PMC:7354481 / 40967-41677 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T278","span":{"begin":154,"end":158},"obj":"Body_part"},{"id":"T279","span":{"begin":185,"end":189},"obj":"Body_part"},{"id":"T280","span":{"begin":260,"end":276},"obj":"Body_part"},{"id":"T281","span":{"begin":271,"end":276},"obj":"Body_part"},{"id":"T282","span":{"begin":413,"end":417},"obj":"Body_part"},{"id":"T283","span":{"begin":508,"end":512},"obj":"Body_part"},{"id":"T284","span":{"begin":616,"end":623},"obj":"Body_part"}],"attributes":[{"id":"A278","pred":"fma_id","subj":"T278","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A279","pred":"fma_id","subj":"T279","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A280","pred":"fma_id","subj":"T280","obj":"http://purl.org/sig/ont/fma/fma66768"},{"id":"A281","pred":"fma_id","subj":"T281","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A282","pred":"fma_id","subj":"T282","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A283","pred":"fma_id","subj":"T283","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A284","pred":"fma_id","subj":"T284","obj":"http://purl.org/sig/ont/fma/fma84116"}],"text":"4.1.6. miR-3691-3p\nIt has been shown that oxidative stress, which has detrimental effects on intercellular communication, plays an important role in many lung pathologies such as acute lung injury and COPD. A proteomic profile of exosomes from human bronchial epithelial cells, under normoxia and hypoxia, has reported reduced expression of miR-3691-3p in hypoxia [100]. Interestingly, miR3691-3p targets several cell signalling pathways, such as TGF-β signalling, FGF2 and also VCAM1, which is relevant for lung injury and repair. In the current study, we have also identified that miR3691-3p exists in four of the genomes, which we have extensively studied here, and therefore it seems to be a conserved miR."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T56","span":{"begin":154,"end":158},"obj":"Body_part"},{"id":"T57","span":{"begin":185,"end":189},"obj":"Body_part"},{"id":"T58","span":{"begin":508,"end":512},"obj":"Body_part"}],"attributes":[{"id":"A56","pred":"uberon_id","subj":"T56","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A57","pred":"uberon_id","subj":"T57","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A58","pred":"uberon_id","subj":"T58","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"}],"text":"4.1.6. miR-3691-3p\nIt has been shown that oxidative stress, which has detrimental effects on intercellular communication, plays an important role in many lung pathologies such as acute lung injury and COPD. A proteomic profile of exosomes from human bronchial epithelial cells, under normoxia and hypoxia, has reported reduced expression of miR-3691-3p in hypoxia [100]. Interestingly, miR3691-3p targets several cell signalling pathways, such as TGF-β signalling, FGF2 and also VCAM1, which is relevant for lung injury and repair. In the current study, we have also identified that miR3691-3p exists in four of the genomes, which we have extensively studied here, and therefore it seems to be a conserved miR."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T247","span":{"begin":179,"end":196},"obj":"Disease"},{"id":"T249","span":{"begin":190,"end":196},"obj":"Disease"},{"id":"T250","span":{"begin":201,"end":205},"obj":"Disease"},{"id":"T251","span":{"begin":513,"end":519},"obj":"Disease"}],"attributes":[{"id":"A247","pred":"mondo_id","subj":"T247","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A248","pred":"mondo_id","subj":"T247","obj":"http://purl.obolibrary.org/obo/MONDO_0015796"},{"id":"A249","pred":"mondo_id","subj":"T249","obj":"http://purl.obolibrary.org/obo/MONDO_0021178"},{"id":"A250","pred":"mondo_id","subj":"T250","obj":"http://purl.obolibrary.org/obo/MONDO_0005002"},{"id":"A251","pred":"mondo_id","subj":"T251","obj":"http://purl.obolibrary.org/obo/MONDO_0021178"}],"text":"4.1.6. miR-3691-3p\nIt has been shown that oxidative stress, which has detrimental effects on intercellular communication, plays an important role in many lung pathologies such as acute lung injury and COPD. A proteomic profile of exosomes from human bronchial epithelial cells, under normoxia and hypoxia, has reported reduced expression of miR-3691-3p in hypoxia [100]. Interestingly, miR3691-3p targets several cell signalling pathways, such as TGF-β signalling, FGF2 and also VCAM1, which is relevant for lung injury and repair. In the current study, we have also identified that miR3691-3p exists in four of the genomes, which we have extensively studied here, and therefore it seems to be a conserved miR."