PMC:7358770 / 13296-14450 JSON TXT

Annnotations TAB JSON ListView MergeView

LitCovid_Glycan-Motif-Structure

{"project":"LitCovid_Glycan-Motif-Structure","denotations":[{"id":"T25","span":{"begin":54,"end":61},"obj":"https://glytoucan.org/Structures/Glycans/G00021MO"},{"id":"T26","span":{"begin":54,"end":61},"obj":"https://glytoucan.org/Structures/Glycans/G54161DR"},{"id":"T27","span":{"begin":612,"end":619},"obj":"https://glytoucan.org/Structures/Glycans/G00021MO"},{"id":"T28","span":{"begin":612,"end":619},"obj":"https://glytoucan.org/Structures/Glycans/G54161DR"},{"id":"T29","span":{"begin":707,"end":714},"obj":"https://glytoucan.org/Structures/Glycans/G00021MO"},{"id":"T30","span":{"begin":707,"end":714},"obj":"https://glytoucan.org/Structures/Glycans/G54161DR"},{"id":"T31","span":{"begin":868,"end":875},"obj":"https://glytoucan.org/Structures/Glycans/G00021MO"},{"id":"T32","span":{"begin":868,"end":875},"obj":"https://glytoucan.org/Structures/Glycans/G54161DR"},{"id":"T33","span":{"begin":1082,"end":1089},"obj":"https://glytoucan.org/Structures/Glycans/G00021MO"},{"id":"T34","span":{"begin":1082,"end":1089},"obj":"https://glytoucan.org/Structures/Glycans/G54161DR"}],"text":"Natural products of HS and the allied polysaccharide, heparin, are involved and prevent infection by a range of viruses including S-associated coronavirus strain HSR1 [66]. HS is known to bind CoV surface proteins and to be used by coronavirus for its attachment to target cells [54]. Currently, there are no commercially available medicinal products designed to treat and/or prevent infections associated with the novel SARS-CoV-2 coronavirus outbreak. The surface plasmon resonance and circular dichroism were used to measure the interaction between the SARS-CoV-2 Spike S1 protein RBD (SARS-CoV-2 S1 RBD) and heparin. Additionally, basic amino acids are known to dictate the binding between proteins and heparin. Primary sequence analysis of the expressed protein domain and analysis of the modeled SARS-CoV-2 S1 RBD structure show that there are several potential heparin binding sites, and more importantly, theses patches of basic amino acids are exposed on the protein surface. This study has implications for the rapid development of a first-line therapeutic by repurposing heparin and for next-generation, tailor-made, GAG-based antivirals [66]."}

