PMC:7386875 / 2351-4613
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T10 | 635-652 | Body_part | denotes | respiratory tract | http://purl.org/sig/ont/fma/fma265130 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T3 | 635-652 | Body_part | denotes | respiratory tract | http://purl.obolibrary.org/obo/UBERON_0000065 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T30 | 21-45 | Disease | denotes | coronavirus disease 2019 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T31 | 47-55 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T32 | 139-142 | Disease | denotes | flu | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T33 | 199-246 | Disease | denotes | severe acute respiratory syndrome coronavirus 2 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T34 | 199-232 | Disease | denotes | severe acute respiratory syndrome | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T35 | 248-256 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T36 | 274-282 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T37 | 427-435 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T38 | 484-492 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T39 | 576-584 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T40 | 664-673 | Disease | denotes | pneumonia | http://purl.obolibrary.org/obo/MONDO_0005249 |
| T41 | 678-713 | Disease | denotes | acute respiratory distress syndrome | http://purl.obolibrary.org/obo/MONDO_0006502 |
| T42 | 684-713 | Disease | denotes | respiratory distress syndrome | http://purl.obolibrary.org/obo/MONDO_0009971 |
| T43 | 715-719 | Disease | denotes | ARDS | http://purl.obolibrary.org/obo/MONDO_0006502 |
| T44 | 754-762 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T45 | 841-851 | Disease | denotes | thrombosis | http://purl.obolibrary.org/obo/MONDO_0000831 |
| T46 | 873-883 | Disease | denotes | thrombosis | http://purl.obolibrary.org/obo/MONDO_0000831 |
| T47 | 994-1002 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T48 | 1083-1091 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T49 | 1103-1113 | Disease | denotes | thrombosis | http://purl.obolibrary.org/obo/MONDO_0000831 |
| T50 | 1237-1245 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T51 | 1329-1339 | Disease | denotes | thrombosis | http://purl.obolibrary.org/obo/MONDO_0000831 |
| T52 | 1412-1420 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T53 | 1535-1543 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T54 | 1555-1565 | Disease | denotes | thrombosis | http://purl.obolibrary.org/obo/MONDO_0000831 |
| T55 | 1664-1672 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T56 | 1675-1684 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T57 | 1686-1696 | Disease | denotes | thrombosis | http://purl.obolibrary.org/obo/MONDO_0000831 |
| T58 | 1768-1784 | Disease | denotes | viral infections | http://purl.obolibrary.org/obo/MONDO_0005108 |
| T59 | 1847-1855 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T60 | 1858-1867 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T61 | 1929-1937 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T62 | 1940-1949 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T63 | 2201-2209 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T64 | 2251-2261 | Disease | denotes | thrombosis | http://purl.obolibrary.org/obo/MONDO_0000831 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T12 | 725-728 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T13 | 782-783 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T14 | 864-872 | http://purl.obolibrary.org/obo/UBERON_0001637 | denotes | arterial |
| T15 | 864-872 | http://www.ebi.ac.uk/efo/EFO_0000814 | denotes | arterial |
| T16 | 1013-1014 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T7 | 664-673 | Phenotype | denotes | pneumonia | http://purl.obolibrary.org/obo/HP_0002090 |
| T8 | 684-704 | Phenotype | denotes | respiratory distress | http://purl.obolibrary.org/obo/HP_0002098 |
| T9 | 864-883 | Phenotype | denotes | arterial thrombosis | http://purl.obolibrary.org/obo/HP_0004420 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T6 | 1309-1324 | http://purl.obolibrary.org/obo/GO_0006955 | denotes | immune response |
| T7 | 1768-1784 | http://purl.obolibrary.org/obo/GO_0016032 | denotes | viral infections |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T13 | 0-171 | Sentence | denotes | The rapidly evolving coronavirus disease 2019 (COVID-19) global pandemic is one of the greatest public health challenges since the Spanish flu pandemic over 100 years ago. |
| T14 | 172-377 | Sentence | denotes | Since the discovery of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes COVID-19, millions of cases have been diagnosed worldwide resulting in hundreds of thousands of deaths. |
