PMC:7340597 / 19120-20205 JSONTXT

{"project":"LitCovid_Glycan-Motif-Structure","denotations":[{"id":"T22","span":{"begin":338,"end":340},"obj":"https://glytoucan.org/Structures/Glycans/G93424OB"}],"text":"A 68-year old male without medical history of cardiopulmonary disease, was presented at the ED in a critical condition with fever and dyspnoea. Patient was in need of endotracheal intubation and mechanical ventilation in prone position to improve his oxygenation. To exclude secondary infection, BAL was performed and revealed a positive GM and cultured Aspergillus fumigatus and Enterococcus faecium. Antifungal therapy was added to his treatment regimen. Chest CT-angiography showed segmental pulmonary emboli along with extensive bilateral areas of ground-glass opacity with reticulation and multiple patchy non-dependant peripheral consolidations. In contrast to normal areas, the abnormal areas showed mild bronchiectasis (Fig. 1-4A). The patient remained unresponsive after cessation of sedative medication. CT head showed extensive bilateral cerebellar ischemia with small haemorrhagic components. After three weeks of mechanical ventilation his respiratory status worsened and treatment was ended due to poor prognosis. The patient passed away 21 days after hospital admission."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T113","span":{"begin":457,"end":462},"obj":"Body_part"},{"id":"T114","span":{"begin":817,"end":821},"obj":"Body_part"}],"attributes":[{"id":"A113","pred":"fma_id","subj":"T113","obj":"http://purl.org/sig/ont/fma/fma9576"},{"id":"A114","pred":"fma_id","subj":"T114","obj":"http://purl.org/sig/ont/fma/fma7154"}],"text":"A 68-year old male without medical history of cardiopulmonary disease, was presented at the ED in a critical condition with fever and dyspnoea. Patient was in need of endotracheal intubation and mechanical ventilation in prone position to improve his oxygenation. To exclude secondary infection, BAL was performed and revealed a positive GM and cultured Aspergillus fumigatus and Enterococcus faecium. Antifungal therapy was added to his treatment regimen. Chest CT-angiography showed segmental pulmonary emboli along with extensive bilateral areas of ground-glass opacity with reticulation and multiple patchy non-dependant peripheral consolidations. In contrast to normal areas, the abnormal areas showed mild bronchiectasis (Fig. 1-4A). The patient remained unresponsive after cessation of sedative medication. CT head showed extensive bilateral cerebellar ischemia with small haemorrhagic components. After three weeks of mechanical ventilation his respiratory status worsened and treatment was ended due to poor prognosis. The patient passed away 21 days after hospital admission."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T67","span":{"begin":457,"end":462},"obj":"Body_part"},{"id":"T68","span":{"begin":817,"end":821},"obj":"Body_part"}],"attributes":[{"id":"A67","pred":"uberon_id","subj":"T67","obj":"http://purl.obolibrary.org/obo/UBERON_0001443"},{"id":"A68","pred":"uberon_id","subj":"T68","obj":"http://purl.obolibrary.org/obo/UBERON_0000033"}],"text":"A 68-year old male without medical history of cardiopulmonary disease, was presented at the ED in a critical condition with fever and dyspnoea. Patient was in need of endotracheal intubation and mechanical ventilation in prone position to improve his oxygenation. To exclude secondary infection, BAL was performed and revealed a positive GM and cultured Aspergillus fumigatus and Enterococcus faecium. Antifungal therapy was added to his treatment regimen. Chest CT-angiography showed segmental pulmonary emboli along with extensive bilateral areas of ground-glass opacity with reticulation and multiple patchy non-dependant peripheral consolidations. In contrast to normal areas, the abnormal areas showed mild bronchiectasis (Fig. 1-4A). The patient remained unresponsive after cessation of sedative medication. CT head showed extensive bilateral cerebellar ischemia with small haemorrhagic components. After three weeks of mechanical ventilation his respiratory status worsened and treatment was ended due to poor prognosis. The patient passed away 21 days after hospital admission."}

