PMC:7318948 / 17582-18503 JSONTXT

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T251","span":{"begin":108,"end":116},"obj":"SP_7"},{"id":"T252","span":{"begin":154,"end":159},"obj":"UBERON:0000062"},{"id":"T253","span":{"begin":184,"end":188},"obj":"PR:000001393"},{"id":"T254","span":{"begin":189,"end":198},"obj":"CHEBI:35222;CHEBI:35222"},{"id":"T255","span":{"begin":298,"end":309},"obj":"DG_35"},{"id":"T256","span":{"begin":386,"end":397},"obj":"UBERON:0001004"},{"id":"T257","span":{"begin":563,"end":574},"obj":"UBERON:0001004"},{"id":"T258","span":{"begin":600,"end":614},"obj":"GO:0007596"},{"id":"T259","span":{"begin":655,"end":666},"obj":"UBERON:0001004"},{"id":"T260","span":{"begin":771,"end":779},"obj":"SP_7"},{"id":"T261","span":{"begin":800,"end":805},"obj":"UBERON:0000062"},{"id":"T262","span":{"begin":889,"end":897},"obj":"SP_7"},{"id":"T53081","span":{"begin":108,"end":116},"obj":"SP_7"},{"id":"T40237","span":{"begin":154,"end":159},"obj":"UBERON:0000062"},{"id":"T50732","span":{"begin":184,"end":188},"obj":"PR:000001393"},{"id":"T20616","span":{"begin":189,"end":198},"obj":"CHEBI:35222;CHEBI:35222"},{"id":"T9065","span":{"begin":298,"end":309},"obj":"DG_35"},{"id":"T92411","span":{"begin":386,"end":397},"obj":"UBERON:0001004"},{"id":"T9846","span":{"begin":563,"end":574},"obj":"UBERON:0001004"},{"id":"T4781","span":{"begin":600,"end":614},"obj":"GO:0007596"},{"id":"T63580","span":{"begin":655,"end":666},"obj":"UBERON:0001004"},{"id":"T70599","span":{"begin":771,"end":779},"obj":"SP_7"},{"id":"T64011","span":{"begin":800,"end":805},"obj":"UBERON:0000062"},{"id":"T48557","span":{"begin":889,"end":897},"obj":"SP_7"}],"text":"In conclusion, there is limited data on the clinical presentation, management, and appropriate treatment of COVID-19 patients who are recipients of solid organ transplants. The use of IL-6 inhibitor in our patient resulted in clinical improvement initially, but it is difficult to determine if the tocilizumab played a role in the management of this patient, specifically in preventing respiratory failure. The cytokine storm appears to play a major role in these patients, and it is possible that several of them experience a second storm that results in severe respiratory distress and intubation. Thromboembolic phenomena also appear to play a role in respiratory failure. A single case does not represent the complex strategy needed when considering the treatment of COVID-19 patients with solid organ transplants. Further studies are necessary to investigate treatment modalities for COVID-19 in special populations."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T94","span":{"begin":148,"end":159},"obj":"Body_part"},{"id":"T95","span":{"begin":411,"end":419},"obj":"Body_part"},{"id":"T96","span":{"begin":794,"end":805},"obj":"Body_part"}],"attributes":[{"id":"A94","pred":"fma_id","subj":"T94","obj":"http://purl.org/sig/ont/fma/fma55670"},{"id":"A95","pred":"fma_id","subj":"T95","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A96","pred":"fma_id","subj":"T96","obj":"http://purl.org/sig/ont/fma/fma55670"}],"text":"In conclusion, there is limited data on the clinical presentation, management, and appropriate treatment of COVID-19 patients who are recipients of solid organ transplants. The use of IL-6 inhibitor in our patient resulted in clinical improvement initially, but it is difficult to determine if the tocilizumab played a role in the management of this patient, specifically in preventing respiratory failure. The cytokine storm appears to play a major role in these patients, and it is possible that several of them experience a second storm that results in severe respiratory distress and intubation. Thromboembolic phenomena also appear to play a role in respiratory failure. A single case does not represent the complex strategy needed when considering the treatment of COVID-19 patients with solid organ transplants. Further studies are necessary to investigate treatment modalities for COVID-19 in special populations."