LitCovid-PD-FMA-UBERON

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T150","span":{"begin":20,"end":22},"obj":"Body_part"},{"id":"T151","span":{"begin":38,"end":52},"obj":"Body_part"},{"id":"T152","span":{"begin":54,"end":61},"obj":"Body_part"},{"id":"T153","span":{"begin":173,"end":175},"obj":"Body_part"},{"id":"T154","span":{"begin":205,"end":213},"obj":"Body_part"},{"id":"T155","span":{"begin":273,"end":278},"obj":"Body_part"},{"id":"T156","span":{"begin":576,"end":583},"obj":"Body_part"},{"id":"T157","span":{"begin":612,"end":619},"obj":"Body_part"},{"id":"T158","span":{"begin":641,"end":652},"obj":"Body_part"},{"id":"T159","span":{"begin":694,"end":702},"obj":"Body_part"},{"id":"T160","span":{"begin":707,"end":714},"obj":"Body_part"},{"id":"T161","span":{"begin":759,"end":766},"obj":"Body_part"},{"id":"T162","span":{"begin":868,"end":875},"obj":"Body_part"},{"id":"T163","span":{"begin":937,"end":948},"obj":"Body_part"},{"id":"T164","span":{"begin":968,"end":975},"obj":"Body_part"},{"id":"T165","span":{"begin":1082,"end":1089},"obj":"Body_part"},{"id":"T166","span":{"begin":1128,"end":1131},"obj":"Body_part"}],"attributes":[{"id":"A150","pred":"fma_id","subj":"T150","obj":"http://purl.org/sig/ont/fma/fma63023"},{"id":"A151","pred":"fma_id","subj":"T151","obj":"http://purl.org/sig/ont/fma/fma82746"},{"id":"A152","pred":"fma_id","subj":"T152","obj":"http://purl.org/sig/ont/fma/fma82839"},{"id":"A153","pred":"fma_id","subj":"T153","obj":"http://purl.org/sig/ont/fma/fma63023"},{"id":"A154","pred":"fma_id","subj":"T154","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A155","pred":"fma_id","subj":"T155","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A156","pred":"fma_id","subj":"T156","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A157","pred":"fma_id","subj":"T157","obj":"http://purl.org/sig/ont/fma/fma82839"},{"id":"A158","pred":"fma_id","subj":"T158","obj":"http://purl.org/sig/ont/fma/fma82739"},{"id":"A159","pred":"fma_id","subj":"T159","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A160","pred":"fma_id","subj":"T160","obj":"http://purl.org/sig/ont/fma/fma82839"},{"id":"A161","pred":"fma_id","subj":"T161","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A162","pred":"fma_id","subj":"T162","obj":"http://purl.org/sig/ont/fma/fma82839"},{"id":"A163","pred":"fma_id","subj":"T163","obj":"http://purl.org/sig/ont/fma/fma82739"},{"id":"A164","pred":"fma_id","subj":"T164","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A165","pred":"fma_id","subj":"T165","obj":"http://purl.org/sig/ont/fma/fma82839"},{"id":"A166","pred":"fma_id","subj":"T166","obj":"http://purl.org/sig/ont/fma/fma63011"}],"text":"Natural products of HS and the allied polysaccharide, heparin, are involved and prevent infection by a range of viruses including S-associated coronavirus strain HSR1 [66]. HS is known to bind CoV surface proteins and to be used by coronavirus for its attachment to target cells [54]. Currently, there are no commercially available medicinal products designed to treat and/or prevent infections associated with the novel SARS-CoV-2 coronavirus outbreak. The surface plasmon resonance and circular dichroism were used to measure the interaction between the SARS-CoV-2 Spike S1 protein RBD (SARS-CoV-2 S1 RBD) and heparin. Additionally, basic amino acids are known to dictate the binding between proteins and heparin. Primary sequence analysis of the expressed protein domain and analysis of the modeled SARS-CoV-2 S1 RBD structure show that there are several potential heparin binding sites, and more importantly, theses patches of basic amino acids are exposed on the protein surface. This study has implications for the rapid development of a first-line therapeutic by repurposing heparin and for next-generation, tailor-made, GAG-based antivirals [66]."}

LitCovid-PubTator

{"project":"LitCovid-PubTator","denotations":[{"id":"458","span":{"begin":143,"end":154},"obj":"Species"},{"id":"459","span":{"begin":193,"end":196},"obj":"Species"},{"id":"460","span":{"begin":232,"end":243},"obj":"Species"},{"id":"461","span":{"begin":421,"end":431},"obj":"Species"},{"id":"462","span":{"begin":432,"end":443},"obj":"Species"},{"id":"463","span":{"begin":556,"end":566},"obj":"Species"},{"id":"464","span":{"begin":589,"end":599},"obj":"Species"},{"id":"465","span":{"begin":802,"end":812},"obj":"Species"},{"id":"466","span":{"begin":38,"end":52},"obj":"Chemical"},{"id":"467","span":{"begin":635,"end":652},"obj":"Chemical"},{"id":"468","span":{"begin":931,"end":948},"obj":"Chemical"},{"id":"469","span":{"begin":1128,"end":1131},"obj":"Chemical"},{"id":"470","span":{"begin":88,"end":97},"obj":"Disease"},{"id":"471","span":{"begin":384,"end":394},"obj":"Disease"}],"attributes":[{"id":"A458","pred":"tao:has_database_id","subj":"458","obj":"Tax:11118"},{"id":"A459","pred":"tao:has_database_id","subj":"459","obj":"Tax:11118"},{"id":"A460","pred":"tao:has_database_id","subj":"460","obj":"Tax:11118"},{"id":"A461","pred":"tao:has_database_id","subj":"461","obj":"Tax:2697049"},{"id":"A462","pred":"tao:has_database_id","subj":"462","obj":"Tax:11118"},{"id":"A463","pred":"tao:has_database_id","subj":"463","obj":"Tax:2697049"},{"id":"A464","pred":"tao:has_database_id","subj":"464","obj":"Tax:2697049"},{"id":"A465","pred":"tao:has_database_id","subj":"465","obj":"Tax:2697049"},{"id":"A466","pred":"tao:has_database_id","subj":"466","obj":"MESH:D011134"},{"id":"A467","pred":"tao:has_database_id","subj":"467","obj":"MESH:D024361"},{"id":"A468","pred":"tao:has_database_id","subj":"468","obj":"MESH:D024361"},{"id":"A469","pred":"tao:has_database_id","subj":"469","obj":"MESH:D006025"},{"id":"A470","pred":"tao:has_database_id","subj":"470","obj":"MESH:D007239"},{"id":"A471","pred":"tao:has_database_id","subj":"471","obj":"MESH:D007239"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Natural products of HS and the allied polysaccharide, heparin, are involved and prevent infection by a range of viruses including S-associated coronavirus strain HSR1 [66]. HS is known to bind CoV surface proteins and to be used by coronavirus for its attachment to target cells [54]. Currently, there are no commercially available medicinal products designed to treat and/or prevent infections associated with the novel SARS-CoV-2 coronavirus outbreak. The surface plasmon resonance and circular dichroism were used to measure the interaction between the SARS-CoV-2 Spike S1 protein RBD (SARS-CoV-2 S1 RBD) and heparin. Additionally, basic amino acids are known to dictate the binding between proteins and heparin. Primary sequence analysis of the expressed protein domain and analysis of the modeled SARS-CoV-2 S1 RBD structure show that there are several potential heparin binding sites, and more importantly, theses patches of basic amino acids are exposed on the protein surface. This study has implications for the rapid development of a first-line therapeutic by repurposing heparin and for next-generation, tailor-made, GAG-based antivirals [66]."}

