PMC:7352545 / 10666-11352 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7352545","sourcedb":"PMC","sourceid":"7352545","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7352545","text":"CoVs are 60–140 nm in size and are enveloped (+) ssRNA viruses, which feature an RNA genome, directly available to function as mRNA and thus result in rapid infection. CoVs exhibit RNA genomes of 28–32 kb, comprised of two large overlapping open reading frames (ORFs), which encode the virus replicase (transcriptase) and structural proteins. The SARS-CoV-2 genome is 29,891 bp in size, which encodes 9860 amino acids. The ssRNA are capped and tailed with a 5′-capping structure and 3′-poly A tail at the termini. The genome is the same sense as virus mRNA indicating that the viral RNA is translated through its own (+) RNA to synthesize RNA dependent RNA polymerase (RdRp; PDB: 6M71).","tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T59","span":{"begin":81,"end":84},"obj":"Body_part"},{"id":"T60","span":{"begin":85,"end":91},"obj":"Body_part"},{"id":"T61","span":{"begin":127,"end":131},"obj":"Body_part"},{"id":"T62","span":{"begin":181,"end":184},"obj":"Body_part"},{"id":"T63","span":{"begin":185,"end":192},"obj":"Body_part"},{"id":"T64","span":{"begin":333,"end":341},"obj":"Body_part"},{"id":"T65","span":{"begin":358,"end":364},"obj":"Body_part"},{"id":"T66","span":{"begin":406,"end":417},"obj":"Body_part"},{"id":"T67","span":{"begin":518,"end":524},"obj":"Body_part"},{"id":"T68","span":{"begin":552,"end":556},"obj":"Body_part"},{"id":"T69","span":{"begin":583,"end":586},"obj":"Body_part"},{"id":"T70","span":{"begin":621,"end":624},"obj":"Body_part"},{"id":"T71","span":{"begin":639,"end":642},"obj":"Body_part"},{"id":"T72","span":{"begin":653,"end":656},"obj":"Body_part"}],"attributes":[{"id":"A59","pred":"fma_id","subj":"T59","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A60","pred":"fma_id","subj":"T60","obj":"http://purl.org/sig/ont/fma/fma84116"},{"id":"A61","pred":"fma_id","subj":"T61","obj":"http://purl.org/sig/ont/fma/fma67122"},{"id":"A62","pred":"fma_id","subj":"T62","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A63","pred":"fma_id","subj":"T63","obj":"http://purl.org/sig/ont/fma/fma84116"},{"id":"A64","pred":"fma_id","subj":"T64","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A65","pred":"fma_id","subj":"T65","obj":"http://purl.org/sig/ont/fma/fma84116"},{"id":"A66","pred":"fma_id","subj":"T66","obj":"http://purl.org/sig/ont/fma/fma82739"},{"id":"A67","pred":"fma_id","subj":"T67","obj":"http://purl.org/sig/ont/fma/fma84116"},{"id":"A68","pred":"fma_id","subj":"T68","obj":"http://purl.org/sig/ont/fma/fma67122"},{"id":"A69","pred":"fma_id","subj":"T69","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A70","pred":"fma_id","subj":"T70","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A71","pred":"fma_id","subj":"T71","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A72","pred":"fma_id","subj":"T72","obj":"http://purl.org/sig/ont/fma/fma67095"},{"subj":"T59","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T60","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T61","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T62","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T63","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T64","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T65","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T66","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T67","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T68","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T69","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T70","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T71","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T72","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T4","span":{"begin":493,"end":497},"obj":"Body_part"}],"attributes":[{"id":"A4","pred":"uberon_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/UBERON_0002415"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"426","span":{"begin":675,"end":678},"obj":"Gene"},{"id":"427","span":{"begin":0,"end":4},"obj":"Species"},{"id":"428","span":{"begin":49,"end":62},"obj":"Species"},{"id":"429","span":{"begin":168,"end":172},"obj":"Species"},{"id":"430","span":{"begin":347,"end":357},"obj":"Species"},{"id":"431","span":{"begin":456,"end":459},"obj":"Gene"},{"id":"432","span":{"begin":423,"end":428},"obj":"Chemical"},{"id":"433","span":{"begin":157,"end":166},"obj":"Disease"}],"attributes":[{"id":"A426","pred":"tao:has_database_id","subj":"426","obj":"Gene:5131"},{"id":"A427","pred":"tao:has_database_id","subj":"427","obj":"Tax:11118"},{"id":"A428","pred":"tao:has_database_id","subj":"428","obj":"Tax:439488"},{"id":"A429","pred":"tao:has_database_id","subj":"429","obj":