PMC:7352545 / 33333-34870
Annnotations
LitCovid_Glycan-Motif-Structure
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T136 | 57-59 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T137 | 108-110 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T138 | 328-330 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T139 | 693-695 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T140 | 775-777 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T141 | 837-839 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T142 | 1029-1031 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T143 | 1085-1087 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T144 | 1263-1265 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T145 | 1341-1343 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T146 | 1455-1457 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T263 | 169-181 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
| T264 | 347-357 | Body_part | denotes | Nucleotide | http://purl.org/sig/ont/fma/fma82740 |
| T265 | 371-375 | Body_part | denotes | gene | http://purl.org/sig/ont/fma/fma74402 |
| T266 | 441-453 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
| T267 | 521-531 | Body_part | denotes | nucleotide | http://purl.org/sig/ont/fma/fma82740 |
| T268 | 556-566 | Body_part | denotes | nucleotide | http://purl.org/sig/ont/fma/fma82740 |
| T269 | 620-632 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
| T270 | 718-730 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
| T271 | 760-767 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T272 | 815-827 | Body_part | denotes | goblet cells | http://purl.org/sig/ont/fma/fma13148 |
| T273 | 822-827 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T274 | 875-880 | Body_part | denotes | mucus | http://purl.org/sig/ont/fma/fma66938 |
| T275 | 894-904 | Body_part | denotes | intestinal | http://purl.org/sig/ont/fma/fma7199 |
| T276 | 905-916 | Body_part | denotes | enterocytes | http://purl.org/sig/ont/fma/fma62122 |
| T277 | 945-957 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
| T278 | 1054-1066 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
| T279 | 1334-1339 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T280 | 1393-1398 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T281 | 1516-1526 | Body_part | denotes | intestinal | http://purl.org/sig/ont/fma/fma7199 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T7 | 875-880 | Body_part | denotes | mucus | http://purl.obolibrary.org/obo/UBERON_0000912 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T123 | 1487-1496 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T124 | 1527-1536 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T445 | 27-35 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T446 | 72-80 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T447 | 196-199 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T448 | 269-272 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T449 | 371-375 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | gene |
| T450 | 517-520 | http://purl.obolibrary.org/obo/CLO_0001602 | denotes | a 6 |
| T451 | 517-520 | http://purl.obolibrary.org/obo/CLO_0001603 | denotes | a 6 |
| T452 | 517-520 | http://purl.obolibrary.org/obo/CLO_0050248 | denotes | a 6 |
| T453 | 517-520 | http://purl.obolibrary.org/obo/CLO_0052463 | denotes | a 6 |
| T454 | 738-739 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T455 | 822-827 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T456 | 855-860 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T457 | 894-904 | http://purl.obolibrary.org/obo/UBERON_0000160 | denotes | intestinal |
| T458 | 894-904 | http://www.ebi.ac.uk/efo/EFO_0000834 | denotes | intestinal |
| T459 | 973-976 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T460 | 997-1005 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T461 | 1096-1104 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T462 | 1151-1154 | http://purl.obolibrary.org/obo/CLO_0051568 | denotes | SAs |
| T463 | 1252-1257 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T464 | 1278-1286 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T465 | 1311-1316 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T466 | 1334-1339 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T467 | 1352-1360 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T468 | 1393-1398 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T469 | 1431-1432 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T470 | 1466-1474 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T471 | 1516-1526 | http://purl.obolibrary.org/obo/UBERON_0000160 | denotes | intestinal |
| T472 | 1516-1526 | http://www.ebi.ac.uk/efo/EFO_0000834 | denotes | intestinal |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T1001 | 24-26 | Chemical | denotes | HA | http://purl.obolibrary.org/obo/CHEBI_73924 |
