PMC:7388103 / 1444-2630 JSONTXT

{"project":"LitCovid_Glycan-Motif-Structure","denotations":[{"id":"T11","span":{"begin":696,"end":703},"obj":"https://glytoucan.org/Structures/Glycans/G00021MO"},{"id":"T12","span":{"begin":696,"end":703},"obj":"https://glytoucan.org/Structures/Glycans/G54161DR"},{"id":"T13","span":{"begin":914,"end":921},"obj":"https://glytoucan.org/Structures/Glycans/G00021MO"},{"id":"T14","span":{"begin":914,"end":921},"obj":"https://glytoucan.org/Structures/Glycans/G54161DR"}],"text":"Introduction\nAn outbreak of novel coronavirus (2019-nCoV) that began in Wuhan, China, is now a major public health concern worldwide. After the first reported case in the state of Washington, the number of cases in the United States has rapidly increased to over 2 000 000 with more than 100 000 deaths.1 In addition to the typical presentation of respiratory symptoms, hematologic complications have been a significant concern in these patients.\nThrombocytopenia has been reported in up to 55% of patients with COVID-19.2 A meta-analysis of 9 studies has shown that platelet counts were significantly lower in those with more severe COVID-19 infection, and thrombocytopenia predicts mortality.2 Heparin-induced thrombocytopenia (HIT) is a differential for thrombocytopenia, especially in the intensive care setting. In one review, the authors suggested that clinicians routinely evaluate all COVID-19 patients on heparin for indices of HIT by performing the 4T score.3 We report a case of HIT in a patient with critical COVID-19 infection. Also, we briefly describe 4 other cases that were initially managed as HIT, until proven later not to be true HIT, based on the functional assay."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T12","span":{"begin":567,"end":575},"obj":"Body_part"},{"id":"T13","span":{"begin":696,"end":703},"obj":"Body_part"},{"id":"T14","span":{"begin":914,"end":921},"obj":"Body_part"}],"attributes":[{"id":"A12","pred":"fma_id","subj":"T12","obj":"http://purl.org/sig/ont/fma/fma62851"},{"id":"A13","pred":"fma_id","subj":"T13","obj":"http://purl.org/sig/ont/fma/fma82839"},{"id":"A14","pred":"fma_id","subj":"T14","obj":"http://purl.org/sig/ont/fma/fma82839"}],"text":"Introduction\nAn outbreak of novel coronavirus (2019-nCoV) that began in Wuhan, China, is now a major public health concern worldwide. After the first reported case in the state of Washington, the number of cases in the United States has rapidly increased to over 2 000 000 with more than 100 000 deaths.1 In addition to the typical presentation of respiratory symptoms, hematologic complications have been a significant concern in these patients.\nThrombocytopenia has been reported in up to 55% of patients with COVID-19.2 A meta-analysis of 9 studies has shown that platelet counts were significantly lower in those with more severe COVID-19 infection, and thrombocytopenia predicts mortality.2 Heparin-induced thrombocytopenia (HIT) is a differential for thrombocytopenia, especially in the intensive care setting. In one review, the authors suggested that clinicians routinely evaluate all COVID-19 patients on heparin for indices of HIT by performing the 4T score.3 We report a case of HIT in a patient with critical COVID-19 infection. Also, we briefly describe 4 other cases that were initially managed as HIT, until proven later not to be true HIT, based on the functional assay."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T25","span":{"begin":447,"end":463},"obj":"Disease"},{"id":"T26","span":{"begin":634,"end":642},"obj":"Disease"},{"id":"T27","span":{"begin":643,"end":652},"obj":"Disease"},{"id":"T28","span":{"begin":658,"end":674},"obj":"Disease"},{"id":"T29","span":{"begin":696,"end":728},"obj":"Disease"},{"id":"T30","span":{"begin":712,"end":728},"obj":"Disease"},{"id":"T31","span":{"begin":730,"end":733},"obj":"Disease"},{"id":"T32","span":{"begin":757,"end":773},"obj":"Disease"},{"id":"T33","span":{"begin":893,"end":901},"obj":"Disease"},{"id":"T34","span":{"begin":937,"end":940},"obj":"Disease"},{"id":"T35","span":{"begin":990,"end":993},"obj":"Disease"},{"id":"T36","span":{"begin":1021,"end":1029},"obj":"Disease"},{"id":"T37","span":{"begin":1030,"end":1039},"obj":"Disease"},{