PMC:7373848 / 17111-18105
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7373848","sourcedb":"PMC","sourceid":"7373848","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7373848","text":"The contribution of platelets to vascular integrity, growth and repair\nThe interactions between platelets and the vascular endothelium are a tightly orchestrated. In response to inflammatory stimuli, P-selectin rapidly translocates from membranes of storage granules (Weibel-Palade bodies) to the plasma membrane. GPIbα present on platelets recognizes and binds to endothelial cell P-selectin. Firm adhesion of platelets to intact endothelial cells depends on platelet integrin αIIbβ3 bridging to endothelial receptors such as αVβ3 and intercellular adhesion molecule-1. Ligands for bridging include fibrinogen, fibronectin, and von Willebrand factor (VWF) [33]. Inflammatory cytokines augment platelet adhesion.\nPlatelets are essential for maintaining vascular integrity [34] and endothelial barrier function, particularly in the setting of inflammation [35]. In addition to physical interactions, platelets promote vascular integrity through synthesis and release of bioactive mediators [36].","divisions":[{"label":"title","span":{"begin":0,"end":70}},{"label":"p","span":{"begin":71,"end":712}}],"tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T277","span":{"begin":20,"end":29},"obj":"Body_part"},{"id":"T278","span":{"begin":96,"end":105},"obj":"Body_part"},{"id":"T279","span":{"begin":123,"end":134},"obj":"Body_part"},{"id":"T280","span":{"begin":200,"end":210},"obj":"Body_part"},{"id":"T281","span":{"begin":268,"end":288},"obj":"Body_part"},{"id":"T282","span":{"begin":297,"end":312},"obj":"Body_part"},{"id":"T283","span":{"begin":331,"end":340},"obj":"Body_part"},{"id":"T284","span":{"begin":365,"end":381},"obj":"Body_part"},{"id":"T285","span":{"begin":377,"end":381},"obj":"Body_part"},{"id":"T286","span":{"begin":382,"end":392},"obj":"Body_part"},{"id":"T287","span":{"begin":411,"end":420},"obj":"Body_part"},{"id":"T288","span":{"begin":431,"end":448},"obj":"Body_part"},{"id":"T289","span":{"begin":443,"end":448},"obj":"Body_part"},{"id":"T290","span":{"begin":460,"end":468},"obj":"Body_part"},{"id":"T291","span":{"begin":469,"end":477},"obj":"Body_part"},{"id":"T292","span":{"begin":612,"end":623},"obj":"Body_part"},{"id":"T293","span":{"begin":629,"end":650},"obj":"Body_part"},{"id":"T294","span":{"begin":676,"end":685},"obj":"Body_part"},{"id":"T295","span":{"begin":694,"end":702},"obj":"Body_part"},{"id":"T296","span":{"begin":713,"end":722},"obj":"Body_part"},{"id":"T297","span":{"begin":899,"end":908},"obj":"Body_part"}],"attributes":[{"id":"A277","pred":"fma_id","subj":"T277","obj":"http://purl.org/sig/ont/fma/fma62851"},{"id":"A278","pred":"fma_id","subj":"T278","obj":"http://purl.org/sig/ont/fma/fma62851"},{"id":"A279","pred":"fma_id","subj":"T279","obj":"http://purl.org/sig/ont/fma/fma63916"},{"id":"A280","pred":"fma_id","subj":"T280","obj":"http://purl.org/sig/ont/fma/fma62933"},{"id":"A281","pred":"fma_id","subj":"T281","obj":"http://purl.org/sig/ont/fma/fma63176"},{"id":"A282","pred":"fma_id","subj":"T282","obj":"http://purl.org/sig/ont/fma/fma63841"},{"id":"A283","pred":"fma_id","subj":"T283","obj":"http://purl.org/sig/ont/fma/fma62851"},{"id":"A284","pred":"fma_id","subj":"T284","obj":"http://purl.org/sig/ont/fma/fma66772"},{"id":"A285","pred":"fma_id","subj":"T285","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A286","pred":"fma_id","subj":"T286","obj":"http://purl.org/sig/ont/fma/fma62933"},{"id":"A287","pred":"fma_id","subj":"T287","obj":"http://purl.org/sig/ont/fma/fma62851"},{"id":"A288","pred":"fma_id","subj":"T288","obj":"http://purl.org/sig/ont/fma/fma66772"},{"id":"A289","pred":"fma_id","subj":"T289","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A290","pred":"fma_id","subj":"T290","obj":"http://purl.org/sig/ont/fma/fma62851"},{"id":"A291","pred":"fma_id","subj":"T291","obj":"http://purl.org/sig/ont/fma/fma67222"},{"id":"A292","pred":"fma_id","subj":"T292","obj":"http://purl.org/sig/ont/fma/fma67311"},{"id":"A293","pred":"fma_id","subj":"T293","obj":"http://purl.org/sig/ont/fma/fma81101"},{"id":"A294