| T1002 | 57-59 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T1007 | 89-94 | Chemical | denotes | NeuGc | http://purl.obolibrary.org/obo/CHEBI_62084 |
| T1008 | 108-110 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T1013 | 169-181 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T1014 | 328-330 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T1019 | 347-357 | Chemical | denotes | Nucleotide | http://purl.obolibrary.org/obo/CHEBI_36976 |
| T1020 | 441-453 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T1021 | 521-531 | Chemical | denotes | nucleotide | http://purl.obolibrary.org/obo/CHEBI_36976 |
| T1022 | 556-566 | Chemical | denotes | nucleotide | http://purl.obolibrary.org/obo/CHEBI_36976 |
| T1023 | 620-632 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T1024 | 693-695 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T1029 | 718-730 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T1030 | 760-767 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T1031 | 775-777 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T1036 | 837-839 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T1041 | 945-957 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T1042 | 1029-1031 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T1047 | 1054-1066 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T1048 | 1085-1087 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T1053 | 1167-1169 | Chemical | denotes | HA | http://purl.obolibrary.org/obo/CHEBI_73924 |
| T1054 | 1263-1265 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T1059 | 1341-1343 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T1064 | 1455-1457 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T53 | 239-246 | http://purl.obolibrary.org/obo/GO_0009606 | denotes | tropism |
| T54 | 401-408 | http://purl.obolibrary.org/obo/GO_0009606 | denotes | tropism |
| T55 | 489-496 | http://purl.obolibrary.org/obo/GO_0009606 | denotes | tropism |
| T56 | 664-671 | http://purl.obolibrary.org/obo/GO_0009606 | denotes | tropism |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T328 | 0-103 | Sentence | denotes | In α-CoVs such as TGEV, HA-activity is attributed to the SA-recognizing activity to α2,3-NeuGc [61,62]. |
| T329 | 104-190 | Sentence | denotes | The SA-binding site is present on the N-terminal region of the S-glycoprotein of TGEV. |
| T330 | 191-247 | Sentence | denotes | TGEV has two types with enteric and respiratory tropism. |
| T331 | 248-346 | Sentence | denotes | The respiratory TGEV has the porcine aminopeptidase N (pAPN)-binding domain and SA-binding domain. |
| T332 | 347-503 | Sentence | denotes | Nucleotide 655 of the S gene is essential for enteric tropism and the S219A mutation of the S glycoprotein confers the enteric to respiratory tropism shift. |
| T333 | 504-672 | Sentence | denotes | In addition, a 6-nucleotide insertional mutation at nucleotide 1124, which yields the Y374-T375insND shift of the S glycoprotein, causes enhanced enteric tract tropism. |
| T334 | 673-832 | Sentence | denotes | TGEV interacts with SA species on mucin-like glycoprotein (MGP), a highly glycosylated protein, in an SA-dependent manner, on mucin-secreting goblet cells [6]. |
| T335 | 833-917 | Sentence | denotes | MGP SA-binding allows virus entry via the mucus layer to the intestinal enterocytes. |
| T336 | 918-1072 | Sentence | denotes | Different from TGEV, the S glycoprotein of porcine CoV has no hemagglutination activity due to deletion of the SA-binding site of the S glycoprotein [61]. |
| T337 | 1073-1150 | Sentence | denotes | The loss of SA-binding activity is correlated to the non-enteropathogenicity. |
| T338 | 1151-1340 | Sentence | denotes | SAs function as HA-mediated entry determinants for TGEV, causing the enteropathogenic outcome of the virus, and SA-recognition activity is also responsible for virus amplification in cells. |
| T339 | 1341-1450 | Sentence | denotes | SA-binding activity-deficient TGEV can propagate in cells through pAPN, known as CD13, as a receptor [62,63]. |
| T340 | 1451-1537 | Sentence | denotes | The SA-binding activity potentiates infection and is crucial for intestinal infection. |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32604730-8764078-51944005 | 96-98 | 8764078 | denotes | 61 |
| 32604730-9060696-51944006 | 99-101 | 9060696 | denotes | 62 |
| 32604730-14557669-51944007 | 829-830 | 14557669 | denotes | 6 |
| 32604730-8764078-51944008 | 1068-1070 | 8764078 | denotes | 61 |
| 32604730-9060696-51944009 | 1443-1445 | 9060696 | denotes | 62 |
| 32604730-10644848-51944010 | 1446-1448 | 10644848 | denotes | 63 |
| T88722 | 96-98 | 8764078 | denotes | 61 |
| T67423 | 99-101 | 9060696 | denotes | 62 |
| T29243 | 829-830 | 14557669 | denotes | 6 |
| T8143 | 1068-1070 | 8764078 | denotes | 61 |
| T44658 | 1443-1445 | 9060696 | denotes | 62 |
| T73054 | 1446-1448 | 10644848 | denotes | 63 |