PMC:7335494 / 13609-14388 JSONTXT

{"project":"LitCovid_Glycan-Motif-Structure","denotations":[{"id":"T2","span":{"begin":543,"end":553},"obj":"https://glytoucan.org/Structures/Glycans/G00017MO"},{"id":"T3","span":{"begin":555,"end":557},"obj":"https://glytoucan.org/Structures/Glycans/G00017MO"}],"text":"Recent developments highlighted the importance of ECM remodelling in metabolic disease and obesity as well as the associated inflammation (Ruiz-Ojeda et al., 2019). Indeed, it was suggested that both the specific remodelling of adipose tissue ECM organization and dysregulated intracellular signalling processes may be correlated with obesity-associated insulin resistance (Guzman-Ruiz et al., 2020). The main components of adipose tissue ECM are collagens, fibronectin and laminin (Mori et al., 2014). Minor constituents include osteopontin, hyaluronan (HA), thrombospondins, MMPs, as well as A disintegrin and metalloproteinase domain-containing protein (ADAMs), and contribute significantly to ECM remodelling and the regulation of adipose tissue functions (Lin et al., 2016)."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T73","span":{"begin":50,"end":53},"obj":"Body_part"},{"id":"T74","span":{"begin":228,"end":242},"obj":"Body_part"},{"id":"T75","span":{"begin":243,"end":246},"obj":"Body_part"},{"id":"T76","span":{"begin":354,"end":361},"obj":"Body_part"},{"id":"T77","span":{"begin":424,"end":438},"obj":"Body_part"},{"id":"T78","span":{"begin":439,"end":442},"obj":"Body_part"},{"id":"T79","span":{"begin":447,"end":456},"obj":"Body_part"},{"id":"T80","span":{"begin":458,"end":469},"obj":"Body_part"},{"id":"T81","span":{"begin":474,"end":481},"obj":"Body_part"},{"id":"T82","span":{"begin":543,"end":553},"obj":"Body_part"},{"id":"T83","span":{"begin":555,"end":557},"obj":"Body_part"},{"id":"T84","span":{"begin":560,"end":575},"obj":"Body_part"},{"id":"T85","span":{"begin":648,"end":655},"obj":"Body_part"},{"id":"T86","span":{"begin":697,"end":700},"obj":"Body_part"},{"id":"T87","span":{"begin":735,"end":749},"obj":"Body_part"}],"attributes":[{"id":"A73","pred":"fma_id","subj":"T73","obj":"http://purl.org/sig/ont/fma/fma9672"},{"id":"A74","pred":"fma_id","subj":"T74","obj":"http://purl.org/sig/ont/fma/fma20110"},{"id":"A75","pred":"fma_id","subj":"T75","obj":"http://purl.org/sig/ont/fma/fma9672"},{"id":"A76","pred":"fma_id","subj":"T76","obj":"http://purl.org/sig/ont/fma/fma83365"},{"id":"A77","pred":"fma_id","subj":"T77","obj":"http://purl.org/sig/ont/fma/fma20110"},{"id":"A78","pred":"fma_id","subj":"T78","obj":"http://purl.org/sig/ont/fma/fma9672"},{"id":"A79","pred":"fma_id","subj":"T79","obj":"http://purl.org/sig/ont/fma/fma63891"},{"id":"A80","pred":"fma_id","subj":"T80","obj":"http://purl.org/sig/ont/fma/fma67311"},{"id":"A81","pred":"fma_id","subj":"T81","obj":"http://purl.org/sig/ont/fma/fma62926"},{"id":"A82","pred":"fma_id","subj":"T82","obj":"http://purl.org/sig/ont/fma/fma63014"},{"id":"A83","pred":"fma_id","subj":"T83","obj":"http://purl.org/sig/ont/fma/fma63014"},{"id":"A84","pred":"fma_id","subj":"T84","obj":"http://purl.org/sig/ont/fma/fma63260"},{"id":"A85","pred":"fma_id","subj":"T85","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A86","pred":"fma_id","subj":"T86","obj":"http://purl.org/sig/ont/fma/fma9672"},{"id":"A87","pred":"fma_id","subj":"T87","obj":"http://purl.org/sig/ont/fma/fma20110"}],"text":"Recent developments highlighted the importance of ECM remodelling in metabolic disease and obesity as well as the associated inflammation (Ruiz-Ojeda et al., 2019). Indeed, it was suggested that both the specific remodelling of adipose tissue ECM organization and dysregulated intracellular signalling processes may be correlated with obesity-associated insulin resistance (Guzman-Ruiz et al., 2020). The main components of adipose tissue ECM are collagens, fibronectin and laminin (Mori et al., 2014). Minor constituents include osteopontin, hyaluronan (HA), thrombospondins, MMPs, as well as A disintegrin and metalloproteinase domain-containing protein (ADAMs), and contribute significantly to ECM remodelling and the regulation of adipose tissue functions (Lin et al., 2016)."