"id":"T38","span":{"begin":1112,"end":1115},"obj":"Disease"},{"id":"T39","span":{"begin":1151,"end":1154},"obj":"Disease"}],"attributes":[{"id":"A25","pred":"mondo_id","subj":"T25","obj":"http://purl.obolibrary.org/obo/MONDO_0002049"},{"id":"A26","pred":"mondo_id","subj":"T26","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A27","pred":"mondo_id","subj":"T27","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A28","pred":"mondo_id","subj":"T28","obj":"http://purl.obolibrary.org/obo/MONDO_0002049"},{"id":"A29","pred":"mondo_id","subj":"T29","obj":"http://purl.obolibrary.org/obo/MONDO_0018048"},{"id":"A30","pred":"mondo_id","subj":"T30","obj":"http://purl.obolibrary.org/obo/MONDO_0002049"},{"id":"A31","pred":"mondo_id","subj":"T31","obj":"http://purl.obolibrary.org/obo/MONDO_0018048"},{"id":"A32","pred":"mondo_id","subj":"T32","obj":"http://purl.obolibrary.org/obo/MONDO_0002049"},{"id":"A33","pred":"mondo_id","subj":"T33","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A34","pred":"mondo_id","subj":"T34","obj":"http://purl.obolibrary.org/obo/MONDO_0018048"},{"id":"A35","pred":"mondo_id","subj":"T35","obj":"http://purl.obolibrary.org/obo/MONDO_0018048"},{"id":"A36","pred":"mondo_id","subj":"T36","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A37","pred":"mondo_id","subj":"T37","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A38","pred":"mondo_id","subj":"T38","obj":"http://purl.obolibrary.org/obo/MONDO_0018048"},{"id":"A39","pred":"mondo_id","subj":"T39","obj":"http://purl.obolibrary.org/obo/MONDO_0018048"}],"text":"Introduction\nAn outbreak of novel coronavirus (2019-nCoV) that began in Wuhan, China, is now a major public health concern worldwide. After the first reported case in the state of Washington, the number of cases in the United States has rapidly increased to over 2 000 000 with more than 100 000 deaths.1 In addition to the typical presentation of respiratory symptoms, hematologic complications have been a significant concern in these patients.\nThrombocytopenia has been reported in up to 55% of patients with COVID-19.2 A meta-analysis of 9 studies has shown that platelet counts were significantly lower in those with more severe COVID-19 infection, and thrombocytopenia predicts mortality.2 Heparin-induced thrombocytopenia (HIT) is a differential for thrombocytopenia, especially in the intensive care setting. In one review, the authors suggested that clinicians routinely evaluate all COVID-19 patients on heparin for indices of HIT by performing the 4T score.3 We report a case of HIT in a patient with critical COVID-19 infection. Also, we briefly describe 4 other cases that were initially managed as HIT, until proven later not to be true HIT, based on the functional assay."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T20","span":{"begin":93,"end":94},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T21","span":{"begin":233,"end":236},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T22","span":{"begin":406,"end":407},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T23","span":{"begin":464,"end":467},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T24","span":{"begin":523,"end":524},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T25","span":{"begin":552,"end":555},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T26","span":{"begin":738,"end":739},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T27","span":{"begin":980,"end":981},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T28","span":{"begin":997,"end":998},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"Introduction\nAn outbreak of novel coronavirus (2019-nCoV) that began in Wuhan, China, is now a major public health concern worldwide. After the first reported case in the state of Washington, the number of cases in the United States has rapidly increased to over 2 000 000 with more than 100 000 deaths.1 In addition to the typical presentation of respiratory symptoms, hematologic complications have been a significant concern in these patients.