PMC:7311890 / 0-742 JSONTXT

{"project":"LitCovid_Glycan-Motif-Structure","denotations":[{"id":"T1","span":{"begin":574,"end":604},"obj":"https://glytoucan.org/Structures/Glycans/G91237TK"},{"id":"T2","span":{"begin":606,"end":609},"obj":"https://glytoucan.org/Structures/Glycans/G56516VH"},{"id":"T3","span":{"begin":606,"end":609},"obj":"https://glytoucan.org/Structures/Glycans/G91237TK"}],"text":"Omics-Driven Systems Interrogation of Metabolic Dysregulation in COVID-19 Pathogenesis\n\nAbstract\nSummary\nThe coronavirus disease 2019 (COVID-19) pandemic presents an unprecedented threat to global public health. Herein, we utilized a combination of targeted and untargeted tandem mass spectrometry to analyze the plasma lipidome and metabolome in mild, moderate, and severe COVID-19 patients and healthy controls. A panel of 10 plasma metabolites effectively distinguished COVID-19 patients from healthy controls (AUC = 0.975). Plasma lipidome of COVID-19 resembled that of monosialodihexosyl ganglioside (GM3)-enriched exosomes, with enhanced levels of sphingomyelins (SMs) and GM3s, and reduced diacylglycerols (DAGs). Systems evaluation of"}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T1","span":{"begin":313,"end":319},"obj":"Body_part"},{"id":"T2","span":{"begin":428,"end":434},"obj":"Body_part"},{"id":"T3","span":{"begin":528,"end":534},"obj":"Body_part"},{"id":"T4","span":{"begin":593,"end":604},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"fma_id","subj":"T1","obj":"http://purl.org/sig/ont/fma/fma62970"},{"id":"A2","pred":"fma_id","subj":"T2","obj":"http://purl.org/sig/ont/fma/fma62970"},{"id":"A3","pred":"fma_id","subj":"T3","obj":"http://purl.org/sig/ont/fma/fma62970"},{"id":"A4","pred":"fma_id","subj":"T4","obj":"http://purl.org/sig/ont/fma/fma82816"}],"text":"Omics-Driven Systems Interrogation of Metabolic Dysregulation in COVID-19 Pathogenesis\n\nAbstract\nSummary\nThe coronavirus disease 2019 (COVID-19) pandemic presents an unprecedented threat to global public health. Herein, we utilized a combination of targeted and untargeted tandem mass spectrometry to analyze the plasma lipidome and metabolome in mild, moderate, and severe COVID-19 patients and healthy controls. A panel of 10 plasma metabolites effectively distinguished COVID-19 patients from healthy controls (AUC = 0.975). Plasma lipidome of COVID-19 resembled that of monosialodihexosyl ganglioside (GM3)-enriched exosomes, with enhanced levels of sphingomyelins (SMs) and GM3s, and reduced diacylglycerols (DAGs). Systems evaluation of"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T1","span":{"begin":65,"end":73},"obj":"Disease"},{"id":"T2","span":{"begin":109,"end":133},"obj":"Disease"},{"id":"T3","span":{"begin":135,"end":143},"obj":"Disease"},{"id":"T4","span":{"begin":374,"end":382},"obj":"Disease"},{"id":"T5","span":{"begin":473,"end":481},"obj":"Disease"},{"id":"T6","span":{"begin":547,"end":555},"obj":"Disease"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A5","pred":"mondo_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A6","pred":"mondo_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"}],"text":"Omics-Driven Systems Interrogation of Metabolic Dysregulation in COVID-19 Pathogenesis\n\nAbstract\nSummary\nThe coronavirus disease 2019 (COVID-19) pandemic presents an unprecedented threat to global public health. Herein, we utilized a combination of targeted and untargeted tandem mass spectrometry to analyze the plasma lipidome and metabolome in mild, moderate, and severe COVID-19 patients and healthy controls. A panel of 10 plasma metabolites effectively distinguished COVID-19 patients from healthy controls (AUC = 0.975). Plasma lipidome of COVID-19 resembled that of monosialodihexosyl ganglioside (GM3)-enriched exosomes, with enhanced levels of sphingomyelins (SMs) and GM3s, and