PMC:7358770 / 30848-32511 JSONTXT

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It also shows that immunity achieved with delta inulin adjuvants is long-lived, thereby overcoming the natural tendency for rapidly waning coronavirus immunity. This suggests that delta inulin polysaccharide adjuvants have the potential to develop more effective coronavirus vaccines [20]. In addition, some Chinese herbal medicinal polysaccharides have been used as safe and effective adjuvants [77,107,112,113]. APS as an adjuvant combined with influenza vaccine can improve the immune response and systemic humoral response to H5N1 virus infection [46,114]. APS can potentially be used as an immunomodulator for a foot-and-mouth disease virus (FMDV), which is an RNA virus vaccine, and provide better protection against FMDV [115]. APS is also a potent adjuvant for hepatitis B DNA vaccine, and can enhance the immune responses of HBV DNA vaccine via promoting dendritic cells maturation and inhibit the regulatory T cells frequency [116]. Polysaccharide extract from RI exerts potent anti-IAV activity against human seasonal influenza viruses (H1N1 and H3N2) and AIV (H6N2 and H9N2) in vitro [49]. The polysaccharides also significantly reduced the expression of pro-inflammatory cytokines (IL-6) and strongly inhibited the protein expression of TLR-3 induced by PR8. The polysaccharide extract from RI, therefore, has the potential to be used as an adjunct to antiviral therapy for the treatment of IAV infection [49]."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T72","span":{"begin":721,"end":736},"obj":"http://purl.obolibrary.org/obo/GO_0006955"},{"id":"T73","span":{"begin":1054,"end":1070},"obj":"http://purl.obolibrary.org/obo/GO_0006955"},{"id":"T74","span":{"begin":1114,"end":1130},"obj":"http://purl.obolibrary.org/obo/GO_0048469"}],"text":"Although SARS-CoV vaccines can protect against lethal infection, the addition of delta inulin-based polysaccharide adjuvant on day 3 post-challenge can significantly increase serum neutralizing-antibody titers and reduce lung virus titers. It also shows that immunity achieved with delta inulin adjuvants is long-lived, thereby overcoming the natural tendency for rapidly waning coronavirus immunity. This suggests that delta inulin polysaccharide adjuvants have the potential to develop more effective coronavirus vaccines [20]. In addition, some Chinese herbal medicinal polysaccharides have been used as safe and effective adjuvants [77,107,112,113]. APS as an adjuvant combined with influenza vaccine can improve the immune response and systemic humoral response to H5N1 virus infection [46,114]. APS can potentially be used as an immunomodulator for a foot-and-mouth disease virus (FMDV), which is an RNA virus vaccine, and provide better protection against FMDV [115]. APS is also a potent adjuvant for hepatitis B DNA vaccine, and can enhance the immune responses of HBV DNA vaccine via promoting dendritic cells maturation and inhibit the regulatory T cells frequency [116]. Polysaccharide extract from RI exerts potent anti-IAV activity against human seasonal influenza viruses (H1N1 and H3N2) and AIV (H6N2 and H9N2) in vitro [49]. The polysaccharides also significantly reduced the expression of pro-inflammatory cytokines (IL-6) and strongly inhibited the protein expression of TLR-3 induced by PR8. The polysaccharide extract from RI, therefore, has the potential to be used as an adjunct to antiviral therapy for the treatment of IAV infection [49]."}

{"project":"2_test","denotations":[{"id":"32679328-25520500-48281332","span":{"begin":525,"end":527},"obj":"25520500"},{"id":"32679328-28826771-48281333","span":{"begin":637,"end":639},"obj":"28826771"},{"id":"32679328-30057282-48281334","span":{"begin":640,"end":643},"obj":"30057282"},{"id":"32679328-16378665-48281335","span":{"begin":644,"end":647},"obj":"16378665"},{"id":"32679328-18602959-48281336","span":{"begin":648,"end":651},"obj":"18602959"},{"id":"32679328-28245781-48281337","span":{"begin":795,"end":798},"obj":"28245781"},{"id":"32679328-21640133-48281338","span":{"begin":969,"end":972},"obj":"21640133"},{"id":"32679328-23006659-48281339","span":{"begin":1177,"end":1180},"obj":"23006659"},{"id":"T25645","span":{"begin":525,"end":527},"obj":"25520500"},{"id":"T19444","span":{"begin":637,"end":639},"obj":"28826771"},{"id":"T61570","span":{"begin":640,"end":643},"obj":"30057282"},{"id":"T89004","span":{"begin":644,"end":647},"obj":"16378665"},{"id":"T72641","span":{"begin":648,"end":651},"obj":"18602959"},{"id":"T23125","span":{"begin":795,"end":798},"obj":"28245781"},{"id":"T12328","span":{"begin":969,"end":972},"obj":"21640133"},{"id":"T44177","span":{"begin":1177,"end":1180},"obj":"23006659"}],"text":"Although SARS-CoV vaccines can protect against lethal infection, the addition of delta inulin-based polysaccharide adjuvant on day 3 post-challenge can significantly increase serum neutralizing-antibody titers and reduce lung virus titers. It also shows that immunity achieved with delta inulin adjuvants is long-lived, thereby overcoming the natural tendency for rapidly waning coronavirus immunity. This suggests that delta inulin polysaccharide adjuvants have the potential to develop more effective coronavirus vaccines [20]. In addition, some Chinese herbal medicinal polysaccharides have been used as safe and effective adjuvants [77,107,112,113]. APS as an adjuvant combined with influenza vaccine can improve the immune response and systemic humoral response to H5N1 virus infection [46,114]. APS can potentially be used as an immunomodulator for a foot-and-mouth disease virus (FMDV), which is an RNA virus vaccine, and provide better protection against FMDV [115]. APS is also a potent adjuvant for hepatitis B DNA vaccine, and can enhance the immune responses of HBV DNA vaccine via promoting dendritic cells maturation and inhibit the regulatory T cells frequency [116]. Polysaccharide extract from RI exerts potent anti-IAV activity against human seasonal influenza viruses (H1N1 and H3N2) and AIV (H6N2 and H9N2) in vitro [49]. The polysaccharides also significantly reduced the expression of pro-inflammatory cytokines (IL-6) and strongly inhibited the protein expression of TLR-3 induced by PR8. The polysaccharide extract from RI, therefore, has the potential to be used as an adjunct to antiviral therapy for the treatment of IAV infection [49]."}

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