PMC:7272971 / 28132-29233 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"889","span":{"begin":100,"end":104},"obj":"Gene"},{"id":"890","span":{"begin":185,"end":189},"obj":"Gene"},{"id":"891","span":{"begin":0,"end":5},"obj":"Species"},{"id":"892","span":{"begin":6,"end":19},"obj":"Species"},{"id":"893","span":{"begin":73,"end":83},"obj":"Species"},{"id":"894","span":{"begin":88,"end":96},"obj":"Species"},{"id":"895","span":{"begin":285,"end":298},"obj":"Species"},{"id":"896","span":{"begin":465,"end":476},"obj":"Species"},{"id":"897","span":{"begin":585,"end":590},"obj":"Species"},{"id":"898","span":{"begin":591,"end":604},"obj":"Species"},{"id":"899","span":{"begin":828,"end":838},"obj":"Species"},{"id":"900","span":{"begin":1007,"end":1015},"obj":"Species"},{"id":"901","span":{"begin":1028,"end":1041},"obj":"Species"},{"id":"902","span":{"begin":520,"end":543},"obj":"Chemical"},{"id":"903","span":{"begin":121,"end":144},"obj":"Disease"},{"id":"904","span":{"begin":204,"end":211},"obj":"Disease"},{"id":"905","span":{"begin":667,"end":676},"obj":"Disease"},{"id":"906","span":{"begin":719,"end":741},"obj":"Disease"},{"id":"907","span":{"begin":783,"end":792},"obj":"Disease"},{"id":"908","span":{"begin":867,"end":888},"obj":"Disease"},{"id":"909","span":{"begin":915,"end":929},"obj":"Disease"},{"id":"910","span":{"begin":970,"end":984},"obj":"Disease"},{"id":"911","span":{"begin":998,"end":1006},"obj":"Disease"}],"attributes":[{"id":"A889","pred":"tao:has_database_id","subj":"889","obj":"Gene:59272"},{"id":"A890","pred":"tao:has_database_id","subj":"890","obj":"Gene:59272"},{"id":"A891","pred":"tao:has_database_id","subj":"891","obj":"Tax:9606"},{"id":"A892","pred":"tao:has_database_id","subj":"892","obj":"Tax:11118"},{"id":"A893","pred":"tao:has_database_id","subj":"893","obj":"Tax:2697049"},{"id":"A894","pred":"tao:has_database_id","subj":"894","obj":"Tax:694009"},{"id":"A895","pred":"tao:has_database_id","subj":"895","obj":"Tax:11118"},{"id":"A896","pred":"tao:has_database_id","subj":"896","obj":"Tax:11118"},{"id":"A897","pred":"tao:has_database_id","subj":"897","obj":"Tax:9606"},{"id":"A898","pred":"tao:has_database_id","subj":"898","obj":"Tax:11118"},{"id":"A899","pred":"tao:has_database_id","subj":"899","obj":"Tax:2697049"},{"id":"A900","pred":"tao:has_database_id","subj":"900","obj":"Tax:9606"},{"id":"A901","pred":"tao:has_database_id","subj":"901","obj":"Tax:11118"},{"id":"A903","pred":"tao:has_database_id","subj":"903","obj":"MESH:D007239"},{"id":"A904","pred":"tao:has_database_id","subj":"904","obj":"MESH:D003316"},{"id":"A905","pred":"tao:has_database_id","subj":"905","obj":"MESH:D007239"},{"id":"A906","pred":"tao:has_database_id","subj":"906","obj":"MESH:D003229"},{"id":"A907","pred":"tao:has_database_id","subj":"907","obj":"MESH:D011014"},{"id":"A908","pred":"tao:has_database_id","subj":"908","obj":"MESH:D018352"},{"id":"A909","pred":"tao:has_database_id","subj":"909","obj":"MESH:D003231"},{"id":"A910","pred":"tao:has_database_id","subj":"910","obj":"MESH:D003231"},{"id":"A911","pred":"tao:has_database_id","subj":"911","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Human coronaviruses bind to specific receptors on host cells. Binding of SARS‐CoV‐2 and SARS‐CoV to ACE2 is required for initiation of infection. There is some preliminary evidence for ACE2 expression on corneal and conjunctival cells, but most of the other receptors known to bind to coronaviruses appear to be found only on fibroblasts and dendritic cells that are found under the surface epithelial layers of the ocular surface. Lactoferrin in tears can inhibit coronavirus binding, as may decoy receptors such as 9‐O‐acetylated sialic acid on tear glycoproteins. Animal studies on human coronaviruses have not focused on the role of ocular surface binding in the infection process, apart from one study that showed conjunctival infection could lead to mild signs and symptoms of pneumonia, but only transient association of SARS‐CoV‐2 with the conjunctiva. While coronavirus infection is rarely associated with conjunctivitis, there have been occasional findings of conjunctivitis in confirmed COVID‐19 patients. Similarly, coronaviruses have been rarely isolated from tears or conjunctival swabs."