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T52","span":{"begin":154,"end":159},"obj":"Body_part"},{"id":"T53","span":{"begin":800,"end":805},"obj":"Body_part"}],"attributes":[{"id":"A52","pred":"uberon_id","subj":"T52","obj":"http://purl.obolibrary.org/obo/UBERON_0000062"},{"id":"A53","pred":"uberon_id","subj":"T53","obj":"http://purl.obolibrary.org/obo/UBERON_0000062"}],"text":"In conclusion, there is limited data on the clinical presentation, management, and appropriate treatment of COVID-19 patients who are recipients of solid organ transplants. The use of IL-6 inhibitor in our patient resulted in clinical improvement initially, but it is difficult to determine if the tocilizumab played a role in the management of this patient, specifically in preventing respiratory failure. The cytokine storm appears to play a major role in these patients, and it is possible that several of them experience a second storm that results in severe respiratory distress and intubation. Thromboembolic phenomena also appear to play a role in respiratory failure. A single case does not represent the complex strategy needed when considering the treatment of COVID-19 patients with solid organ transplants. Further studies are necessary to investigate treatment modalities for COVID-19 in special populations."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T88","span":{"begin":108,"end":116},"obj":"Disease"},{"id":"T89","span":{"begin":386,"end":405},"obj":"Disease"},{"id":"T90","span":{"begin":655,"end":674},"obj":"Disease"},{"id":"T91","span":{"begin":771,"end":779},"obj":"Disease"},{"id":"T92","span":{"begin":889,"end":897},"obj":"Disease"}],"attributes":[{"id":"A88","pred":"mondo_id","subj":"T88","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A89","pred":"mondo_id","subj":"T89","obj":"http://purl.obolibrary.org/obo/MONDO_0021113"},{"id":"A90","pred":"mondo_id","subj":"T90","obj":"http://purl.obolibrary.org/obo/MONDO_0021113"},{"id":"A91","pred":"mondo_id","subj":"T91","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A92","pred":"mondo_id","subj":"T92","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"}],"text":"In conclusion, there is limited data on the clinical presentation, management, and appropriate treatment of COVID-19 patients who are recipients of solid organ transplants. The use of IL-6 inhibitor in our patient resulted in clinical improvement initially, but it is difficult to determine if the tocilizumab played a role in the management of this patient, specifically in preventing respiratory failure. The cytokine storm appears to play a major role in these patients, and it is possible that several of them experience a second storm that results in severe respiratory distress and intubation. Thromboembolic phenomena also appear to play a role in respiratory failure. A single case does not represent the complex strategy needed when considering the treatment of COVID-19 patients with solid organ transplants. Further studies are necessary to investigate treatment modalities for COVID-19 in special populations."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T220","span":{"begin":154,"end":159},"obj":"http://purl.obolibrary.org/obo/UBERON_0003103"},{"id":"T221","span":{"begin":317,"end":318},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T222","span":{"begin":442,"end":443},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T223","span":{"begin":525,"end":526},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T224","span":{"begin":645,"end":646},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T225","span":{"begin":676,"end":677},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T226","span":{"begin":800,"end":805},"obj":"http://purl.obolibrary.org/obo/UBERON_0003103"}],"text":"In conclusion, there is limited data on the clinical presentation, management, and appropriate treatment of COVID-19 patients who are recipients of solid organ transplants. The use of IL-6 inhibitor in our patient resulted in clinical improvement initially, but it is difficult to determine if the tocilizumab played a role in the management of this patient, specifically in preventing respiratory failure. The cytokine storm appears to play a major role in these patients, and it is possible that several of them experience a second storm that results in severe respiratory distress and intubation. Thromboembolic phenomena also appear to play a role in respiratory failure. A single case does not represent the complex strategy needed when considering the treatment of COVID-19 patients with solid organ transplants. Further studies are necessary to investigate treatment modalities for COVID-19 in special populations."