{"project":"LitCovid-PubTator","denotations":[{"id":"450","span":{"begin":144,"end":151},"obj":"Species"},{"id":"451","span":{"begin":354,"end":375},"obj":"Species"},{"id":"452","span":{"begin":744,"end":751},"obj":"Species"},{"id":"453","span":{"begin":1032,"end":1039},"obj":"Species"},{"id":"454","span":{"begin":380,"end":392},"obj":"Species"},{"id":"455","span":{"begin":338,"end":340},"obj":"Chemical"},{"id":"456","span":{"begin":46,"end":69},"obj":"Disease"},{"id":"457","span":{"begin":124,"end":129},"obj":"Disease"},{"id":"458","span":{"begin":134,"end":142},"obj":"Disease"},{"id":"459","span":{"begin":285,"end":294},"obj":"Disease"},{"id":"460","span":{"begin":495,"end":511},"obj":"Disease"},{"id":"461","span":{"begin":839,"end":868},"obj":"Disease"}],"attributes":[{"id":"A450","pred":"tao:has_database_id","subj":"450","obj":"Tax:9606"},{"id":"A451","pred":"tao:has_database_id","subj":"451","obj":"Tax:746128"},{"id":"A452","pred":"tao:has_database_id","subj":"452","obj":"Tax:9606"},{"id":"A453","pred":"tao:has_database_id","subj":"453","obj":"Tax:9606"},{"id":"A454","pred":"tao:has_database_id","subj":"454","obj":"Tax:1351"},{"id":"A455","pred":"tao:has_database_id","subj":"455","obj":"MESH:C012990"},{"id":"A456","pred":"tao:has_database_id","subj":"456","obj":"MESH:D006323"},{"id":"A457","pred":"tao:has_database_id","subj":"457","obj":"MESH:D005334"},{"id":"A458","pred":"tao:has_database_id","subj":"458","obj":"MESH:D004417"},{"id":"A459","pred":"tao:has_database_id","subj":"459","obj":"MESH:D007239"},{"id":"A460","pred":"tao:has_database_id","subj":"460","obj":"MESH:D011655"},{"id":"A461","pred":"tao:has_database_id","subj":"461","obj":"MESH:D007511"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"A 68-year old male without medical history of cardiopulmonary disease, was presented at the ED in a critical condition with fever and dyspnoea. Patient was in need of endotracheal intubation and mechanical ventilation in prone position to improve his oxygenation. To exclude secondary infection, BAL was performed and revealed a positive GM and cultured Aspergillus fumigatus and Enterococcus faecium. Antifungal therapy was added to his treatment regimen. Chest CT-angiography showed segmental pulmonary emboli along with extensive bilateral areas of ground-glass opacity with reticulation and multiple patchy non-dependant peripheral consolidations. In contrast to normal areas, the abnormal areas showed mild bronchiectasis (Fig. 1-4A). The patient remained unresponsive after cessation of sedative medication. CT head showed extensive bilateral cerebellar ischemia with small haemorrhagic components. After three weeks of mechanical ventilation his respiratory status worsened and treatment was ended due to poor prognosis. The patient passed away 21 days after hospital admission."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T161","span":{"begin":46,"end":69},"obj":"Disease"},{"id":"T162","span":{"begin":285,"end":294},"obj":"Disease"},{"id":"T163","span":{"begin":712,"end":726},"obj":"Disease"},{"id":"T164","span":{"begin":860,"end":868},"obj":"Disease"}],"attributes":[{"id":"A161","pred":"mondo_id","subj":"T161","obj":"http://purl.obolibrary.org/obo/MONDO_0004596"},{"id":"A162","pred":"mondo_id","subj":"T162","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A163","pred":"mondo_id","subj":"T163","obj":"http://purl.obolibrary.org/obo/MONDO_0004822"},{"id":"A164","pred":"mondo_id","subj":"T164","obj":"http://purl.obolibrary.org/obo/MONDO_0005053"}],"text":"A 68-year old male without medical history of cardiopulmonary disease, was presented at the ED in a critical condition with fever and dyspnoea. Patient was in need of endotracheal intubation and mechanical ventilation in prone position to improve his oxygenation. To exclude secondary infection, BAL was performed and revealed a positive GM and cultured Aspergillus fumigatus and Enterococcus faecium. Antifungal therapy was added to his treatment regimen. Chest CT-angiography showed segmental pulmonary emboli along with extensive bilateral areas of ground-glass opacity with reticulation and multiple patchy non-dependant peripheral consolidations. In contrast to normal areas, the abnormal areas showed mild bronchiectasis (Fig. 1-4A). The patient remained unresponsive after cessation of sedative medication. CT head showed extensive bilateral cerebellar ischemia with small haemorrhagic components. After three weeks of mechanical ventilation his respiratory status worsened and treatment was ended due to poor prognosis. The patient passed away 21 days after hospital admission."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T169","span":{"begin":0,"end":1},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T170","span":{"begin":14,"end":18},"obj":"http://purl.obolibrary.org/obo/UBERON_0003101"},{"id":"T171","span":{"begin":14,"end":18},"obj":"http://www.ebi.ac.uk/efo/EFO_0000970"},{"id":"T172","span":{"begin":98,"end":99},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T173","span":{"begin":327,"end":328},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T174","span":{"begin":457,"end":462},"obj":"http://www.ebi.ac.uk/efo/EFO_0000965"},{"id":"T175","span":{"begin":817,"end":821},"obj":"http://purl.obolibrary.org/obo/UBERON_0000033"},{"id":"T176","span":{"begin":817,"end":821},"obj":"http://www.ebi.ac.uk/efo/EFO_0000964"}],"text":"A 