PMC:7291971 / 40471-41123 JSONTXT

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T835","span":{"begin":45,"end":54},"obj":"CHEBI:36357;CHEBI:36357"},{"id":"T836","span":{"begin":146,"end":151},"obj":"CHEBI:15377;CHEBI:15377"},{"id":"T837","span":{"begin":236,"end":240},"obj":"CHEBI:32145;CHEBI:32145"},{"id":"T838","span":{"begin":243,"end":251},"obj":"CHEBI:46787;CHEBI:46787"},{"id":"T839","span":{"begin":319,"end":322},"obj":"CHEBI:62946;CHEBI:62946"},{"id":"T840","span":{"begin":326,"end":330},"obj":"CHEBI:32145;CHEBI:32145"},{"id":"T841","span":{"begin":408,"end":414},"obj":"CHEBI:30563;CHEBI:30563"},{"id":"T842","span":{"begin":469,"end":481},"obj":"CHEBI:38472;CHEBI:38472"},{"id":"T843","span":{"begin":545,"end":553},"obj":"CHEBI:36357;CHEBI:36357"},{"id":"T844","span":{"begin":601,"end":606},"obj":"CHEBI:15377;CHEBI:15377"},{"id":"T845","span":{"begin":607,"end":614},"obj":"CHEBI:46923;CHEBI:46923"},{"id":"T846","span":{"begin":631,"end":639},"obj":"CHEBI:36357;CHEBI:36357"},{"id":"T98523","span":{"begin":45,"end":54},"obj":"CHEBI:36357;CHEBI:36357"},{"id":"T86450","span":{"begin":146,"end":151},"obj":"CHEBI:15377;CHEBI:15377"},{"id":"T52872","span":{"begin":236,"end":240},"obj":"CHEBI:32145;CHEBI:32145"},{"id":"T28770","span":{"begin":243,"end":251},"obj":"CHEBI:46787;CHEBI:46787"},{"id":"T10210","span":{"begin":319,"end":322},"obj":"CHEBI:62946;CHEBI:62946"},{"id":"T88591","span":{"begin":326,"end":330},"obj":"CHEBI:32145;CHEBI:32145"},{"id":"T84694","span":{"begin":408,"end":414},"obj":"CHEBI:30563;CHEBI:30563"},{"id":"T97793","span":{"begin":469,"end":481},"obj":"CHEBI:38472;CHEBI:38472"},{"id":"T99254","span":{"begin":545,"end":553},"obj":"CHEBI:36357;CHEBI:36357"},{"id":"T33833","span":{"begin":601,"end":606},"obj":"CHEBI:15377;CHEBI:15377"},{"id":"T70218","span":{"begin":607,"end":614},"obj":"CHEBI:46923;CHEBI:46923"},{"id":"T61315","span":{"begin":631,"end":639},"obj":"CHEBI:36357;CHEBI:36357"}],"text":"4.1.7 General method C for the synthesis of compounds 1, 3, 5–7, 9, 10-16\nThe synthesis intermediate was treated at room temperature with TFA in water (8/2, conc. 0.14 M). After stirring for 3–6 h until completion of reaction (TLC DCM/MeOH), solvents were removed and the residue was coevaporated three times with 7 M NH3 in MeOH. The residue was purified by flash column chromatography on a reversed-phase silica gel column C18 (4 g, 40 μm) with a linear gradient of acetonitrile in TEAAc buffer 50 mM, pH 7. The fractions containing the pure compound were pooled, concentrated and lyophilized with water/dioxane to give desired compound as a powder."}

{"project":"LitCovid-PubTator","denotations":[{"id":"703","span":{"begin":139,"end":142},"obj":"Chemical"},{"id":"704","span":{"begin":146,"end":151},"obj":"Chemical"},{"id":"705","span":{"begin":236,"end":240},"obj":"Chemical"},{"id":"706","span":{"begin":319,"end":322},"obj":"Chemical"},{"id":"707","span":{"begin":326,"end":330},"obj":"Chemical"},{"id":"708","span":{"begin":408,"end":418},"obj":"Chemical"},{"id":"709","span":{"begin":469,"end":481},"obj":"Chemical"},{"id":"710","span":{"begin":485,"end":490},"obj":"Chemical"},{"id":"711","span":{"begin":601,"end":606},"obj":"Chemical"},{"id":"712","span":{"begin":607,"end":614},"obj":"Chemical"},{"id":"713","span":{"begin":228,"end":235},"obj":"Disease"}],"attributes":[{"id":"A703","pred":"tao:has_database_id","subj":"703","obj":"MESH:D014269"},{"id":"A704","pred":"tao:has_database_id","subj":"704","obj":"MESH:D014867"},{"id":"A708","pred":"tao:has_database_id","subj":"708","obj":"MESH:D058428"},{"id":"A709","pred":"tao:has_database_id","subj":"709","obj":"MESH:C032159"},{"id":"A711","pred":"tao:has_database_id","subj":"711","obj":"MESH:D014867"},{"id":"A712","pred":"tao:has_database_id","subj":"712","obj":"MESH:C025223"},{"id":"A713","pred":"tao:has_database_id","subj":"713","obj":"MESH:D002311"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"4.1.7 