PMC:7306567 / 10902-12362
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7306567","sourcedb":"PMC","sourceid":"7306567","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7306567","text":"Lesions that are suggestive of invasive mold disease on imaging in neutropenic patients, such as the halo sign, are often absent in critically ill patients. However, in some IAPA patients with autopsy-confirmed Aspergillus tracheobronchitis, chest CT demonstrated peribronchial infiltrates. The main diagnostic clue for airway-invasive Aspergillus tracheobronchitis is epithelial plaques, pseudomembranes or ulcers that can be visualized via bronchoscopy, as radiological features may be subtle [31]. Worsening of radiographic pulmonary infiltrates in patients with influenza is often attributed to progression of ARDS or bacterial infection, leading to a change of antimicrobial therapy without performing diagnostic procedures [32]. Patients who survived IAPA received antifungal therapy much earlier than those who did not (2 days after diagnosis of influenza among survivors versus 9 days among non-survivors) [8], suggesting that early diagnosis and administration of antifungal therapy may be important. Lateral flow tests have recently become available as an alternative for diagnosing IPA (AspLFD, OLM Diagnostics and the sōna Aspergillus GM, IMMY) showing overall good performance in hematology patients [33]. The very quick assessment, with results available within 30–45 min, makes this type of test very attractive for the management of IAPA and use in clinical trials. However, lateral flow tests have not yet been validated in the ICU population.","tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T15","span":{"begin":242,"end":247},"obj":"Body_part"}],"attributes":[{"id":"A15","pred":"fma_id","subj":"T15","obj":"http://purl.org/sig/ont/fma/fma9576"},{"subj":"T15","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T13","span":{"begin":242,"end":247},"obj":"Body_part"}],"attributes":[{"id":"A13","pred":"uberon_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/UBERON_0001443"},{"subj":"T13","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"113","span":{"begin":31,"end":44},"obj":"Disease"},{"id":"114","span":{"begin":67,"end":78},"obj":"Disease"},{"id":"115","span":{"begin":132,"end":146},"obj":"Disease"},{"id":"116","span":{"begin":211,"end":240},"obj":"Disease"},{"id":"117","span":{"begin":320,"end":365},"obj":"Disease"},{"id":"118","span":{"begin":408,"end":414},"obj":"Disease"},{"id":"119","span":{"begin":527,"end":548},"obj":"Disease"},{"id":"120","span":{"begin":614,"end":618},"obj":"Disease"},{"id":"121","span":{"begin":622,"end":641},"obj":"Disease"}],"attributes":[{"id":"A113","pred":"tao:has_database_id","subj":"113","obj":"MESH:D009361"},{"id":"A114","pred":"tao:has_database_id","subj":"114","obj":"MESH:D009503"},{"id":"A115","pred":"tao:has_database_id","subj":"115","obj":"MESH:D016638"},{"id":"A116","pred":"tao:has_database_id","subj":"116","obj":"MESH:D001228"},{"id":"A117","pred":"tao:has_database_id","subj":"117","obj":"MESH:D001228"},{"id":"A118","pred":"tao:has_database_id","subj":"118","obj":"MESH:D014456"},{"id":"A119","pred":"tao:has_database_id","subj":"119","obj":"MESH:D017254"},{"id":"A120","pred":"tao:has_database_id","subj":"120","obj":"MESH:D012128"},{"id":"A121","pred":"tao:has_database_id","subj":"121","obj":"MESH:D001424"},{"subj":"113","pred":"source","obj":"LitCovid-PubTator"},{"subj":"114","pred":"source","obj":"LitCovid-PubTator"},{"subj":"115","pred":"source","obj":"LitCovid-PubTator"},{"subj":"116","pred":"source","obj":"LitCovid-PubTator"},{"subj":"117","pred":"source","obj":"LitCovid-PubTator"},{"subj":"118","pred":"source","obj":"LitCovid-PubTator"},{"subj":"119","pred":"source","obj":"LitCovid-PubTator"},{"subj":"120","pred":"source","obj":"LitCovid-PubTator"},{"subj":"121","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T58","span":{"begin":223,"end":240},"obj":"Disease"},{"id":"T59","span":{"begin":348,"end":365},"obj":"Disease"},{"id":"T60","span":{"begin":408,"end":414},"obj":"Disease"},{"id":"T61","span":{"begin":566,"end":575},"obj":"Disease"},{"id":"T62","span":{"begin":614,"end":618},"obj":"Disease"},{"id":"T63","span":{"begin":622,"end":641},"obj":"Disease"},{"id":"T64","span":{"begin":632,"end":641},"obj":"Disease"},{"id":"T65","span":{"begin":853,"end":862},"obj":"Disease"}],"attributes":[{"id":"A58","pred":"mondo_id","subj":"T58","obj":"http://purl.obolibrary.org/obo/MONDO_0021925"},{"id":"A59","pred":"mondo_id","subj":"T59","obj":"http://purl.obolibrary.org/obo/MONDO_0021925"},{"id":"A60","pred":"mondo_id","subj":"T60","obj":"http://purl.obolibrary.org/obo/MONDO_0043839"},{"id":"A61","pred":"mondo_id","subj":"T61","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"},{"id":