LitCovid-PD-MONDO

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T42","span":{"begin":88,"end":97},"obj":"Disease"},{"id":"T43","span":{"begin":384,"end":394},"obj":"Disease"},{"id":"T44","span":{"begin":421,"end":429},"obj":"Disease"},{"id":"T45","span":{"begin":556,"end":564},"obj":"Disease"},{"id":"T46","span":{"begin":589,"end":597},"obj":"Disease"},{"id":"T47","span":{"begin":802,"end":810},"obj":"Disease"}],"attributes":[{"id":"A42","pred":"mondo_id","subj":"T42","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A43","pred":"mondo_id","subj":"T43","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A44","pred":"mondo_id","subj":"T44","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A45","pred":"mondo_id","subj":"T45","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A46","pred":"mondo_id","subj":"T46","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A47","pred":"mondo_id","subj":"T47","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"Natural products of HS and the allied polysaccharide, heparin, are involved and prevent infection by a range of viruses including S-associated coronavirus strain HSR1 [66]. HS is known to bind CoV surface proteins and to be used by coronavirus for its attachment to target cells [54]. Currently, there are no commercially available medicinal products designed to treat and/or prevent infections associated with the novel SARS-CoV-2 coronavirus outbreak. The surface plasmon resonance and circular dichroism were used to measure the interaction between the SARS-CoV-2 Spike S1 protein RBD (SARS-CoV-2 S1 RBD) and heparin. Additionally, basic amino acids are known to dictate the binding between proteins and heparin. Primary sequence analysis of the expressed protein domain and analysis of the modeled SARS-CoV-2 S1 RBD structure show that there are several potential heparin binding sites, and more importantly, theses patches of basic amino acids are exposed on the protein surface. This study has implications for the rapid development of a first-line therapeutic by repurposing heparin and for next-generation, tailor-made, GAG-based antivirals [66]."}

LitCovid-PD-CLO

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T117","span":{"begin":101,"end":102},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T118","span":{"begin":112,"end":119},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T119","span":{"begin":273,"end":278},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T120","span":{"begin":573,"end":575},"obj":"http://purl.obolibrary.org/obo/CLO_0050050"},{"id":"T121","span":{"begin":600,"end":602},"obj":"http://purl.obolibrary.org/obo/CLO_0050050"},{"id":"T122","span":{"begin":813,"end":815},"obj":"http://purl.obolibrary.org/obo/CLO_0050050"},{"id":"T123","span":{"begin":996,"end":999},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T124","span":{"begin":1042,"end":1043},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"Natural products of HS and the allied polysaccharide, heparin, are involved and prevent infection by a range of viruses including S-associated coronavirus strain HSR1 [66]. HS is known to bind CoV surface proteins and to be used by coronavirus for its attachment to target cells [54]. Currently, there are no commercially available medicinal products designed to treat and/or prevent infections associated with the novel SARS-CoV-2 coronavirus outbreak. The surface plasmon resonance and circular dichroism were used to measure the interaction between the SARS-CoV-2 Spike S1 protein RBD (SARS-CoV-2 S1 RBD) and heparin. Additionally, basic amino acids are known to dictate the binding between proteins and heparin. Primary sequence analysis of the expressed protein domain and analysis of the modeled SARS-CoV-2 S1 RBD structure show that there are several potential heparin binding sites, and more importantly, theses patches of basic amino acids are exposed on the protein surface. This study has implications for the rapid development of a first-line therapeutic by repurposing heparin and for next-generation, tailor-made, GAG-based antivirals [66]."}

