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LitCovid_Glycan-Motif-Structure

{"project":"LitCovid_Glycan-Motif-Structure","denotations":[{"id":"T173","span":{"begin":124,"end":126},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T174","span":{"begin":175,"end":177},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T175","span":{"begin":533,"end":535},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T176","span":{"begin":633,"end":635},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T177","span":{"begin":838,"end":845},"obj":"https://glytoucan.org/Structures/Glycans/G15021LG"}],"text":"CoV HEs are functionally similar to influenza virus C/D HEF glycoproteins. In CoV, the S glycoprotein recognizes the 9-O-Ac-SA sugar, while the HE acts as the RDE enzyme with SA-O-acetyl-esterase activity to release virions from infected host cells. For example, HCoV-OC43 also has a similar HE as an RDE [71]. In influenza C and D viruses, HEF glycoproteins act similarly to the CoV HE [74]. In influenza A virus, RDE NA releases virions from host cells. However, MERS-CoV does not have a similar enzyme and thus MER-CoV binding to SA receptors is mediated by energetically reversible interactions of the lipid rafts with increased SA receptors [75], thus enhancing dipeptidyl peptidase 4 (DPP4) or carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) recognition power and viral entry [76] and membrane-associated 78-kDa glucose-regulated protein (GRP78) [77]."}

LitCovid-PD-FMA-UBERON

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T341","span":{"begin":60,"end":73},"obj":"Body_part"},{"id":"T342","span":{"begin":89,"end":101},"obj":"Body_part"},{"id":"T343","span":{"begin":127,"end":132},"obj":"Body_part"},{"id":"T344","span":{"begin":243,"end":248},"obj":"Body_part"},{"id":"T345","span":{"begin":345,"end":358},"obj":"Body_part"},{"id":"T346","span":{"begin":449,"end":454},"obj":"Body_part"},{"id":"T347","span":{"begin":606,"end":611},"obj":"Body_part"},{"id":"T348","span":{"begin":733,"end":755},"obj":"Body_part"},{"id":"T349","span":{"begin":733,"end":737},"obj":"Body_part"},{"id":"T350","span":{"begin":838,"end":845},"obj":"Body_part"},{"id":"T351","span":{"begin":856,"end":863},"obj":"Body_part"}],"attributes":[{"id":"A341","pred":"fma_id","subj":"T341","obj":"http://purl.org/sig/ont/fma/fma62925"},{"id":"A342","pred":"fma_id","subj":"T342","obj":"http://purl.org/sig/ont/fma/fma62925"},{"id":"A343","pred":"fma_id","subj":"T343","obj":"http://purl.org/sig/ont/fma/fma82737"},{"id":"A344","pred":"fma_id","subj":"T344","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A345","pred":"fma_id","subj":"T345","obj":"http://purl.org/sig/ont/fma/fma62925"},{"id":"A346","pred":"fma_id","subj":"T346","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A347","pred":"fma_id","subj":"T347","obj":"http://purl.org/sig/ont/fma/fma67264"},{"id":"A348","pred":"fma_id","subj":"T348","obj":"http://purl.org/sig/ont/fma/fma67214"},{"id":"A349","pred":"fma_id","subj":"T349","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A350","pred":"fma_id","subj":"T350","obj":"http://purl.org/sig/ont/fma/fma82743"},{"id":"A351","pred":"fma_id","subj":"T351","obj":"http://purl.org/sig/ont/fma/fma67257"}],"text":"CoV HEs are functionally similar to influenza virus C/D HEF glycoproteins. In CoV, the S glycoprotein recognizes the 9-O-Ac-SA sugar, while the HE acts as the RDE enzyme with SA-O-acetyl-esterase activity to release virions from infected host cells. For example, HCoV-OC43 also has a similar HE as an RDE [71]. In influenza C and D viruses, HEF glycoproteins act similarly to the CoV HE [74]. In influenza A virus, RDE NA releases virions from host cells. However, MERS-CoV does not have a similar enzyme and thus MER-CoV binding to SA receptors is mediated by energetically reversible interactions of the lipid rafts with increased SA receptors [75], thus enhancing dipeptidyl peptidase 4 (DPP4) or carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) recognition power and viral entry [76] and membrane-associated 78-kDa glucose-regulated protein (GRP78) [77]."}