68-year old male without medical history of cardiopulmonary disease, was presented at the ED in a critical condition with fever and dyspnoea. Patient was in need of endotracheal intubation and mechanical ventilation in prone position to improve his oxygenation. To exclude secondary infection, BAL was performed and revealed a positive GM and cultured Aspergillus fumigatus and Enterococcus faecium. Antifungal therapy was added to his treatment regimen. Chest CT-angiography showed segmental pulmonary emboli along with extensive bilateral areas of ground-glass opacity with reticulation and multiple patchy non-dependant peripheral consolidations. In contrast to normal areas, the abnormal areas showed mild bronchiectasis (Fig. 1-4A). The patient remained unresponsive after cessation of sedative medication. CT head showed extensive bilateral cerebellar ischemia with small haemorrhagic components. After three weeks of mechanical ventilation his respiratory status worsened and treatment was ended due to poor prognosis. The patient passed away 21 days after hospital admission."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T103","span":{"begin":14,"end":18},"obj":"Chemical"},{"id":"T104","span":{"begin":92,"end":94},"obj":"Chemical"},{"id":"T105","span":{"begin":296,"end":299},"obj":"Chemical"},{"id":"T106","span":{"begin":338,"end":340},"obj":"Chemical"},{"id":"T108","span":{"begin":793,"end":801},"obj":"Chemical"}],"attributes":[{"id":"A103","pred":"chebi_id","subj":"T103","obj":"http://purl.obolibrary.org/obo/CHEBI_30780"},{"id":"A104","pred":"chebi_id","subj":"T104","obj":"http://purl.obolibrary.org/obo/CHEBI_73503"},{"id":"A105","pred":"chebi_id","subj":"T105","obj":"http://purl.obolibrary.org/obo/CHEBI_64198"},{"id":"A106","pred":"chebi_id","subj":"T106","obj":"http://purl.obolibrary.org/obo/CHEBI_74120"},{"id":"A107","pred":"chebi_id","subj":"T106","obj":"http://purl.obolibrary.org/obo/CHEBI_27680"},{"id":"A108","pred":"chebi_id","subj":"T108","obj":"http://purl.obolibrary.org/obo/CHEBI_35717"}],"text":"A 68-year old male without medical history of cardiopulmonary disease, was presented at the ED in a critical condition with fever and dyspnoea. Patient was in need of endotracheal intubation and mechanical ventilation in prone position to improve his oxygenation. To exclude secondary infection, BAL was performed and revealed a positive GM and cultured Aspergillus fumigatus and Enterococcus faecium. Antifungal therapy was added to his treatment regimen. Chest CT-angiography showed segmental pulmonary emboli along with extensive bilateral areas of ground-glass opacity with reticulation and multiple patchy non-dependant peripheral consolidations. In contrast to normal areas, the abnormal areas showed mild bronchiectasis (Fig. 1-4A). The patient remained unresponsive after cessation of sedative medication. CT head showed extensive bilateral cerebellar ischemia with small haemorrhagic components. After three weeks of mechanical ventilation his respiratory status worsened and treatment was ended due to poor prognosis. The patient passed away 21 days after hospital admission."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T49","span":{"begin":124,"end":129},"obj":"Phenotype"},{"id":"T50","span":{"begin":134,"end":142},"obj":"Phenotype"},{"id":"T51","span":{"begin":712,"end":726},"obj":"Phenotype"}],"attributes":[{"id":"A49","pred":"hp_id","subj":"T49","obj":"http://purl.obolibrary.org/obo/HP_0001945"},{"id":"A50","pred":"hp_id","subj":"T50","obj":"http://purl.obolibrary.org/obo/HP_0002094"},{"id":"A51","pred":"hp_id","subj":"T51","obj":"http://purl.obolibrary.org/obo/HP_0002110"}],"text":"A 68-year old male without medical history of cardiopulmonary disease, was presented at the ED in a critical condition with fever and dyspnoea. Patient was in need of endotracheal intubation and mechanical ventilation in prone position to improve his oxygenation. To exclude secondary infection, BAL was performed and revealed a positive GM and cultured Aspergillus fumigatus and Enterococcus faecium. Antifungal therapy was added to his treatment regimen. Chest CT-angiography showed segmental pulmonary emboli along with extensive bilateral areas of ground-glass opacity with reticulation and multiple patchy non-dependant peripheral consolidations. In contrast to normal areas, the abnormal areas showed mild bronchiectasis (Fig. 1-4A). The patient remained unresponsive after cessation of sedative medication. CT head showed extensive bilateral cerebellar ischemia with small haemorrhagic components. After three weeks of mechanical ventilation his respiratory status worsened and treatment was ended due to poor prognosis. The patient passed away 21 days after hospital admission."}

