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PMC:7291971 / 19399-20188 JSONTXT

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LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T426 4-9 SP_6;NCBITaxon:9606 denotes human
T427 24-29 PR:O43148 denotes hRNMT
T428 84-88 CHEBI:51231;CHEBI:51231 denotes DMSO
T443 162-171 CHEBI:36357;CHEBI:36357 denotes compounds
T444 218-230 NCBITaxon:31032 denotes flaviviruses
T445 234-245 NCBITaxon:11118 denotes coronavirus
T446 246-254 SP_10 denotes SARS-CoV
T447 281-290 CHEBI:36357;CHEBI:36357 denotes compounds
T448 424-429 NCBITaxon:10239 denotes viral
T449 466-474 NCBITaxon:7742 denotes Vaccinia
T450 490-498 SP_10 denotes SARS-CoV
T451 515-523 CHEBI:36357;CHEBI:36357 denotes compound
T452 564-569 PR:O43148 denotes hRNMT
T453 595-600 NCBITaxon:10239 denotes viral
T454 649-654 SP_6;NCBITaxon:9606 denotes human
T455 659-664 NCBITaxon:10239 denotes viral
T456 689-694 CHEBI:24433;CHEBI:24433 denotes group
T41 162-171 CHEBI:36357;CHEBI:36357 denotes compounds

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T68 10-13 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T69 353-363 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T70 678-688 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
373 84-88 Chemical denotes DMSO MESH:D004121
396 326-338 Chemical denotes Dinucleoside

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T47 246-254 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T48 466-474 Disease denotes Vaccinia http://purl.obolibrary.org/obo/MONDO_0002595
T49 490-498 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T160 4-9 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T161 184-190 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T162 353-369 http://purl.obolibrary.org/obo/PR_000018263 denotes amino acid chain
T163 445-446 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T164 454-462 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T165 541-542 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T166 619-620 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T167 649-654 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T168 753-754 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T337 84-88 Chemical denotes DMSO http://purl.obolibrary.org/obo/CHEBI_28262
T338 353-363 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T339 353-358 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T340 359-363 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T341 377-380 Chemical denotes SAM http://purl.obolibrary.org/obo/CHEBI_15414|http://purl.obolibrary.org/obo/CHEBI_67040
T343 678-688 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T344 678-683 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T345 684-688 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T346 689-694 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T347 771-773 Chemical denotes NH http://purl.obolibrary.org/obo/CHEBI_29339|http://purl.obolibrary.org/obo/CHEBI_73424

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T137 40-127 Sentence denotes Compounds were previously dissolved in 100% DMSO. n.i: no inhibition detected at 50 μM.
T138 128-255 Sentence denotes Unexpectedly, all the bisubstrate compounds were barely active against the 2′-O MTases of flaviviruses or coronavirus SARS-CoV.
T139 256-325 Sentence denotes In contrast, most of the compounds displayed inhibition of N7-MTases.
T140 326-505 Sentence denotes Dinucleoside 2 bearing the amino acid chain of the SAM showed some significant inhibition of both viral N7-MTases with a better activity on Vaccinia D1-D12 than on SARS-CoV nsp14.
T141 506-673 Sentence denotes However, compound 2 also displayed a potent inhibition of hRNMT in the same range as the viral MTases displaying a lack of specificity against human and viral enzymes.