LitCovid-PD-MONDO

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T143","span":{"begin":36,"end":45},"obj":"Disease"},{"id":"T144","span":{"begin":314,"end":323},"obj":"Disease"},{"id":"T145","span":{"begin":396,"end":405},"obj":"Disease"}],"attributes":[{"id":"A143","pred":"mondo_id","subj":"T143","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"},{"id":"A144","pred":"mondo_id","subj":"T144","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"},{"id":"A145","pred":"mondo_id","subj":"T145","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"}],"text":"CoV HEs are functionally similar to influenza virus C/D HEF glycoproteins. In CoV, the S glycoprotein recognizes the 9-O-Ac-SA sugar, while the HE acts as the RDE enzyme with SA-O-acetyl-esterase activity to release virions from infected host cells. For example, HCoV-OC43 also has a similar HE as an RDE [71]. In influenza C and D viruses, HEF glycoproteins act similarly to the CoV HE [74]. In influenza A virus, RDE NA releases virions from host cells. However, MERS-CoV does not have a similar enzyme and thus MER-CoV binding to SA receptors is mediated by energetically reversible interactions of the lipid rafts with increased SA receptors [75], thus enhancing dipeptidyl peptidase 4 (DPP4) or carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) recognition power and viral entry [76] and membrane-associated 78-kDa glucose-regulated protein (GRP78) [77]."}

LitCovid-PD-CLO

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T554","span":{"begin":4,"end":7},"obj":"http://purl.obolibrary.org/obo/CLO_0053120"},{"id":"T555","span":{"begin":46,"end":51},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T556","span":{"begin":196,"end":204},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T557","span":{"begin":243,"end":248},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T558","span":{"begin":278,"end":281},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T559","span":{"begin":282,"end":283},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T560","span":{"begin":306,"end":308},"obj":"http://purl.obolibrary.org/obo/CLO_0054055"},{"id":"T561","span":{"begin":332,"end":339},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T562","span":{"begin":406,"end":407},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T563","span":{"begin":408,"end":413},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T564","span":{"begin":449,"end":454},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T565","span":{"begin":488,"end":489},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T566","span":{"begin":733,"end":737},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T567","span":{"begin":811,"end":819},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"}],"text":"CoV HEs are functionally similar to influenza virus C/D HEF glycoproteins. In CoV, the S glycoprotein recognizes the 9-O-Ac-SA sugar, while the HE acts as the RDE enzyme with SA-O-acetyl-esterase activity to release virions from infected host cells. For example, HCoV-OC43 also has a similar HE as an RDE [71]. In influenza C and D viruses, HEF glycoproteins act similarly to the CoV HE [74]. In influenza A virus, RDE NA releases virions from host cells. However, MERS-CoV does not have a similar enzyme and thus MER-CoV binding to SA receptors is mediated by energetically reversible interactions of the lipid rafts with increased SA receptors [75], thus enhancing dipeptidyl peptidase 4 (DPP4) or carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) recognition power and viral entry [76] and membrane-associated 78-kDa glucose-regulated protein (GRP78) [77]."}

