PMC:7299399 / 33616-34672 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T163","span":{"begin":50,"end":59},"obj":"Body_part"},{"id":"T164","span":{"begin":182,"end":191},"obj":"Body_part"},{"id":"T165","span":{"begin":197,"end":202},"obj":"Body_part"},{"id":"T166","span":{"begin":342,"end":347},"obj":"Body_part"},{"id":"T167","span":{"begin":451,"end":460},"obj":"Body_part"},{"id":"T168","span":{"begin":472,"end":474},"obj":"Body_part"},{"id":"T169","span":{"begin":621,"end":630},"obj":"Body_part"},{"id":"T170","span":{"begin":636,"end":641},"obj":"Body_part"},{"id":"T171","span":{"begin":856,"end":865},"obj":"Body_part"},{"id":"T172","span":{"begin":1026,"end":1036},"obj":"Body_part"}],"attributes":[{"id":"A163","pred":"fma_id","subj":"T163","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A164","pred":"fma_id","subj":"T164","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A165","pred":"fma_id","subj":"T165","obj":"http://purl.org/sig/ont/fma/fma63083"},{"id":"A166","pred":"fma_id","subj":"T166","obj":"http://purl.org/sig/ont/fma/fma9670"},{"id":"A167","pred":"fma_id","subj":"T167","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A168","pred":"fma_id","subj":"T168","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A169","pred":"fma_id","subj":"T169","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A170","pred":"fma_id","subj":"T170","obj":"http://purl.org/sig/ont/fma/fma9670"},{"id":"A171","pred":"fma_id","subj":"T171","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A172","pred":"fma_id","subj":"T172","obj":"http://purl.org/sig/ont/fma/fma305853"}],"text":"The fast and complete removal of pro-inflammatory cytokines from the bloodstream has been shown to increase survival significantly in patients with early stage sepsis. Adsorption of cytokines from serum by extracorporeal perfusion through porous carbons is one of the most promising ways for their selective, quick, and complete removal from blood circulation. Hierarchical carbon materials with tuned porosity have shown effective adsorption of many cytokines, including IL-6 and even the largest ones, such as TNF-α.103 Based on their demonstrated outstanding performance in removing sepsis-associated pro-inflammatory cytokines from blood, mesoporous carbon adsorbents with hierarchical structure, tuned pore size, and surface chemistry, as well as graphene with open and accessible surfaces104 have significant potential to quickly remove inflammatory cytokines associated with CRS and to prevent mortality arising from an uncontrolled inflammatory cascade, thereby providing enough time for the defense mechanisms of the human body to fight the virus."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T43","span":{"begin":197,"end":202},"obj":"Body_part"},{"id":"T44","span":{"begin":342,"end":347},"obj":"Body_part"},{"id":"T45","span":{"begin":636,"end":641},"obj":"Body_part"},{"id":"T46","span":{"begin":707,"end":711},"obj":"Body_part"}],"attributes":[{"id":"A43","pred":"uberon_id","subj":"T43","obj":"http://purl.obolibrary.org/obo/UBERON_0001977"},{"id":"A44","pred":"uberon_id","subj":"T44","obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"A45","pred":"uberon_id","subj":"T45","obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"A46","pred":"uberon_id","subj":"T46","obj":"http://purl.obolibrary.org/obo/UBERON_0008915"}],"text":"The fast and complete removal of pro-inflammatory cytokines from the bloodstream has been shown to increase survival significantly in patients with early stage sepsis. Adsorption of cytokines from serum by extracorporeal perfusion through porous carbons is one of the most promising ways for their selective, quick, and complete removal from blood circulation. Hierarchical carbon materials with tuned porosity have shown effective adsorption of many cytokines, including IL-6 and even the largest ones, such as TNF-α.103 Based on their demonstrated outstanding performance in removing sepsis-associated pro-inflammatory cytokines from blood, mesoporous carbon adsorbents with hierarchical structure, tuned pore size, and surface chemistry, as well as graphene with open and accessible surfaces104 have significant potential to quickly remove inflammatory cytokines associated with CRS and to prevent mortality arising from an uncontrolled inflammatory cascade, thereby providing enough time for the defense mechanisms of the human body to fight the virus."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T126","span":{"begin":882,"end":885},"obj":"Disease"}],"attributes":[{"id":"A126","pred":"mondo_id","subj":"T126","obj":"http://purl.obolibrary.org/obo/MONDO_0007399"},{"id":"A127","pred":"mondo_id","subj":"T126","obj":"http://purl.obolibrary.org/obo/MONDO_0017361"}],"text":"The fast and complete removal of pro-inflammatory cytokines from the bloodstream has been shown to increase survival significantly in patients with early stage sepsis. Adsorption of cytokines from serum by extracorporeal perfusion through porous carbons is one of the most promising ways for their selective, quick, and complete removal from blood circulation. Hierarchical carbon materials with tuned porosity have shown effective adsorption of many cytokines, including IL-6 and even the largest ones, such as TNF-α.103 Based on their demonstrated outstanding performance in removing sepsis-associated pro-inflammatory cytokines from blood, mesoporous carbon adsorbents with hierarchical structure, tuned pore size, and surface chemistry, as well as graphene with open and accessible surfaces104 have significant potential to quickly remove inflammatory cytokines associated with CRS and to prevent mortality arising from an uncontrolled inflammatory cascade, thereby providing enough time for the defense mechanisms of the human body to fight the virus."