reduced diacylglycerols (DAGs). Systems evaluation of"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T1","span":{"begin":232,"end":233},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T2","span":{"begin":313,"end":319},"obj":"http://purl.obolibrary.org/obo/UBERON_0001969"},{"id":"T3","span":{"begin":414,"end":415},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T4","span":{"begin":428,"end":434},"obj":"http://purl.obolibrary.org/obo/UBERON_0001969"},{"id":"T5","span":{"begin":528,"end":534},"obj":"http://purl.obolibrary.org/obo/UBERON_0001969"}],"text":"Omics-Driven Systems Interrogation of Metabolic Dysregulation in COVID-19 Pathogenesis\n\nAbstract\nSummary\nThe coronavirus disease 2019 (COVID-19) pandemic presents an unprecedented threat to global public health. Herein, we utilized a combination of targeted and untargeted tandem mass spectrometry to analyze the plasma lipidome and metabolome in mild, moderate, and severe COVID-19 patients and healthy controls. A panel of 10 plasma metabolites effectively distinguished COVID-19 patients from healthy controls (AUC = 0.975). Plasma lipidome of COVID-19 resembled that of monosialodihexosyl ganglioside (GM3)-enriched exosomes, with enhanced levels of sphingomyelins (SMs) and GM3s, and reduced diacylglycerols (DAGs). Systems evaluation of"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T1","span":{"begin":435,"end":446},"obj":"Chemical"},{"id":"T2","span":{"begin":574,"end":604},"obj":"Chemical"},{"id":"T3","span":{"begin":593,"end":604},"obj":"Chemical"},{"id":"T4","span":{"begin":606,"end":609},"obj":"Chemical"},{"id":"T6","span":{"begin":654,"end":668},"obj":"Chemical"},{"id":"T8","span":{"begin":670,"end":673},"obj":"Chemical"},{"id":"T9","span":{"begin":697,"end":712},"obj":"Chemical"},{"id":"T10","span":{"begin":714,"end":718},"obj":"Chemical"}],"attributes":[{"id":"A1","pred":"chebi_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_25212"},{"id":"A2","pred":"chebi_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CHEBI_84118"},{"id":"A3","pred":"chebi_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CHEBI_28892"},{"id":"A4","pred":"chebi_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/CHEBI_15681"},{"id":"A5","pred":"chebi_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/CHEBI_84118"},{"id":"A6","pred":"chebi_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/CHEBI_17636"},{"id":"A7","pred":"chebi_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/CHEBI_62490"},{"id":"A8","pred":"chebi_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/CHEBI_17636"},{"id":"A9","pred":"chebi_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/CHEBI_18035"},{"id":"A10","pred":"chebi_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/CHEBI_18035"}],"text":"Omics-Driven Systems Interrogation of Metabolic Dysregulation in COVID-19 Pathogenesis\n\nAbstract\nSummary\nThe coronavirus disease 2019 (COVID-19) pandemic presents an unprecedented threat to global public health. Herein, we utilized a combination of targeted and untargeted tandem mass spectrometry to analyze the plasma lipidome and metabolome in mild, moderate, and severe COVID-19 patients and healthy controls. A panel of 10 plasma metabolites effectively distinguished COVID-19 patients from healthy controls (AUC = 0.975). Plasma lipidome of COVID-19 resembled that of monosialodihexosyl ganglioside (GM3)-enriched exosomes, with enhanced levels of sphingomyelins (SMs) and GM3s, and reduced diacylglycerols (DAGs). Systems evaluation of"}

{"project":"LitCovid-PubTator","denotations":[{"id":"1","span":{"begin":65,"end":73},"obj":"Disease"},{"id":"24","span":{"begin":383,"end":391},"obj":"Species"},{"id":"25","span":{"begin":482,"end":490},"obj":"Species"},{"id":"27","span":{"begin":574,"end":604},"obj":"Chemical"},{"id":"28","span":{"begin":606,"end":609},"obj":"Chemical"},{"id":"29","span":{"begin":654,"end":668},"obj":"Chemical"},{"id":"30","span":{"begin":670,"end":673},"obj":"Chemical"},{"id":"31","span":{"begin":679,"end":683},"obj":"Chemical"},{"id":"32","span":{"begin":697,"end":712},"obj":"Chemical"},{"id":"33","span":{"begin":714,"end":718},"obj":"Chemical"},{"id":"36","span":{"begin":109,"end":133},"obj":"Disease"},{"id":"37","span":{"begin":135,"end":143},"obj":"Disease"},{"id":"38","span":{"begin":374,"end":382},"obj":"Disease"},{"id":"39","span":{"begin":473,"end":481},"obj":"Disease"},{"id":"40","span":{"begin":547,"end":555},"obj":"Disease"}],"attributes":[{"id":"A1","pred":"tao:has_database_id","subj":"1","obj":"MESH:C000657245"},{"id":"A24","pred":"tao:has_database_id","subj":"24","obj":"Tax:9606"},{"id":"A25","pred":"tao:has_database_id","subj":"25","obj":"Tax:9606"},{"id":"A29","pred":"tao:has_database_id","subj":"29","obj":"MESH:D013109"},{"id":"A30","pred":"tao:has_database_id","subj":"30","obj":"MESH:D013109"},{"id":"A32","pred":"tao:has_database_id","subj":"32","obj":"MESH:D004075"},{"id":"A33","pred":"tao:has_database_id","subj":"33","obj":"MESH:D004075"},{"id":"A36","pred":"tao:has_database_id","subj":"36","obj":"MESH:C000657245"},{"id":"A37","pred":"tao:has_database_id","subj":"37","obj":"MESH:C000657245"},{"id":"A38","pred":"tao:has_database_id","subj":"38","obj":"MESH:C000657245"},{"id":"A39","pred":"tao:has_database_id","subj":"39","obj":"MESH:C000657245"},{"id":"A40","pred":"tao:has_database_id","subj":"40","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Omics-Driven Systems Interrogation of Metabolic Dysregulation in COVID-19 Pathogenesis\n\nAbstract\nSummary\nThe coronavirus disease 2019 (COVID-19) pandemic presents an unprecedented threat to global public health. Herein, we utilized a combination of targeted and untargeted tandem mass spectrometry to analyze the plasma lipidome and metabolome in mild, moderate, and severe COVID-19 patients and healthy controls. A panel of 10 plasma metabolites effectively distinguished COVID-19 patients from healthy controls (AUC = 0.975). Plasma lipidome of COVID-19 resembled that of monosialodihexosyl ganglioside (GM3)-enriched exosomes, with enhanced levels of sphingomyelins (SMs) and GM3s, and reduced diacylglycerols (DAGs). Systems evaluation of"}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T1","span":{"begin":74,"end":86},"obj":"http://purl.obolibrary.org/obo/GO_0009405"}],"text":"Omics-Driven Systems Interrogation of Metabolic Dysregulation in COVID-19 Pathogenesis\n\nAbstract\nSummary\nThe coronavirus disease 2019 (COVID-19) pandemic presents an unprecedented threat to global public health. Herein, we utilized a combination of targeted and untargeted tandem mass spectrometry to analyze the plasma lipidome and metabolome in mild, moderate, and severe COVID-19 patients and healthy controls. A panel of 10 plasma metabolites effectively distinguished COVID-19 patients from healthy controls (AUC = 0.975). Plasma lipidome of COVID-19 resembled that of monosialodihexosyl ganglioside (GM3)-enriched exosomes, with enhanced levels of sphingomyelins (SMs) and GM3s, and reduced diacylglycerols (DAGs). Systems evaluation of"}

{"project":"LitCovid-sentences","denotations":[{"id":"T1","span":{"begin":0,"end":86},"obj":"Sentence"},{"id":"T2","span":{"begin":88,"end":96},"obj":"Sentence"},{"id":"T3","span":{"begin":97,"end":104},"obj":"Sentence"},{"id":"T4","span":{"begin":105,"end":211},"obj":"Sentence"},{"id":"T5","span":{"begin":212,"end":413},"obj":"Sentence"},{"id":"T6","span":{"begin":414,"end":527},"obj":"Sentence"},{"id":"T7","span":{"begin":528,"end":720},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Omics-Driven Systems Interrogation of Metabolic Dysregulation in COVID-19 Pathogenesis\n\nAbstract\nSummary\nThe