PMC:7311890 / 0-742 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue
T1	574-604	https://glytoucan.org/Structures/Glycans/G91237TK	denotes	monosialodihexosyl ganglioside
T2	606-609	https://glytoucan.org/Structures/Glycans/G56516VH	denotes	GM3
T3	606-609	https://glytoucan.org/Structures/Glycans/G91237TK	denotes	GM3

Id	Subject	Object	Predicate	Lexical cue	fma_id
T1	313-319	Body_part	denotes	plasma	http://purl.org/sig/ont/fma/fma62970
T2	428-434	Body_part	denotes	plasma	http://purl.org/sig/ont/fma/fma62970
T3	528-534	Body_part	denotes	Plasma	http://purl.org/sig/ont/fma/fma62970
T4	593-604	Body_part	denotes	ganglioside	http://purl.org/sig/ont/fma/fma82816

Id	Subject	Object	Predicate	Lexical cue	mondo_id
T1	65-73	Disease	denotes	COVID-19	http://purl.obolibrary.org/obo/MONDO_0100096
T2	109-133	Disease	denotes	coronavirus disease 2019	http://purl.obolibrary.org/obo/MONDO_0100096
T3	135-143	Disease	denotes	COVID-19	http://purl.obolibrary.org/obo/MONDO_0100096
T4	374-382	Disease	denotes	COVID-19	http://purl.obolibrary.org/obo/MONDO_0100096
T5	473-481	Disease	denotes	COVID-19	http://purl.obolibrary.org/obo/MONDO_0100096
T6	547-555	Disease	denotes	COVID-19	http://purl.obolibrary.org/obo/MONDO_0100096

Id	Subject	Object	Predicate	Lexical cue
T1	232-233	http://purl.obolibrary.org/obo/CLO_0001020	denotes	a
T2	313-319	http://purl.obolibrary.org/obo/UBERON_0001969	denotes	plasma
T3	414-415	http://purl.obolibrary.org/obo/CLO_0001020	denotes	A
T4	428-434	http://purl.obolibrary.org/obo/UBERON_0001969	denotes	plasma
T5	528-534	http://purl.obolibrary.org/obo/UBERON_0001969	denotes	Plasma

Id	Subject	Object	Predicate	Lexical cue	chebi_id
T1	435-446	Chemical	denotes	metabolites	http://purl.obolibrary.org/obo/CHEBI_25212
T2	574-604	Chemical	denotes	monosialodihexosyl ganglioside	http://purl.obolibrary.org/obo/CHEBI_84118
T3	593-604	Chemical	denotes	ganglioside	http://purl.obolibrary.org/obo/CHEBI_28892
T4	606-609	Chemical	denotes	GM3	http://purl.obolibrary.org/obo/CHEBI_15681\|http://purl.obolibrary.org/obo/CHEBI_84118
T6	654-668	Chemical	denotes	sphingomyelins	http://purl.obolibrary.org/obo/CHEBI_17636\|http://purl.obolibrary.org/obo/CHEBI_62490
T8	670-673	Chemical	denotes	SMs	http://purl.obolibrary.org/obo/CHEBI_17636
T9	697-712	Chemical	denotes	diacylglycerols	http://purl.obolibrary.org/obo/CHEBI_18035
T10	714-718	Chemical	denotes	DAGs	http://purl.obolibrary.org/obo/CHEBI_18035

Id	Subject	Object	Predicate	Lexical cue	tao:has_database_id
1	65-73	Disease	denotes	COVID-19	MESH:C000657245
24	383-391	Species	denotes	patients	Tax:9606
25	482-490	Species	denotes	patients	Tax:9606
27	574-604	Chemical	denotes	monosialodihexosyl ganglioside
28	606-609	Chemical	denotes	GM3
29	654-668	Chemical	denotes	sphingomyelins	MESH:D013109
30	670-673	Chemical	denotes	SMs	MESH:D013109
31	679-683	Chemical	denotes	GM3s
32	697-712	Chemical	denotes	diacylglycerols	MESH:D004075
33	714-718	Chemical	denotes	DAGs	MESH:D004075
36	109-133	Disease	denotes	coronavirus disease 2019	MESH:C000657245
37	135-143	Disease	denotes	COVID-19	MESH:C000657245
38	374-382	Disease	denotes	COVID-19	MESH:C000657245
39	473-481	Disease	denotes	COVID-19	MESH:C000657245
40	547-555	Disease	denotes	COVID-19	MESH:C000657245