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T307","span":{"begin":81,"end":84},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T308","span":{"begin":342,"end":347},"obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"T309","span":{"begin":342,"end":347},"obj":"http://www.ebi.ac.uk/efo/EFO_0000296"},{"id":"T310","span":{"begin":636,"end":641},"obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"T311","span":{"begin":636,"end":641},"obj":"http://www.ebi.ac.uk/efo/EFO_0000296"},{"id":"T312","span":{"begin":1026,"end":1031},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T313","span":{"begin":1050,"end":1055},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"}],"text":"The fast and complete removal of pro-inflammatory cytokines from the bloodstream has been shown to increase survival significantly in patients with early stage sepsis. Adsorption of cytokines from serum by extracorporeal perfusion through porous carbons is one of the most promising ways for their selective, quick, and complete removal from blood circulation. Hierarchical carbon materials with tuned porosity have shown effective adsorption of many cytokines, including IL-6 and even the largest ones, such as TNF-α.103 Based on their demonstrated outstanding performance in removing sepsis-associated pro-inflammatory cytokines from blood, mesoporous carbon adsorbents with hierarchical structure, tuned pore size, and surface chemistry, as well as graphene with open and accessible surfaces104 have significant potential to quickly remove inflammatory cytokines associated with CRS and to prevent mortality arising from an uncontrolled inflammatory cascade, thereby providing enough time for the defense mechanisms of the human body to fight the virus."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T240","span":{"begin":374,"end":380},"obj":"Chemical"},{"id":"T242","span":{"begin":472,"end":474},"obj":"Chemical"},{"id":"T244","span":{"begin":654,"end":660},"obj":"Chemical"},{"id":"T246","span":{"begin":752,"end":760},"obj":"Chemical"}],"attributes":[{"id":"A240","pred":"chebi_id","subj":"T240","obj":"http://purl.obolibrary.org/obo/CHEBI_27594"},{"id":"A241","pred":"chebi_id","subj":"T240","obj":"http://purl.obolibrary.org/obo/CHEBI_33415"},{"id":"A242","pred":"chebi_id","subj":"T242","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A243","pred":"chebi_id","subj":"T242","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A244","pred":"chebi_id","subj":"T244","obj":"http://purl.obolibrary.org/obo/CHEBI_27594"},{"id":"A245","pred":"chebi_id","subj":"T244","obj":"http://purl.obolibrary.org/obo/CHEBI_33415"},{"id":"A246","pred":"chebi_id","subj":"T246","obj":"http://purl.obolibrary.org/obo/CHEBI_36973"}],"text":"The fast and complete removal of pro-inflammatory cytokines from the bloodstream has been shown to increase survival significantly in patients with early stage sepsis. Adsorption of cytokines from serum by extracorporeal perfusion through porous carbons is one of the most promising ways for their selective, quick, and complete removal from blood circulation. Hierarchical carbon materials with tuned porosity have shown effective adsorption of many cytokines, including IL-6 and even the largest ones, such as TNF-α.103 Based on their demonstrated outstanding performance in removing sepsis-associated pro-inflammatory cytokines from blood, mesoporous carbon adsorbents with hierarchical structure, tuned pore size, and surface chemistry, as well as graphene with open and accessible surfaces104 have significant potential to quickly remove inflammatory cytokines associated with CRS and to prevent mortality arising from an uncontrolled inflammatory cascade, thereby providing enough time for the defense mechanisms of the human body to fight the virus."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T30","span":{"begin":160,"end":166},"obj":"Phenotype"},{"id":"T31","span":{"begin":586,"end":592},"obj":"Phenotype"}],"attributes":[{"id":"A30","pred":"hp_id","subj":"T30","obj":"http://purl.obolibrary.org/obo/HP_0100806"},{"id":"A31","pred":"hp_id","subj":"T31","obj":"http://purl.obolibrary.org/obo/HP_0100806"}],"text":"The fast and complete removal of pro-inflammatory cytokines from the bloodstream has been shown to increase survival significantly in patients with early stage sepsis. Adsorption of cytokines from serum by extracorporeal perfusion through porous carbons is one of the most promising ways for their selective, quick, and complete removal from blood circulation. Hierarchical carbon materials with tuned porosity have shown effective adsorption of many cytokines, including IL-6 and even the largest ones, such as TNF-α.103 Based on their demonstrated outstanding performance in removing sepsis-associated pro-inflammatory cytokines from blood, mesoporous carbon adsorbents with hierarchical structure, tuned pore size, and surface chemistry, as well as graphene with open and accessible surfaces104 have significant potential to quickly remove inflammatory cytokines associated with CRS and to prevent mortality arising from an uncontrolled inflammatory cascade, thereby providing enough time for the defense mechanisms of the human body to fight the virus."