coronavirus disease 2019 (COVID-19) pandemic presents an unprecedented threat to global public health. Herein, we utilized a combination of targeted and untargeted tandem mass spectrometry to analyze the plasma lipidome and metabolome in mild, moderate, and severe COVID-19 patients and healthy controls. A panel of 10 plasma metabolites effectively distinguished COVID-19 patients from healthy controls (AUC = 0.975). Plasma lipidome of COVID-19 resembled that of monosialodihexosyl ganglioside (GM3)-enriched exosomes, with enhanced levels of sphingomyelins (SMs) and GM3s, and reduced diacylglycerols (DAGs). Systems evaluation of"}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T1","span":{"begin":38,"end":47},"obj":"GO:0008152"},{"id":"T2","span":{"begin":48,"end":61},"obj":"GO:0019222"},{"id":"T3","span":{"begin":65,"end":73},"obj":"SP_7"},{"id":"T4","span":{"begin":109,"end":120},"obj":"NCBITaxon:11118"},{"id":"T5","span":{"begin":135,"end":143},"obj":"SP_7"},{"id":"T6","span":{"begin":313,"end":319},"obj":"UBERON:0001969"},{"id":"T7","span":{"begin":374,"end":382},"obj":"SP_7"},{"id":"T8","span":{"begin":428,"end":434},"obj":"UBERON:0001969"},{"id":"T9","span":{"begin":435,"end":446},"obj":"CHEBI:25212;CHEBI:25212"},{"id":"T10","span":{"begin":473,"end":481},"obj":"SP_7"},{"id":"T11","span":{"begin":528,"end":534},"obj":"UBERON:0001969"},{"id":"T12","span":{"begin":547,"end":555},"obj":"SP_7"},{"id":"T13","span":{"begin":593,"end":604},"obj":"CHEBI:24195;CHEBI:24195"},{"id":"T14","span":{"begin":620,"end":628},"obj":"GO:0070062"},{"id":"T15","span":{"begin":654,"end":668},"obj":"CHEBI:64583;CHEBI:64583"},{"id":"T16","span":{"begin":679,"end":683},"obj":"PR:000015682"},{"id":"T17","span":{"begin":697,"end":712},"obj":"CHEBI:18035;CHEBI:18035"},{"id":"T18","span":{"begin":714,"end":718},"obj":"CHEBI:18035;CHEBI:18035"},{"id":"T82870","span":{"begin":38,"end":47},"obj":"GO:0008152"},{"id":"T24925","span":{"begin":48,"end":61},"obj":"GO:0019222"},{"id":"T54167","span":{"begin":65,"end":73},"obj":"SP_7"},{"id":"T79216","span":{"begin":109,"end":120},"obj":"NCBITaxon:11118"},{"id":"T16736","span":{"begin":135,"end":143},"obj":"SP_7"},{"id":"T67927","span":{"begin":313,"end":319},"obj":"UBERON:0001969"},{"id":"T27466","span":{"begin":374,"end":382},"obj":"SP_7"},{"id":"T90215","span":{"begin":428,"end":434},"obj":"UBERON:0001969"},{"id":"T16585","span":{"begin":435,"end":446},"obj":"CHEBI:25212;CHEBI:25212"},{"id":"T99740","span":{"begin":473,"end":481},"obj":"SP_7"},{"id":"T25314","span":{"begin":528,"end":534},"obj":"UBERON:0001969"},{"id":"T13014","span":{"begin":547,"end":555},"obj":"SP_7"},{"id":"T73199","span":{"begin":593,"end":604},"obj":"CHEBI:24195;CHEBI:24195"},{"id":"T82491","span":{"begin":620,"end":628},"obj":"GO:0070062"},{"id":"T3559","span":{"begin":654,"end":668},"obj":"CHEBI:64583;CHEBI:64583"},{"id":"T50733","span":{"begin":679,"end":683},"obj":"PR:000015682"},{"id":"T34334","span":{"begin":697,"end":712},"obj":"CHEBI:18035;CHEBI:18035"},{"id":"T71152","span":{"begin":714,"end":718},"obj":"CHEBI:18035;CHEBI:18035"}],"text":"Omics-Driven Systems Interrogation of Metabolic Dysregulation in COVID-19 Pathogenesis\n\nAbstract\nSummary\nThe coronavirus disease 2019 (COVID-19) pandemic presents an unprecedented threat to global public health. Herein, we utilized a combination of targeted and untargeted tandem mass spectrometry to analyze the plasma lipidome and metabolome in mild, moderate, and severe COVID-19 patients and healthy controls. A panel of 10 plasma metabolites effectively distinguished COVID-19 patients from healthy controls (AUC = 0.975). Plasma lipidome of COVID-19 resembled that of monosialodihexosyl ganglioside (GM3)-enriched exosomes, with enhanced levels of sphingomyelins (SMs) and GM3s, and reduced diacylglycerols (DAGs). Systems evaluation of"}