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T17","span":{"begin":228,"end":242},"obj":"Body_part"},{"id":"T18","span":{"begin":236,"end":242},"obj":"Body_part"},{"id":"T19","span":{"begin":424,"end":438},"obj":"Body_part"},{"id":"T20","span":{"begin":432,"end":438},"obj":"Body_part"},{"id":"T21","span":{"begin":735,"end":749},"obj":"Body_part"},{"id":"T22","span":{"begin":743,"end":749},"obj":"Body_part"}],"attributes":[{"id":"A17","pred":"uberon_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/UBERON_0001013"},{"id":"A18","pred":"uberon_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"A19","pred":"uberon_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/UBERON_0001013"},{"id":"A20","pred":"uberon_id","subj":"T20","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"A21","pred":"uberon_id","subj":"T21","obj":"http://purl.obolibrary.org/obo/UBERON_0001013"},{"id":"A22","pred":"uberon_id","subj":"T22","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"}],"text":"Recent developments highlighted the importance of ECM remodelling in metabolic disease and obesity as well as the associated inflammation (Ruiz-Ojeda et al., 2019). Indeed, it was suggested that both the specific remodelling of adipose tissue ECM organization and dysregulated intracellular signalling processes may be correlated with obesity-associated insulin resistance (Guzman-Ruiz et al., 2020). The main components of adipose tissue ECM are collagens, fibronectin and laminin (Mori et al., 2014). Minor constituents include osteopontin, hyaluronan (HA), thrombospondins, MMPs, as well as A disintegrin and metalloproteinase domain-containing protein (ADAMs), and contribute significantly to ECM remodelling and the regulation of adipose tissue functions (Lin et al., 2016)."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T53","span":{"begin":69,"end":86},"obj":"Disease"},{"id":"T54","span":{"begin":91,"end":98},"obj":"Disease"},{"id":"T55","span":{"begin":125,"end":137},"obj":"Disease"},{"id":"T56","span":{"begin":335,"end":342},"obj":"Disease"}],"attributes":[{"id":"A53","pred":"mondo_id","subj":"T53","obj":"http://purl.obolibrary.org/obo/MONDO_0005066"},{"id":"A54","pred":"mondo_id","subj":"T54","obj":"http://purl.obolibrary.org/obo/MONDO_0011122"},{"id":"A55","pred":"mondo_id","subj":"T55","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"},{"id":"A56","pred":"mondo_id","subj":"T56","obj":"http://purl.obolibrary.org/obo/MONDO_0011122"}],"text":"Recent developments highlighted the importance of ECM remodelling in metabolic disease and obesity as well as the associated inflammation (Ruiz-Ojeda et al., 2019). Indeed, it was suggested that both the specific remodelling of adipose tissue ECM organization and dysregulated intracellular signalling processes may be correlated with obesity-associated insulin resistance (Guzman-Ruiz et al., 2020). The main components of adipose tissue ECM are collagens, fibronectin and laminin (Mori et al., 2014). Minor constituents include osteopontin, hyaluronan (HA), thrombospondins, MMPs, as well as A disintegrin and metalloproteinase domain-containing protein (ADAMs), and contribute significantly to ECM remodelling and the regulation of adipose tissue functions (Lin et al., 2016)."