\nThrombocytopenia has been reported in up to 55% of patients with COVID-19.2 A meta-analysis of 9 studies has shown that platelet counts were significantly lower in those with more severe COVID-19 infection, and thrombocytopenia predicts mortality.2 Heparin-induced thrombocytopenia (HIT) is a differential for thrombocytopenia, especially in the intensive care setting. In one review, the authors suggested that clinicians routinely evaluate all COVID-19 patients on heparin for indices of HIT by performing the 4T score.3 We report a case of HIT in a patient with critical COVID-19 infection. Also, we briefly describe 4 other cases that were initially managed as HIT, until proven later not to be true HIT, based on the functional assay."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T10","span":{"begin":696,"end":703},"obj":"Chemical"},{"id":"T11","span":{"begin":914,"end":921},"obj":"Chemical"}],"attributes":[{"id":"A10","pred":"chebi_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/CHEBI_28304"},{"id":"A11","pred":"chebi_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/CHEBI_28304"}],"text":"Introduction\nAn outbreak of novel coronavirus (2019-nCoV) that began in Wuhan, China, is now a major public health concern worldwide. After the first reported case in the state of Washington, the number of cases in the United States has rapidly increased to over 2 000 000 with more than 100 000 deaths.1 In addition to the typical presentation of respiratory symptoms, hematologic complications have been a significant concern in these patients.\nThrombocytopenia has been reported in up to 55% of patients with COVID-19.2 A meta-analysis of 9 studies has shown that platelet counts were significantly lower in those with more severe COVID-19 infection, and thrombocytopenia predicts mortality.2 Heparin-induced thrombocytopenia (HIT) is a differential for thrombocytopenia, especially in the intensive care setting. In one review, the authors suggested that clinicians routinely evaluate all COVID-19 patients on heparin for indices of HIT by performing the 4T score.3 We report a case of HIT in a patient with critical COVID-19 infection. Also, we briefly describe 4 other cases that were initially managed as HIT, until proven later not to be true HIT, based on the functional assay."}

{"project":"LitCovid-sentences","denotations":[{"id":"T17","span":{"begin":0,"end":12},"obj":"Sentence"},{"id":"T18","span":{"begin":13,"end":133},"obj":"Sentence"},{"id":"T19","span":{"begin":134,"end":446},"obj":"Sentence"},{"id":"T20","span":{"begin":447,"end":816},"obj":"Sentence"},{"id":"T21","span":{"begin":817,"end":1040},"obj":"Sentence"},{"id":"T22","span":{"begin":1041,"end":1186},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Introduction\nAn outbreak of novel coronavirus (2019-nCoV) that began in Wuhan, China, is now a major public health concern worldwide. After the first reported case in the state of Washington, the number of cases in the United States has rapidly increased to over 2 000 000 with more than 100 000 deaths.1 In addition to the typical presentation of respiratory symptoms, hematologic complications have been a significant concern in these patients.\nThrombocytopenia has been reported in up to 55% of patients with COVID-19.2 A meta-analysis of 9 studies has shown that platelet counts were significantly lower in those with more severe COVID-19 infection, and thrombocytopenia predicts mortality.2 Heparin-induced thrombocytopenia (HIT) is a differential for thrombocytopenia, especially in the intensive care setting. In one review, the authors suggested that clinicians routinely evaluate all COVID-19 patients on heparin for indices of HIT by performing the 4T score.3 We report a case of HIT in a patient with critical COVID-19 infection. Also, we briefly describe 4 other cases that were initially managed as HIT, until proven later not to be true HIT, based on the functional assay."