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T255","span":{"begin":55,"end":60},"obj":"Body_part"},{"id":"T256","span":{"begin":229,"end":234},"obj":"Body_part"},{"id":"T257","span":{"begin":326,"end":337},"obj":"Body_part"},{"id":"T258","span":{"begin":342,"end":357},"obj":"Body_part"},{"id":"T259","span":{"begin":352,"end":357},"obj":"Body_part"},{"id":"T260","span":{"begin":447,"end":452},"obj":"Body_part"},{"id":"T261","span":{"begin":547,"end":551},"obj":"Body_part"},{"id":"T262","span":{"begin":552,"end":565},"obj":"Body_part"},{"id":"T263","span":{"begin":848,"end":859},"obj":"Body_part"},{"id":"T264","span":{"begin":1073,"end":1078},"obj":"Body_part"}],"attributes":[{"id":"A255","pred":"fma_id","subj":"T255","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A256","pred":"fma_id","subj":"T256","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A257","pred":"fma_id","subj":"T257","obj":"http://purl.org/sig/ont/fma/fma63877"},{"id":"A258","pred":"fma_id","subj":"T258","obj":"http://purl.org/sig/ont/fma/fma273565"},{"id":"A259","pred":"fma_id","subj":"T259","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A260","pred":"fma_id","subj":"T260","obj":"http://purl.org/sig/ont/fma/fma59756"},{"id":"A261","pred":"fma_id","subj":"T261","obj":"http://purl.org/sig/ont/fma/fma59756"},{"id":"A262","pred":"fma_id","subj":"T262","obj":"http://purl.org/sig/ont/fma/fma62925"},{"id":"A263","pred":"fma_id","subj":"T263","obj":"http://purl.org/sig/ont/fma/fma59011"},{"id":"A264","pred":"fma_id","subj":"T264","obj":"http://purl.org/sig/ont/fma/fma59756"}],"text":"Human coronaviruses bind to specific receptors on host cells. Binding of SARS‐CoV‐2 and SARS‐CoV to ACE2 is required for initiation of infection. There is some preliminary evidence for ACE2 expression on corneal and conjunctival cells, but most of the other receptors known to bind to coronaviruses appear to be found only on fibroblasts and dendritic cells that are found under the surface epithelial layers of the ocular surface. Lactoferrin in tears can inhibit coronavirus binding, as may decoy receptors such as 9‐O‐acetylated sialic acid on tear glycoproteins. Animal studies on human coronaviruses have not focused on the role of ocular surface binding in the infection process, apart from one study that showed conjunctival infection could lead to mild signs and symptoms of pneumonia, but only transient association of SARS‐CoV‐2 with the conjunctiva. While coronavirus infection is rarely associated with conjunctivitis, there have been occasional findings of conjunctivitis in confirmed COVID‐19 patients. Similarly, coronaviruses have been rarely isolated from tears or conjunctival swabs."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T98","span":{"begin":848,"end":859},"obj":"Body_part"}],"attributes":[{"id":"A98","pred":"uberon_id","subj":"T98","obj":"http://purl.obolibrary.org/obo/UBERON_0001811"}],"text":"Human coronaviruses bind to specific receptors on host cells. Binding of SARS‐CoV‐2 and SARS‐CoV to ACE2 is required for initiation of infection. There is some preliminary evidence for ACE2 expression on corneal and conjunctival cells, but most of the other receptors known to bind to coronaviruses appear to be found only on fibroblasts and dendritic cells that are found under the surface epithelial layers of the ocular surface. Lactoferrin in tears can inhibit coronavirus binding, as may decoy receptors such as 9‐O‐acetylated sialic acid on tear glycoproteins. Animal studies on human coronaviruses have not focused on the role of ocular surface binding in the infection process, apart from one study that showed conjunctival infection could lead to mild signs and symptoms of pneumonia, but only transient association of SARS‐CoV‐2 with the conjunctiva. While coronavirus infection is rarely associated with conjunctivitis, there have been occasional findings of conjunctivitis in confirmed COVID‐19 patients. Similarly, coronaviruses have been rarely isolated from tears or conjunctival swabs."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T78","span":{"begin":783,"end":792},"obj":"Phenotype"},{"id":"T79","span":{"begin":915,"end":929},"obj":"Phenotype"},{"id":"T80","span":{"begin":970,"end":984},"obj":"Phenotype"}],"attributes":[{"id":"A78","pred":"hp_id","subj":"T78","obj":"http://purl.obolibrary.org/obo/HP_0002090"},{"id":"A79","pred":"hp_id","subj":"T79","obj":"http://purl.obolibrary.org/obo/HP_0000509"},{"id":"A80","pred":"hp_id","subj":"T80","obj":"http://purl.obolibrary.org/obo/HP_0000509"}],"text":"Human coronaviruses bind to specific receptors on host cells. Binding of SARS‐CoV‐2 and SARS‐CoV to ACE2 is required for initiation of infection. There is some preliminary evidence for ACE2 expression on corneal and conjunctival cells, but most of the other receptors known to bind to coronaviruses appear to