General method C for the synthesis of compounds 1, 3, 5–7, 9, 10-16\nThe synthesis intermediate was treated at room temperature with TFA in water (8/2, conc. 0.14 M). After stirring for 3–6 h until completion of reaction (TLC DCM/MeOH), solvents were removed and the residue was coevaporated three times with 7 M NH3 in MeOH. The residue was purified by flash column chromatography on a reversed-phase silica gel column C18 (4 g, 40 μm) with a linear gradient of acetonitrile in TEAAc buffer 50 mM, pH 7. The fractions containing the pure compound were pooled, concentrated and lyophilized with water/dioxane to give desired compound as a powder."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T292","span":{"begin":58,"end":62},"obj":"http://purl.obolibrary.org/obo/CLO_0001000"},{"id":"T293","span":{"begin":192,"end":195},"obj":"http://purl.obolibrary.org/obo/CLO_0001313"},{"id":"T294","span":{"begin":391,"end":392},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T295","span":{"begin":448,"end":449},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T296","span":{"begin":643,"end":644},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"4.1.7 General method C for the synthesis of compounds 1, 3, 5–7, 9, 10-16\nThe synthesis intermediate was treated at room temperature with TFA in water (8/2, conc. 0.14 M). After stirring for 3–6 h until completion of reaction (TLC DCM/MeOH), solvents were removed and the residue was coevaporated three times with 7 M NH3 in MeOH. The residue was purified by flash column chromatography on a reversed-phase silica gel column C18 (4 g, 40 μm) with a linear gradient of acetonitrile in TEAAc buffer 50 mM, pH 7. The fractions containing the pure compound were pooled, concentrated and lyophilized with water/dioxane to give desired compound as a powder."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T704","span":{"begin":139,"end":142},"obj":"Chemical"},{"id":"T705","span":{"begin":146,"end":151},"obj":"Chemical"},{"id":"T706","span":{"begin":232,"end":235},"obj":"Chemical"},{"id":"T707","span":{"begin":236,"end":240},"obj":"Chemical"},{"id":"T708","span":{"begin":243,"end":251},"obj":"Chemical"},{"id":"T709","span":{"begin":319,"end":322},"obj":"Chemical"},{"id":"T710","span":{"begin":326,"end":330},"obj":"Chemical"},{"id":"T711","span":{"begin":408,"end":414},"obj":"Chemical"},{"id":"T712","span":{"begin":469,"end":481},"obj":"Chemical"},{"id":"T713","span":{"begin":491,"end":497},"obj":"Chemical"},{"id":"T714","span":{"begin":601,"end":606},"obj":"Chemical"},{"id":"T715","span":{"begin":607,"end":614},"obj":"Chemical"}],"attributes":[{"id":"A704","pred":"chebi_id","subj":"T704","obj":"http://purl.obolibrary.org/obo/CHEBI_45892"},{"id":"A705","pred":"chebi_id","subj":"T705","obj":"http://purl.obolibrary.org/obo/CHEBI_15377"},{"id":"A706","pred":"chebi_id","subj":"T706","obj":"http://purl.obolibrary.org/obo/CHEBI_15767"},{"id":"A707","pred":"chebi_id","subj":"T707","obj":"http://purl.obolibrary.org/obo/CHEBI_17790"},{"id":"A708","pred":"chebi_id","subj":"T708","obj":"http://purl.obolibrary.org/obo/CHEBI_46787"},{"id":"A709","pred":"chebi_id","subj":"T709","obj":"http://purl.obolibrary.org/obo/CHEBI_16134"},{"id":"A710","pred":"chebi_id","subj":"T710","obj":"http://purl.obolibrary.org/obo/CHEBI_17790"},{"id":"A711","pred":"chebi_id","subj":"T711","obj":"http://purl.obolibrary.org/obo/CHEBI_30563"},{"id":"A712","pred":"chebi_id","subj":"T712","obj":"http://purl.obolibrary.org/obo/CHEBI_38472"},{"id":"A713","pred":"chebi_id","subj":"T713","obj":"http://purl.obolibrary.org/obo/CHEBI_35225"},{"id":"A714","pred":"chebi_id","subj":"T714","obj":"http://purl.obolibrary.org/obo/CHEBI_15377"},{"id":"A715","pred":"chebi_id","subj":"T715","obj":"http://purl.obolibrary.org/obo/CHEBI_46923"}],"text":"4.1.7 