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T459","span":{"begin":22,"end":25},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T460","span":{"begin":66,"end":69},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T461","span":{"begin":154,"end":158},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T462","span":{"begin":154,"end":158},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T463","span":{"begin":185,"end":189},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T464","span":{"begin":185,"end":189},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T465","span":{"begin":207,"end":208},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T466","span":{"begin":244,"end":249},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T467","span":{"begin":260,"end":270},"obj":"http://purl.obolibrary.org/obo/CL_0000066"},{"id":"T468","span":{"begin":271,"end":276},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T469","span":{"begin":306,"end":309},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T470","span":{"begin":413,"end":417},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T471","span":{"begin":418,"end":428},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T472","span":{"begin":453,"end":463},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T473","span":{"begin":508,"end":512},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T474","span":{"begin":508,"end":512},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T475","span":{"begin":694,"end":695},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"4.1.6. miR-3691-3p\nIt has been shown that oxidative stress, which has detrimental effects on intercellular communication, plays an important role in many lung pathologies such as acute lung injury and COPD. A proteomic profile of exosomes from human bronchial epithelial cells, under normoxia and hypoxia, has reported reduced expression of miR-3691-3p in hypoxia [100]. Interestingly, miR3691-3p targets several cell signalling pathways, such as TGF-β signalling, FGF2 and also VCAM1, which is relevant for lung injury and repair. In the current study, we have also identified that miR3691-3p exists in four of the genomes, which we have extensively studied here, and therefore it seems to be a conserved miR."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T73","span":{"begin":42,"end":58},"obj":"Phenotype"},{"id":"T74","span":{"begin":179,"end":196},"obj":"Phenotype"},{"id":"T75","span":{"begin":201,"end":205},"obj":"Phenotype"},{"id":"T76","span":{"begin":297,"end":304},"obj":"Phenotype"},{"id":"T77","span":{"begin":356,"end":363},"obj":"Phenotype"}],"attributes":[{"id":"A73","pred":"hp_id","subj":"T73","obj":"http://purl.obolibrary.org/obo/HP_0025464"},{"id":"A74","pred":"hp_id","subj":"T74","obj":"http://www.orpha.net/ORDO/Orphanet_178320"},{"id":"A75","pred":"hp_id","subj":"T75","obj":"http://purl.obolibrary.org/obo/HP_0006510"},{"id":"A76","pred":"hp_id","subj":"T76","obj":"http://purl.obolibrary.org/obo/HP_0012418"},{"id":"A77","pred":"hp_id","subj":"T77","obj":"http://purl.obolibrary.org/obo/HP_0012418"}],"text":"4.1.6. miR-3691-3p\nIt has been shown that oxidative stress, which has detrimental effects on intercellular communication, plays an important role in many lung pathologies such as acute lung injury and COPD. A proteomic profile of exosomes from human bronchial epithelial cells, under normoxia and hypoxia, has reported reduced expression of miR-3691-3p in hypoxia [100]. Interestingly, miR3691-3p targets several cell signalling pathways, such as TGF-β signalling, FGF2 and also VCAM1, which is relevant for lung injury and repair. In the current study, we have also identified that miR3691-3p exists in four of the genomes, which we have extensively studied here, and therefore it seems to be a conserved miR."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T151","span":{"begin":418,"end":437},"obj":"http://purl.obolibrary.org/obo/GO_0007165"},{"id":"T152","span":{"begin":418,"end":428},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T153","span":{"begin":453,"end":463},"obj":"http://purl.obolibrary.org/obo/GO_0023052"}],"text":"4.1.6. miR-3691-3p\nIt has been shown that oxidative stress, which has detrimental effects on intercellular communication, plays an important role in many lung pathologies such as acute lung injury and COPD. A proteomic profile of exosomes from human bronchial epithelial cells, under normoxia and hypoxia, has reported reduced expression of miR-3691-3p in hypoxia [100]. Interestingly, miR3691-3p targets several cell signalling pathways, such as TGF-β signalling, FGF2 and also VCAM1, which is relevant for lung injury and repair. In the current study, we have also identified that miR3691-3p exists in four of the genomes, which we have extensively studied here, and therefore it seems to be a conserved miR."}