| T15 | 378-527 | Sentence | denotes | With no current effective therapy or vaccine for COVID-19, the enormous number of cases and deaths due to COVID-19 is likely to continue to increase. |
| T16 | 528-945 | Sentence | denotes | In this regard, although the adverse effects of COVID-19 were initially considered to primarily affect the respiratory tract by causing pneumonia and acute respiratory distress syndrome (ARDS), it has now become apparent that COVID-19 is associated with a prothrombotic state, which can manifest as microvascular thrombosis, venous, or arterial thrombosis, the presence of which usually portends an adverse prognosis. |
| T17 | 946-1114 | Sentence | denotes | Thus, there is an urgent need to understand how SARS-CoV-2 induces a prothrombotic state to develop effective therapeutic approaches for COVID-19-associated thrombosis. |
| T18 | 1115-1246 | Sentence | denotes | This review will detail the significant emerging clinical findings of the prothrombotic status of patients suffering from COVID-19. |
| T19 | 1247-1423 | Sentence | denotes | We then provide an overview of the inherent links between the immune response and thrombosis, and how these mechanisms may help explain the prothrombotic effects of SARS-CoV-2. |
| T20 | 1424-1566 | Sentence | denotes | Finally, we will use this data to explore available therapeutic approaches for the prevention and treatment of COVID-19-associated thrombosis. |
| T21 | 1567-1868 | Sentence | denotes | Given the relative lack of data to date demonstrating the precise mechanisms of the link between SARS-CoV-2 infection, thrombosis, and clinical outcomes, we also highlight experimental data from other viral infections and thromboinflammatory disorders that are likely relevant to SARS-CoV-2 infection. |
| T22 | 1869-2039 | Sentence | denotes | Further research is urgently required to clearly define how SARS-CoV-2 infection results in thrombotic complications and how this impacts the disease course and severity. |
| T23 | 2040-2262 | Sentence | denotes | Therefore, this review will hopefully spark further interest and research, and importantly raise awareness of the importance of anticoagulation in patients with COVID-19 for both the prevention and treatment of thrombosis. |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 128 | 199-246 | Species | denotes | severe acute respiratory syndrome coronavirus 2 | Tax:2697049 |
| 129 | 248-258 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 130 | 994-1004 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 131 | 1213-1221 | Species | denotes | patients | Tax:9606 |
| 132 | 1412-1422 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 133 | 2187-2195 | Species | denotes | patients | Tax:9606 |
| 134 | 21-45 | Disease | denotes | coronavirus disease 2019 | MESH:C000657245 |
| 135 | 47-55 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 136 | 274-282 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 137 | 370-376 | Disease | denotes | deaths | MESH:D003643 |
| 138 | 427-435 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 139 | 470-476 | Disease | denotes | deaths | MESH:D003643 |
| 140 | 484-492 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 141 | 576-584 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 142 | 664-673 | Disease | denotes | pneumonia | MESH:D011014 |
| 143 | 678-713 | Disease | denotes | acute respiratory distress syndrome | MESH:D012128 |
| 144 | 715-719 | Disease | denotes | ARDS | MESH:D012128 |
| 145 | 754-762 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 146 | 841-851 | Disease | denotes | thrombosis | MESH:D013927 |
| 147 | 873-883 | Disease | denotes | thrombosis | MESH:D013927 |
| 148 | 1083-1091 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 149 | 1103-1113 | Disease | denotes | thrombosis | MESH:D013927 |
| 150 | 1237-1245 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 151 | 1329-1339 | Disease | denotes | thrombosis | MESH:D013927 |
| 152 | 1535-1543 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 153 | 1555-1565 | Disease | denotes | thrombosis | MESH:D013927 |
| 154 | 1669-1684 | Disease | denotes | CoV-2 infection | MESH:C000657245 |
| 155 | 1686-1696 | Disease | denotes | thrombosis | MESH:D013927 |
| 156 | 1768-1784 | Disease | denotes | viral infections | MESH:D001102 |
| 157 | 1789-1818 | Disease | denotes | thromboinflammatory disorders | MESH:D030342 |
| 158 | 1847-1867 | Disease | denotes | SARS-CoV-2 infection | MESH:C000657245 |
| 159 | 1929-1949 | Disease | denotes | SARS-CoV-2 infection | MESH:C000657245 |
| 160 | 1961-1985 | Disease | denotes | thrombotic complications | MESH:D013927 |
| 161 | 1999-2018 | Disease | denotes | impacts the disease | MESH:D014095 |
| 162 | 2201-2209 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 163 | 2251-2261 | Disease | denotes | thrombosis | MESH:D013927 |