PMC:7335494 / 13609-14388 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7335494","sourcedb":"PMC","sourceid":"7335494","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7335494","text":"Recent developments highlighted the importance of ECM remodelling in metabolic disease and obesity as well as the associated inflammation (Ruiz-Ojeda et al., 2019). Indeed, it was suggested that both the specific remodelling of adipose tissue ECM organization and dysregulated intracellular signalling processes may be correlated with obesity-associated insulin resistance (Guzman-Ruiz et al., 2020). The main components of adipose tissue ECM are collagens, fibronectin and laminin (Mori et al., 2014). Minor constituents include osteopontin, hyaluronan (HA), thrombospondins, MMPs, as well as A disintegrin and metalloproteinase domain-containing protein (ADAMs), and contribute significantly to ECM remodelling and the regulation of adipose tissue functions (Lin et al., 2016).","tracks":[{"project":"LitCovid_Glycan-Motif-Structure","denotations":[{"id":"T2","span":{"begin":543,"end":553},"obj":"https://glytoucan.org/Structures/Glycans/G00017MO"},{"id":"T3","span":{"begin":555,"end":557},"obj":"https://glytoucan.org/Structures/Glycans/G00017MO"}],"attributes":[{"subj":"T2","pred":"source","obj":"LitCovid_Glycan-Motif-Structure"},{"subj":"T3","pred":"source","obj":"LitCovid_Glycan-Motif-Structure"}]},{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T73","span":{"begin":50,"end":53},"obj":"Body_part"},{"id":"T74","span":{"begin":228,"end":242},"obj":"Body_part"},{"id":"T75","span":{"begin":243,"end":246},"obj":"Body_part"},{"id":"T76","span":{"begin":354,"end":361},"obj":"Body_part"},{"id":"T77","span":{"begin":424,"end":438},"obj":"Body_part"},{"id":"T78","span":{"begin":439,"end":442},"obj":"Body_part"},{"id":"T79","span":{"begin":447,"end":456},"obj":"Body_part"},{"id":"T80","span":{"begin":458,"end":469},"obj":"Body_part"},{"id":"T81","span":{"begin":474,"end":481},"obj":"Body_part"},{"id":"T82","span":{"begin":543,"end":553},"obj":"Body_part"},{"id":"T83","span":{"begin":555,"end":557},"obj":"Body_part"},{"id":"T84","span":{"begin":560,"end":575},"obj":"Body_part"},{"id":"T85","span":{"begin":648,"end":655},"obj":"Body_part"},{"id":"T86","span":{"begin":697,"end":700},"obj":"Body_part"},{"id":"T87","span":{"begin":735,"end":749},"obj":"Body_part"}],"attributes":[{"id":"A73","pred":"fma_id","subj":"T73","obj":"http://purl.org/sig/ont/fma/fma9672"},{"id":"A74","pred":"fma_id","subj":"T74","obj":"http://purl.org/sig/ont/fma/fma20110"},{"id":"A75","pred":"fma_id","subj":"T75","obj":"http://purl.org/sig/ont/fma/fma9672"},{"id":"A76","pred":"fma_id","subj":"T76","obj":"http://purl.org/sig/ont/fma/fma83365"},{"id":"A77","pred":"fma_id","subj":"T77","obj":"http://purl.org/sig/ont/fma/fma20110"},{"id":"A78","pred":"fma_id","subj":"T78","obj":"http://purl.org/sig/ont/fma/fma9672"},{"id":"A79","pred":"fma_id","subj":"T79","obj":"http://purl.org/sig/ont/fma/fma63891"},{"id":"A80","pred":"fma_id","subj":"T80","obj":"http://purl.org/sig/ont/fma/fma67311"},{"id":"A81","pred":"fma_id","subj":"T81","obj":"http://purl.org/sig/ont/fma/fma62926"},{"id":"A82","pred":"fma_id","subj":"T82","obj":"http://purl.org/sig/ont/fma/fma63014"},{"id":"A83","pred":"fma_id","subj":"T83","obj":"http://purl.org/sig/ont/fma/fma63014"},{"id":"A84","pred":"fma_id","subj":"T84","obj":"http://purl.org/sig/ont/fma/fma63260"},{"id":"A85","pred":"fma_id","subj":"T85","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A86","pred":"fma_id","subj":"T86","obj":"http://purl.org/sig/ont/fma/fma9672"},{"id":"A87","pred":"fma_id","subj":"T87","obj":"http://purl.org/sig/ont/fma/fma20110"},{"subj":"T73","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T74","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T75","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T76","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T77","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T78","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T79","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T80","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T81","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T82","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T83","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T84","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T85","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T86","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T87","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T17","span":{"begin":228,"end":242},"obj":"Body_part"},{"id":"T18","span":{"begin":236,"end":242},"obj":"Body_part"},{"id":"T19","span":{"begin":424,"end":438},"obj":"Body_part"},{"id":"T20","span":{"begin":432,"end":438},"obj":"Body_part"},{"id":"T21","span":{"begin":735,"end":749},"obj":"Body_part"},{"id":"T22","span":{"begin":743,"end":749},"obj":"Body_part"}],"attributes":[{"id":"A17","pred":"uberon_