"Tax:11118"},{"id":"A430","pred":"tao:has_database_id","subj":"430","obj":"Tax:2697049"},{"id":"A431","pred":"tao:has_database_id","subj":"431","obj":"Gene:28884"},{"id":"A433","pred":"tao:has_database_id","subj":"433","obj":"MESH:D007239"},{"subj":"426","pred":"source","obj":"LitCovid-PubTator"},{"subj":"427","pred":"source","obj":"LitCovid-PubTator"},{"subj":"428","pred":"source","obj":"LitCovid-PubTator"},{"subj":"429","pred":"source","obj":"LitCovid-PubTator"},{"subj":"430","pred":"source","obj":"LitCovid-PubTator"},{"subj":"431","pred":"source","obj":"LitCovid-PubTator"},{"subj":"432","pred":"source","obj":"LitCovid-PubTator"},{"subj":"433","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T56","span":{"begin":157,"end":166},"obj":"Disease"},{"id":"T57","span":{"begin":347,"end":355},"obj":"Disease"}],"attributes":[{"id":"A56","pred":"mondo_id","subj":"T56","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A57","pred":"mondo_id","subj":"T57","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"subj":"T56","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T57","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T111","span":{"begin":55,"end":62},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T112","span":{"begin":202,"end":204},"obj":"http://purl.obolibrary.org/obo/CLO_0007074"},{"id":"T113","span":{"begin":202,"end":204},"obj":"http://purl.obolibrary.org/obo/CLO_0051988"},{"id":"T114","span":{"begin":286,"end":291},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T115","span":{"begin":444,"end":450},"obj":"http://purl.obolibrary.org/obo/UBERON_0002415"},{"id":"T116","span":{"begin":456,"end":457},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T117","span":{"begin":491,"end":492},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T118","span":{"begin":493,"end":497},"obj":"http://purl.obolibrary.org/obo/UBERON_0002415"},{"id":"T119","span":{"begin":546,"end":551},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"}],"attributes":[{"subj":"T111","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T112","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T113","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T114","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T115","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T116","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T117","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T118","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T119","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T259","span":{"begin":333,"end":341},"obj":"Chemical"},{"id":"T260","span":{"begin":406,"end":417},"obj":"Chemical"},{"id":"T261","span":{"begin":406,"end":411},"obj":"Chemical"},{"id":"T262","span":{"begin":412,"end":417},"obj":"Chemical"}],"attributes":[{"id":"A259","pred":"chebi_id","subj":"T259","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A260","pred":"chebi_id","subj":"T260","obj":"http://purl.obolibrary.org/obo/CHEBI_33709"},{"id":"A261","pred":"chebi_id","subj":"T261","obj":"http://purl.obolibrary.org/obo/CHEBI_46882"},{"id":"A262","pred":"chebi_id","subj":"T262","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"subj":"T259","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T260","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T261","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T262","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T9","span":{"begin":303,"end":316},"obj":"http://purl.obolibrary.org/obo/GO_0003968"},{"id":"T10","span":{"begin":303,"end":316},"obj":"http://purl.obolibrary.org/obo/GO_0003899"}],"attributes":[{"subj":"T9","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T10","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T89","span":{"begin":0,"end":167},"obj":"Sentence"},{"id":"T90","span":{"begin":168,"end":342},"obj":"Sentence"},{"id":"T91","span":{"begin":343,"end":418},"obj":"Sentence"},{"id":"T92","span":{"begin":419,"end":513},"obj":"Sentence"},{"id":"T93","span":{"begin":514,"end":679},"obj":"Sentence"},{"id":"T94","span":{"begin":680,"end":686},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T89","pred":"source","obj":"LitCovid-sentences"},{"subj":"T90","pred":"source","obj":"LitCovid-sentences"},{"subj":"T91","pred":"source","obj":"LitCovid-sentences"},{"subj":"T92","pred":"source","obj":"LitCovid-sentences"},{"subj":"T93","pred":"source","obj":"LitCovid-sentences"},{"subj":"T94","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#93e1ec","default":true},{"id":"LitCovid-PD-UBERON","color":"#ecdd93"},{"id":"LitCovid-PubTator","color":"#c393ec"},{"id":"LitCovid-PD-MONDO","color":"#93eca9"},{"id":"LitCovid-PD-CLO","color":"#ec9397"},{"id":"LitCovid-PD-CHEBI","color":"#93b1ec"},{"id":"LitCovid-PD-GO-BP","color":"#cbec93"},{"id":"LitCovid-sentences","color":"#ec93e5"}]}]}}