be found only on fibroblasts and dendritic cells that are found under the surface epithelial layers of the ocular surface. Lactoferrin in tears can inhibit coronavirus binding, as may decoy receptors such as 9‐O‐acetylated sialic acid on tear glycoproteins. Animal studies on human coronaviruses have not focused on the role of ocular surface binding in the infection process, apart from one study that showed conjunctival infection could lead to mild signs and symptoms of pneumonia, but only transient association of SARS‐CoV‐2 with the conjunctiva. While coronavirus infection is rarely associated with conjunctivitis, there have been occasional findings of conjunctivitis in confirmed COVID‐19 patients. Similarly, coronaviruses have been rarely isolated from tears or conjunctival swabs."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T202","span":{"begin":73,"end":77},"obj":"Disease"},{"id":"T203","span":{"begin":88,"end":92},"obj":"Disease"},{"id":"T204","span":{"begin":135,"end":144},"obj":"Disease"},{"id":"T205","span":{"begin":667,"end":676},"obj":"Disease"},{"id":"T206","span":{"begin":732,"end":741},"obj":"Disease"},{"id":"T207","span":{"begin":783,"end":792},"obj":"Disease"},{"id":"T208","span":{"begin":828,"end":832},"obj":"Disease"},{"id":"T209","span":{"begin":879,"end":888},"obj":"Disease"},{"id":"T210","span":{"begin":915,"end":929},"obj":"Disease"},{"id":"T211","span":{"begin":970,"end":984},"obj":"Disease"},{"id":"T212","span":{"begin":998,"end":1006},"obj":"Disease"}],"attributes":[{"id":"A202","pred":"mondo_id","subj":"T202","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A203","pred":"mondo_id","subj":"T203","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A204","pred":"mondo_id","subj":"T204","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A205","pred":"mondo_id","subj":"T205","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A206","pred":"mondo_id","subj":"T206","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A207","pred":"mondo_id","subj":"T207","obj":"http://purl.obolibrary.org/obo/MONDO_0005249"},{"id":"A208","pred":"mondo_id","subj":"T208","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A209","pred":"mondo_id","subj":"T209","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A210","pred":"mondo_id","subj":"T210","obj":"http://purl.obolibrary.org/obo/MONDO_0003799"},{"id":"A211","pred":"mondo_id","subj":"T211","obj":"http://purl.obolibrary.org/obo/MONDO_0003799"},{"id":"A212","pred":"mondo_id","subj":"T212","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"}],"text":"Human coronaviruses bind to specific receptors on host cells. Binding of SARS‐CoV‐2 and SARS‐CoV to ACE2 is required for initiation of infection. There is some preliminary evidence for ACE2 expression on corneal and conjunctival cells, but most of the other receptors known to bind to coronaviruses appear to be found only on fibroblasts and dendritic cells that are found under the surface epithelial layers of the ocular surface. Lactoferrin in tears can inhibit coronavirus binding, as may decoy receptors such as 9‐O‐acetylated sialic acid on tear glycoproteins. Animal studies on human coronaviruses have not focused on the role of ocular surface binding in the infection process, apart from one study that showed conjunctival infection could lead to mild signs and symptoms of pneumonia, but only transient association of SARS‐CoV‐2 with the conjunctiva. While coronavirus infection is rarely associated with conjunctivitis, there have been occasional findings of conjunctivitis in confirmed COVID‐19 patients. Similarly, coronaviruses have been rarely isolated from tears or conjunctival swabs."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T342","span":{"begin":0,"end":5},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T343","span":{"begin":55,"end":60},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T344","span":{"begin":229,"end":234},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T345","span":{"begin":326,"end":337},"obj":"http://purl.obolibrary.org/obo/CL_0000057"},{"id":"T346","span":{"begin":342,"end":357},"obj":"http://purl.obolibrary.org/obo/CL_0000451"},{"id":"T347","span":{"begin":391,"end":401},"obj":"http://purl.obolibrary.org/obo/CL_0000066"},{"id":"T348","span":{"begin":567,"end":573},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_33208"},{"id":"T349","span":{"begin":585,"end":590},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T350","span":{"begin":614,"end":621},"obj":"http://purl.obolibrary.org/obo/CLO_0009985"},{"id":"T351","span":{"begin":848,"end":859},"obj":"http://purl.obolibrary.org/obo/UBERON_0001811"},{"id":"T352","span":{"begin":848,"end":859},"obj":"http://www.ebi.ac.uk/efo/EFO_0000374"}],"text":"Human