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T116","span":{"begin":228,"end":242},"obj":"http://purl.obolibrary.org/obo/UBERON_0001013"},{"id":"T117","span":{"begin":247,"end":259},"obj":"http://purl.obolibrary.org/obo/OBI_0000245"},{"id":"T118","span":{"begin":291,"end":301},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T119","span":{"begin":354,"end":361},"obj":"http://purl.obolibrary.org/obo/PR_000009054"},{"id":"T120","span":{"begin":424,"end":438},"obj":"http://purl.obolibrary.org/obo/UBERON_0001013"},{"id":"T121","span":{"begin":447,"end":456},"obj":"http://purl.obolibrary.org/obo/CHEBI_3815"},{"id":"T122","span":{"begin":458,"end":469},"obj":"http://purl.obolibrary.org/obo/PR_000007581"},{"id":"T123","span":{"begin":530,"end":541},"obj":"http://purl.obolibrary.org/obo/PR_000015561"},{"id":"T124","span":{"begin":594,"end":595},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T125","span":{"begin":735,"end":749},"obj":"http://purl.obolibrary.org/obo/UBERON_0001013"}],"text":"Recent developments highlighted the importance of ECM remodelling in metabolic disease and obesity as well as the associated inflammation (Ruiz-Ojeda et al., 2019). Indeed, it was suggested that both the specific remodelling of adipose tissue ECM organization and dysregulated intracellular signalling processes may be correlated with obesity-associated insulin resistance (Guzman-Ruiz et al., 2020). The main components of adipose tissue ECM are collagens, fibronectin and laminin (Mori et al., 2014). Minor constituents include osteopontin, hyaluronan (HA), thrombospondins, MMPs, as well as A disintegrin and metalloproteinase domain-containing protein (ADAMs), and contribute significantly to ECM remodelling and the regulation of adipose tissue functions (Lin et al., 2016)."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T124","span":{"begin":354,"end":361},"obj":"Chemical"},{"id":"T125","span":{"begin":543,"end":553},"obj":"Chemical"},{"id":"T127","span":{"begin":555,"end":557},"obj":"Chemical"},{"id":"T129","span":{"begin":648,"end":655},"obj":"Chemical"},{"id":"T130","span":{"begin":761,"end":764},"obj":"Chemical"}],"attributes":[{"id":"A124","pred":"chebi_id","subj":"T124","obj":"http://purl.obolibrary.org/obo/CHEBI_145810"},{"id":"A125","pred":"chebi_id","subj":"T125","obj":"http://purl.obolibrary.org/obo/CHEBI_132153"},{"id":"A126","pred":"chebi_id","subj":"T125","obj":"http://purl.obolibrary.org/obo/CHEBI_16336"},{"id":"A127","pred":"chebi_id","subj":"T127","obj":"http://purl.obolibrary.org/obo/CHEBI_73924"},{"id":"A128","pred":"chebi_id","subj":"T127","obj":"http://purl.obolibrary.org/obo/CHEBI_132153"},{"id":"A129","pred":"chebi_id","subj":"T129","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A130","pred":"chebi_id","subj":"T130","obj":"http://purl.obolibrary.org/obo/CHEBI_32386"}],"text":"Recent developments highlighted the importance of ECM remodelling in metabolic disease and obesity as well as the associated inflammation (Ruiz-Ojeda et al., 2019). Indeed, it was suggested that both the specific remodelling of adipose tissue ECM organization and dysregulated intracellular signalling processes may be correlated with obesity-associated insulin resistance (Guzman-Ruiz et al., 2020). The main components of adipose tissue ECM are collagens, fibronectin and laminin (Mori et al., 2014). Minor constituents include osteopontin, hyaluronan (HA), thrombospondins, MMPs, as well as A disintegrin and metalloproteinase domain-containing protein (ADAMs), and contribute significantly to ECM remodelling and the regulation of adipose tissue functions (Lin et al., 2016)."