PMC:7291971 / 19399-20188 JSONTXT

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T426","span":{"begin":4,"end":9},"obj":"SP_6;NCBITaxon:9606"},{"id":"T427","span":{"begin":24,"end":29},"obj":"PR:O43148"},{"id":"T428","span":{"begin":84,"end":88},"obj":"CHEBI:51231;CHEBI:51231"},{"id":"T443","span":{"begin":162,"end":171},"obj":"CHEBI:36357;CHEBI:36357"},{"id":"T444","span":{"begin":218,"end":230},"obj":"NCBITaxon:31032"},{"id":"T445","span":{"begin":234,"end":245},"obj":"NCBITaxon:11118"},{"id":"T446","span":{"begin":246,"end":254},"obj":"SP_10"},{"id":"T447","span":{"begin":281,"end":290},"obj":"CHEBI:36357;CHEBI:36357"},{"id":"T448","span":{"begin":424,"end":429},"obj":"NCBITaxon:10239"},{"id":"T449","span":{"begin":466,"end":474},"obj":"NCBITaxon:7742"},{"id":"T450","span":{"begin":490,"end":498},"obj":"SP_10"},{"id":"T451","span":{"begin":515,"end":523},"obj":"CHEBI:36357;CHEBI:36357"},{"id":"T452","span":{"begin":564,"end":569},"obj":"PR:O43148"},{"id":"T453","span":{"begin":595,"end":600},"obj":"NCBITaxon:10239"},{"id":"T454","span":{"begin":649,"end":654},"obj":"SP_6;NCBITaxon:9606"},{"id":"T455","span":{"begin":659,"end":664},"obj":"NCBITaxon:10239"},{"id":"T456","span":{"begin":689,"end":694},"obj":"CHEBI:24433;CHEBI:24433"},{"id":"T41","span":{"begin":162,"end":171},"obj":"CHEBI:36357;CHEBI:36357"}],"text":"U), human RNA N7 MTase (hRNMT) (50 nM). Compounds were previously dissolved in 100% DMSO. n.i: no inhibition detected at 50 μM.\nUnexpectedly, all the bisubstrate compounds were barely active against the 2′-O MTases of flaviviruses or coronavirus SARS-CoV. In contrast, most of the compounds displayed inhibition of N7-MTases. Dinucleoside 2 bearing the amino acid chain of the SAM showed some significant inhibition of both viral N7-MTases with a better activity on Vaccinia D1-D12 than on SARS-CoV nsp14. However, compound 2 also displayed a potent inhibition of hRNMT in the same range as the viral MTases displaying a lack of specificity against human and viral enzymes. The amino acid group of 2 seems essential for inhibition since compound 1 with a non-substituted NH linker weakly i"}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T68","span":{"begin":10,"end":13},"obj":"Body_part"},{"id":"T69","span":{"begin":353,"end":363},"obj":"Body_part"},{"id":"T70","span":{"begin":678,"end":688},"obj":"Body_part"}],"attributes":[{"id":"A68","pred":"fma_id","subj":"T68","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A69","pred":"fma_id","subj":"T69","obj":"http://purl.org/sig/ont/fma/fma82739"},{"id":"A70","pred":"fma_id","subj":"T70","obj":"http://purl.org/sig/ont/fma/fma82739"}],"text":"U), human RNA N7 MTase (hRNMT) (50 nM). Compounds were previously dissolved in 100% DMSO. n.i: no inhibition detected at 50 μM.\nUnexpectedly, all the bisubstrate compounds were barely active against the 2′-O MTases of flaviviruses or coronavirus SARS-CoV. In contrast, most of the compounds displayed inhibition of N7-MTases. Dinucleoside 2 bearing the amino acid chain of the SAM showed some significant inhibition of both viral N7-MTases with a better activity on Vaccinia D1-D12 than on SARS-CoV nsp14. However, compound 2 also displayed a potent inhibition of hRNMT in the same range as the viral MTases displaying a lack of specificity against human and viral enzymes. The amino acid group of 2 seems essential for inhibition since compound 1 with a non-substituted NH linker weakly i"}