","pred":"fma_id","subj":"T294","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A295","pred":"fma_id","subj":"T295","obj":"http://purl.org/sig/ont/fma/fma62851"},{"id":"A296","pred":"fma_id","subj":"T296","obj":"http://purl.org/sig/ont/fma/fma62851"},{"id":"A297","pred":"fma_id","subj":"T297","obj":"http://purl.org/sig/ont/fma/fma62851"},{"subj":"T277","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T278","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T279","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T280","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T281","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T282","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T283","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T284","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T285","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T286","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T287","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T288","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T289","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T290","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T291","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T292","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T293","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T294","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T295","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T296","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T297","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T89","span":{"begin":123,"end":134},"obj":"Body_part"}],"attributes":[{"id":"A89","pred":"uberon_id","subj":"T89","obj":"http://purl.obolibrary.org/obo/UBERON_0001986"},{"subj":"T89","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"283","span":{"begin":200,"end":210},"obj":"Gene"},{"id":"284","span":{"begin":314,"end":319},"obj":"Gene"},{"id":"285","span":{"begin":382,"end":392},"obj":"Gene"},{"id":"286","span":{"begin":600,"end":610},"obj":"Gene"},{"id":"287","span":{"begin":612,"end":623},"obj":"Gene"},{"id":"288","span":{"begin":629,"end":650},"obj":"Gene"},{"id":"289","span":{"begin":652,"end":655},"obj":"Gene"},{"id":"291","span":{"begin":842,"end":854},"obj":"Disease"}],"attributes":[{"id":"A283","pred":"tao:has_database_id","subj":"283","obj":"Gene:6403"},{"id":"A284","pred":"tao:has_database_id","subj":"284","obj":"Gene:2811"},{"id":"A285","pred":"tao:has_database_id","subj":"285","obj":"Gene:6403"},{"id":"A286","pred":"tao:has_database_id","subj":"286","obj":"Gene:2244"},{"id":"A287","pred":"tao:has_database_id","subj":"287","obj":"Gene:2335"},{"id":"A288","pred":"tao:has_database_id","subj":"288","obj":"Gene:7450"},{"id":"A289","pred":"tao:has_database_id","subj":"289","obj":"Gene:7450"},{"id":"A291","pred":"tao:has_database_id","subj":"291","obj":"MESH:D007249"},{"subj":"283","pred":"source","obj":"LitCovid-PubTator"},{"subj":"284","pred":"source","obj":"LitCovid-PubTator"},{"subj":"285","pred":"source","obj":"LitCovid-PubTator"},{"subj":"286","pred":"source","obj":"LitCovid-PubTator"},{"subj":"287","pred":"source","obj":"LitCovid-PubTator"},{"subj":"288","pred":"source","obj":"LitCovid-PubTator"},{"subj":"289","pred":"source","obj":"LitCovid-PubTator"},{"subj":"291","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T61","span":{"begin":842,"end":854},"obj":"Disease"}],"attributes":[{"id":"A61","pred":"mondo_id","subj":"T61","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"},{"subj":"T61","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T286","span":{"begin":123,"end":134},"obj":"http://purl.obolibrary.org/obo/UBERON_0001986"},{"id":"T287","span":{"begin":139,"end":140},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T288","span":{"begin":237,"end":246},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T289","span":{"begin":297,"end":303},"obj":"http://purl.obolibrary.org/obo/UBERON_0001969"},{"id":"T290","span":{"begin":304,"end":312},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T291","span":{"begin":365,"end":381},"obj":"http://purl.obolibrary.org/obo/CL_0000115"},{"id":"T292","span":{"begin":431,"end