PMC:7321036 / 57745-58256 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T433","span":{"begin":81,"end":85},"obj":"Body_part"},{"id":"T434","span":{"begin":172,"end":176},"obj":"Body_part"},{"id":"T435","span":{"begin":384,"end":388},"obj":"Body_part"},{"id":"T436","span":{"begin":399,"end":404},"obj":"Body_part"},{"id":"T437","span":{"begin":428,"end":433},"obj":"Body_part"},{"id":"T438","span":{"begin":500,"end":504},"obj":"Body_part"}],"attributes":[{"id":"A433","pred":"fma_id","subj":"T433","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A434","pred":"fma_id","subj":"T434","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A435","pred":"fma_id","subj":"T435","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A436","pred":"fma_id","subj":"T436","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A437","pred":"fma_id","subj":"T437","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A438","pred":"fma_id","subj":"T438","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"Limitations of Study\nA limitation of the current study is the use of a non-human cell line for proteomics analysis upon SARS-CoV-2 infection; here, an African green monkey cell line (Vero E6) was used because it has been shown previously to be highly permissible to SARS-CoV-2 infection (Harcourt et al., 2020). However, pharmacological inhibition of SARS-CoV-2 was assessed in human lung A549-ACE2 cells in addition to Vero E6 cells. The majority of drug effects were found to be replicated between cell lines."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T19","span":{"begin":384,"end":388},"obj":"Body_part"}],"attributes":[{"id":"A19","pred":"uberon_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"}],"text":"Limitations of Study\nA limitation of the current study is the use of a non-human cell line for proteomics analysis upon SARS-CoV-2 infection; here, an African green monkey cell line (Vero E6) was used because it has been shown previously to be highly permissible to SARS-CoV-2 infection (Harcourt et al., 2020). However, pharmacological inhibition of SARS-CoV-2 was assessed in human lung A549-ACE2 cells in addition to Vero E6 cells. The majority of drug effects were found to be replicated between cell lines."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T303","span":{"begin":120,"end":128},"obj":"Disease"},{"id":"T304","span":{"begin":131,"end":140},"obj":"Disease"},{"id":"T305","span":{"begin":266,"end":274},"obj":"Disease"},{"id":"T306","span":{"begin":277,"end":286},"obj":"Disease"},{"id":"T307","span":{"begin":351,"end":359},"obj":"Disease"}],"attributes":[{"id":"A303","pred":"mondo_id","subj":"T303","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A304","pred":"mondo_id","subj":"T304","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A305","pred":"mondo_id","subj":"T305","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A306","pred":"mondo_id","subj":"T306","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A307","pred":"mondo_id","subj":"T307","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"Limitations of Study\nA limitation of the current study is the use of a non-human cell line for proteomics analysis upon SARS-CoV-2 infection; here, an African green monkey cell line (Vero E6) was used because it has been shown previously to be highly permissible to SARS-CoV-2 infection (Harcourt et al., 2020). However, pharmacological inhibition of SARS-CoV-2 was assessed in human lung A549-ACE2 cells in addition to Vero E6 cells. The majority of drug effects were found to be replicated between cell lines."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T753","span":{"begin":21,"end":22},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T754","span":{"begin":69,"end":70},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T755","span":{"begin":75,"end":90},"obj":"http://www.ebi.ac.uk/cellline#human_cell_line"},{"id":"T756","span":{"begin":165,"end":171},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9479"},{"id":"T757","span":{"begin":172,"end":181},"obj":"http://purl.obolibrary.org/obo/CLO_0000031"},{"id":"T758","span":{"begin":183,"end":187},"obj":"http://purl.obolibrary.org/obo/CLO_0009524"},{"id":"T759","span":{"begin":183,"end":187},"obj":"http://purl.obolibrary.org/obo/CLO_0050515"},{"id":"T760","span":{"begin":212,"end":215},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T761","span":{"begin":378,"end":383},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T762","span":{"begin":384,"end":388},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T763","span":{"begin":384,"end":388},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T764","span":{"begin":389,"end":393},"obj":"http://purl.obolibrary.org/obo/CLO_0001601"},{"id":"T765","span":{"begin":389,"end":393},"obj":"http://purl.obolibrary.org/obo/CLO_0050025"},{"id":"T766","span":{"begin":389,"end":393},"obj":"http://purl.obolibrary.org/obo/CLO_0054264"},{"id":"T767","span":{"begin":389,"end":393},"obj":"http://purl.obolibrary.org/obo/CLO_0054265"},{"id":"T768","span":{"begin":389,"end":393},"obj":"http://purl.obolibrary.org/obo/CLO_0054266"},{"id":"T769","span":{"begin":389,"end":393},"obj":"http://purl.obolibrary.org/obo/CLO_0054267"},{"id":"T770","span":{"begin":389,"end":393},"obj":"http://purl.obolibrary.org/obo/CLO_0054268"},{"id":"T771","span":{"begin":389,"end":393},"obj":"http://purl.obolibrary.org/obo/CLO_0054269"},{"id":"T772","span":{"begin":399,"end":404},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T773","span":{"begin":420,"end":433},"obj":"http://purl.obolibrary.org/obo/CLO_0051719"},{"id":"T774","span":{"begin":500,"end":510},"obj":"http://purl.obolibrary.org/obo/CLO_0000031"}],"text":"Limitations of Study\nA limitation of the current study is the use of a non-human cell line for proteomics analysis upon SARS-CoV-2 infection; here, an African green monkey cell line (Vero E6) was used because it has been shown previously to be highly permissible to SARS-CoV-2 infection (Harcourt et al., 2020). However, pharmacological inhibition of SARS-CoV-2 was assessed in human lung A549-ACE2 cells in addition to Vero E6 cells. The majority of drug effects were found to be replicated between cell lines."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T51","span":{"begin":451,"end":455},"obj":"Chemical"}],"attributes":[{"id":"A90181","pred":"chebi_id","subj":"T51","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"}],"text":"Limitations of Study\nA limitation of the current study is the use of a non-human cell line for proteomics analysis upon SARS-CoV-2 infection; here, an African green monkey cell line (Vero E6) was used because it has been shown previously to be highly permissible to SARS-CoV-2 infection (Harcourt et al., 2020). However, pharmacological inhibition of SARS-CoV-2 was assessed in human lung A549-ACE2 cells in addition to Vero E6 cells. The majority of drug effects were found to be replicated between cell lines."}