General method C for the synthesis of compounds 1, 3, 5–7, 9, 10-16\nThe synthesis intermediate was treated at room temperature with TFA in water (8/2, conc. 0.14 M). After stirring for 3–6 h until completion of reaction (TLC DCM/MeOH), solvents were removed and the residue was coevaporated three times with 7 M NH3 in MeOH. The residue was purified by flash column chromatography on a reversed-phase silica gel column C18 (4 g, 40 μm) with a linear gradient of acetonitrile in TEAAc buffer 50 mM, pH 7. The fractions containing the pure compound were pooled, concentrated and lyophilized with water/dioxane to give desired compound as a powder."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T11","span":{"begin":232,"end":235},"obj":"Phenotype"}],"attributes":[{"id":"A11","pred":"hp_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/HP_0001644"}],"text":"4.1.7 General method C for the synthesis of compounds 1, 3, 5–7, 9, 10-16\nThe synthesis intermediate was treated at room temperature with TFA in water (8/2, conc. 0.14 M). After stirring for 3–6 h until completion of reaction (TLC DCM/MeOH), solvents were removed and the residue was coevaporated three times with 7 M NH3 in MeOH. The residue was purified by flash column chromatography on a reversed-phase silica gel column C18 (4 g, 40 μm) with a linear gradient of acetonitrile in TEAAc buffer 50 mM, pH 7. The fractions containing the pure compound were pooled, concentrated and lyophilized with water/dioxane to give desired compound as a powder."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T48","span":{"begin":32,"end":41},"obj":"http://purl.obolibrary.org/obo/GO_0009058"},{"id":"T49","span":{"begin":79,"end":88},"obj":"http://purl.obolibrary.org/obo/GO_0009058"}],"text":"4.1.7 General method C for the synthesis of compounds 1, 3, 5–7, 9, 10-16\nThe synthesis intermediate was treated at room temperature with TFA in water (8/2, conc. 0.14 M). After stirring for 3–6 h until completion of reaction (TLC DCM/MeOH), solvents were removed and the residue was coevaporated three times with 7 M NH3 in MeOH. The residue was purified by flash column chromatography on a reversed-phase silica gel column C18 (4 g, 40 μm) with a linear gradient of acetonitrile in TEAAc buffer 50 mM, pH 7. The fractions containing the pure compound were pooled, concentrated and lyophilized with water/dioxane to give desired compound as a powder."}

{"project":"LitCovid-sentences","denotations":[{"id":"T298","span":{"begin":0,"end":74},"obj":"Sentence"},{"id":"T299","span":{"begin":75,"end":163},"obj":"Sentence"},{"id":"T300","span":{"begin":164,"end":172},"obj":"Sentence"},{"id":"T301","span":{"begin":173,"end":331},"obj":"Sentence"},{"id":"T302","span":{"begin":332,"end":510},"obj":"Sentence"},{"id":"T303","span":{"begin":511,"end":652},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"4.1.7 General method C for the synthesis of compounds 1, 3, 5–7, 9, 10-16\nThe synthesis intermediate was treated at room temperature with TFA in water (8/2, conc. 0.14 M). After stirring for 3–6 h until completion of reaction (TLC DCM/MeOH), solvents were removed and the residue was coevaporated three times with 7 M NH3 in MeOH. The residue was purified by flash column chromatography on a reversed-phase silica gel column C18 (4 g, 40 μm) with a linear gradient of acetonitrile in TEAAc buffer 50 mM, pH 7. The fractions containing the pure compound were pooled, concentrated and lyophilized with water/dioxane to give desired compound as a powder."}