PMC:7291971 / 40471-41123
Annnotations
LitCovid-PMC-OGER-BB
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T835 | 45-54 | CHEBI:36357;CHEBI:36357 | denotes | compounds |
T836 | 146-151 | CHEBI:15377;CHEBI:15377 | denotes | water |
T837 | 236-240 | CHEBI:32145;CHEBI:32145 | denotes | MeOH |
T838 | 243-251 | CHEBI:46787;CHEBI:46787 | denotes | solvents |
T839 | 319-322 | CHEBI:62946;CHEBI:62946 | denotes | NH3 |
T840 | 326-330 | CHEBI:32145;CHEBI:32145 | denotes | MeOH |
T841 | 408-414 | CHEBI:30563;CHEBI:30563 | denotes | silica |
T842 | 469-481 | CHEBI:38472;CHEBI:38472 | denotes | acetonitrile |
T843 | 545-553 | CHEBI:36357;CHEBI:36357 | denotes | compound |
T844 | 601-606 | CHEBI:15377;CHEBI:15377 | denotes | water |
T845 | 607-614 | CHEBI:46923;CHEBI:46923 | denotes | dioxane |
T846 | 631-639 | CHEBI:36357;CHEBI:36357 | denotes | compound |
T98523 | 45-54 | CHEBI:36357;CHEBI:36357 | denotes | compounds |
T86450 | 146-151 | CHEBI:15377;CHEBI:15377 | denotes | water |
T52872 | 236-240 | CHEBI:32145;CHEBI:32145 | denotes | MeOH |
T28770 | 243-251 | CHEBI:46787;CHEBI:46787 | denotes | solvents |
T10210 | 319-322 | CHEBI:62946;CHEBI:62946 | denotes | NH3 |
T88591 | 326-330 | CHEBI:32145;CHEBI:32145 | denotes | MeOH |
T84694 | 408-414 | CHEBI:30563;CHEBI:30563 | denotes | silica |
T97793 | 469-481 | CHEBI:38472;CHEBI:38472 | denotes | acetonitrile |
T99254 | 545-553 | CHEBI:36357;CHEBI:36357 | denotes | compound |
T33833 | 601-606 | CHEBI:15377;CHEBI:15377 | denotes | water |
T70218 | 607-614 | CHEBI:46923;CHEBI:46923 | denotes | dioxane |
T61315 | 631-639 | CHEBI:36357;CHEBI:36357 | denotes | compound |
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
703 | 139-142 | Chemical | denotes | TFA | MESH:D014269 |
704 | 146-151 | Chemical | denotes | water | MESH:D014867 |
705 | 236-240 | Chemical | denotes | MeOH | |
706 | 319-322 | Chemical | denotes | NH3 | |
707 | 326-330 | Chemical | denotes | MeOH | |
708 | 408-418 | Chemical | denotes | silica gel | MESH:D058428 |
709 | 469-481 | Chemical | denotes | acetonitrile | MESH:C032159 |
710 | 485-490 | Chemical | denotes | TEAAc | |
711 | 601-606 | Chemical | denotes | water | MESH:D014867 |
712 | 607-614 | Chemical | denotes | dioxane | MESH:C025223 |
713 | 228-235 | Disease | denotes | TLC DCM | MESH:D002311 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T292 | 58-62 | http://purl.obolibrary.org/obo/CLO_0001000 | denotes | 3, 5 |
T293 | 192-195 | http://purl.obolibrary.org/obo/CLO_0001313 | denotes | 3–6 |
T294 | 391-392 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T295 | 448-449 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T296 | 643-644 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T704 | 139-142 | Chemical | denotes | TFA | http://purl.obolibrary.org/obo/CHEBI_45892 |
T705 | 146-151 | Chemical | denotes | water | http://purl.obolibrary.org/obo/CHEBI_15377 |
T706 | 232-235 | Chemical | denotes | DCM | http://purl.obolibrary.org/obo/CHEBI_15767 |
T707 | 236-240 | Chemical | denotes | MeOH | http://purl.obolibrary.org/obo/CHEBI_17790 |
T708 | 243-251 | Chemical | denotes | solvents | http://purl.obolibrary.org/obo/CHEBI_46787 |
T709 | 319-322 | Chemical | denotes | NH3 | http://purl.obolibrary.org/obo/CHEBI_16134 |
T710 | 326-330 | Chemical | denotes | MeOH | http://purl.obolibrary.org/obo/CHEBI_17790 |
T711 | 408-414 | Chemical | denotes | silica | http://purl.obolibrary.org/obo/CHEBI_30563 |
T712 | 469-481 | Chemical | denotes | acetonitrile | http://purl.obolibrary.org/obo/CHEBI_38472 |
T713 | 491-497 | Chemical | denotes | buffer | http://purl.obolibrary.org/obo/CHEBI_35225 |
T714 | 601-606 | Chemical | denotes | water | http://purl.obolibrary.org/obo/CHEBI_15377 |
T715 | 607-614 | Chemical | denotes | dioxane | http://purl.obolibrary.org/obo/CHEBI_46923 |
LitCovid-PD-HP
Id | Subject | Object | Predicate | Lexical cue | hp_id |
---|---|---|---|---|---|
T11 | 232-235 | Phenotype | denotes | DCM | http://purl.obolibrary.org/obo/HP_0001644 |
LitCovid-PD-GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T48 | 32-41 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | synthesis |
T49 | 79-88 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | synthesis |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T298 | 0-74 | Sentence | denotes | 4.1.7 General method C for the synthesis of compounds 1, 3, 5–7, 9, 10-16 |
T299 | 75-163 | Sentence | denotes | The synthesis intermediate was treated at room temperature with TFA in water (8/2, conc. |
T300 | 164-172 | Sentence | denotes | 0.14 M). |
T301 | 173-331 | Sentence | denotes | After stirring for 3–6 h until completion of reaction (TLC DCM/MeOH), solvents were removed and the residue was coevaporated three times with 7 M NH3 in MeOH. |
T302 | 332-510 | Sentence | denotes | The residue was purified by flash column chromatography on a reversed-phase silica gel column C18 (4 g, 40 μm) with a linear gradient of acetonitrile in TEAAc buffer 50 mM, pH 7. |
T303 | 511-652 | Sentence | denotes | The fractions containing the pure compound were pooled, concentrated and lyophilized with water/dioxane to give desired compound as a powder. |