PMC:7272971 / 28132-29233 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue	tao:has_database_id
889	100-104	Gene	denotes	ACE2	Gene:59272
890	185-189	Gene	denotes	ACE2	Gene:59272
891	0-5	Species	denotes	Human	Tax:9606
892	6-19	Species	denotes	coronaviruses	Tax:11118
893	73-83	Species	denotes	SARS‐CoV‐2	Tax:2697049
894	88-96	Species	denotes	SARS‐CoV	Tax:694009
895	285-298	Species	denotes	coronaviruses	Tax:11118
896	465-476	Species	denotes	coronavirus	Tax:11118
897	585-590	Species	denotes	human	Tax:9606
898	591-604	Species	denotes	coronaviruses	Tax:11118
899	828-838	Species	denotes	SARS‐CoV‐2	Tax:2697049
900	1007-1015	Species	denotes	patients	Tax:9606
901	1028-1041	Species	denotes	coronaviruses	Tax:11118
902	520-543	Chemical	denotes	‐acetylated sialic acid
903	121-144	Disease	denotes	initiation of infection	MESH:D007239
904	204-211	Disease	denotes	corneal	MESH:D003316
905	667-676	Disease	denotes	infection	MESH:D007239
906	719-741	Disease	denotes	conjunctival infection	MESH:D003229
907	783-792	Disease	denotes	pneumonia	MESH:D011014
908	867-888	Disease	denotes	coronavirus infection	MESH:D018352
909	915-929	Disease	denotes	conjunctivitis	MESH:D003231
910	970-984	Disease	denotes	conjunctivitis	MESH:D003231
911	998-1006	Disease	denotes	COVID‐19	MESH:C000657245

Id	Subject	Object	Predicate	Lexical cue	fma_id
T255	55-60	Body_part	denotes	cells	http://purl.org/sig/ont/fma/fma68646
T256	229-234	Body_part	denotes	cells	http://purl.org/sig/ont/fma/fma68646
T257	326-337	Body_part	denotes	fibroblasts	http://purl.org/sig/ont/fma/fma63877
T258	342-357	Body_part	denotes	dendritic cells	http://purl.org/sig/ont/fma/fma273565
T259	352-357	Body_part	denotes	cells	http://purl.org/sig/ont/fma/fma68646
T260	447-452	Body_part	denotes	tears	http://purl.org/sig/ont/fma/fma59756
T261	547-551	Body_part	denotes	tear	http://purl.org/sig/ont/fma/fma59756
T262	552-565	Body_part	denotes	glycoproteins	http://purl.org/sig/ont/fma/fma62925
T263	848-859	Body_part	denotes	conjunctiva	http://purl.org/sig/ont/fma/fma59011
T264	1073-1078	Body_part	denotes	tears	http://purl.org/sig/ont/fma/fma59756

Id	Subject	Object	Predicate	Lexical cue	uberon_id
T98	848-859	Body_part	denotes	conjunctiva	http://purl.obolibrary.org/obo/UBERON_0001811

Id	Subject	Object	Predicate	Lexical cue	hp_id
T78	783-792	Phenotype	denotes	pneumonia	http://purl.obolibrary.org/obo/HP_0002090
T79	915-929	Phenotype	denotes	conjunctivitis	http://purl.obolibrary.org/obo/HP_0000509
T80	970-984	Phenotype	denotes	conjunctivitis	http://purl.obolibrary.org/obo/HP_0000509

Id	Subject	Object	Predicate	Lexical cue	mondo_id
T202	73-77	Disease	denotes	SARS	http://purl.obolibrary.org/obo/MONDO_0005091
T203	88-92	Disease	denotes	SARS	http://purl.obolibrary.org/obo/MONDO_0005091
T204	135-144	Disease	denotes	infection	http://purl.obolibrary.org/obo/MONDO_0005550
T205	667-676	Disease	denotes	infection	http://purl.obolibrary.org/obo/MONDO_0005550
T206	732-741	Disease	denotes	infection	http://purl.obolibrary.org/obo/MONDO_0005550
T207	783-792	Disease	denotes	pneumonia	http://purl.obolibrary.org/obo/MONDO_0005249
T208	828-832	Disease	denotes	SARS	http://purl.obolibrary.org/obo/MONDO_0005091
T209	879-888	Disease	denotes	infection	http://purl.obolibrary.org/obo/MONDO_0005550
T210	915-929	Disease	denotes	conjunctivitis	http://purl.obolibrary.org/obo/MONDO_0003799
T211	970-984	Disease	denotes	conjunctivitis	http://purl.obolibrary.org/obo/MONDO_0003799
T212	998-1006	Disease	denotes	COVID‐19	http://purl.obolibrary.org/obo/MONDO_0100096

Id	Subject	Object	Predicate	Lexical cue
T342	0-5	http://purl.obolibrary.org/obo/NCBITaxon_9606	denotes	Human
T343	55-60	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T344	229-234	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T345	326-337	http://purl.obolibrary.org/obo/CL_0000057	denotes	fibroblasts
T346	342-357	http://purl.obolibrary.org/obo/CL_0000451	denotes	dendritic cells
T347	391-401	http://purl.obolibrary.org/obo/CL_0000066	denotes	epithelial
T348	567-573	http://purl.obolibrary.org/obo/NCBITaxon_33208	denotes	Animal
T349	585-590	http://purl.obolibrary.org/obo/NCBITaxon_9606	denotes	human
T350	614-621	http://purl.obolibrary.org/obo/CLO_0009985	denotes	focused
T351	848-859	http://purl.obolibrary.org/obo/UBERON_0001811	denotes	conjunctiva
T352	848-859	http://www.ebi.ac.uk/efo/EFO_0000374	denotes	conjunctiva

Id	Subject	Object	Predicate	Lexical cue	chebi_id
T72	532-543	Chemical	denotes	sialic acid	http://purl.obolibrary.org/obo/CHEBI_26667
T73	539-543	Chemical	denotes	acid	http://purl.obolibrary.org/obo/CHEBI_37527
T74	552-565	Chemical	denotes	glycoproteins	http://purl.obolibrary.org/obo/CHEBI_17089

Id	Subject	Object	Predicate	Lexical cue
T190	0-61	Sentence	denotes	Human coronaviruses bind to specific receptors on host cells.
T191	62-145	Sentence	denotes	Binding of SARS‐CoV‐2 and SARS‐CoV to ACE2 is required for initiation of infection.
T192	146-431	Sentence	denotes	There is some preliminary evidence for ACE2 expression on corneal and conjunctival cells, but most of the other receptors known to bind to coronaviruses appear to be found only on fibroblasts and dendritic cells that are found under the surface epithelial layers of the ocular surface.
T193	432-566	Sentence	denotes	Lactoferrin in tears can inhibit coronavirus binding, as may decoy receptors such as 9‐O‐acetylated sialic acid on tear glycoproteins.
T194	567-860	Sentence	denotes	Animal studies on human coronaviruses have not focused on the role of ocular surface binding in the infection process, apart from one study that showed conjunctival infection could lead to mild signs and symptoms of pneumonia, but only transient association of SARS‐CoV‐2 with the conjunctiva.
T195	861-1016	Sentence	denotes	While coronavirus infection is rarely associated with conjunctivitis, there have been occasional findings of conjunctivitis in confirmed COVID‐19 patients.
T196	1017-1101	Sentence	denotes	Similarly, coronaviruses have been rarely isolated from tears or conjunctival swabs.