end":1319},"obj":"http://purl.obolibrary.org/obo/GO_0006954"}],"attributes":[{"subj":"T66","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T67","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T174","span":{"begin":0,"end":138},"obj":"Sentence"},{"id":"T175","span":{"begin":139,"end":312},"obj":"Sentence"},{"id":"T176","span":{"begin":313,"end":544},"obj":"Sentence"},{"id":"T177","span":{"begin":545,"end":803},"obj":"Sentence"},{"id":"T178","span":{"begin":804,"end":1004},"obj":"Sentence"},{"id":"T179","span":{"begin":1005,"end":1128},"obj":"Sentence"},{"id":"T180","span":{"begin":1129,"end":1368},"obj":"Sentence"},{"id":"T181","span":{"begin":1369,"end":1609},"obj":"Sentence"},{"id":"T182","span":{"begin":1610,"end":1793},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T174","pred":"source","obj":"LitCovid-sentences"},{"subj":"T175","pred":"source","obj":"LitCovid-sentences"},{"subj":"T176","pred":"source","obj":"LitCovid-sentences"},{"subj":"T177","pred":"source","obj":"LitCovid-sentences"},{"subj":"T178","pred":"source","obj":"LitCovid-sentences"},{"subj":"T179","pred":"source","obj":"LitCovid-sentences"},{"subj":"T180","pred":"source","obj":"LitCovid-sentences"},{"subj":"T181","pred":"source","obj":"LitCovid-sentences"},{"subj":"T182","pred":"source","obj":"LitCovid-sentences"}]},{"project":"2_test","denotations":[{"id":"32669297-28620653-135105210","span":{"begin":134,"end":136},"obj":"28620653"}],"attributes":[{"subj":"32669297-28620653-135105210","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#a593ec","default":true},{"id":"LitCovid-PD-UBERON","color":"#9aec93"},{"id":"LitCovid-PubTator","color":"#ec93b4"},{"id":"LitCovid-PD-MONDO","color":"#93ceec"},{"id":"LitCovid-PD-CLO","color":"#e8ec93"},{"id":"LitCovid-PD-CHEBI","color":"#d693ec"},{"id":"LitCovid-PD-GO-BP","color":"#93ecbc"},{"id":"LitCovid-sentences","color":"#eca293"},{"id":"2_test","color":"#939eec"}]}]}}