PMC:7272971 / 28132-29233 JSONTXT

Annnotations TAB JSON ListView MergeView

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7272971","sourcedb":"PMC","sourceid":"7272971","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7272971","text":"Human coronaviruses bind to specific receptors on host cells. Binding of SARS‐CoV‐2 and SARS‐CoV to ACE2 is required for initiation of infection. There is some preliminary evidence for ACE2 expression on corneal and conjunctival cells, but most of the other receptors known to bind to coronaviruses appear to be found only on fibroblasts and dendritic cells that are found under the surface epithelial layers of the ocular surface. Lactoferrin in tears can inhibit coronavirus binding, as may decoy receptors such as 9‐O‐acetylated sialic acid on tear glycoproteins. Animal studies on human coronaviruses have not focused on the role of ocular surface binding in the infection process, apart from one study that showed conjunctival infection could lead to mild signs and symptoms of pneumonia, but only transient association of SARS‐CoV‐2 with the conjunctiva. While coronavirus infection is rarely associated with conjunctivitis, there have been occasional findings of conjunctivitis in confirmed COVID‐19 patients. Similarly, coronaviruses have been rarely isolated from tears or conjunctival swabs.","tracks":[{"project":"LitCovid-PubTator","denotations":[{"id":"889","span":{"begin":100,"end":104},"obj":"Gene"},{"id":"890","span":{"begin":185,"end":189},"obj":"Gene"},{"id":"891","span":{"begin":0,"end":5},"obj":"Species"},{"id":"892","span":{"begin":6,"end":19},"obj":"Species"},{"id":"893","span":{"begin":73,"end":83},"obj":"Species"},{"id":"894","span":{"begin":88,"end":96},"obj":"Species"},{"id":"895","span":{"begin":285,"end":298},"obj":"Species"},{"id":"896","span":{"begin":465,"end":476},"obj":"Species"},{"id":"897","span":{"begin":585,"end":590},"obj":"Species"},{"id":"898","span":{"begin":591,"end":604},"obj":"Species"},{"id":"899","span":{"begin":828,"end":838},"obj":"Species"},{"id":"900","span":{"begin":1007,"end":1015},"obj":"Species"},{"id":"901","span":{"begin":1028,"end":1041},"obj":"Species"},{"id":"902","span":{"begin":520,"end":543},"obj":"Chemical"},{"id":"903","span":{"begin":121,"end":144},"obj":"Disease"},{"id":"904","span":{"begin":204,"end":211},"obj":"Disease"},{"id":"905","span":{"begin":667,"end":676},"obj":"Disease"},{"id":"906","span":{"begin":719,"end":741},"obj":"Disease"},{"id":"907","span":{"begin":783,"end":792},"obj":"Disease"},{"id":"908","span":{"begin":867,"end":888},"obj":"Disease"},{"id":"909","span":{"begin":915,"end":929},"obj":"Disease"},{"id":"910","span":{"begin":970,"end":984},"obj":"Disease"},{"id":"911","span":{"begin":998,"end":1006},"obj":"Disease"}],"attributes":[{"id":"A889","pred":"tao:has_database_id","subj":"889","obj":"Gene:59272"},{"id":"A890","pred":"tao:has_database_id","subj":"890","obj":"Gene:59272"},{"id":"A891","pred":"tao:has_database_id","subj":"891","obj":"Tax:9606"},{"id":"A892","pred":"tao:has_database_id","subj":"892","obj":"Tax:11118"},{"id":"A893","pred":"tao:has_database_id","subj":"893","obj":"Tax:2697049"},{"id":"A894","pred":"tao:has_database_id","subj":"894","obj":"Tax:694009"},{"id":"A895","pred":"tao:has_database_id","subj":"895","obj":"Tax:11118"},{"id":"A896","pred":"tao:has_database_id","subj":"896","obj":"Tax:11118"},{"id":"A897","pred":"tao:has_database_id","subj":"897","obj":"Tax:9606"},{"id":"A898","pred":"tao:has_database_id","subj":"898","obj":"Tax:11118"},{"id":"A899","pred":"tao:has_database_id","subj":"899","obj":"Tax:2697049"},{"id":"A900","pred":"tao:has_database_id","subj":"900","obj":"Tax:9606"},{"id":"A901","pred":"tao:has_database_id","subj":"901","obj":"Tax:11118"},{"id":"A903","pred":"tao:has_database_id","subj":"903","obj":"MESH:D007239"},{"id":"A904","pred":"tao:has_database_id","subj":"904","obj":"MESH:D003316"},{"id":"A905","pred":"tao:has_database_id","subj":"905","obj":"MESH:D007239"},{"id":"A906","pred":"tao:has_database_id","subj":"906","obj":"MESH:D003229"},{"id":"A907","pred":"tao:has_database_id","subj":"907","obj":"MESH:D011014"},{"id":"A908","pred":"tao:has_database_id","subj":"908","obj":"MESH:D018352"},{"id":"A909","pred":"tao:has_database_id","subj":"909","obj":"MESH:D003231"},{"id":"A910","pred":"tao:has_database_id","subj":"910","obj":"MESH:D003231"},{"id":"A911","pred":"tao:has_database_id","subj":"911","obj":"MESH:C000657245"},{"subj":"889","pred":"source","obj":"LitCovid-PubTator"},{"subj":"890","pred":"source","obj":"LitCovid-PubTator"},{"subj":"891","pred":"source","obj":"LitCovid-PubTator"},{"subj":"892","pred":"source","obj":"LitCovid-PubTator"},{"subj":"893","pred":"source","obj":"LitCovid-PubTator"},{"subj":"894","pred":"source","obj":"LitCovid-PubTator"},{"subj":"895","pred":"source","obj":"LitCovid-PubTator"},{"subj":"896","pred":"source","obj":"LitCovid-PubTator"},{"subj":"897","pred":"source","obj":"LitCovid