LitCovid-PD-CHEBI

2_test

{"project":"2_test","denotations":[{"id":"32679328-25187545-48281281","span":{"begin":280,"end":282},"obj":"25187545"},{"id":"T82176","span":{"begin":280,"end":282},"obj":"25187545"}],"text":"Natural products of HS and the allied polysaccharide, heparin, are involved and prevent infection by a range of viruses including S-associated coronavirus strain HSR1 [66]. HS is known to bind CoV surface proteins and to be used by coronavirus for its attachment to target cells [54]. Currently, there are no commercially available medicinal products designed to treat and/or prevent infections associated with the novel SARS-CoV-2 coronavirus outbreak. The surface plasmon resonance and circular dichroism were used to measure the interaction between the SARS-CoV-2 Spike S1 protein RBD (SARS-CoV-2 S1 RBD) and heparin. Additionally, basic amino acids are known to dictate the binding between proteins and heparin. Primary sequence analysis of the expressed protein domain and analysis of the modeled SARS-CoV-2 S1 RBD structure show that there are several potential heparin binding sites, and more importantly, theses patches of basic amino acids are exposed on the protein surface. This study has implications for the rapid development of a first-line therapeutic by repurposing heparin and for next-generation, tailor-made, GAG-based antivirals [66]."}

LitCovid-sentences

{"project":"LitCovid-sentences","denotations":[{"id":"T84","span":{"begin":0,"end":172},"obj":"Sentence"},{"id":"T85","span":{"begin":173,"end":284},"obj":"Sentence"},{"id":"T86","span":{"begin":285,"end":453},"obj":"Sentence"},{"id":"T87","span":{"begin":454,"end":620},"obj":"Sentence"},{"id":"T88","span":{"begin":621,"end":715},"obj":"Sentence"},{"id":"T89","span":{"begin":716,"end":984},"obj":"Sentence"},{"id":"T90","span":{"begin":985,"end":1154},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Natural products of HS and the allied polysaccharide, heparin, are involved and prevent infection by a range of viruses including S-associated coronavirus strain HSR1 [66]. HS is known to bind CoV surface proteins and to be used by coronavirus for its attachment to target cells [54]. Currently, there are no commercially available medicinal products designed to treat and/or prevent infections associated with the novel SARS-CoV-2 coronavirus outbreak. The surface plasmon resonance and circular dichroism were used to measure the interaction between the SARS-CoV-2 Spike S1 protein RBD (SARS-CoV-2 S1 RBD) and heparin. Additionally, basic amino acids are known to dictate the binding between proteins and heparin. Primary sequence analysis of the expressed protein domain and analysis of the modeled SARS-CoV-2 S1 RBD structure show that there are several potential heparin binding sites, and more importantly, theses patches of basic amino acids are exposed on the protein surface. This study has implications for the rapid development of a first-line therapeutic by repurposing heparin and for next-generation, tailor-made, GAG-based antivirals [66]."}

LitCovid-PD-GlycoEpitope

{"project":"LitCovid-PD-GlycoEpitope","denotations":[{"id":"T11","span":{"begin":20,"end":22},"obj":"GlycoEpitope"},{"id":"T12","span":{"begin":173,"end":175},"obj":"GlycoEpitope"}],"attributes":[{"id":"A11","pred":"glyco_epitope_db_id","subj":"T11","obj":"http://www.glycoepitope.jp/epitopes/EP0086"},{"id":"A12","pred":"glyco_epitope_db_id","subj":"T12","obj":"http://www.glycoepitope.jp/epitopes/EP0086"}],"text":"Natural products of HS and the allied polysaccharide, heparin, are involved and prevent infection by a range of viruses including S-associated coronavirus strain HSR1 [66]. HS is known to bind CoV surface proteins and to be used by coronavirus for its attachment to target cells [54]. Currently, there are no commercially available medicinal products designed to treat and/or prevent infections associated with the novel SARS-CoV-2 coronavirus outbreak. The surface plasmon resonance and circular dichroism were used to measure the interaction between the SARS-CoV-2 Spike S1 protein RBD (SARS-CoV-2 S1 RBD) and heparin. Additionally, basic amino acids are known to dictate the binding between proteins and heparin. Primary sequence analysis of the expressed protein domain and analysis of the modeled SARS-CoV-2 S1 RBD structure show that there are several potential heparin binding sites, and more importantly, theses patches of basic amino acids are exposed on the protein surface. This study has implications for the rapid development of a first-line therapeutic by repurposing heparin and for next-generation, tailor-made, GAG-based antivirals [66]."}