coronaviruses bind to specific receptors on host cells. Binding of SARS‐CoV‐2 and SARS‐CoV to ACE2 is required for initiation of infection. There is some preliminary evidence for ACE2 expression on corneal and conjunctival cells, but most of the other receptors known to bind to coronaviruses appear to be found only on fibroblasts and dendritic cells that are found under the surface epithelial layers of the ocular surface. Lactoferrin in tears can inhibit coronavirus binding, as may decoy receptors such as 9‐O‐acetylated sialic acid on tear glycoproteins. Animal studies on human coronaviruses have not focused on the role of ocular surface binding in the infection process, apart from one study that showed conjunctival infection could lead to mild signs and symptoms of pneumonia, but only transient association of SARS‐CoV‐2 with the conjunctiva. While coronavirus infection is rarely associated with conjunctivitis, there have been occasional findings of conjunctivitis in confirmed COVID‐19 patients. Similarly, coronaviruses have been rarely isolated from tears or conjunctival swabs."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T72","span":{"begin":532,"end":543},"obj":"Chemical"},{"id":"T73","span":{"begin":539,"end":543},"obj":"Chemical"},{"id":"T74","span":{"begin":552,"end":565},"obj":"Chemical"}],"attributes":[{"id":"A72","pred":"chebi_id","subj":"T72","obj":"http://purl.obolibrary.org/obo/CHEBI_26667"},{"id":"A73","pred":"chebi_id","subj":"T73","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A74","pred":"chebi_id","subj":"T74","obj":"http://purl.obolibrary.org/obo/CHEBI_17089"}],"text":"Human coronaviruses bind to specific receptors on host cells. Binding of SARS‐CoV‐2 and SARS‐CoV to ACE2 is required for initiation of infection. There is some preliminary evidence for ACE2 expression on corneal and conjunctival cells, but most of the other receptors known to bind to coronaviruses appear to be found only on fibroblasts and dendritic cells that are found under the surface epithelial layers of the ocular surface. Lactoferrin in tears can inhibit coronavirus binding, as may decoy receptors such as 9‐O‐acetylated sialic acid on tear glycoproteins. Animal studies on human coronaviruses have not focused on the role of ocular surface binding in the infection process, apart from one study that showed conjunctival infection could lead to mild signs and symptoms of pneumonia, but only transient association of SARS‐CoV‐2 with the conjunctiva. While coronavirus infection is rarely associated with conjunctivitis, there have been occasional findings of conjunctivitis in confirmed COVID‐19 patients. Similarly, coronaviruses have been rarely isolated from tears or conjunctival swabs."}

{"project":"LitCovid-sentences","denotations":[{"id":"T190","span":{"begin":0,"end":61},"obj":"Sentence"},{"id":"T191","span":{"begin":62,"end":145},"obj":"Sentence"},{"id":"T192","span":{"begin":146,"end":431},"obj":"Sentence"},{"id":"T193","span":{"begin":432,"end":566},"obj":"Sentence"},{"id":"T194","span":{"begin":567,"end":860},"obj":"Sentence"},{"id":"T195","span":{"begin":861,"end":1016},"obj":"Sentence"},{"id":"T196","span":{"begin":1017,"end":1101},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Human coronaviruses bind to specific receptors on host cells. Binding of SARS‐CoV‐2 and SARS‐CoV to ACE2 is required for initiation of infection. There is some preliminary evidence for ACE2 expression on corneal and conjunctival cells, but most of the other receptors known to bind to coronaviruses appear to be found only on fibroblasts and dendritic cells that are found under the surface epithelial layers of the ocular surface. Lactoferrin in tears can inhibit coronavirus binding, as may decoy receptors such as 9‐O‐acetylated sialic acid on tear glycoproteins. Animal studies on human coronaviruses have not focused on the role of ocular surface binding in the infection process, apart from one study that showed conjunctival infection could lead to mild signs and symptoms of pneumonia, but only transient association of SARS‐CoV‐2 with the conjunctiva. While coronavirus infection is rarely associated with conjunctivitis, there have been occasional findings of conjunctivitis in confirmed COVID‐19 patients. Similarly, coronaviruses have been rarely isolated from tears or conjunctival swabs."}