{"project":"LitCovid-sentences","denotations":[{"id":"T269","span":{"begin":0,"end":18},"obj":"Sentence"},{"id":"T270","span":{"begin":19,"end":206},"obj":"Sentence"},{"id":"T271","span":{"begin":207,"end":370},"obj":"Sentence"},{"id":"T272","span":{"begin":371,"end":531},"obj":"Sentence"},{"id":"T273","span":{"begin":532,"end":710},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"4.1.6. miR-3691-3p\nIt has been shown that oxidative stress, which has detrimental effects on intercellular communication, plays an important role in many lung pathologies such as acute lung injury and COPD. A proteomic profile of exosomes from human bronchial epithelial cells, under normoxia and hypoxia, has reported reduced expression of miR-3691-3p in hypoxia [100]. Interestingly, miR3691-3p targets several cell signalling pathways, such as TGF-β signalling, FGF2 and also VCAM1, which is relevant for lung injury and repair. In the current study, we have also identified that miR3691-3p exists in four of the genomes, which we have extensively studied here, and therefore it seems to be a conserved miR."}

{"project":"2_test","denotations":[{"id":"32512929-19934357-144200780","span":{"begin":365,"end":368},"obj":"19934357"}],"text":"4.1.6. miR-3691-3p\nIt has been shown that oxidative stress, which has detrimental effects on intercellular communication, plays an important role in many lung pathologies such as acute lung injury and COPD. A proteomic profile of exosomes from human bronchial epithelial cells, under normoxia and hypoxia, has reported reduced expression of miR-3691-3p in hypoxia [100]. Interestingly, miR3691-3p targets several cell signalling pathways, such as TGF-β signalling, FGF2 and also VCAM1, which is relevant for lung injury and repair. In the current study, we have also identified that miR3691-3p exists in four of the genomes, which we have extensively studied here, and therefore it seems to be a conserved miR."}

{"project":"LitCovid-PubTator","denotations":[{"id":"1005","span":{"begin":386,"end":393},"obj":"Gene"},{"id":"1006","span":{"begin":447,"end":452},"obj":"Gene"},{"id":"1007","span":{"begin":465,"end":469},"obj":"Gene"},{"id":"1008","span":{"begin":479,"end":484},"obj":"Gene"},{"id":"1009","span":{"begin":583,"end":590},"obj":"Gene"},{"id":"1010","span":{"begin":244,"end":249},"obj":"Species"},{"id":"1011","span":{"begin":179,"end":196},"obj":"Disease"},{"id":"1012","span":{"begin":201,"end":205},"obj":"Disease"},{"id":"1013","span":{"begin":297,"end":304},"obj":"Disease"},{"id":"1014","span":{"begin":356,"end":363},"obj":"Disease"},{"id":"1015","span":{"begin":508,"end":519},"obj":"Disease"}],"attributes":[{"id":"A1005","pred":"tao:has_database_id","subj":"1005","obj":"Gene:100500900"},{"id":"A1006","pred":"tao:has_database_id","subj":"1006","obj":"Gene:7039"},{"id":"A1007","pred":"tao:has_database_id","subj":"1007","obj":"Gene:2247"},{"id":"A1008","pred":"tao:has_database_id","subj":"1008","obj":"Gene:7412"},{"id":"A1009","pred":"tao:has_database_id","subj":"1009","obj":"Gene:100500900"},{"id":"A1010","pred":"tao:has_database_id","subj":"1010","obj":"Tax:9606"},{"id":"A1011","pred":"tao:has_database_id","subj":"1011","obj":"MESH:D055371"},{"id":"A1012","pred":"tao:has_database_id","subj":"1012","obj":"MESH:D029424"},{"id":"A1013","pred":"tao:has_database_id","subj":"1013","obj":"MESH:D000860"},{"id":"A1014","pred":"tao:has_database_id","subj":"1014","obj":"MESH:D000860"},{"id":"A1015","pred":"tao:has_database_id","subj":"1015","obj":"MESH:D055370"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"4.1.6. miR-3691-3p\nIt has been shown that oxidative stress, which has detrimental effects on intercellular communication, plays an important role in many lung pathologies such as acute lung injury and COPD. A proteomic profile of exosomes from human bronchial epithelial cells, under normoxia and hypoxia, has reported reduced expression of miR-3691-3p in hypoxia [100]. Interestingly, miR3691-3p targets several cell signalling pathways, such as TGF-β signalling, FGF2 and also VCAM1, which is relevant for lung injury and repair. In the current study, we have also identified that miR3691-3p exists in four of the genomes, which we have extensively studied here, and therefore it seems to be a conserved miR."}