{"project":"LitCovid-PubTator","denotations":[{"id":"1298","span":{"begin":394,"end":398},"obj":"Gene"},{"id":"1299","span":{"begin":75,"end":80},"obj":"Species"},{"id":"1300","span":{"begin":151,"end":171},"obj":"Species"},{"id":"1301","span":{"begin":351,"end":361},"obj":"Species"},{"id":"1302","span":{"begin":378,"end":383},"obj":"Species"},{"id":"1303","span":{"begin":120,"end":140},"obj":"Disease"},{"id":"1304","span":{"begin":266,"end":286},"obj":"Disease"},{"id":"1305","span":{"begin":188,"end":190},"obj":"CellLine"},{"id":"1306","span":{"begin":389,"end":393},"obj":"CellLine"},{"id":"1307","span":{"begin":425,"end":427},"obj":"CellLine"}],"attributes":[{"id":"A1298","pred":"tao:has_database_id","subj":"1298","obj":"Gene:59272"},{"id":"A1299","pred":"tao:has_database_id","subj":"1299","obj":"Tax:9606"},{"id":"A1300","pred":"tao:has_database_id","subj":"1300","obj":"Tax:9534"},{"id":"A1301","pred":"tao:has_database_id","subj":"1301","obj":"Tax:2697049"},{"id":"A1302","pred":"tao:has_database_id","subj":"1302","obj":"Tax:9606"},{"id":"A1303","pred":"tao:has_database_id","subj":"1303","obj":"MESH:C000657245"},{"id":"A1304","pred":"tao:has_database_id","subj":"1304","obj":"MESH:C000657245"},{"id":"A1305","pred":"tao:has_database_id","subj":"1305","obj":"CVCL:4582"},{"id":"A1306","pred":"tao:has_database_id","subj":"1306","obj":"CVCL:0023"},{"id":"A1307","pred":"tao:has_database_id","subj":"1307","obj":"CVCL:4582"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Limitations of Study\nA limitation of the current study is the use of a non-human cell line for proteomics analysis upon SARS-CoV-2 infection; here, an African green monkey cell line (Vero E6) was used because it has been shown previously to be highly permissible to SARS-CoV-2 infection (Harcourt et al., 2020). However, pharmacological inhibition of SARS-CoV-2 was assessed in human lung A549-ACE2 cells in addition to Vero E6 cells. The majority of drug effects were found to be replicated between cell lines."}

{"project":"LitCovid-sentences","denotations":[{"id":"T372","span":{"begin":0,"end":20},"obj":"Sentence"},{"id":"T373","span":{"begin":21,"end":311},"obj":"Sentence"},{"id":"T374","span":{"begin":312,"end":434},"obj":"Sentence"},{"id":"T375","span":{"begin":435,"end":511},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Limitations of Study\nA limitation of the current study is the use of a non-human cell line for proteomics analysis upon SARS-CoV-2 infection; here, an African green monkey cell line (Vero E6) was used because it has been shown previously to be highly permissible to SARS-CoV-2 infection (Harcourt et al., 2020). However, pharmacological inhibition of SARS-CoV-2 was assessed in human lung A549-ACE2 cells in addition to Vero E6 cells. The majority of drug effects were found to be replicated between cell lines."}

{"project":"2_test","denotations":[{"id":"32645325-32160149-20773098","span":{"begin":305,"end":309},"obj":"32160149"}],"text":"Limitations of Study\nA limitation of the current study is the use of a non-human cell line for proteomics analysis upon SARS-CoV-2 infection; here, an African green monkey cell line (Vero E6) was used because it has been shown previously to be highly permissible to SARS-CoV-2 infection (Harcourt et al., 2020). However, pharmacological inhibition of SARS-CoV-2 was assessed in human lung A549-ACE2 cells in addition to Vero E6 cells. The majority of drug effects were found to be replicated between cell lines."}