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T14","span":{"begin":447,"end":463},"obj":"Phenotype"},{"id":"T15","span":{"begin":658,"end":674},"obj":"Phenotype"},{"id":"T16","span":{"begin":696,"end":728},"obj":"Phenotype"},{"id":"T17","span":{"begin":730,"end":733},"obj":"Phenotype"},{"id":"T18","span":{"begin":757,"end":773},"obj":"Phenotype"},{"id":"T19","span":{"begin":937,"end":940},"obj":"Phenotype"},{"id":"T20","span":{"begin":990,"end":993},"obj":"Phenotype"},{"id":"T21","span":{"begin":1112,"end":1115},"obj":"Phenotype"},{"id":"T22","span":{"begin":1151,"end":1154},"obj":"Phenotype"}],"attributes":[{"id":"A14","pred":"hp_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/HP_0001873"},{"id":"A15","pred":"hp_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/HP_0001873"},{"id":"A16","pred":"hp_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/HP_0011874"},{"id":"A17","pred":"hp_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/HP_0011874"},{"id":"A18","pred":"hp_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/HP_0001873"},{"id":"A19","pred":"hp_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/HP_0011874"},{"id":"A20","pred":"hp_id","subj":"T20","obj":"http://purl.obolibrary.org/obo/HP_0011874"},{"id":"A21","pred":"hp_id","subj":"T21","obj":"http://purl.obolibrary.org/obo/HP_0011874"},{"id":"A22","pred":"hp_id","subj":"T22","obj":"http://purl.obolibrary.org/obo/HP_0011874"}],"text":"Introduction\nAn outbreak of novel coronavirus (2019-nCoV) that began in Wuhan, China, is now a major public health concern worldwide. After the first reported case in the state of Washington, the number of cases in the United States has rapidly increased to over 2 000 000 with more than 100 000 deaths.1 In addition to the typical presentation of respiratory symptoms, hematologic complications have been a significant concern in these patients.\nThrombocytopenia has been reported in up to 55% of patients with COVID-19.2 A meta-analysis of 9 studies has shown that platelet counts were significantly lower in those with more severe COVID-19 infection, and thrombocytopenia predicts mortality.2 Heparin-induced thrombocytopenia (HIT) is a differential for thrombocytopenia, especially in the intensive care setting. In one review, the authors suggested that clinicians routinely evaluate all COVID-19 patients on heparin for indices of HIT by performing the 4T score.3 We report a case of HIT in a patient with critical COVID-19 infection. Also, we briefly describe 4 other cases that were initially managed as HIT, until proven later not to be true HIT, based on the functional assay."}

{"project":"LitCovid-PubTator","denotations":[{"id":"61","span":{"begin":28,"end":45},"obj":"Species"},{"id":"62","span":{"begin":47,"end":56},"obj":"Species"},{"id":"63","span":{"begin":437,"end":445},"obj":"Species"},{"id":"64","span":{"begin":296,"end":302},"obj":"Disease"},{"id":"65","span":{"begin":348,"end":368},"obj":"Disease"},{"id":"87","span":{"begin":498,"end":506},"obj":"Species"},{"id":"88","span":{"begin":902,"end":910},"obj":"Species"},{"id":"89","span":{"begin":999,"end":1006},"obj":"Species"},{"id":"90","span":{"begin":696,"end":703},"obj":"Chemical"},{"id":"91","span":{"begin":914,"end":921},"obj":"Chemical"},{"id":"92","span":{"begin":447,"end":463},"obj":"Disease"},{"id":"93","span":{"begin":512,"end":520},"obj":"Disease"},{"id":"94","span":{"begin":634,"end":642},"obj":"Disease"},{"id":"95","span":{"begin":643,"end":652},"obj":"Disease"},{"id":"96","span":{"begin":658,"end":674},"obj":"Disease"},{"id":"97","span":{"begin":684,"end":693},"obj":"Disease"},{"id":"98","span":{"begin":712,"end":728},"obj":"Disease"},{"id":"99","span":{"begin":730,"end":733},"obj":"Disease"},{"id":"100","span":{"begin":757,"end":773},"obj":"Disease"},{"id":"101","span":{"begin":893,"end":901},"obj":"Disease"},{"id":"102","span":{"begin":937,"end":940},"obj":"Disease"},{"id":"103","span":{"begin":990,"end":993},"obj":"Disease"},{"id":"104","span":{"begin":1021,"end":1029},"obj":"Disease"},{"id":"105","span":{"begin":1030,"end":1039},"obj":"Disease"},{"id":"106","span":{"begin":1112,"end":1115},"obj":"Disease"},{"id":"107","span":{"begin":1151,"end":1154},"obj":"Disease"}],"attributes":[{"id":"A61","pred":"tao:has_database_id","subj":"61","obj":"Tax:2697049"},{"id":"A62","pred":"tao:has_database_id","subj":"62","obj":"Tax:2697049"},{"id":"A63","pred":"tao:has_database_id","subj":"63","obj":"Tax:9606"},{"id":"A64","pred":"tao:has_database_id","subj":"64","obj":"MESH:D003643"},{"id":"A65","pred":"tao:has_database_id","subj":"65","obj":"MESH:D012818"},{"id":"A87","pred":"tao:has_database_id","subj":"87","obj":"Tax:9606"},{"id":"A88","