PMC:7352545 / 15761-16749 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7352545","sourcedb":"PMC","sourceid":"7352545","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7352545","text":"In RNA viruses, the N protein recognizes the viral RNA genome. The N protein (PDB: 6M3M) binds to the RNA genome via the NTD and CTD. The N protein tethers to the viral RNA and replicase–transcriptase complex (RTC). NSP3 (PDB: 6VXS) of CoV blocks the innate immune responses of hosts. After entrance into the host cells, for CoV transcription and particle release, RNA chaperones such as nonspecific nucleic acid binding proteins potentiate ssRNA conformation shifts. Representatively, the N protein is known as the RNA chaperone protein. For example, glycogen synthase kinase 3 (GSK3) phosphorylates the SARS-CoV N-protein and thus, GSK3 inhibition contributes to reduced replication activity of SARS-CoV [19]. In addition, heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) regulates the preformed mRNA splicing in the nucleus and continuous translation. hnRNPA1 interacts with SARS-CoV N protein to form a replication and transcription complex during ssRNA genome biosynthesis [20].","tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T142","span":{"begin":3,"end":6},"obj":"Body_part"},{"id":"T143","span":{"begin":22,"end":29},"obj":"Body_part"},{"id":"T144","span":{"begin":51,"end":54},"obj":"Body_part"},{"id":"T145","span":{"begin":55,"end":61},"obj":"Body_part"},{"id":"T146","span":{"begin":69,"end":76},"obj":"Body_part"},{"id":"T147","span":{"begin":102,"end":105},"obj":"Body_part"},{"id":"T148","span":{"begin":106,"end":112},"obj":"Body_part"},{"id":"T149","span":{"begin":140,"end":147},"obj":"Body_part"},{"id":"T150","span":{"begin":169,"end":172},"obj":"Body_part"},{"id":"T151","span":{"begin":314,"end":319},"obj":"Body_part"},{"id":"T152","span":{"begin":365,"end":368},"obj":"Body_part"},{"id":"T153","span":{"begin":421,"end":429},"obj":"Body_part"},{"id":"T154","span":{"begin":492,"end":499},"obj":"Body_part"},{"id":"T155","span":{"begin":516,"end":519},"obj":"Body_part"},{"id":"T156","span":{"begin":530,"end":537},"obj":"Body_part"},{"id":"T157","span":{"begin":552,"end":560},"obj":"Body_part"},{"id":"T158","span":{"begin":616,"end":623},"obj":"Body_part"},{"id":"T159","span":{"begin":765,"end":767},"obj":"Body_part"},{"id":"T160","span":{"begin":775,"end":777},"obj":"Body_part"},{"id":"T161","span":{"begin":803,"end":807},"obj":"Body_part"},{"id":"T162","span":{"begin":894,"end":901},"obj":"Body_part"},{"id":"T163","span":{"begin":963,"end":969},"obj":"Body_part"}],"attributes":[{"id":"A142","pred":"fma_id","subj":"T142","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A143","pred":"fma_id","subj":"T143","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A144","pred":"fma_id","subj":"T144","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A145","pred":"fma_id","subj":"T145","obj":"http://purl.org/sig/ont/fma/fma84116"},{"id":"A146","pred":"fma_id","subj":"T146","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A147","pred":"fma_id","subj":"T147","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A148","pred":"fma_id","subj":"T148","obj":"http://purl.org/sig/ont/fma/fma84116"},{"id":"A149","pred":"fma_id","subj":"T149","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A150","pred":"fma_id","subj":"T150","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A151","pred":"fma_id","subj":"T151","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A152","pred":"fma_id","subj":"T152","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A153","pred":"fma_id","subj":"T153","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A154","pred":"fma_id","subj":"T154","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A155","pred":"fma_id","subj":"T155","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A156","pred":"fma_id","subj":"T156","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A157","pred":"fma_id","subj":"T157","obj":"http://purl.org/sig/ont/fma/fma82747"},{"id":"A158","pred":"fma_id","subj":"T158","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A159","pred":"fma_id","subj":"T159","obj":"http://purl.org/sig/ont/fma/fma66592"},{"id":"A160","pred":"fma_id","subj":"T160","obj":"http://purl.org/sig/ont/fma/fma66592"},{"id":"A161","pred":"fma_id","subj":"T161","obj":"http://purl.org/sig/ont/fma/fma67122"},{"id":"A162","pred":"fma_id","subj":"T162","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A163","pred":"fma_id","subj":"T163","obj":"http://purl.org/sig/ont/fma/fma84116"},{"subj":"T142","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T143","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T144","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T145","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T146","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T147","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T148","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T149","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T150","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T151","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T152","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T153","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T154","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T155","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T156","