PMC:7358770 / 13296-14450
Annnotations
LitCovid_Glycan-Motif-Structure
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T25 | 54-61 | https://glytoucan.org/Structures/Glycans/G00021MO | denotes | heparin |
T26 | 54-61 | https://glytoucan.org/Structures/Glycans/G54161DR | denotes | heparin |
T27 | 612-619 | https://glytoucan.org/Structures/Glycans/G00021MO | denotes | heparin |
T28 | 612-619 | https://glytoucan.org/Structures/Glycans/G54161DR | denotes | heparin |
T29 | 707-714 | https://glytoucan.org/Structures/Glycans/G00021MO | denotes | heparin |
T30 | 707-714 | https://glytoucan.org/Structures/Glycans/G54161DR | denotes | heparin |
T31 | 868-875 | https://glytoucan.org/Structures/Glycans/G00021MO | denotes | heparin |
T32 | 868-875 | https://glytoucan.org/Structures/Glycans/G54161DR | denotes | heparin |
T33 | 1082-1089 | https://glytoucan.org/Structures/Glycans/G00021MO | denotes | heparin |
T34 | 1082-1089 | https://glytoucan.org/Structures/Glycans/G54161DR | denotes | heparin |
LitCovid-PD-FMA-UBERON
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T150 | 20-22 | Body_part | denotes | HS | http://purl.org/sig/ont/fma/fma63023 |
T151 | 38-52 | Body_part | denotes | polysaccharide | http://purl.org/sig/ont/fma/fma82746 |
T152 | 54-61 | Body_part | denotes | heparin | http://purl.org/sig/ont/fma/fma82839 |
T153 | 173-175 | Body_part | denotes | HS | http://purl.org/sig/ont/fma/fma63023 |
T154 | 205-213 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
T155 | 273-278 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T156 | 576-583 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T157 | 612-619 | Body_part | denotes | heparin | http://purl.org/sig/ont/fma/fma82839 |
T158 | 641-652 | Body_part | denotes | amino acids | http://purl.org/sig/ont/fma/fma82739 |
T159 | 694-702 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
T160 | 707-714 | Body_part | denotes | heparin | http://purl.org/sig/ont/fma/fma82839 |
T161 | 759-766 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T162 | 868-875 | Body_part | denotes | heparin | http://purl.org/sig/ont/fma/fma82839 |
T163 | 937-948 | Body_part | denotes | amino acids | http://purl.org/sig/ont/fma/fma82739 |
T164 | 968-975 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T165 | 1082-1089 | Body_part | denotes | heparin | http://purl.org/sig/ont/fma/fma82839 |
T166 | 1128-1131 | Body_part | denotes | GAG | http://purl.org/sig/ont/fma/fma63011 |
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
458 | 143-154 | Species | denotes | coronavirus | Tax:11118 |
459 | 193-196 | Species | denotes | CoV | Tax:11118 |
460 | 232-243 | Species | denotes | coronavirus | Tax:11118 |
461 | 421-431 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
462 | 432-443 | Species | denotes | coronavirus | Tax:11118 |
463 | 556-566 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
464 | 589-599 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
465 | 802-812 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
466 | 38-52 | Chemical | denotes | polysaccharide | MESH:D011134 |
467 | 635-652 | Chemical | denotes | basic amino acids | MESH:D024361 |
468 | 931-948 | Chemical | denotes | basic amino acids | MESH:D024361 |
469 | 1128-1131 | Chemical | denotes | GAG | MESH:D006025 |
470 | 88-97 | Disease | denotes | infection | MESH:D007239 |
471 | 384-394 | Disease | denotes | infections | MESH:D007239 |
LitCovid-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T42 | 88-97 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
T43 | 384-394 | Disease | denotes | infections | http://purl.obolibrary.org/obo/MONDO_0005550 |
T44 | 421-429 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T45 | 556-564 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T46 | 589-597 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T47 | 802-810 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T117 | 101-102 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T118 | 112-119 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
T119 | 273-278 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T120 | 573-575 | http://purl.obolibrary.org/obo/CLO_0050050 | denotes | S1 |
T121 | 600-602 | http://purl.obolibrary.org/obo/CLO_0050050 | denotes | S1 |
T122 | 813-815 | http://purl.obolibrary.org/obo/CLO_0050050 | denotes | S1 |
T123 | 996-999 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