LitCovid-PD-CHEBI

LitCovid-PD-GO-BP

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T65","span":{"begin":733,"end":755},"obj":"http://purl.obolibrary.org/obo/GO_0098631"},{"id":"T66","span":{"begin":733,"end":746},"obj":"http://purl.obolibrary.org/obo/GO_0007155"}],"text":"CoV HEs are functionally similar to influenza virus C/D HEF glycoproteins. In CoV, the S glycoprotein recognizes the 9-O-Ac-SA sugar, while the HE acts as the RDE enzyme with SA-O-acetyl-esterase activity to release virions from infected host cells. For example, HCoV-OC43 also has a similar HE as an RDE [71]. In influenza C and D viruses, HEF glycoproteins act similarly to the CoV HE [74]. In influenza A virus, RDE NA releases virions from host cells. However, MERS-CoV does not have a similar enzyme and thus MER-CoV binding to SA receptors is mediated by energetically reversible interactions of the lipid rafts with increased SA receptors [75], thus enhancing dipeptidyl peptidase 4 (DPP4) or carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) recognition power and viral entry [76] and membrane-associated 78-kDa glucose-regulated protein (GRP78) [77]."}

LitCovid-sentences

{"project":"LitCovid-sentences","denotations":[{"id":"T397","span":{"begin":0,"end":74},"obj":"Sentence"},{"id":"T398","span":{"begin":75,"end":249},"obj":"Sentence"},{"id":"T399","span":{"begin":250,"end":310},"obj":"Sentence"},{"id":"T400","span":{"begin":311,"end":392},"obj":"Sentence"},{"id":"T401","span":{"begin":393,"end":455},"obj":"Sentence"},{"id":"T402","span":{"begin":456,"end":877},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"CoV HEs are functionally similar to influenza virus C/D HEF glycoproteins. In CoV, the S glycoprotein recognizes the 9-O-Ac-SA sugar, while the HE acts as the RDE enzyme with SA-O-acetyl-esterase activity to release virions from infected host cells. For example, HCoV-OC43 also has a similar HE as an RDE [71]. In influenza C and D viruses, HEF glycoproteins act similarly to the CoV HE [74]. In influenza A virus, RDE NA releases virions from host cells. However, MERS-CoV does not have a similar enzyme and thus MER-CoV binding to SA receptors is mediated by energetically reversible interactions of the lipid rafts with increased SA receptors [75], thus enhancing dipeptidyl peptidase 4 (DPP4) or carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) recognition power and viral entry [76] and membrane-associated 78-kDa glucose-regulated protein (GRP78) [77]."}

2_test

{"project":"2_test","denotations":[{"id":"32604730-30679277-51944031","span":{"begin":306,"end":308},"obj":"30679277"},{"id":"32604730-26816272-51944032","span":{"begin":388,"end":390},"obj":"26816272"},{"id":"32604730-28923942-51944033","span":{"begin":647,"end":649},"obj":"28923942"},{"id":"32604730-27489282-51944034","span":{"begin":803,"end":805},"obj":"27489282"},{"id":"T1253","span":{"begin":306,"end":308},"obj":"30679277"},{"id":"T30147","span":{"begin":388,"end":390},"obj":"26816272"},{"id":"T88685","span":{"begin":647,"end":649},"obj":"28923942"},{"id":"T40332","span":{"begin":803,"end":805},"obj":"27489282"}],"text":"CoV HEs are functionally similar to influenza virus C/D HEF glycoproteins. In CoV, the S glycoprotein recognizes the 9-O-Ac-SA sugar, while the HE acts as the RDE enzyme with SA-O-acetyl-esterase activity to release virions from infected host cells. For example, HCoV-OC43 also has a similar HE as an RDE [71]. In influenza C and D viruses, HEF glycoproteins act similarly to the CoV HE [74]. In influenza A virus, RDE NA releases virions from host cells. However, MERS-CoV does not have a similar enzyme and thus MER-CoV binding to SA receptors is mediated by energetically reversible interactions of the lipid rafts with increased SA receptors [75], thus enhancing dipeptidyl peptidase 4 (DPP4) or carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) recognition power and viral entry [76] and membrane-associated 78-kDa glucose-regulated protein (GRP78) [77]."}

PMC:7352545 / 41180-42057 JSONTXT

Annnotations TAB JSON ListView MergeView

PMC:7352545 / 41180-42057 JSON TXT