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T157","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T158","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T159","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T160","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T161","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T162","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T163","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"510","span":{"begin":129,"end":132},"obj":"Gene"},{"id":"511","span":{"begin":725,"end":767},"obj":"Gene"},{"id":"512","span":{"begin":769,"end":777},"obj":"Gene"},{"id":"513","span":{"begin":860,"end":867},"obj":"Gene"},{"id":"514","span":{"begin":222,"end":225},"obj":"Gene"},{"id":"515","span":{"begin":236,"end":239},"obj":"Species"},{"id":"516","span":{"begin":325,"end":328},"obj":"Species"},{"id":"517","span":{"begin":605,"end":613},"obj":"Species"},{"id":"518","span":{"begin":697,"end":705},"obj":"Species"},{"id":"519","span":{"begin":883,"end":891},"obj":"Species"}],"attributes":[{"id":"A510","pred":"tao:has_database_id","subj":"510","obj":"Gene:1283"},{"id":"A511","pred":"tao:has_database_id","subj":"511","obj":"Gene:3178"},{"id":"A512","pred":"tao:has_database_id","subj":"512","obj":"Gene:3178"},{"id":"A513","pred":"tao:has_database_id","subj":"513","obj":"Gene:3178"},{"id":"A514","pred":"tao:has_database_id","subj":"514","obj":"Gene:5131"},{"id":"A515","pred":"tao:has_database_id","subj":"515","obj":"Tax:11118"},{"id":"A516","pred":"tao:has_database_id","subj":"516","obj":"Tax:11118"},{"id":"A517","pred":"tao:has_database_id","subj":"517","obj":"Tax:694009"},{"id":"A518","pred":"tao:has_database_id","subj":"518","obj":"Tax:694009"},{"id":"A519","pred":"tao:has_database_id","subj":"519","obj":"Tax:694009"},{"subj":"510","pred":"source","obj":"LitCovid-PubTator"},{"subj":"511","pred":"source","obj":"LitCovid-PubTator"},{"subj":"512","pred":"source","obj":"LitCovid-PubTator"},{"subj":"513","pred":"source","obj":"LitCovid-PubTator"},{"subj":"514","pred":"source","obj":"LitCovid-PubTator"},{"subj":"515","pred":"source","obj":"LitCovid-PubTator"},{"subj":"516","pred":"source","obj":"LitCovid-PubTator"},{"subj":"517","pred":"source","obj":"LitCovid-PubTator"},{"subj":"518","pred":"source","obj":"LitCovid-PubTator"},{"subj":"519","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T67","span":{"begin":121,"end":124},"obj":"Disease"},{"id":"T69","span":{"begin":605,"end":613},"obj":"Disease"},{"id":"T70","span":{"begin":697,"end":705},"obj":"Disease"},{"id":"T71","span":{"begin":883,"end":891},"obj":"Disease"}],"attributes":[{"id":"A67","pred":"mondo_id","subj":"T67","obj":"http://purl.obolibrary.org/obo/MONDO_0008449"},{"id":"A68","pred":"mondo_id","subj":"T67","obj":"http://purl.obolibrary.org/obo/MONDO_0018075"},{"id":"A69","pred":"mondo_id","subj":"T69","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A70","pred":"mondo_id","subj":"T70","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A71","pred":"mondo_id","subj":"T71","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"subj":"T67","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T69","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T70","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T71","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T186","span":{"begin":7,"end":14},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T187","span":{"begin":314,"end":319},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T188","span":{"begin":685,"end":693},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T189","span":{"begin":910,"end":911},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"attributes":[{"subj":"T186","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T187","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T188","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T189","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T317","span":{"begin":22,"end":29},"obj":"Chemical"},{"id":"T318","span":{"begin":69,"end":76},"obj":"Chemical"},{"id":"T319","span":{"begin":140,"end":147},"obj":"Chemical"},{"id":"T320","span":{"begin":400,"end":412},"obj":"Chemical"},{"id":"T321","span":{"begin":408,"end":412},"obj":"Chemical"},{"id":"T322","span":{"begin":421,"end":429},"obj":"Chemical"},{"id":"T323","span":{"begin":492,"end":499},"obj":"Chemical"},{"id":"T324","span":{"begin":530,"end":537},"obj":"Chemical"},{"id":"T325","span":{"begin":552,"end":560},"obj":"Chemical"},{"id":"T326","span":{"begin":616,"end":623},"obj":"Chemical"},{"id":"T327","span":{"begin":824,"end":831},"obj":"Chemical"},{"id":"T328","span":{"begin":894,"end":901},"obj":"Chemical"}],"attributes":[{"id":"A317","pred":"chebi_id","subj":"T317","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A318","pred":"chebi_id","subj":"T318","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A319","pred":"chebi_id","subj":"T319","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A320","pred":"chebi_id","subj":"T320","obj":"http://purl.obolibrary.org/obo/CHEBI_33696"},{"id":"A321","pred":"chebi_id","subj":"T321","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A322","pred":"chebi_id","subj":"T322","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A323","pred":"chebi_id","subj":"T323","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A324","pred":"chebi_id","subj":"T324","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A325