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/UBERON_0001013"},{"id":"A18","pred":"uberon_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"A19","pred":"uberon_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/UBERON_0001013"},{"id":"A20","pred":"uberon_id","subj":"T20","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"A21","pred":"uberon_id","subj":"T21","obj":"http://purl.obolibrary.org/obo/UBERON_0001013"},{"id":"A22","pred":"uberon_id","subj":"T22","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"subj":"T17","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T18","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T19","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T20","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T21","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T22","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T53","span":{"begin":69,"end":86},"obj":"Disease"},{"id":"T54","span":{"begin":91,"end":98},"obj":"Disease"},{"id":"T55","span":{"begin":125,"end":137},"obj":"Disease"},{"id":"T56","span":{"begin":335,"end":342},"obj":"Disease"}],"attributes":[{"id":"A53","pred":"mondo_id","subj":"T53","obj":"http://purl.obolibrary.org/obo/MONDO_0005066"},{"id":"A54","pred":"mondo_id","subj":"T54","obj":"http://purl.obolibrary.org/obo/MONDO_0011122"},{"id":"A55","pred":"mondo_id","subj":"T55","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"},{"id":"A56","pred":"mondo_id","subj":"T56","obj":"http://purl.obolibrary.org/obo/MONDO_0011122"},{"subj":"T53","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T54","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T55","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T56","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T116","span":{"begin":228,"end":242},"obj":"http://purl.obolibrary.org/obo/UBERON_0001013"},{"id":"T117","span":{"begin":247,"end":259},"obj":"http://purl.obolibrary.org/obo/OBI_0000245"},{"id":"T118","span":{"begin":291,"end":301},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T119","span":{"begin":354,"end":361},"obj":"http://purl.obolibrary.org/obo/PR_000009054"},{"id":"T120","span":{"begin":424,"end":438},"obj":"http://purl.obolibrary.org/obo/UBERON_0001013"},{"id":"T121","span":{"begin":447,"end":456},"obj":"http://purl.obolibrary.org/obo/CHEBI_3815"},{"id":"T122","span":{"begin":458,"end":469},"obj":"http://purl.obolibrary.org/obo/PR_000007581"},{"id":"T123","span":{"begin":530,"end":541},"obj":"http://purl.obolibrary.org/obo/PR_000015561"},{"id":"T124","span":{"begin":594,"end":595},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T125","span":{"begin":735,"end":749},"obj":"http://purl.obolibrary.org/obo/UBERON_0001013"}],"attributes":[{"subj":"T116","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T117","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T118","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T119","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T120","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T121","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T122","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T123","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T124","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T125","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T124","span":{"begin":354,"end":361},"obj":"Chemical"},{"id":"T125","span":{"begin":543,"end":553},"obj":"Chemical"},{"id":"T127","span":{"begin":555,"end":557},"obj":"Chemical"},{"id":"T129","span":{"begin":648,"end":655},"obj":"Chemical"},{"id":"T130","span":{"begin":761,"end":764},"obj":"Chemical"}],"attributes":[{"id":"A124","pred":"chebi_id","subj":"T124","obj":"http://purl.obolibrary.org/obo/CHEBI_145810"},{"id":"A125","pred":"chebi_id","subj":"T125","obj":"http://purl.obolibrary.org/obo/CHEBI_132153"},{"id":"A126","pred":"chebi_id","subj":"T125","obj":"http://purl.obolibrary.org/obo/CHEBI_16336"},{"id":"A127","pred":"chebi_id","subj":"T127","obj":"http://purl.obolibrary.org/obo/CHEBI_73924"},{"id":"A128","pred":"chebi_id","subj":"T127","obj":"http://purl.obolibrary.org/obo/CHEBI_132153"},{"id":"A129","pred":"chebi_id","subj":"T129","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A130","pred":"chebi_id","subj":"T130","obj":"http://purl.obolibrary.org/obo/CHEBI_32386"},{"subj":"T124","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T125","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T127","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T129","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T130","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T63","span":{"begin":125,"end":137},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T64","span":{"begin":291,"end":301},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T65","span":{"begin":721,"end":731},"obj":"http://purl.obolibrary.org/obo/GO_0065007"}],"attributes":[{"subj":"T63","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T64","