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T185","span":{"begin":184,"end":186},"obj":"Chemical"},{"id":"T187","span":{"begin":189,"end":198},"obj":"Chemical"},{"id":"T188","span":{"begin":298,"end":309},"obj":"Chemical"}],"attributes":[{"id":"A185","pred":"chebi_id","subj":"T185","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A186","pred":"chebi_id","subj":"T185","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A187","pred":"chebi_id","subj":"T187","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A188","pred":"chebi_id","subj":"T188","obj":"http://purl.obolibrary.org/obo/CHEBI_64360"}],"text":"In conclusion, there is limited data on the clinical presentation, management, and appropriate treatment of COVID-19 patients who are recipients of solid organ transplants. The use of IL-6 inhibitor in our patient resulted in clinical improvement initially, but it is difficult to determine if the tocilizumab played a role in the management of this patient, specifically in preventing respiratory failure. The cytokine storm appears to play a major role in these patients, and it is possible that several of them experience a second storm that results in severe respiratory distress and intubation. Thromboembolic phenomena also appear to play a role in respiratory failure. A single case does not represent the complex strategy needed when considering the treatment of COVID-19 patients with solid organ transplants. Further studies are necessary to investigate treatment modalities for COVID-19 in special populations."}

{"project":"LitCovid-PubTator","denotations":[{"id":"434","span":{"begin":184,"end":188},"obj":"Gene"},{"id":"435","span":{"begin":117,"end":125},"obj":"Species"},{"id":"436","span":{"begin":206,"end":213},"obj":"Species"},{"id":"437","span":{"begin":350,"end":357},"obj":"Species"},{"id":"438","span":{"begin":464,"end":472},"obj":"Species"},{"id":"439","span":{"begin":780,"end":788},"obj":"Species"},{"id":"440","span":{"begin":298,"end":309},"obj":"Chemical"},{"id":"441","span":{"begin":108,"end":116},"obj":"Disease"},{"id":"442","span":{"begin":386,"end":405},"obj":"Disease"},{"id":"443","span":{"begin":563,"end":583},"obj":"Disease"},{"id":"444","span":{"begin":600,"end":624},"obj":"Disease"},{"id":"445","span":{"begin":655,"end":674},"obj":"Disease"},{"id":"446","span":{"begin":771,"end":779},"obj":"Disease"},{"id":"447","span":{"begin":889,"end":897},"obj":"Disease"}],"attributes":[{"id":"A434","pred":"tao:has_database_id","subj":"434","obj":"Gene:3569"},{"id":"A435","pred":"tao:has_database_id","subj":"435","obj":"Tax:9606"},{"id":"A436","pred":"tao:has_database_id","subj":"436","obj":"Tax:9606"},{"id":"A437","pred":"tao:has_database_id","subj":"437","obj":"Tax:9606"},{"id":"A438","pred":"tao:has_database_id","subj":"438","obj":"Tax:9606"},{"id":"A439","pred":"tao:has_database_id","subj":"439","obj":"Tax:9606"},{"id":"A440","pred":"tao:has_database_id","subj":"440","obj":"MESH:C502936"},{"id":"A441","pred":"tao:has_database_id","subj":"441","obj":"MESH:C000657245"},{"id":"A442","pred":"tao:has_database_id","subj":"442","obj":"MESH:D012131"},{"id":"A443","pred":"tao:has_database_id","subj":"443","obj":"MESH:D012128"},{"id":"A444","pred":"tao:has_database_id","subj":"444","obj":"MESH:D013923"},{"id":"A445","pred":"tao:has_database_id","subj":"445","obj":"MESH:D012131"},{"id":"A446","pred":"tao:has_database_id","subj":"446","obj":"MESH:C000657245"},{"id":"A447","pred":"tao:has_database_id","subj":"447","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"In