-PubTator"},{"subj":"898","pred":"source","obj":"LitCovid-PubTator"},{"subj":"899","pred":"source","obj":"LitCovid-PubTator"},{"subj":"900","pred":"source","obj":"LitCovid-PubTator"},{"subj":"901","pred":"source","obj":"LitCovid-PubTator"},{"subj":"902","pred":"source","obj":"LitCovid-PubTator"},{"subj":"903","pred":"source","obj":"LitCovid-PubTator"},{"subj":"904","pred":"source","obj":"LitCovid-PubTator"},{"subj":"905","pred":"source","obj":"LitCovid-PubTator"},{"subj":"906","pred":"source","obj":"LitCovid-PubTator"},{"subj":"907","pred":"source","obj":"LitCovid-PubTator"},{"subj":"908","pred":"source","obj":"LitCovid-PubTator"},{"subj":"909","pred":"source","obj":"LitCovid-PubTator"},{"subj":"910","pred":"source","obj":"LitCovid-PubTator"},{"subj":"911","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T255","span":{"begin":55,"end":60},"obj":"Body_part"},{"id":"T256","span":{"begin":229,"end":234},"obj":"Body_part"},{"id":"T257","span":{"begin":326,"end":337},"obj":"Body_part"},{"id":"T258","span":{"begin":342,"end":357},"obj":"Body_part"},{"id":"T259","span":{"begin":352,"end":357},"obj":"Body_part"},{"id":"T260","span":{"begin":447,"end":452},"obj":"Body_part"},{"id":"T261","span":{"begin":547,"end":551},"obj":"Body_part"},{"id":"T262","span":{"begin":552,"end":565},"obj":"Body_part"},{"id":"T263","span":{"begin":848,"end":859},"obj":"Body_part"},{"id":"T264","span":{"begin":1073,"end":1078},"obj":"Body_part"}],"attributes":[{"id":"A255","pred":"fma_id","subj":"T255","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A256","pred":"fma_id","subj":"T256","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A257","pred":"fma_id","subj":"T257","obj":"http://purl.org/sig/ont/fma/fma63877"},{"id":"A258","pred":"fma_id","subj":"T258","obj":"http://purl.org/sig/ont/fma/fma273565"},{"id":"A259","pred":"fma_id","subj":"T259","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A260","pred":"fma_id","subj":"T260","obj":"http://purl.org/sig/ont/fma/fma59756"},{"id":"A261","pred":"fma_id","subj":"T261","obj":"http://purl.org/sig/ont/fma/fma59756"},{"id":"A262","pred":"fma_id","subj":"T262","obj":"http://purl.org/sig/ont/fma/fma62925"},{"id":"A263","pred":"fma_id","subj":"T263","obj":"http://purl.org/sig/ont/fma/fma59011"},{"id":"A264","pred":"fma_id","subj":"T264","obj":"http://purl.org/sig/ont/fma/fma59756"},{"subj":"T255","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T256","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T257","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T258","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T259","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T260","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T261","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T262","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T263","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T264","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T98","span":{"begin":848,"end":859},"obj":"Body_part"}],"attributes":[{"id":"A98","pred":"uberon_id","subj":"T98","obj":"http://purl.obolibrary.org/obo/UBERON_0001811"},{"subj":"T98","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PD-HP","denotations":[{"id":"T78","span":{"begin":783,"end":792},"obj":"Phenotype"},{"id":"T79","span":{"begin":915,"end":929},"obj":"Phenotype"},{"id":"T80","span":{"begin":970,"end":984},"obj":"Phenotype"}],"attributes":[{"id":"A78","pred":"hp_id","subj":"T78","obj":"http://purl.obolibrary.org/obo/HP_0002090"},{"id":"A79","pred":"hp_id","subj":"T79","obj":"http://purl.obolibrary.org/obo/HP_0000509"},{"id":"A80","pred":"hp_id","subj":"T80","obj":"http://purl.obolibrary.org/obo/HP_0000509"},{"subj":"T78","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T79","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T80","pred":"source","obj":"LitCovid-PD-HP"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T202","span":{"begin":73,"end":77},"obj":"Disease"},{"id":"T203","span":{"begin":88,"end":92},"obj":"Disease"},{"id":"T204","span":{"begin":135,"end":144},"obj":"Disease"},{"id":"T205","span":{"begin":667,"end":676},"obj":"Disease"},{"id":"T206","span":{"begin":732,"end":741},"obj":"Disease"},{"id":"T207","span":{"begin":783,"end":792},"obj":"Disease"},{"id":"T208","span":{"begin":828,"end":832},"obj":"Disease"},{"id":"T209","span":{"begin":879,"end":888},"obj":"Disease"},{"id":"T210","span":{"begin":915,"end":929},"obj":"Disease"},{"id":"T211","span":{"begin":970,"end":984},"obj":"Disease"},{"id":"T212","span":{"begin":998,"end":1006},"obj":"Disease"}],"attributes":[{"id":"A202","pred":"mondo_id","subj":"T202","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A203","pred":"mondo_id","subj":"T203","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A204","pred":"mondo_id","subj":"T204","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A205","pred":"mondo_id","subj":"T205","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