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T65","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T60","span":{"begin":0,"end":164},"obj":"Sentence"},{"id":"T61","span":{"begin":165,"end":400},"obj":"Sentence"},{"id":"T62","span":{"begin":401,"end":502},"obj":"Sentence"},{"id":"T63","span":{"begin":503,"end":779},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T60","pred":"source","obj":"LitCovid-sentences"},{"subj":"T61","pred":"source","obj":"LitCovid-sentences"},{"subj":"T62","pred":"source","obj":"LitCovid-sentences"},{"subj":"T63","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PD-HP","denotations":[{"id":"T29","span":{"begin":91,"end":98},"obj":"Phenotype"},{"id":"T30","span":{"begin":335,"end":342},"obj":"Phenotype"},{"id":"T31","span":{"begin":354,"end":372},"obj":"Phenotype"}],"attributes":[{"id":"A29","pred":"hp_id","subj":"T29","obj":"http://purl.obolibrary.org/obo/HP_0001513"},{"id":"A30","pred":"hp_id","subj":"T30","obj":"http://purl.obolibrary.org/obo/HP_0001513"},{"id":"A31","pred":"hp_id","subj":"T31","obj":"http://purl.obolibrary.org/obo/HP_0000855"},{"subj":"T29","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T30","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T31","pred":"source","obj":"LitCovid-PD-HP"}]},{"project":"MyTest","denotations":[{"id":"32640331-32293066-30720751","span":{"begin":394,"end":398},"obj":"32293066"},{"id":"32640331-25076859-30720752","span":{"begin":496,"end":500},"obj":"25076859"},{"id":"32640331-27179976-30720753","span":{"begin":773,"end":777},"obj":"27179976"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"attributes":[{"subj":"32640331-32293066-30720751","pred":"source","obj":"MyTest"},{"subj":"32640331-25076859-30720752","pred":"source","obj":"MyTest"},{"subj":"32640331-27179976-30720753","pred":"source","obj":"MyTest"}]},{"project":"2_test","denotations":[{"id":"32640331-32293066-30720751","span":{"begin":394,"end":398},"obj":"32293066"},{"id":"32640331-25076859-30720752","span":{"begin":496,"end":500},"obj":"25076859"},{"id":"32640331-27179976-30720753","span":{"begin":773,"end":777},"obj":"27179976"}],"attributes":[{"subj":"32640331-32293066-30720751","pred":"source","obj":"2_test"},{"subj":"32640331-25076859-30720752","pred":"source","obj":"2_test"},{"subj":"32640331-27179976-30720753","pred":"source","obj":"2_test"}]},{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T259","span":{"begin":50,"end":53},"obj":"GO:0044420"},{"id":"T260","span":{"begin":69,"end":78},"obj":"GO:0008152"},{"id":"T261","span":{"begin":228,"end":242},"obj":"UBERON:0001013"},{"id":"T262","span":{"begin":243,"end":246},"obj":"GO:0044420"},{"id":"T263","span":{"begin":264,"end":276},"obj":"GO:0065007"},{"id":"T264","span":{"begin":277,"end":290},"obj":"GO:0005622;GO:0035556"},{"id":"T265","span":{"begin":291,"end":301},"obj":"GO:0035556"},{"id":"T266","span":{"begin":354,"end":361},"obj":"PR:000009054"},{"id":"T267","span":{"begin":424,"end":438},"obj":"UBERON:0001013"},{"id":"T268","span":{"begin":439,"end":442},"obj":"GO:0044420"},{"id":"T269","span":{"begin":458,"end":469},"obj":"PR:000007581"},{"id":"T270","span":{"begin":530,"end":541},"obj":"PR:000015561"},{"id":"T271","span":{"begin":630,"end":636},"obj":"SO:0000417"},{"id":"T272","span":{"begin":697,"end":700},"obj":"GO:0044420"},{"id":"T273","span":{"begin":721,"end":731},"obj":"GO:0065007"},{"id":"T274","span":{"begin":735,"end":749},"obj":"UBERON:0001013"}],"attributes":[{"subj":"T259","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T260","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T261","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T262","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T263","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T264","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T265","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T266","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T267","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T268","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T269","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T270","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T271","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T272","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T273","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T274","pred":"source","obj":"LitCovid-PMC-OGER-BB"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid_Glycan-Motif-Structure","color":"#93eca6","default":true},{"id":"LitCovid-PD-FMA-UBERON","color":"#ec9399"},{"id":"LitCovid-PD-UBERON","color":"#93b3ec"},{"id":"LitCovid-PD-MONDO","color":"#cdec93"},{"id":"LitCovid-PD-CLO","color":"#ec93e7"},{"id":"LitCovid-PD-CHEBI","color":"#93ecd7"},{"id":"LitCovid-PD-GO-BP","color":"#ecbd93"},{"id":"LitCovid-sentences","color":"#a393ec"},{"id":"LitCovid-PD-HP","color":"#9dec93"},{"id":"MyTest","color":"#ec93b7"},{"id":"2_test","color":"#93d1ec"},{"id":"LitCovid-PMC-OGER-BB","color":"#ebec93"}]}]}}