":448},"obj":"http://purl.obolibrary.org/obo/CL_0000115"},{"id":"T293","span":{"begin":612,"end":623},"obj":"http://purl.obolibrary.org/obo/PR_000007581"},{"id":"T294","span":{"begin":773,"end":775},"obj":"http://purl.obolibrary.org/obo/CLO_0001302"},{"id":"T295","span":{"begin":856,"end":858},"obj":"http://purl.obolibrary.org/obo/CLO_0001000"},{"id":"T296","span":{"begin":990,"end":992},"obj":"http://purl.obolibrary.org/obo/CLO_0001313"}],"attributes":[{"subj":"T286","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T287","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T288","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T289","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T290","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T291","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T292","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T293","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T294","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T295","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T296","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T105","span":{"begin":559,"end":567},"obj":"Chemical"}],"attributes":[{"id":"A105","pred":"chebi_id","subj":"T105","obj":"http://purl.obolibrary.org/obo/CHEBI_25367"},{"subj":"T105","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T71","span":{"begin":53,"end":59},"obj":"http://purl.obolibrary.org/obo/GO_0040007"},{"id":"T72","span":{"begin":250,"end":257},"obj":"http://purl.obolibrary.org/obo/GO_0051235"},{"id":"T73","span":{"begin":842,"end":854},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T74","span":{"begin":944,"end":953},"obj":"http://purl.obolibrary.org/obo/GO_0009058"}],"attributes":[{"subj":"T71","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T72","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T73","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T74","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T116","span":{"begin":0,"end":70},"obj":"Sentence"},{"id":"T117","span":{"begin":71,"end":162},"obj":"Sentence"},{"id":"T118","span":{"begin":163,"end":313},"obj":"Sentence"},{"id":"T119","span":{"begin":314,"end":393},"obj":"Sentence"},{"id":"T120","span":{"begin":394,"end":570},"obj":"Sentence"},{"id":"T121","span":{"begin":571,"end":662},"obj":"Sentence"},{"id":"T122","span":{"begin":663,"end":712},"obj":"Sentence"},{"id":"T123","span":{"begin":713,"end":860},"obj":"Sentence"},{"id":"T124","span":{"begin":861,"end":994},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T116","pred":"source","obj":"LitCovid-sentences"},{"subj":"T117","pred":"source","obj":"LitCovid-sentences"},{"subj":"T118","pred":"source","obj":"LitCovid-sentences"},{"subj":"T119","pred":"source","obj":"LitCovid-sentences"},{"subj":"T120","pred":"source","obj":"LitCovid-sentences"},{"subj":"T121","pred":"source","obj":"LitCovid-sentences"},{"subj":"T122","pred":"source","obj":"LitCovid-sentences"},{"subj":"T123","pred":"source","obj":"LitCovid-sentences"},{"subj":"T124","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T576","span":{"begin":20,"end":29},"obj":"CL:0000233"},{"id":"T577","span":{"begin":96,"end":105},"obj":"CL:0000233"},{"id":"T578","span":{"begin":123,"end":134},"obj":"UBERON:0001986"},{"id":"T579","span":{"begin":200,"end":210},"obj":"PR:000001432"},{"id":"T580","span":{"begin":237,"end":246},"obj":"GO:0016020"},{"id":"T581","span":{"begin":250,"end":257},"obj":"GO:0000322"},{"id":"T582","span":{"begin":258,"end":266},"obj":"GO:0009542"},{"id":"T583","span":{"begin":297,"end":312},"obj":"GO:0005886"},{"id":"T584","span":{"begin":331,"end":340},"obj":"CL:0000233"},{"id":"T585","span":{"begin":365,"end":376},"obj":"UBERON:0001986;CL:0000115"},{"id":"T586","span":{"begin":377,"end":381},"obj":"CL:0000115"},{"id":"T587","span":{"begin":382,"end":392},"obj":"PR:000001432"},{"id":"T588","span":{"begin":411,"end":420},"obj":"CL:0000233"},{"id":"T589","span":{"begin":431,"end":442},"obj":"UBERON:0001986;CL:0000115"},{"id":"T590","span":{"begin":443,"end":448},"obj":"CL:0000115"},{"id":"T591","span":{"begin":460,"end":468},"obj":"CL:0000233"},{"id":"T592","span":{"begin":469,"end":484},"obj":"GO:0034