conclusion, there is limited data on the clinical presentation, management, and appropriate treatment of COVID-19 patients who are recipients of solid organ transplants. The use of IL-6 inhibitor in our patient resulted in clinical improvement initially, but it is difficult to determine if the tocilizumab played a role in the management of this patient, specifically in preventing respiratory failure. The cytokine storm appears to play a major role in these patients, and it is possible that several of them experience a second storm that results in severe respiratory distress and intubation. Thromboembolic phenomena also appear to play a role in respiratory failure. A single case does not represent the complex strategy needed when considering the treatment of COVID-19 patients with solid organ transplants. Further studies are necessary to investigate treatment modalities for COVID-19 in special populations."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T37","span":{"begin":386,"end":405},"obj":"Phenotype"},{"id":"T38","span":{"begin":411,"end":425},"obj":"Phenotype"},{"id":"T39","span":{"begin":563,"end":583},"obj":"Phenotype"},{"id":"T40","span":{"begin":600,"end":614},"obj":"Phenotype"},{"id":"T41","span":{"begin":655,"end":674},"obj":"Phenotype"}],"attributes":[{"id":"A37","pred":"hp_id","subj":"T37","obj":"http://purl.obolibrary.org/obo/HP_0002878"},{"id":"A38","pred":"hp_id","subj":"T38","obj":"http://purl.obolibrary.org/obo/HP_0033041"},{"id":"A39","pred":"hp_id","subj":"T39","obj":"http://purl.obolibrary.org/obo/HP_0002098"},{"id":"A40","pred":"hp_id","subj":"T40","obj":"http://purl.obolibrary.org/obo/HP_0001907"},{"id":"A41","pred":"hp_id","subj":"T41","obj":"http://purl.obolibrary.org/obo/HP_0002878"}],"text":"In conclusion, there is limited data on the clinical presentation, management, and appropriate treatment of COVID-19 patients who are recipients of solid organ transplants. The use of IL-6 inhibitor in our patient resulted in clinical improvement initially, but it is difficult to determine if the tocilizumab played a role in the management of this patient, specifically in preventing respiratory failure. The cytokine storm appears to play a major role in these patients, and it is possible that several of them experience a second storm that results in severe respiratory distress and intubation. Thromboembolic phenomena also appear to play a role in respiratory failure. A single case does not represent the complex strategy needed when considering the treatment of COVID-19 patients with solid organ transplants. Further studies are necessary to investigate treatment modalities for COVID-19 in special populations."}

{"project":"LitCovid-sentences","denotations":[{"id":"T156","span":{"begin":0,"end":172},"obj":"Sentence"},{"id":"T157","span":{"begin":173,"end":406},"obj":"Sentence"},{"id":"T158","span":{"begin":407,"end":599},"obj":"Sentence"},{"id":"T159","span":{"begin":600,"end":675},"obj":"Sentence"},{"id":"T160","span":{"begin":676,"end":818},"obj":"Sentence"},{"id":"T161","span":{"begin":819,"end":921},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"In conclusion, there is limited data on the clinical presentation, management, and appropriate treatment of COVID-19 patients who are recipients of solid organ transplants. The use of IL-6 inhibitor in our patient resulted in clinical improvement initially, but it is difficult to determine if the tocilizumab played a role in the management of this patient, specifically in preventing respiratory failure. The cytokine storm appears to play a major role in these patients, and it is possible that several of them experience a second storm that results in severe respiratory distress and intubation. Thromboembolic phenomena also appear to play a role in respiratory failure. A single case does not represent the complex strategy needed when considering the treatment of COVID-19 patients with solid organ transplants. Further studies are necessary to investigate treatment modalities for COVID-19 in special populations."}