In conclusion, there is limited data on the clinical presentation, management, and appropriate treatment of COVID-19 patients who are recipients of solid organ transplants. The use of IL-6 inhibitor in our patient resulted in clinical improvement initially, but it is difficult to determine if the tocilizumab played a role in the management of this patient, specifically in preventing respiratory failure. The cytokine storm appears to play a major role in these patients, and it is possible that several of them experience a second storm that results in severe respiratory distress and intubation. Thromboembolic phenomena also appear to play a role in respiratory failure. A single case does not represent the complex strategy needed when considering the treatment of COVID-19 patients with solid organ transplants. Further studies are necessary to investigate treatment modalities for COVID-19 in special populations.