T124 | 1042-1043 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T234 | 20-22 | Chemical | denotes | HS | http://purl.obolibrary.org/obo/CHEBI_74056|http://purl.obolibrary.org/obo/CHEBI_28815 |
T236 | 38-52 | Chemical | denotes | polysaccharide | http://purl.obolibrary.org/obo/CHEBI_18154 |
T237 | 54-61 | Chemical | denotes | heparin | http://purl.obolibrary.org/obo/CHEBI_28304 |
T238 | 173-175 | Chemical | denotes | HS | http://purl.obolibrary.org/obo/CHEBI_74056|http://purl.obolibrary.org/obo/CHEBI_28815 |
T240 | 205-213 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
T241 | 576-583 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T242 | 612-619 | Chemical | denotes | heparin | http://purl.obolibrary.org/obo/CHEBI_28304 |
T243 | 641-652 | Chemical | denotes | amino acids | http://purl.obolibrary.org/obo/CHEBI_33709 |
T244 | 641-646 | Chemical | denotes | amino | http://purl.obolibrary.org/obo/CHEBI_46882 |
T245 | 647-652 | Chemical | denotes | acids | http://purl.obolibrary.org/obo/CHEBI_37527 |
T246 | 694-702 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
T247 | 707-714 | Chemical | denotes | heparin | http://purl.obolibrary.org/obo/CHEBI_28304 |
T248 | 759-766 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T249 | 868-875 | Chemical | denotes | heparin | http://purl.obolibrary.org/obo/CHEBI_28304 |
T250 | 937-948 | Chemical | denotes | amino acids | http://purl.obolibrary.org/obo/CHEBI_33709 |
T251 | 937-942 | Chemical | denotes | amino | http://purl.obolibrary.org/obo/CHEBI_46882 |
T252 | 943-948 | Chemical | denotes | acids | http://purl.obolibrary.org/obo/CHEBI_37527 |
T253 | 968-975 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T254 | 1082-1089 | Chemical | denotes | heparin | http://purl.obolibrary.org/obo/CHEBI_28304 |
T255 | 1128-1131 | Chemical | denotes | GAG | http://purl.obolibrary.org/obo/CHEBI_143889 |
T256 | 1138-1148 | Chemical | denotes | antivirals | http://purl.obolibrary.org/obo/CHEBI_22587 |
2_test
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
32679328-25187545-48281281 | 280-282 | 25187545 | denotes | 54 |
T82176 | 280-282 | 25187545 | denotes | 54 |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T84 | 0-172 | Sentence | denotes | Natural products of HS and the allied polysaccharide, heparin, are involved and prevent infection by a range of viruses including S-associated coronavirus strain HSR1 [66]. |
T85 | 173-284 | Sentence | denotes | HS is known to bind CoV surface proteins and to be used by coronavirus for its attachment to target cells [54]. |
T86 | 285-453 | Sentence | denotes | Currently, there are no commercially available medicinal products designed to treat and/or prevent infections associated with the novel SARS-CoV-2 coronavirus outbreak. |
T87 | 454-620 | Sentence | denotes | The surface plasmon resonance and circular dichroism were used to measure the interaction between the SARS-CoV-2 Spike S1 protein RBD (SARS-CoV-2 S1 RBD) and heparin. |
T88 | 621-715 | Sentence | denotes | Additionally, basic amino acids are known to dictate the binding between proteins and heparin. |
T89 | 716-984 | Sentence | denotes | Primary sequence analysis of the expressed protein domain and analysis of the modeled SARS-CoV-2 S1 RBD structure show that there are several potential heparin binding sites, and more importantly, theses patches of basic amino acids are exposed on the protein surface. |
T90 | 985-1154 | Sentence | denotes | This study has implications for the rapid development of a first-line therapeutic by repurposing heparin and for next-generation, tailor-made, GAG-based antivirals [66]. |
LitCovid-PD-GlycoEpitope
Id | Subject | Object | Predicate | Lexical cue | glyco_epitope_db_id |
---|---|---|---|---|---|
T11 | 20-22 | GlycoEpitope | denotes | HS | http://www.glycoepitope.jp/epitopes/EP0086 |
T12 | 173-175 | GlycoEpitope | denotes | HS | http://www.glycoepitope.jp/epitopes/EP0086 |
LitCovid-PMC-OGER-BB
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T365 | 38-52 | CHEBI:18154;CHEBI:18154 | denotes | polysaccharide |
T366 | 54-61 | CHEBI:24505;CHEBI:24505 | denotes | heparin |
T367 | 112-119 | NCBITaxon:10239 | denotes | viruses |
T368 | 131-132 | NCBITaxon:11118 | denotes | - |
T369 | 143-154 | NCBITaxon:11118 | denotes | coronavirus |
T370 | 197-204 | GO:0009986 | denotes | surface |