A206","pred":"mondo_id","subj":"T206","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A207","pred":"mondo_id","subj":"T207","obj":"http://purl.obolibrary.org/obo/MONDO_0005249"},{"id":"A208","pred":"mondo_id","subj":"T208","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A209","pred":"mondo_id","subj":"T209","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A210","pred":"mondo_id","subj":"T210","obj":"http://purl.obolibrary.org/obo/MONDO_0003799"},{"id":"A211","pred":"mondo_id","subj":"T211","obj":"http://purl.obolibrary.org/obo/MONDO_0003799"},{"id":"A212","pred":"mondo_id","subj":"T212","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"subj":"T202","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T203","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T204","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T205","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T206","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T207","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T208","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T209","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T210","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T211","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T212","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T342","span":{"begin":0,"end":5},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T343","span":{"begin":55,"end":60},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T344","span":{"begin":229,"end":234},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T345","span":{"begin":326,"end":337},"obj":"http://purl.obolibrary.org/obo/CL_0000057"},{"id":"T346","span":{"begin":342,"end":357},"obj":"http://purl.obolibrary.org/obo/CL_0000451"},{"id":"T347","span":{"begin":391,"end":401},"obj":"http://purl.obolibrary.org/obo/CL_0000066"},{"id":"T348","span":{"begin":567,"end":573},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_33208"},{"id":"T349","span":{"begin":585,"end":590},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T350","span":{"begin":614,"end":621},"obj":"http://purl.obolibrary.org/obo/CLO_0009985"},{"id":"T351","span":{"begin":848,"end":859},"obj":"http://purl.obolibrary.org/obo/UBERON_0001811"},{"id":"T352","span":{"begin":848,"end":859},"obj":"http://www.ebi.ac.uk/efo/EFO_0000374"}],"attributes":[{"subj":"T342","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T343","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T344","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T345","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T346","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T347","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T348","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T349","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T350","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T351","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T352","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T72","span":{"begin":532,"end":543},"obj":"Chemical"},{"id":"T73","span":{"begin":539,"end":543},"obj":"Chemical"},{"id":"T74","span":{"begin":552,"end":565},"obj":"Chemical"}],"attributes":[{"id":"A72","pred":"chebi_id","subj":"T72","obj":"http://purl.obolibrary.org/obo/CHEBI_26667"},{"id":"A73","pred":"chebi_id","subj":"T73","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A74","pred":"chebi_id","subj":"T74","obj":"http://purl.obolibrary.org/obo/CHEBI_17089"},{"subj":"T72","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T73","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T74","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T190","span":{"begin":0,"end":61},"obj":"Sentence"},{"id":"T191","span":{"begin":62,"end":145},"obj":"Sentence"},{"id":"T192","span":{"begin":146,"end":431},"obj":"Sentence"},{"id":"T193","span":{"begin":432,"end":566},"obj":"Sentence"},{"id":"T194","span":{"begin":567,"end":860},"obj":"Sentence"},{"id":"T195","span":{"begin":861,"end":1016},"obj":"Sentence"},{"id":"T196","span":{"begin":1017,"end":1101},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T190","pred":"source","obj":"LitCovid-sentences"},{"subj":"T191","pred":"source","obj":"LitCovid-sentences"},{"subj":"T192","pred":"source","obj":"LitCovid-sentences"},{"subj":"T193","pred":"source","obj":"LitCovid-sentences"},{"subj":"T194","pred":"source","obj":"LitCovid-sentences"},{"subj":"T195","pred":"source","obj":"LitCovid-sentences"},{"subj":"T196","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PubTator","color":"#caec93","default":true},{"id":"LitCovid-PD-FMA-UBERON","color":"#ec93e4"},{"id":"LitCovid-PD-UBERON","color":"#93ecda"},{"id":"LitCovid-PD-HP","color":"#ecc093"},{"id":"LitCovid-PD-MONDO","color":"#a593ec"},{"id":"LitCovid-PD-CLO","color":"#9aec93"},{"id":"LitCovid-PD-CHEBI","color":"#ec93b4"},{"id":"LitCovid-sentences","color":"#93ceec"}]}]}}