","pred":"chebi_id","subj":"T325","obj":"http://purl.obolibrary.org/obo/CHEBI_28087"},{"id":"A326","pred":"chebi_id","subj":"T326","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A327","pred":"chebi_id","subj":"T327","obj":"http://purl.obolibrary.org/obo/CHEBI_33252"},{"id":"A328","pred":"chebi_id","subj":"T328","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"subj":"T317","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T318","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T319","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T320","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T321","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T322","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T323","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T324","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T325","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T326","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T327","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T328","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T20","span":{"begin":187,"end":200},"obj":"http://purl.obolibrary.org/obo/GO_0003968"},{"id":"T21","span":{"begin":187,"end":200},"obj":"http://purl.obolibrary.org/obo/GO_0003899"},{"id":"T22","span":{"begin":251,"end":274},"obj":"http://purl.obolibrary.org/obo/GO_0045087"},{"id":"T23","span":{"begin":329,"end":342},"obj":"http://purl.obolibrary.org/obo/GO_0006351"},{"id":"T24","span":{"begin":365,"end":379},"obj":"http://purl.obolibrary.org/obo/GO_0034337"},{"id":"T25","span":{"begin":516,"end":529},"obj":"http://purl.obolibrary.org/obo/GO_0034337"},{"id":"T26","span":{"begin":586,"end":600},"obj":"http://purl.obolibrary.org/obo/GO_0016310"},{"id":"T27","span":{"begin":803,"end":816},"obj":"http://purl.obolibrary.org/obo/GO_0000398"},{"id":"T28","span":{"begin":803,"end":816},"obj":"http://purl.obolibrary.org/obo/GO_0000394"},{"id":"T29","span":{"begin":803,"end":816},"obj":"http://purl.obolibrary.org/obo/GO_0000374"},{"id":"T30","span":{"begin":803,"end":816},"obj":"http://purl.obolibrary.org/obo/GO_0000373"},{"id":"T31","span":{"begin":803,"end":816},"obj":"http://purl.obolibrary.org/obo/GO_0000372"},{"id":"T32","span":{"begin":808,"end":816},"obj":"http://purl.obolibrary.org/obo/GO_0045292"},{"id":"T33","span":{"begin":847,"end":858},"obj":"http://purl.obolibrary.org/obo/GO_0006412"},{"id":"T34","span":{"begin":928,"end":941},"obj":"http://purl.obolibrary.org/obo/GO_0006351"},{"id":"T35","span":{"begin":970,"end":982},"obj":"http://purl.obolibrary.org/obo/GO_0009058"}],"attributes":[{"subj":"T20","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T21","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T22","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T23","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T24","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T25","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T26","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T27","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T28","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T29","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T30","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T31","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T32","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T33","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T34","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T35","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T142","span":{"begin":0,"end":62},"obj":"Sentence"},{"id":"T143","span":{"begin":63,"end":82},"obj":"Sentence"},{"id":"T144","span":{"begin":83,"end":133},"obj":"Sentence"},{"id":"T145","span":{"begin":134,"end":215},"obj":"Sentence"},{"id":"T146","span":{"begin":216,"end":226},"obj":"Sentence"},{"id":"T147","span":{"begin":227,"end":284},"obj":"Sentence"},{"id":"T148","span":{"begin":285,"end":467},"obj":"Sentence"},{"id":"T149","span":{"begin":468,"end":538},"obj":"Sentence"},{"id":"T150","span":{"begin":539,"end":711},"obj":"Sentence"},{"id":"T151","span":{"begin":712,"end":988},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T142","pred":"source","obj":"LitCovid-sentences"},{"subj":"T143","pred":"source","obj":"LitCovid-sentences"},{"subj":"T144","pred":"source","obj":"LitCovid-sentences"},{"subj":"T145","pred":"source","obj":"LitCovid-sentences"},{"subj":"T146","pred":"source","obj":"LitCovid-sentences"},{"subj":"T147","pred":"source","obj":"LitCovid-sentences"},{"subj":"T148","pred":"source","obj":"LitCovid-sentences"},{"subj":"T149","pred":"source","obj":"LitCovid-sentences"},{"subj":"T150","pred":"source","obj":"LitCovid-sentences"},{"subj":"T151","pred":"source","obj":"LitCovid-sentences"}]},{"project":"2_test","denotations":[{"id":"32604730-15862300-51943963","span":{"begin":984,"end":986},"obj":"15862300"},{"id":"T39967","span":{"begin":984,"end":986},"obj":"15862300"}],"attributes":[{"subj":"32604730-15862300-51943963","pred":"source","obj":"2_test"},{"subj":"T39967","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#93ecdb","default":true},{"id":"LitCovid-PubTator","color":"#ecc193"},{"id":"LitCovid-PD-MONDO","color":"#a693ec"},{"id":"LitCovid-PD-CLO","color":"#99ec93"},{"id":"LitCovid-PD-CHEBI","color":"#ec93b3"},{"id":"LitCovid-PD-GO-BP","color":"#93cdec"},{"id":"LitCovid-sentences","color":"#e7ec93"},{"id":"2_test","color":"#d793ec"}]}]}}