T371 | 232-243 | NCBITaxon:11118 | denotes | coronavirus |
T372 | 421-431 | SP_7 | denotes | SARS-CoV-2 |
T373 | 432-443 | NCBITaxon:11118 | denotes | coronavirus |
T374 | 556-566 | SP_7 | denotes | SARS-CoV-2 |
T375 | 589-599 | SP_7 | denotes | SARS-CoV-2 |
T376 | 612-619 | CHEBI:24505;CHEBI:24505 | denotes | heparin |
T377 | 707-714 | CHEBI:24505;CHEBI:24505 | denotes | heparin |
T378 | 749-758 | GO:0010467 | denotes | expressed |
T379 | 767-773 | SO:0000417 | denotes | domain |
T380 | 802-812 | SP_7 | denotes | SARS-CoV-2 |
T381 | 868-875 | CHEBI:24505;CHEBI:24505 | denotes | heparin |
T382 | 876-889 | SO:0000409 | denotes | binding sites |
T383 | 931-936 | CHEBI:22695;CHEBI:22695 | denotes | basic |
T384 | 976-983 | GO:0009986 | denotes | surface |
T385 | 1082-1089 | CHEBI:24505;CHEBI:24505 | denotes | heparin |
T88403 | 29-44 | CHEBI:18154;CHEBI:18154 | denotes | e allied polysa |
T61829 | 52-67 | CHEBI:18154;CHEBI:18154 | denotes | , heparin, are |
T5723 | 77-88 | CHEBI:3435;CHEBI:3435 | denotes | nd prevent |
T64126 | 95-101 | CHEBI:16261;CHEBI:16261 | denotes | on by |
T10756 | 172-179 | NCBITaxon:10239 | denotes | HS is |
T71525 | 230-241 | NCBITaxon:11118 | denotes | y coronavir |
T21264 | 245-256 | CHEBI:37168;CHEBI:37168 | denotes | or its atta |
T34882 | 304-309 | SP_6;NCBITaxon:9606 | denotes | e no |
T1149 | 310-320 | NCBITaxon:7729 | denotes | ommerciall |
T40067 | 322-325 | NCBITaxon:10298 | denotes | ava |
T40605 | 328-337 | NCBITaxon:7719 | denotes | ble medic |
T90028 | 338-343 | NCBITaxon:10239 | denotes | nal p |
T40868 | 445-450 | NCBITaxon:10239 | denotes | utbre |
T87296 | 465-471 | UBERON:0000341 | denotes | plasm |
T75615 | 482-494 | CHEBI:36916;CHEBI:36916 | denotes | e and circul |
T61186 | 504-510 | CHEBI:16261;CHEBI:16261 | denotes | sm wer |
T51389 | 512-514 | CHEBI:8502;CHEBI:8502 | denotes | us |
T67375 | 514-515 | CHEBI:62946;CHEBI:62946 | denotes | e |
T40926 | 515-516 | CHEBI:86228;CHEBI:86228 | denotes | d |
T27090 | 516-530 | CHEBI:20067;CHEBI:20067 | denotes | to measure th |
T31907 | 532-534 | CHEBI:53233;CHEBI:53233 | denotes | in |
T91402 | 534-551 | CHEBI:58389;CHEBI:58389 | denotes | teraction between |
T8734 | 552-558 | CHEBI:16261;CHEBI:16261 | denotes | the SA |
T19220 | 559-567 | CHEBI:17996;CHEBI:17996 | denotes | S-CoV-2 |
T3856 | 618-623 | SP_6;NCBITaxon:9606 | denotes | n. Ad |
T38444 | 624-635 | NCBITaxon:11118 | denotes | itionally, |
T48275 | 750-759 | CHEBI:35222;CHEBI:35222 | denotes | xpressed |
T48215 | 767-778 | NCBITaxon:11118 | denotes | domain and |
T77121 | 811-819 | CHEBI:60027;CHEBI:60027 | denotes | 2 S1 RBD |
T15032 | 829-835 | CHEBI:16261;CHEBI:16261 | denotes | show |
T97949 | 850-860 | CHEBI:35222;CHEBI:35222 | denotes | several po |
T37794 | 883-888 | SP_6;NCBITaxon:9606 | denotes | site |
T43701 | 889-902 | NCBITaxon:11118 | denotes | , and more im |
T2120 | 915-920 | NCBITaxon:10239 | denotes | eses |
T20905 | 921-943 | UBERON:0001557 | denotes | atches of basic amino |
T47355 | 1002-1012 | NCBITaxon:11886;UBERON:0001004 | denotes | plications |
T87148 | 1013-1020 | NCBITaxon:10239 | denotes | for the |
T13297 | 1030-1040 | NCBITaxon:11632 | denotes | elopment o |
T46132 | 1042-1053 | NCBITaxon:11118 | denotes | a first-lin |
T69701 | 1055-1064 | NCBITaxon:7719 | denotes | therapeut |
T9813 | 1065-1070 | NCBITaxon:10239 | denotes | c by |
T5078 | 1130-1135 | UBERON:0000004 | denotes | G-bas |
MyTest
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
458 | 143-154 | Species | denotes | coronavirus | Tax:11118 |
459 | 193-196 | Species | denotes | CoV | Tax:11118 |
460 | 232-243 | Species | denotes | coronavirus | Tax:11118 |
461 | 421-431 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
462 | 432-443 | Species | denotes | coronavirus | Tax:11118 |
463 | 556-566 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
464 | 589-599 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
465 | 802-812 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
466 | 38-52 | Chemical | denotes | polysaccharide | MESH:D011134 |
467 | 635-652 | Chemical | denotes | basic amino acids | MESH:D024361 |
468 | 931-948 | Chemical | denotes | basic amino acids | MESH:D024361 |
469 | 1128-1131 | Chemical | denotes | GAG | MESH:D006025 |
470 | 88-97 | Disease | denotes | infection | MESH:D007239 |
471 | 384-394 | Disease | denotes | infections | MESH:D007239 |