Id	Subject	Object	Predicate	Lexical cue
T1	74-86	http://purl.obolibrary.org/obo/GO_0009405	denotes	Pathogenesis

Id	Subject	Object	Predicate	Lexical cue
T1	0-86	Sentence	denotes	Omics-Driven Systems Interrogation of Metabolic Dysregulation in COVID-19 Pathogenesis
T2	88-96	Sentence	denotes	Abstract
T3	97-104	Sentence	denotes	Summary
T4	105-211	Sentence	denotes	The coronavirus disease 2019 (COVID-19) pandemic presents an unprecedented threat to global public health.
T5	212-413	Sentence	denotes	Herein, we utilized a combination of targeted and untargeted tandem mass spectrometry to analyze the plasma lipidome and metabolome in mild, moderate, and severe COVID-19 patients and healthy controls.
T6	414-527	Sentence	denotes	A panel of 10 plasma metabolites effectively distinguished COVID-19 patients from healthy controls (AUC = 0.975).
T7	528-720	Sentence	denotes	Plasma lipidome of COVID-19 resembled that of monosialodihexosyl ganglioside (GM3)-enriched exosomes, with enhanced levels of sphingomyelins (SMs) and GM3s, and reduced diacylglycerols (DAGs).

Id	Subject	Object	Predicate	Lexical cue
T1	38-47	GO:0008152	denotes	Metabolic
T2	48-61	GO:0019222	denotes	Dysregulation
T3	65-73	SP_7	denotes	COVID-19
T4	109-120	NCBITaxon:11118	denotes	coronavirus
T5	135-143	SP_7	denotes	COVID-19
T6	313-319	UBERON:0001969	denotes	plasma
T7	374-382	SP_7	denotes	COVID-19
T8	428-434	UBERON:0001969	denotes	plasma
T9	435-446	CHEBI:25212;CHEBI:25212	denotes	metabolites
T10	473-481	SP_7	denotes	COVID-19
T11	528-534	UBERON:0001969	denotes	Plasma
T12	547-555	SP_7	denotes	COVID-19
T13	593-604	CHEBI:24195;CHEBI:24195	denotes	ganglioside
T14	620-628	GO:0070062	denotes	exosomes
T15	654-668	CHEBI:64583;CHEBI:64583	denotes	sphingomyelins
T16	679-683	PR:000015682	denotes	GM3s
T17	697-712	CHEBI:18035;CHEBI:18035	denotes	diacylglycerols
T18	714-718	CHEBI:18035;CHEBI:18035	denotes	DAGs
T82870	38-47	GO:0008152	denotes	Metabolic
T24925	48-61	GO:0019222	denotes	Dysregulation
T54167	65-73	SP_7	denotes	COVID-19
T79216	109-120	NCBITaxon:11118	denotes	coronavirus
T16736	135-143	SP_7	denotes	COVID-19
T67927	313-319	UBERON:0001969	denotes	plasma
T27466	374-382	SP_7	denotes	COVID-19
T90215	428-434	UBERON:0001969	denotes	plasma
T16585	435-446	CHEBI:25212;CHEBI:25212	denotes	metabolites
T99740	473-481	SP_7	denotes	COVID-19
T25314	528-534	UBERON:0001969	denotes	Plasma
T13014	547-555	SP_7	denotes	COVID-19
T73199	593-604	CHEBI:24195;CHEBI:24195	denotes	ganglioside
T82491	620-628	GO:0070062	denotes	exosomes
T3559	654-668	CHEBI:64583;CHEBI:64583	denotes	sphingomyelins
T50733	679-683	PR:000015682	denotes	GM3s
T34334	697-712	CHEBI:18035;CHEBI:18035	denotes	diacylglycerols
T71152	714-718	CHEBI:18035;CHEBI:18035	denotes	DAGs