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T63","span":{"begin":125,"end":137},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T64","span":{"begin":291,"end":301},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T65","span":{"begin":721,"end":731},"obj":"http://purl.obolibrary.org/obo/GO_0065007"}],"text":"Recent developments highlighted the importance of ECM remodelling in metabolic disease and obesity as well as the associated inflammation (Ruiz-Ojeda et al., 2019). Indeed, it was suggested that both the specific remodelling of adipose tissue ECM organization and dysregulated intracellular signalling processes may be correlated with obesity-associated insulin resistance (Guzman-Ruiz et al., 2020). The main components of adipose tissue ECM are collagens, fibronectin and laminin (Mori et al., 2014). Minor constituents include osteopontin, hyaluronan (HA), thrombospondins, MMPs, as well as A disintegrin and metalloproteinase domain-containing protein (ADAMs), and contribute significantly to ECM remodelling and the regulation of adipose tissue functions (Lin et al., 2016)."}

{"project":"LitCovid-sentences","denotations":[{"id":"T60","span":{"begin":0,"end":164},"obj":"Sentence"},{"id":"T61","span":{"begin":165,"end":400},"obj":"Sentence"},{"id":"T62","span":{"begin":401,"end":502},"obj":"Sentence"},{"id":"T63","span":{"begin":503,"end":779},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Recent developments highlighted the importance of ECM remodelling in metabolic disease and obesity as well as the associated inflammation (Ruiz-Ojeda et al., 2019). Indeed, it was suggested that both the specific remodelling of adipose tissue ECM organization and dysregulated intracellular signalling processes may be correlated with obesity-associated insulin resistance (Guzman-Ruiz et al., 2020). The main components of adipose tissue ECM are collagens, fibronectin and laminin (Mori et al., 2014). Minor constituents include osteopontin, hyaluronan (HA), thrombospondins, MMPs, as well as A disintegrin and metalloproteinase domain-containing protein (ADAMs), and contribute significantly to ECM remodelling and the regulation of adipose tissue functions (Lin et al., 2016)."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T29","span":{"begin":91,"end":98},"obj":"Phenotype"},{"id":"T30","span":{"begin":335,"end":342},"obj":"Phenotype"},{"id":"T31","span":{"begin":354,"end":372},"obj":"Phenotype"}],"attributes":[{"id":"A29","pred":"hp_id","subj":"T29","obj":"http://purl.obolibrary.org/obo/HP_0001513"},{"id":"A30","pred":"hp_id","subj":"T30","obj":"http://purl.obolibrary.org/obo/HP_0001513"},{"id":"A31","pred":"hp_id","subj":"T31","obj":"http://purl.obolibrary.org/obo/HP_0000855"}],"text":"Recent developments highlighted the importance of ECM remodelling in metabolic disease and obesity as well as the associated inflammation (Ruiz-Ojeda et al., 2019). Indeed, it was suggested that both the specific remodelling of adipose tissue ECM organization and dysregulated intracellular signalling processes may be correlated with obesity-associated insulin resistance (Guzman-Ruiz et al., 2020). The main components of adipose tissue ECM are collagens, fibronectin and laminin (Mori et al., 2014). Minor constituents include osteopontin, hyaluronan (HA), thrombospondins, MMPs, as well as A disintegrin and metalloproteinase domain-containing protein (ADAMs), and contribute significantly to ECM remodelling and the regulation of adipose tissue functions (Lin et al., 2016)."}