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T54","span":{"begin":342,"end":359},"obj":"http://purl.obolibrary.org/obo/GO_0008015"}],"text":"The fast and complete removal of pro-inflammatory cytokines from the bloodstream has been shown to increase survival significantly in patients with early stage sepsis. Adsorption of cytokines from serum by extracorporeal perfusion through porous carbons is one of the most promising ways for their selective, quick, and complete removal from blood circulation. Hierarchical carbon materials with tuned porosity have shown effective adsorption of many cytokines, including IL-6 and even the largest ones, such as TNF-α.103 Based on their demonstrated outstanding performance in removing sepsis-associated pro-inflammatory cytokines from blood, mesoporous carbon adsorbents with hierarchical structure, tuned pore size, and surface chemistry, as well as graphene with open and accessible surfaces104 have significant potential to quickly remove inflammatory cytokines associated with CRS and to prevent mortality arising from an uncontrolled inflammatory cascade, thereby providing enough time for the defense mechanisms of the human body to fight the virus."}

{"project":"LitCovid-sentences","denotations":[{"id":"T130","span":{"begin":0,"end":167},"obj":"Sentence"},{"id":"T131","span":{"begin":168,"end":360},"obj":"Sentence"},{"id":"T132","span":{"begin":361,"end":1056},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"The fast and complete removal of pro-inflammatory cytokines from the bloodstream has been shown to increase survival significantly in patients with early stage sepsis. Adsorption of cytokines from serum by extracorporeal perfusion through porous carbons is one of the most promising ways for their selective, quick, and complete removal from blood circulation. Hierarchical carbon materials with tuned porosity have shown effective adsorption of many cytokines, including IL-6 and even the largest ones, such as TNF-α.103 Based on their demonstrated outstanding performance in removing sepsis-associated pro-inflammatory cytokines from blood, mesoporous carbon adsorbents with hierarchical structure, tuned pore size, and surface chemistry, as well as graphene with open and accessible surfaces104 have significant potential to quickly remove inflammatory cytokines associated with CRS and to prevent mortality arising from an uncontrolled inflammatory cascade, thereby providing enough time for the defense mechanisms of the human body to fight the virus."}

{"project":"LitCovid-PubTator","denotations":[{"id":"554","span":{"begin":472,"end":476},"obj":"Gene"},{"id":"555","span":{"begin":512,"end":517},"obj":"Gene"},{"id":"556","span":{"begin":134,"end":142},"obj":"Species"},{"id":"557","span":{"begin":1026,"end":1031},"obj":"Species"},{"id":"558","span":{"begin":246,"end":253},"obj":"Chemical"},{"id":"559","span":{"begin":374,"end":380},"obj":"Chemical"},{"id":"560","span":{"begin":643,"end":660},"obj":"Chemical"},{"id":"561","span":{"begin":752,"end":760},"obj":"Chemical"},{"id":"562","span":{"begin":160,"end":166},"obj":"Disease"},{"id":"563","span":{"begin":586,"end":592},"obj":"Disease"},{"id":"564","span":{"begin":882,"end":885},"obj":"Disease"},{"id":"565","span":{"begin":901,"end":910},"obj":"Disease"}],"attributes":[{"id":"A554","pred":"tao:has_database_id","subj":"554","obj":"Gene:3569"},{"id":"A555","pred":"tao:has_database_id","subj":"555","obj":"Gene:7124"},{"id":"A556","pred":"tao:has_database_id","subj":"556","obj":"Tax:9606"},{"id":"A557","pred":"tao:has_database_id","subj":"557","obj":"Tax:9606"},{"id":"A558","pred":"tao:has_database_id","subj":"558","obj":"MESH:D002244"},{"id":"A559","pred":"tao:has_database_id","subj":"559","obj":"MESH:D002244"},{"id":"A561","pred":"tao:has_database_id","subj":"561","obj":"MESH:D006108"},{"id":"A562","pred":"tao:has_database_id","subj":"562","obj":"MESH:D018805"},{"id":"A563","pred":"tao:has_database_id","subj":"563","obj":"MESH:D018805"},{"id":"A564","pred":"tao:has_database_id","subj":"564","obj":"MESH:D003398"},{"id":"A565","pred":"tao:has_database_id","subj":"565","obj":"MESH:D003643"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"The fast and complete removal of pro-inflammatory cytokines from the bloodstream has been shown to increase survival significantly in patients with early stage sepsis. Adsorption of cytokines from serum by extracorporeal perfusion through porous carbons is one of the most promising ways for their selective, quick, and complete removal from blood circulation. Hierarchical carbon materials with tuned porosity have shown effective adsorption of many cytokines, including IL-6 and even the largest ones, such as TNF-α.103 Based on their demonstrated outstanding performance in removing sepsis-associated pro-inflammatory cytokines from blood, mesoporous carbon adsorbents with hierarchical structure, tuned pore size, and surface chemistry, as well as graphene with open and accessible surfaces104 have significant potential to quickly remove inflammatory cytokines associated with CRS and to prevent mortality arising from an uncontrolled inflammatory cascade, thereby providing enough time for the defense mechanisms of the human body to fight the virus."}