{"project":"LitCovid-PubTator","denotations":[{"id":"373","span":{"begin":84,"end":88},"obj":"Chemical"},{"id":"396","span":{"begin":326,"end":338},"obj":"Chemical"}],"attributes":[{"id":"A373","pred":"tao:has_database_id","subj":"373","obj":"MESH:D004121"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"U), human RNA N7 MTase (hRNMT) (50 nM). Compounds were previously dissolved in 100% DMSO. n.i: no inhibition detected at 50 μM.\nUnexpectedly, all the bisubstrate compounds were barely active against the 2′-O MTases of flaviviruses or coronavirus SARS-CoV. In contrast, most of the compounds displayed inhibition of N7-MTases. Dinucleoside 2 bearing the amino acid chain of the SAM showed some significant inhibition of both viral N7-MTases with a better activity on Vaccinia D1-D12 than on SARS-CoV nsp14. However, compound 2 also displayed a potent inhibition of hRNMT in the same range as the viral MTases displaying a lack of specificity against human and viral enzymes. The amino acid group of 2 seems essential for inhibition since compound 1 with a non-substituted NH linker weakly i"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T47","span":{"begin":246,"end":254},"obj":"Disease"},{"id":"T48","span":{"begin":466,"end":474},"obj":"Disease"},{"id":"T49","span":{"begin":490,"end":498},"obj":"Disease"}],"attributes":[{"id":"A47","pred":"mondo_id","subj":"T47","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A48","pred":"mondo_id","subj":"T48","obj":"http://purl.obolibrary.org/obo/MONDO_0002595"},{"id":"A49","pred":"mondo_id","subj":"T49","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"U), human RNA N7 MTase (hRNMT) (50 nM). Compounds were previously dissolved in 100% DMSO. n.i: no inhibition detected at 50 μM.\nUnexpectedly, all the bisubstrate compounds were barely active against the 2′-O MTases of flaviviruses or coronavirus SARS-CoV. In contrast, most of the compounds displayed inhibition of N7-MTases. Dinucleoside 2 bearing the amino acid chain of the SAM showed some significant inhibition of both viral N7-MTases with a better activity on Vaccinia D1-D12 than on SARS-CoV nsp14. However, compound 2 also displayed a potent inhibition of hRNMT in the same range as the viral MTases displaying a lack of specificity against human and viral enzymes. The amino acid group of 2 seems essential for inhibition since compound 1 with a non-substituted NH linker weakly i"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T160","span":{"begin":4,"end":9},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T161","span":{"begin":184,"end":190},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T162","span":{"begin":353,"end":369},"obj":"http://purl.obolibrary.org/obo/PR_000018263"},{"id":"T163","span":{"begin":445,"end":446},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T164","span":{"begin":454,"end":462},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T165","span":{"begin":541,"end":542},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T166","span":{"begin":619,"end":620},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T167","span":{"begin":649,"end":654},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T168","span":{"begin":753,"end":754},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"U), human RNA N7 MTase (hRNMT) (50 nM). Compounds were previously dissolved in 100% DMSO. n.i: no inhibition detected at 50 μM.\nUnexpectedly, all the bisubstrate compounds were barely active against the 2′-O MTases of flaviviruses or coronavirus SARS-CoV. In contrast, most of the compounds displayed inhibition of N7-MTases. Dinucleoside 2 bearing the amino acid chain of the SAM showed some significant inhibition of both viral N7-MTases with a better activity on Vaccinia D1-D12 than on SARS-CoV nsp14. However, compound 2 also displayed a potent inhibition of hRNMT in the same range as the viral MTases displaying a lack of specificity against human and viral enzymes. The amino acid group of 2 seems essential for inhibition since compound 1 with a non-substituted NH linker weakly