683"},{"id":"T593","span":{"begin":485,"end":493},"obj":"GO:0030674"},{"id":"T594","span":{"begin":497,"end":508},"obj":"UBERON:0001986"},{"id":"T595","span":{"begin":527,"end":531},"obj":"GO:0034683"},{"id":"T596","span":{"begin":536,"end":558},"obj":"PR:000001467"},{"id":"T597","span":{"begin":559,"end":567},"obj":"PR:000001467;CHEBI:36357;CHEBI:36357"},{"id":"T598","span":{"begin":583,"end":591},"obj":"GO:0030674"},{"id":"T599","span":{"begin":600,"end":610},"obj":"GO:0005577"},{"id":"T600","span":{"begin":612,"end":623},"obj":"PR:000007581"},{"id":"T601","span":{"begin":629,"end":650},"obj":"PR:000017364"},{"id":"T602","span":{"begin":652,"end":655},"obj":"PR:000017364"},{"id":"T603","span":{"begin":694,"end":702},"obj":"CL:0000233"},{"id":"T604","span":{"begin":713,"end":722},"obj":"CL:0000233"},{"id":"T605","span":{"begin":781,"end":792},"obj":"UBERON:0001986"},{"id":"T606","span":{"begin":899,"end":908},"obj":"CL:0000233"},{"id":"T607","span":{"begin":969,"end":978},"obj":"CHEBI:15956;CHEBI:15956"},{"id":"T608","span":{"begin":979,"end":988},"obj":"CHEBI:67079;CHEBI:67079"}],"attributes":[{"subj":"T576","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T577","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T578","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T579","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T580","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T581","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T582","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T583","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T584","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T585","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T586","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T587","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T588","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T589","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T590","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T591","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T592","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T593","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T594","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T595","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T596","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T597","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T598","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T599","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T600","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T601","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T602","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T603","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T604","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T605","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T606","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T607","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T608","pred":"source","obj":"LitCovid-PMC-OGER-BB"}]},{"project":"2_test","denotations":[{"id":"32700024-11071623-64991470","span":{"begin":658,"end":660},"obj":"11071623"},{"id":"32700024-26749528-64991471","span":{"begin":773,"end":775},"obj":"26749528"},{"id":"32700024-18256319-64991472","span":{"begin":856,"end":858},"obj":"18256319"},{"id":"32700024-27582371-64991473","span":{"begin":990,"end":992},"obj":"27582371"}],"attributes":[{"subj":"32700024-11071623-64991470","pred":"source","obj":"2_test"},{"subj":"32700024-26749528-64991471","pred":"source","obj":"2_test"},{"subj":"32700024-18256319-64991472","pred":"source","obj":"2_test"},{"subj":"32700024-27582371-64991473","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#93ecd1","default":true},{"id":"LitCovid-PD-UBERON","color":"#ecb793"},{"id":"LitCovid-PubTator","color":"#9d93ec"},{"id":"LitCovid-PD-MONDO","color":"#a2ec93"},{"id":"LitCovid-PD-CLO","color":"#ec93bc"},{"id":"LitCovid-PD-CHEBI","color":"#93d6ec"},{"id":"LitCovid-PD-GO-BP","color":"#ece893"},{"id":"LitCovid-sentences","color":"#ce93ec"},{"id":"LitCovid-PMC-OGER-BB","color":"#93ecb4"},{"id":"2_test","color":"#ec9a93"}]}]}}