PMC:7299399 / 33616-34672
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7299399","sourcedb":"PMC","sourceid":"7299399","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7299399","text":"The fast and complete removal of pro-inflammatory cytokines from the bloodstream has been shown to increase survival significantly in patients with early stage sepsis. Adsorption of cytokines from serum by extracorporeal perfusion through porous carbons is one of the most promising ways for their selective, quick, and complete removal from blood circulation. Hierarchical carbon materials with tuned porosity have shown effective adsorption of many cytokines, including IL-6 and even the largest ones, such as TNF-α.103 Based on their demonstrated outstanding performance in removing sepsis-associated pro-inflammatory cytokines from blood, mesoporous carbon adsorbents with hierarchical structure, tuned pore size, and surface chemistry, as well as graphene with open and accessible surfaces104 have significant potential to quickly remove inflammatory cytokines associated with CRS and to prevent mortality arising from an uncontrolled inflammatory cascade, thereby providing enough time for the defense mechanisms of the human body to fight the virus.","tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T163","span":{"begin":50,"end":59},"obj":"Body_part"},{"id":"T164","span":{"begin":182,"end":191},"obj":"Body_part"},{"id":"T165","span":{"begin":197,"end":202},"obj":"Body_part"},{"id":"T166","span":{"begin":342,"end":347},"obj":"Body_part"},{"id":"T167","span":{"begin":451,"end":460},"obj":"Body_part"},{"id":"T168","span":{"begin":472,"end":474},"obj":"Body_part"},{"id":"T169","span":{"begin":621,"end":630},"obj":"Body_part"},{"id":"T170","span":{"begin":636,"end":641},"obj":"Body_part"},{"id":"T171","span":{"begin":856,"end":865},"obj":"Body_part"},{"id":"T172","span":{"begin":1026,"end":1036},"obj":"Body_part"}],"attributes":[{"id":"A163","pred":"fma_id","subj":"T163","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A164","pred":"fma_id","subj":"T164","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A165","pred":"fma_id","subj":"T165","obj":"http://purl.org/sig/ont/fma/fma63083"},{"id":"A166","pred":"fma_id","subj":"T166","obj":"http://purl.org/sig/ont/fma/fma9670"},{"id":"A167","pred":"fma_id","subj":"T167","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A168","pred":"fma_id","subj":"T168","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A169","pred":"fma_id","subj":"T169","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A170","pred":"fma_id","subj":"T170","obj":"http://purl.org/sig/ont/fma/fma9670"},{"id":"A171","pred":"fma_id","subj":"T171","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A172","pred":"fma_id","subj":"T172","obj":"http://purl.org/sig/ont/fma/fma305853"},{"subj":"T163","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T164","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T165","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T166","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T167","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T168","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T169","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T170","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T171","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T172","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T43","span":{"begin":197,"end":202},"obj":"Body_part"},{"id":"T44","span":{"begin":342,"end":347},"obj":"Body_part"},{"id":"T45","span":{"begin":636,"end":641},"obj":"Body_part"},{"id":"T46","span":{"begin":707,"end":711},"obj":"Body_part"}],"attributes":[{"id":"A43","pred":"uberon_id","subj":"T43","obj":"http://purl.obolibrary.org/obo/UBERON_0001977"},{"id":"A44","pred":"uberon_id","subj":"T44","obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"A45","pred":"uberon_id","subj":"T45","obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"A46","pred":"uberon_id","subj":"T46","obj":"http://purl.obolibrary.org/obo/UBERON_0008915"},{"subj":"T43","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T44","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T45","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T46","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T126","span":{"begin":882,"end":885},"obj":"Disease"}],"attributes":[{"id":"A126","pred":"mondo_id","subj":"T126","obj":"http://purl.obolibrary.org/obo/MONDO_0007399"},{"id":"A127","pred":"mondo_id","subj":"T126","obj":"http://purl.obolibrary.org/obo/MONDO_0017361"},{"subj":"T126","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T307","span":{"begin":81,"end":84},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T308","span":{"begin":342,"end":347},"obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"T309","span":{"begin":342,"end":347},"obj":"http://www.ebi.ac.uk/efo/EFO_0000296"},{"id":"T310","span":{"begin":636,"end":641},"obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"T311","span":{"begin":636,"end":641},"obj":"http://www.ebi.ac.uk/efo/EFO_0000296"},{"id":"T312","span":{"begin":1026,"end":1031},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T313","span":{"begin":1050,"end":1055},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"}],"attributes":[{"subj":"T307","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T308","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T309","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T310","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T311","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T312","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T313","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T240","span":{"begin":374,"end":380},"obj":"Chemical"},{"id":"T242","span":{"begin":472,"end":474},"obj":"Chemical"},{"id":"T244","span":{"begin":654,"end":660},"obj":"Chemical"},{"id":"T246","span":{"begin":752,"end":760},"obj":"Chemical"}],"attributes":[{"id":"A240","pred":"chebi_id","subj":"T240","obj":"http://purl.obolibrary.org/obo/CHEBI_27594"},{"id":"A241","pred":"chebi_id","subj":"T240","obj":"http://purl.obolibrary.org/obo/CHEBI_33415"},{"id":"A242","pred":"chebi_id","subj":"T242","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A243","pred":"chebi_id","subj":"T242","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A244","pred":"chebi_id","subj":"T244","obj":"http://purl.obolibrary.org/obo/CHEBI_27594"},{"id":"A245","pred":"chebi_id","subj":"T244","obj":"http://purl.obolibrary.org/obo/CHEBI_33415"},{"id":"A246","pred":"chebi_id","subj":"T246","obj":"http://purl.obolibrary.org/obo/CHEBI_36973"},{"subj":"T240","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T242","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T244","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T246","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-HP","denotations":[{"id":"T30","span":{"begin":160,"end":166},"obj":"Phenotype"},{"id":"T31","span":{"begin":586,"end":592},"obj":"Phenotype"}],"attributes":[{"id":"A30","pred":"hp_id","subj":"T30","obj":"http://purl.obolibrary.org/obo/HP_0100806"},{"id":"A31","pred":"hp_id","subj":"T31","obj":"http://purl.obolibrary.org/obo/HP_0100806"},{"subj":"T30","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T31","pred":"source","obj":"LitCovid-PD-HP"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T54","span":{"begin":342,"end":359},"obj":"http://purl.obolibrary.org/obo/GO_0008015"}],"attributes":[{"subj":"T54","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T130","span":{"begin":0,"end":167},"obj":"Sentence"},{"id":"T131","span":{"begin":168,"end":360},"obj":"Sentence"},{"id":"T132","span":{"begin":361,"end":1056},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T130","pred":"source","obj":"LitCovid-sentences"},{"subj":"T131","pred":"source","obj":"LitCovid-sentences"},{"subj":"T132","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"554","span":{"begin":472,"end":476},"obj":"Gene"},{"id":"555","span":{"begin":512,"end":517},"obj":"Gene"},{"id":"556","span":{"begin":134,"end":142},"obj":"Species"},{"id":"557","span":{"begin":1026,"end":1031},"obj":"Species"},{"id":"558","span":{"begin":246,"end":253},"obj":"Chemical"},{"id":"559","span":{"begin":374,"end":380},"obj":"Chemical"},{"id":"560","span":{"begin":643,"end":660},"obj":"Chemical"},{"id":"561","span":{"begin":752,"end":760},"obj":"Chemical"},{"id":"562","span":{"begin":160,"end":166},"obj":"Disease"},{"id":"563","span":{"begin":586,"end":592},"obj":"Disease"},{"id":"564","span":{"begin":882,"end":885},"obj":"Disease"},{"id":"565","span":{"begin":901,"end":910},"obj":"Disease"}],"attributes":[{"id":"A554","pred":"tao:has_database_id","subj":"554","obj":"Gene:3569"},{"id":"A555","pred":"tao:has_database_id","subj":"555","obj":"Gene:7124"},{"id":"A556","pred":"tao:has_database_id","subj":"556","obj":"Tax:9606"},{"id":"A557","pred":"tao:has_database_id","subj":"557","obj":"Tax:9606"},{"id":"A558","pred":"tao:has_database_id","subj":"558","obj":"MESH:D002244"},{"id":"A559","pred":"tao:has_database_id","subj":"559","obj":"MESH:D002244"},{"id":"A561","pred":"tao:has_database_id","subj":"561","obj":"MESH:D006108"},{"id":"A562","pred":"tao:has_database_id","subj":"562","obj":"MESH:D018805"},{"id":"A563","pred":"tao:has_database_id","subj":"563","obj":"MESH:D018805"},{"id":"A564","pred":"tao:has_database_id","subj":"564","obj":"MESH:D003398"},{"id":"A565","pred":"tao:has_database_id","subj":"565","obj":"MESH:D003643"},{"subj":"554","pred":"source","obj":"LitCovid-PubTator"},{"subj":"555","pred":"source","obj":"LitCovid-PubTator"},{"subj":"556","pred":"source","obj":"LitCovid-PubTator"},{"subj":"557","pred":"source","obj":"LitCovid-PubTator"},{"subj":"558","pred":"source","obj":"LitCovid-PubTator"},{"subj":"559","pred":"source","obj":"LitCovid-PubTator"},{"subj":"560","pred":"source","obj":"LitCovid-PubTator"},{"subj":"561","pred":"source","obj":"LitCovid-PubTator"},{"subj":"562","pred":"source","obj":"LitCovid-PubTator"},{"subj":"563","pred":"source","obj":"LitCovid-PubTator"},{"subj":"564","pred":"source","obj":"LitCovid-PubTator"},{"subj":"565","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#93eca3","default":true},{"id":"LitCovid-PD-UBERON","color":"#ec939c"},{"id":"LitCovid-PD-MONDO","color":"#93b6ec"},{"id":"LitCovid-PD-CLO","color":"#d0ec93"},{"id":"LitCovid-PD-CHEBI","color":"#ec93ea"},{"id":"LitCovid-PD-HP","color":"#93ecd4"},{"id":"LitCovid-PD-GO-BP","color":"#ecba93"},{"id":"LitCovid-sentences","color":"#a093ec"},{"id":"LitCovid-PubTator","color":"#a0ec93"}]}]}}