pred":"tao:has_database_id","subj":"88","obj":"Tax:9606"},{"id":"A89","pred":"tao:has_database_id","subj":"89","obj":"Tax:9606"},{"id":"A90","pred":"tao:has_database_id","subj":"90","obj":"MESH:D006493"},{"id":"A91","pred":"tao:has_database_id","subj":"91","obj":"MESH:D006493"},{"id":"A92","pred":"tao:has_database_id","subj":"92","obj":"MESH:D013921"},{"id":"A93","pred":"tao:has_database_id","subj":"93","obj":"MESH:C000657245"},{"id":"A94","pred":"tao:has_database_id","subj":"94","obj":"MESH:C000657245"},{"id":"A95","pred":"tao:has_database_id","subj":"95","obj":"MESH:D007239"},{"id":"A96","pred":"tao:has_database_id","subj":"96","obj":"MESH:D013921"},{"id":"A97","pred":"tao:has_database_id","subj":"97","obj":"MESH:D003643"},{"id":"A98","pred":"tao:has_database_id","subj":"98","obj":"MESH:D013921"},{"id":"A99","pred":"tao:has_database_id","subj":"99","obj":"MESH:D013921"},{"id":"A100","pred":"tao:has_database_id","subj":"100","obj":"MESH:D013921"},{"id":"A101","pred":"tao:has_database_id","subj":"101","obj":"MESH:C000657245"},{"id":"A102","pred":"tao:has_database_id","subj":"102","obj":"MESH:D013921"},{"id":"A103","pred":"tao:has_database_id","subj":"103","obj":"MESH:D013921"},{"id":"A104","pred":"tao:has_database_id","subj":"104","obj":"MESH:C000657245"},{"id":"A105","pred":"tao:has_database_id","subj":"105","obj":"MESH:D007239"},{"id":"A106","pred":"tao:has_database_id","subj":"106","obj":"MESH:D013921"},{"id":"A107","pred":"tao:has_database_id","subj":"107","obj":"MESH:D013921"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Introduction\nAn outbreak of novel coronavirus (2019-nCoV) that began in Wuhan, China, is now a major public health concern worldwide. After the first reported case in the state of Washington, the number of cases in the United States has rapidly increased to over 2 000 000 with more than 100 000 deaths.1 In addition to the typical presentation of respiratory symptoms, hematologic complications have been a significant concern in these patients.\nThrombocytopenia has been reported in up to 55% of patients with COVID-19.2 A meta-analysis of 9 studies has shown that platelet counts were significantly lower in those with more severe COVID-19 infection, and thrombocytopenia predicts mortality.2 Heparin-induced thrombocytopenia (HIT) is a differential for thrombocytopenia, especially in the intensive care setting. In one review, the authors suggested that clinicians routinely evaluate all COVID-19 patients on heparin for indices of HIT by performing the 4T score.3 We report a case of HIT in a patient with critical COVID-19 infection. Also, we briefly describe 4 other cases that were initially managed as HIT, until proven later not to be true HIT, based on the functional assay."}

{"project":"2_test","denotations":[{"id":"32720827-32178975-61488848","span":{"begin":521,"end":522},"obj":"32178975"},{"id":"32720827-32178975-61488849","span":{"begin":694,"end":695},"obj":"32178975"},{"id":"32720827-32282949-61488850","span":{"begin":968,"end":969},"obj":"32282949"}],"text":"Introduction\nAn outbreak of novel coronavirus (2019-nCoV) that began in Wuhan, China, is now a major public health concern worldwide. After the first reported case in the state of Washington, the number of cases in the United States has rapidly increased to over 2 000 000 with more than 100 000 deaths.1 In addition to the typical presentation of respiratory symptoms, hematologic complications have been a significant concern in these patients.\nThrombocytopenia has been reported in up to 55% of patients with COVID-19.2 A meta-analysis of 9 studies has shown that platelet counts were significantly lower in those with more severe COVID-19 infection, and thrombocytopenia predicts mortality.2 Heparin-induced thrombocytopenia (HIT) is a differential for thrombocytopenia, especially in the intensive care setting. In one review, the authors suggested that clinicians routinely evaluate all COVID-19 patients on heparin for indices of HIT by performing the 4T score.3 We report a case of HIT in a patient with critical COVID-19 infection. Also, we briefly describe 4 other cases that were initially managed as HIT, until proven later not to be true HIT, based on the functional assay."}