LitCovid-PMC-OGER-BB

MyTest

{"project":"MyTest","denotations":[{"id":"458","span":{"begin":143,"end":154},"obj":"Species"},{"id":"459","span":{"begin":193,"end":196},"obj":"Species"},{"id":"460","span":{"begin":232,"end":243},"obj":"Species"},{"id":"461","span":{"begin":421,"end":431},"obj":"Species"},{"id":"462","span":{"begin":432,"end":443},"obj":"Species"},{"id":"463","span":{"begin":556,"end":566},"obj":"Species"},{"id":"464","span":{"begin":589,"end":599},"obj":"Species"},{"id":"465","span":{"begin":802,"end":812},"obj":"Species"},{"id":"466","span":{"begin":38,"end":52},"obj":"Chemical"},{"id":"467","span":{"begin":635,"end":652},"obj":"Chemical"},{"id":"468","span":{"begin":931,"end":948},"obj":"Chemical"},{"id":"469","span":{"begin":1128,"end":1131},"obj":"Chemical"},{"id":"470","span":{"begin":88,"end":97},"obj":"Disease"},{"id":"471","span":{"begin":384,"end":394},"obj":"Disease"}],"attributes":[{"id":"A459","pred":"tao:has_database_id","subj":"459","obj":"Tax:11118"},{"id":"A471","pred":"tao:has_database_id","subj":"471","obj":"MESH:D007239"},{"id":"A470","pred":"tao:has_database_id","subj":"470","obj":"MESH:D007239"},{"id":"A461","pred":"tao:has_database_id","subj":"461","obj":"Tax:2697049"},{"id":"A469","pred":"tao:has_database_id","subj":"469","obj":"MESH:D006025"},{"id":"A464","pred":"tao:has_database_id","subj":"464","obj":"Tax:2697049"},{"id":"A463","pred":"tao:has_database_id","subj":"463","obj":"Tax:2697049"},{"id":"A462","pred":"tao:has_database_id","subj":"462","obj":"Tax:11118"},{"id":"A468","pred":"tao:has_database_id","subj":"468","obj":"MESH:D024361"},{"id":"A467","pred":"tao:has_database_id","subj":"467","obj":"MESH:D024361"},{"id":"A466","pred":"tao:has_database_id","subj":"466","obj":"MESH:D011134"},{"id":"A460","pred":"tao:has_database_id","subj":"460","obj":"Tax:11118"},{"id":"A458","pred":"tao:has_database_id","subj":"458","obj":"Tax:11118"},{"id":"A465","pred":"tao:has_database_id","subj":"465","obj":"Tax:2697049"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"text":"Natural products of HS and the allied polysaccharide, heparin, are involved and prevent infection by a range of viruses including S-associated coronavirus strain HSR1 [66]. HS is known to bind CoV surface proteins and to be used by coronavirus for its attachment to target cells [54]. Currently, there are no commercially available medicinal products designed to treat and/or prevent infections associated with the novel SARS-CoV-2 coronavirus outbreak. The surface plasmon resonance and circular dichroism were used to measure the interaction between the SARS-CoV-2 Spike S1 protein RBD (SARS-CoV-2 S1 RBD) and heparin. Additionally, basic amino acids are known to dictate the binding between proteins and heparin. Primary sequence analysis of the expressed protein domain and analysis of the modeled SARS-CoV-2 S1 RBD structure show that there are several potential heparin binding sites, and more importantly, theses patches of basic amino acids are exposed on the protein surface. This study has implications for the rapid development of a first-line therapeutic by repurposing heparin and for next-generation, tailor-made, GAG-based antivirals [66]."}

PMC:7358770 / 13296-14450 JSONTXT

Annnotations TAB JSON ListView MergeView

PMC:7358770 / 13296-14450 JSON TXT