{"project":"MyTest","denotations":[{"id":"32640331-32293066-30720751","span":{"begin":394,"end":398},"obj":"32293066"},{"id":"32640331-25076859-30720752","span":{"begin":496,"end":500},"obj":"25076859"},{"id":"32640331-27179976-30720753","span":{"begin":773,"end":777},"obj":"27179976"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"text":"Recent developments highlighted the importance of ECM remodelling in metabolic disease and obesity as well as the associated inflammation (Ruiz-Ojeda et al., 2019). Indeed, it was suggested that both the specific remodelling of adipose tissue ECM organization and dysregulated intracellular signalling processes may be correlated with obesity-associated insulin resistance (Guzman-Ruiz et al., 2020). The main components of adipose tissue ECM are collagens, fibronectin and laminin (Mori et al., 2014). Minor constituents include osteopontin, hyaluronan (HA), thrombospondins, MMPs, as well as A disintegrin and metalloproteinase domain-containing protein (ADAMs), and contribute significantly to ECM remodelling and the regulation of adipose tissue functions (Lin et al., 2016)."}

{"project":"2_test","denotations":[{"id":"32640331-32293066-30720751","span":{"begin":394,"end":398},"obj":"32293066"},{"id":"32640331-25076859-30720752","span":{"begin":496,"end":500},"obj":"25076859"},{"id":"32640331-27179976-30720753","span":{"begin":773,"end":777},"obj":"27179976"}],"text":"Recent developments highlighted the importance of ECM remodelling in metabolic disease and obesity as well as the associated inflammation (Ruiz-Ojeda et al., 2019). Indeed, it was suggested that both the specific remodelling of adipose tissue ECM organization and dysregulated intracellular signalling processes may be correlated with obesity-associated insulin resistance (Guzman-Ruiz et al., 2020). The main components of adipose tissue ECM are collagens, fibronectin and laminin (Mori et al., 2014). Minor constituents include osteopontin, hyaluronan (HA), thrombospondins, MMPs, as well as A disintegrin and metalloproteinase domain-containing protein (ADAMs), and contribute significantly to ECM remodelling and the regulation of adipose tissue functions (Lin et al., 2016)."}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T259","span":{"begin":50,"end":53},"obj":"GO:0044420"},{"id":"T260","span":{"begin":69,"end":78},"obj":"GO:0008152"},{"id":"T261","span":{"begin":228,"end":242},"obj":"UBERON:0001013"},{"id":"T262","span":{"begin":243,"end":246},"obj":"GO:0044420"},{"id":"T263","span":{"begin":264,"end":276},"obj":"GO:0065007"},{"id":"T264","span":{"begin":277,"end":290},"obj":"GO:0005622;GO:0035556"},{"id":"T265","span":{"begin":291,"end":301},"obj":"GO:0035556"},{"id":"T266","span":{"begin":354,"end":361},"obj":"PR:000009054"},{"id":"T267","span":{"begin":424,"end":438},"obj":"UBERON:0001013"},{"id":"T268","span":{"begin":439,"end":442},"obj":"GO:0044420"},{"id":"T269","span":{"begin":458,"end":469},"obj":"PR:000007581"},{"id":"T270","span":{"begin":530,"end":541},"obj":"PR:000015561"},{"id":"T271","span":{"begin":630,"end":636},"obj":"SO:0000417"},{"id":"T272","span":{"begin":697,"end":700},"obj":"GO:0044420"},{"id":"T273","span":{"begin":721,"end":731},"obj":"GO:0065007"},{"id":"T274","span":{"begin":735,"end":749},"obj":"UBERON:0001013"}],"text":"Recent developments highlighted the importance of ECM remodelling in metabolic disease and obesity as well as the associated inflammation (Ruiz-Ojeda et al., 2019). Indeed, it was suggested that both the specific remodelling of adipose tissue ECM organization and dysregulated intracellular signalling processes may be correlated with obesity-associated insulin resistance (Guzman-Ruiz et al., 2020). The main components of adipose tissue ECM are collagens, fibronectin and laminin (Mori et al., 2014). Minor constituents include osteopontin, hyaluronan (HA), thrombospondins, MMPs, as well as A disintegrin and metalloproteinase domain-containing protein (ADAMs), and contribute significantly to ECM remodelling and the regulation of adipose tissue functions (Lin et al., 2016)."}