{"project":"LitCovid-PD-GlycoEpitope","denotations":[{"id":"T20","span":{"begin":338,"end":340},"obj":"GlycoEpitope"}],"attributes":[{"id":"A20","pred":"glyco_epitope_db_id","subj":"T20","obj":"http://www.glycoepitope.jp/epitopes/EP0510"}],"text":"A 68-year old male without medical history of cardiopulmonary disease, was presented at the ED in a critical condition with fever and dyspnoea. Patient was in need of endotracheal intubation and mechanical ventilation in prone position to improve his oxygenation. To exclude secondary infection, BAL was performed and revealed a positive GM and cultured Aspergillus fumigatus and Enterococcus faecium. Antifungal therapy was added to his treatment regimen. Chest CT-angiography showed segmental pulmonary emboli along with extensive bilateral areas of ground-glass opacity with reticulation and multiple patchy non-dependant peripheral consolidations. In contrast to normal areas, the abnormal areas showed mild bronchiectasis (Fig. 1-4A). The patient remained unresponsive after cessation of sedative medication. CT head showed extensive bilateral cerebellar ischemia with small haemorrhagic components. After three weeks of mechanical ventilation his respiratory status worsened and treatment was ended due to poor prognosis. The patient passed away 21 days after hospital admission."}

{"project":"LitCovid-sentences","denotations":[{"id":"T162","span":{"begin":0,"end":143},"obj":"Sentence"},{"id":"T163","span":{"begin":144,"end":263},"obj":"Sentence"},{"id":"T164","span":{"begin":264,"end":401},"obj":"Sentence"},{"id":"T165","span":{"begin":402,"end":456},"obj":"Sentence"},{"id":"T166","span":{"begin":457,"end":651},"obj":"Sentence"},{"id":"T167","span":{"begin":652,"end":739},"obj":"Sentence"},{"id":"T168","span":{"begin":740,"end":813},"obj":"Sentence"},{"id":"T169","span":{"begin":814,"end":904},"obj":"Sentence"},{"id":"T170","span":{"begin":905,"end":1027},"obj":"Sentence"},{"id":"T171","span":{"begin":1028,"end":1085},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"A 68-year old male without medical history of cardiopulmonary disease, was presented at the ED in a critical condition with fever and dyspnoea. Patient was in need of endotracheal intubation and mechanical ventilation in prone position to improve his oxygenation. To exclude secondary infection, BAL was performed and revealed a positive GM and cultured Aspergillus fumigatus and Enterococcus faecium. Antifungal therapy was added to his treatment regimen. Chest CT-angiography showed segmental pulmonary emboli along with extensive bilateral areas of ground-glass opacity with reticulation and multiple patchy non-dependant peripheral consolidations. In contrast to normal areas, the abnormal areas showed mild bronchiectasis (Fig. 1-4A). The patient remained unresponsive after cessation of sedative medication. CT head showed extensive bilateral cerebellar ischemia with small haemorrhagic components. After three weeks of mechanical ventilation his respiratory status worsened and treatment was ended due to poor prognosis. The patient passed away 21 days after hospital admission."}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T31499","span":{"begin":167,"end":179},"obj":"UBERON:0001852"},{"id":"T16403","span":{"begin":251,"end":262},"obj":"GO:0015671"},{"id":"T14517","span":{"begin":354,"end":375},"obj":"NCBITaxon:746128"},{"id":"T4434","span":{"begin":380,"end":400},"obj":"NCBITaxon:1352"},{"id":"T32949","span":{"begin":495,"end":504},"obj":"UBERON:0002048"},{"id":"T23048","span":{"begin":817,"end":821},"obj":"UBERON:0000033"},{"id":"T39092","span":{"begin":849,"end":859},"obj":"UBERON:0002037"},{"id":"T74431","span":{"begin":953,"end":964},"obj":"UBERON:0001004"}],"text":"A 68-year old male without medical history of cardiopulmonary disease, was presented at the ED in a critical condition with fever and dyspnoea. Patient was in need of endotracheal intubation and mechanical ventilation in prone position to improve his oxygenation. To exclude secondary infection, BAL was performed and revealed a positive GM and cultured Aspergillus fumigatus and Enterococcus faecium. Antifungal therapy was added to his treatment regimen. Chest CT-angiography showed segmental pulmonary emboli along with extensive bilateral areas of ground-glass opacity with reticulation and multiple patchy non-dependant peripheral consolidations. In contrast to normal areas, the abnormal areas showed mild bronchiectasis (Fig. 1-4A). The patient remained unresponsive after cessation of sedative medication. CT head showed extensive bilateral cerebellar ischemia with small haemorrhagic components. After three weeks of mechanical ventilation his respiratory status worsened and treatment was ended due to poor prognosis. The patient passed away 21 days after hospital admission."}