"A62","pred":"mondo_id","subj":"T62","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A63","pred":"mondo_id","subj":"T63","obj":"http://purl.obolibrary.org/obo/MONDO_0005113"},{"id":"A64","pred":"mondo_id","subj":"T64","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A65","pred":"mondo_id","subj":"T65","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"},{"subj":"T58","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T59","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T60","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T61","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T62","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T63","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T64","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T65","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T68","span":{"begin":242,"end":247},"obj":"http://www.ebi.ac.uk/efo/EFO_0000965"},{"id":"T69","span":{"begin":320,"end":326},"obj":"http://purl.obolibrary.org/obo/UBERON_0001005"},{"id":"T70","span":{"begin":369,"end":379},"obj":"http://purl.obolibrary.org/obo/CL_0000066"},{"id":"T71","span":{"begin":654,"end":655},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T72","span":{"begin":1023,"end":1028},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T73","span":{"begin":1279,"end":1281},"obj":"http://purl.obolibrary.org/obo/CLO_0053799"},{"id":"T74","span":{"begin":1306,"end":1310},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T75","span":{"begin":1404,"end":1409},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"}],"attributes":[{"subj":"T68","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T69","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T70","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T71","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T72","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T73","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T74","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T75","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T58","span":{"begin":666,"end":679},"obj":"Chemical"},{"id":"T59","span":{"begin":771,"end":781},"obj":"Chemical"},{"id":"T60","span":{"begin":973,"end":983},"obj":"Chemical"},{"id":"T61","span":{"begin":1093,"end":1096},"obj":"Chemical"},{"id":"T63","span":{"begin":1147,"end":1149},"obj":"Chemical"}],"attributes":[{"id":"A58","pred":"chebi_id","subj":"T58","obj":"http://purl.obolibrary.org/obo/CHEBI_33281"},{"id":"A59","pred":"chebi_id","subj":"T59","obj":"http://purl.obolibrary.org/obo/CHEBI_35718"},{"id":"A60","pred":"chebi_id","subj":"T60","obj":"http://purl.obolibrary.org/obo/CHEBI_35718"},{"id":"A61","pred":"chebi_id","subj":"T61","obj":"http://purl.obolibrary.org/obo/CHEBI_17824"},{"id":"A62","pred":"chebi_id","subj":"T61","obj":"http://purl.obolibrary.org/obo/CHEBI_30802"},{"id":"A63","pred":"chebi_id","subj":"T63","obj":"http://purl.obolibrary.org/obo/CHEBI_74120"},{"id":"A64","pred":"chebi_id","subj":"T63","obj":"http://purl.obolibrary.org/obo/CHEBI_27680"},{"subj":"T58","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T59","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T60","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T61","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T63","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GlycoEpitope","denotations":[{"id":"T8","span":{"begin":1147,"end":1149},"obj":"GlycoEpitope"}],"attributes":[{"id":"A8","pred":"glyco_epitope_db_id","subj":"T8","obj":"http://www.glycoepitope.jp/epitopes/EP0510"},{"subj":"T8","pred":"source","obj":"LitCovid-PD-GlycoEpitope"}]},{"project":"LitCovid-PD-HP","denotations":[{"id":"T19","span":{"begin":527,"end":548},"obj":"Phenotype"},{"id":"T20","span":{"begin":1093,"end":1096},"obj":"Phenotype"}],"attributes":[{"id":"A19","pred":"hp_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/HP_0002113"},{"id":"A20","pred":"hp_id","subj":"T20","obj":"http://purl.obolibrary.org/obo/HP_0020103"},{"subj":"T19","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T20","pred":"source","obj":"LitCovid-PD-HP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T72","span":{"begin":0,"end":156},"obj":"Sentence"},{"id":"T73","span":{"begin":157,"end":290},"obj":"Sentence"},{"id":"T74","span":{"begin":291,"end":500},"obj":"Sentence"},{"id":"T75","span":{"begin":501,"end":734},"obj":"Sentence"},{"id":"T76","span":{"begin":735,"end":1009},"obj":"Sentence"},{"id":"T77","span":{"begin":1010,"end":1218},"obj":"Sentence"},{"id":"T78","span":{"begin":1219,"end":1381},"obj":"Sentence"},{"id":"T79","span":{"begin":1382,"end":1460},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T72","pred":"source","obj":"LitCovid-sentences"},{"subj":"T73","pred":"source","obj":"LitCovid-sentences"},{"subj":"