i"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T337","span":{"begin":84,"end":88},"obj":"Chemical"},{"id":"T338","span":{"begin":353,"end":363},"obj":"Chemical"},{"id":"T339","span":{"begin":353,"end":358},"obj":"Chemical"},{"id":"T340","span":{"begin":359,"end":363},"obj":"Chemical"},{"id":"T341","span":{"begin":377,"end":380},"obj":"Chemical"},{"id":"T343","span":{"begin":678,"end":688},"obj":"Chemical"},{"id":"T344","span":{"begin":678,"end":683},"obj":"Chemical"},{"id":"T345","span":{"begin":684,"end":688},"obj":"Chemical"},{"id":"T346","span":{"begin":689,"end":694},"obj":"Chemical"},{"id":"T347","span":{"begin":771,"end":773},"obj":"Chemical"}],"attributes":[{"id":"A337","pred":"chebi_id","subj":"T337","obj":"http://purl.obolibrary.org/obo/CHEBI_28262"},{"id":"A338","pred":"chebi_id","subj":"T338","obj":"http://purl.obolibrary.org/obo/CHEBI_33709"},{"id":"A339","pred":"chebi_id","subj":"T339","obj":"http://purl.obolibrary.org/obo/CHEBI_46882"},{"id":"A340","pred":"chebi_id","subj":"T340","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A341","pred":"chebi_id","subj":"T341","obj":"http://purl.obolibrary.org/obo/CHEBI_15414"},{"id":"A342","pred":"chebi_id","subj":"T341","obj":"http://purl.obolibrary.org/obo/CHEBI_67040"},{"id":"A343","pred":"chebi_id","subj":"T343","obj":"http://purl.obolibrary.org/obo/CHEBI_33709"},{"id":"A344","pred":"chebi_id","subj":"T344","obj":"http://purl.obolibrary.org/obo/CHEBI_46882"},{"id":"A345","pred":"chebi_id","subj":"T345","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A346","pred":"chebi_id","subj":"T346","obj":"http://purl.obolibrary.org/obo/CHEBI_24433"},{"id":"A347","pred":"chebi_id","subj":"T347","obj":"http://purl.obolibrary.org/obo/CHEBI_29339"},{"id":"A348","pred":"chebi_id","subj":"T347","obj":"http://purl.obolibrary.org/obo/CHEBI_73424"}],"text":"U), human RNA N7 MTase (hRNMT) (50 nM). Compounds were previously dissolved in 100% DMSO. n.i: no inhibition detected at 50 μM.\nUnexpectedly, all the bisubstrate compounds were barely active against the 2′-O MTases of flaviviruses or coronavirus SARS-CoV. In contrast, most of the compounds displayed inhibition of N7-MTases. Dinucleoside 2 bearing the amino acid chain of the SAM showed some significant inhibition of both viral N7-MTases with a better activity on Vaccinia D1-D12 than on SARS-CoV nsp14. However, compound 2 also displayed a potent inhibition of hRNMT in the same range as the viral MTases displaying a lack of specificity against human and viral enzymes. The amino acid group of 2 seems essential for inhibition since compound 1 with a non-substituted NH linker weakly i"}

{"project":"LitCovid-sentences","denotations":[{"id":"T137","span":{"begin":40,"end":127},"obj":"Sentence"},{"id":"T138","span":{"begin":128,"end":255},"obj":"Sentence"},{"id":"T139","span":{"begin":256,"end":325},"obj":"Sentence"},{"id":"T140","span":{"begin":326,"end":505},"obj":"Sentence"},{"id":"T141","span":{"begin":506,"end":673},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"U), human RNA N7 MTase (hRNMT) (50 nM). Compounds were previously dissolved in 100% DMSO. n.i: no inhibition detected at 50 μM.\nUnexpectedly, all the bisubstrate compounds were barely active against the 2′-O MTases of flaviviruses or coronavirus SARS-CoV. In contrast, most of the compounds displayed inhibition of N7-MTases. Dinucleoside 2 bearing the amino acid chain of the SAM showed some significant inhibition of both viral N7-MTases with a better activity on Vaccinia D1-D12 than on SARS-CoV nsp14. However, compound 2 also displayed a potent inhibition of hRNMT in the same range as the viral MTases displaying a lack of specificity against human and viral enzymes. The amino acid group of 2 seems essential for inhibition since compound 1 with a non-substituted NH linker weakly i"}