T74","pred":"source","obj":"LitCovid-sentences"},{"subj":"T75","pred":"source","obj":"LitCovid-sentences"},{"subj":"T76","pred":"source","obj":"LitCovid-sentences"},{"subj":"T77","pred":"source","obj":"LitCovid-sentences"},{"subj":"T78","pred":"source","obj":"LitCovid-sentences"},{"subj":"T79","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T79","span":{"begin":211,"end":222},"obj":"NCBITaxon:5052"},{"id":"T80","span":{"begin":223,"end":240},"obj":"UBERON:0007196"},{"id":"T81","span":{"begin":242,"end":247},"obj":"UBERON:0001443"},{"id":"T82","span":{"begin":264,"end":277},"obj":"UBERON:0001845"},{"id":"T83","span":{"begin":320,"end":326},"obj":"UBERON:0001005"},{"id":"T84","span":{"begin":336,"end":347},"obj":"NCBITaxon:5052"},{"id":"T85","span":{"begin":348,"end":365},"obj":"UBERON:0007196"},{"id":"T86","span":{"begin":369,"end":379},"obj":"UBERON:0000483"},{"id":"T87","span":{"begin":527,"end":536},"obj":"UBERON:0002048"},{"id":"T88","span":{"begin":622,"end":631},"obj":"NCBITaxon:2"},{"id":"T89","span":{"begin":666,"end":679},"obj":"CHEBI:35718;CHEBI:35718"},{"id":"T48603","span":{"begin":211,"end":222},"obj":"NCBITaxon:5052"},{"id":"T84469","span":{"begin":223,"end":240},"obj":"UBERON:0007196"},{"id":"T9111","span":{"begin":242,"end":247},"obj":"UBERON:0001443"},{"id":"T12913","span":{"begin":264,"end":277},"obj":"UBERON:0001845"},{"id":"T37746","span":{"begin":320,"end":326},"obj":"UBERON:0001005"},{"id":"T32093","span":{"begin":336,"end":347},"obj":"NCBITaxon:5052"},{"id":"T90534","span":{"begin":348,"end":365},"obj":"UBERON:0007196"},{"id":"T78753","span":{"begin":369,"end":379},"obj":"UBERON:0000483"},{"id":"T63798","span":{"begin":527,"end":536},"obj":"UBERON:0002048"},{"id":"T2169","span":{"begin":622,"end":631},"obj":"NCBITaxon:2"},{"id":"T80813","span":{"begin":666,"end":679},"obj":"CHEBI:35718;CHEBI:35718"}],"attributes":[{"subj":"T79","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T80","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T81","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T82","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T83","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T84","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T85","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T86","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T87","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T88","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T89","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T48603","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T84469","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T9111","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T12913","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T37746","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T32093","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T90534","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T78753","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T63798","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T2169","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T80813","pred":"source","obj":"LitCovid-PMC-OGER-BB"}]},{"project":"2_test","denotations":[{"id":"32572532-31102782-47963423","span":{"begin":496,"end":498},"obj":"31102782"},{"id":"32572532-27177530-47963424","span":{"begin":730,"end":732},"obj":"27177530"},{"id":"32572532-28387526-47963425","span":{"begin":915,"end":916},"obj":"28387526"},{"id":"32572532-31292663-47963426","span":{"begin":1214,"end":1216},"obj":"31292663"},{"id":"T30112","span":{"begin":496,"end":498},"obj":"31102782"},{"id":"T25822","span":{"begin":730,"end":732},"obj":"27177530"},{"id":"T48506","span":{"begin":915,"end":916},"obj":"28387526"},{"id":"T39271","span":{"begin":1214,"end":1216},"obj":"31292663"}],"attributes":[{"subj":"32572532-31102782-47963423","pred":"source","obj":"2_test"},{"subj":"32572532-27177530-47963424","pred":"source","obj":"2_test"},{"subj":"32572532-28387526-47963425","pred":"source","obj":"2_test"},{"subj":"32572532-31292663-47963426","pred":"source","obj":"2_test"},{"subj":"T30112","pred":"source","obj":"2_test"},{"subj":"T25822","pred":"source","obj":"2_test"},{"subj":"T48506","pred":"source","obj":"2_test"},{"subj":"T39271","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#93d2ec","default":true},{"id":"LitCovid-PD-UBERON","color":"#ecec93"},{"id":"LitCovid-PubTator","color":"#d293ec"},{"id":"LitCovid-PD-MONDO","color":"#93ecb8"},{"id":"LitCovid-PD-CLO","color":"#ec9e93"},{"id":"LitCovid-PD-CHEBI","color":"#93a2ec"},{"id":"LitCovid-PD-GlycoEpitope","color":"#bcec93"},{"id":"LitCovid-PD-HP","color":"#ec93d6"},{"id":"LitCovid-sentences","color":"#93ece8"},{"id":"LitCovid-PMC-OGER-BB","color":"#ecce93"},{"id":"2_test","color":"#b493ec"}]}]}}