PMC:7271924 / 14968-15607
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7271924","sourcedb":"PMC","sourceid":"7271924","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7271924","text":"Figure 3 Bacterial binding to various receptors, e.g., Toll-like receptors 2 and 4 (TLR2 and 4), as well as complement receptors, leads to protein arginine deiminase 4 (PAD4) activation, followed by chromatin decondensation, hypercitrullination of histones 3 and 4 in the nucleus, and nuclear membrane disruption. Granules also release lactoferrin. Neutrophil Extracellular Traps (NETs) and their protein constituents (including lactoferrin) are released from the neutrophil. Adapted from Jorch and Kubes (142) and Law and Gray (143). Bacteria are expelled and trapped in the NETs. Diagram created with BioRender (https://biorender.com/).","divisions":[{"label":"label","span":{"begin":0,"end":8}}],"tracks":[{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T247","span":{"begin":85,"end":89},"obj":"PR:000001153"},{"id":"T248","span":{"begin":170,"end":174},"obj":"PR:O88807"},{"id":"T249","span":{"begin":200,"end":209},"obj":"GO:0000785;GO:0006338"},{"id":"T250","span":{"begin":210,"end":224},"obj":"GO:0006338"},{"id":"T251","span":{"begin":249,"end":257},"obj":"CHEBI:15358;CHEBI:15358"},{"id":"T252","span":{"begin":273,"end":280},"obj":"GO:0005634"},{"id":"T253","span":{"begin":286,"end":302},"obj":"GO:0031965"},{"id":"T254","span":{"begin":350,"end":360},"obj":"CL:0000775"},{"id":"T255","span":{"begin":361,"end":374},"obj":"GO:0005576"},{"id":"T256","span":{"begin":465,"end":475},"obj":"CL:0000775"},{"id":"T98033","span":{"begin":85,"end":89},"obj":"PR:000001153"},{"id":"T2481","span":{"begin":170,"end":174},"obj":"PR:O88807"},{"id":"T31813","span":{"begin":200,"end":209},"obj":"GO:0000785;GO:0006338"},{"id":"T18232","span":{"begin":210,"end":224},"obj":"GO:0006338"},{"id":"T86315","span":{"begin":249,"end":257},"obj":"CHEBI:15358;CHEBI:15358"},{"id":"T88880","span":{"begin":273,"end":280},"obj":"GO:0005634"},{"id":"T7872","span":{"begin":286,"end":302},"obj":"GO:0031965"},{"id":"T65967","span":{"begin":350,"end":360},"obj":"CL:0000775"},{"id":"T66338","span":{"begin":361,"end":374},"obj":"GO:0005576"},{"id":"T6335","span":{"begin":465,"end":475},"obj":"CL:0000775"}],"attributes":[{"subj":"T247","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T248","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T249","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T250","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T251","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T252","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T253","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T254","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T255","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T256","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T98033","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T2481","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T31813","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T18232","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T86315","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T88880","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T7872","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T65967","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T66338","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T6335","pred":"source","obj":"LitCovid-PMC-OGER-BB"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"244","span":{"begin":56,"end":83},"obj":"Gene"},{"id":"338","span":{"begin":170,"end":174},"obj":"Gene"},{"id":"339","span":{"begin":337,"end":348},"obj":"Gene"},{"id":"340","span":{"begin":430,"end":441},"obj":"Gene"},{"id":"341","span":{"begin":140,"end":168},"obj":"Gene"},{"id":"342","span":{"begin":294,"end":302},"obj":"Gene"},{"id":"343","span":{"begin":226,"end":245},"obj":"Disease"}],"attributes":[{"id":"A244","pred":"tao:has_database_id","subj":"244","obj":"Gene:7097"},{"id":"A338","pred":"tao:has_database_id","subj":"338","obj":"Gene:23569"},{"id":"A339","pred":"tao:has_database_id","subj":"339","obj":"Gene:280846"},{"id":"A340","pred":"tao:has_database_id","subj":"340","obj":"Gene:280846"},{"id":"A341","pred":"tao:has_database_id","subj":"341","obj":"Gene:23569"},{"id":"A342","pred":"tao:has_database_id","subj":"342","obj":"Gene:43740571"},{"subj":"244","pred":"source","obj":"LitCovid-PubTator"},{"subj":"338","pred":"source","obj":"LitCovid-PubTator"},{"subj":"339","pred":"source","obj":"LitCovid-PubTator"},{"subj":"340","pred":"source","obj":"LitCovid-PubTator"},{"subj":"341","pred":"source","obj":"LitCovid-PubTator"},{"subj":"342","pred":"source","obj":"LitCovid-PubTator"},{"subj":"343","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T189","span":{"begin":140,"end":147},"obj":"Body_part"},{"id":"T190","span":{"begin":148,"end":156},"obj":"Body_part"},{"id":"T191","span":{"begin":200,"end":209},"obj":"Body_part"},{"id":"T192","span":{"begin":249,"end":257},"obj":"Body_part"},{"id":"T193","span":{"begin":286,"end":302},"obj":"Body_part"},{"id":"T194","span":{"begin":350,"end":360},"obj":"Body_part"},{"id":"T195","span":{"begin":398,"end":405},"obj":"Body_part"},{"id":"T196","span":{"begin":465,"end":475},"obj":"Body_part"}],"attributes":[{"id":"A189","pred":"fma_id","subj":"T189","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A190","pred":"fma_id","subj":"T190","obj":"http://purl.org/sig/ont/fma/fma82763"},{"id":"A191","pred":"fma_id","subj":"T191","obj":"http://purl.org/sig/ont/fma/fma67526"},{"id":"A192","pred":"fma_id","subj":"T192","obj":"http://purl.org/sig/ont/fma/fma74413"},{"id":"A193","pred":"fma_id","subj":"T193","obj":"http://purl.org/sig/ont/fma/fma63888"},{"id":"A194","pred":"fma_id","subj":"T194","obj":"http://purl.org/sig/ont/fma/fma62860"},{"id":"A195","pred":"fma_id","subj":"T195","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A196","pred":"fma_id","subj":"T196","obj":"http://purl.org/sig/ont/fma/fma62860"},{"subj":"T189","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T190","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T191","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T192","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T193","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T194","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T195","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T196","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T214","span":{"begin":85,"end":89},"obj":"http://purl.obolibrary.org/obo/CLO_0050768"},{"id":"T215","span":{"begin":176,"end":186},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T216","span":{"begin":294,"end":302},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T217","span":{"begin":536,"end":544},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_2"}],"attributes":[{"subj":"T214","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T215","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T216","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T217","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T187","span":{"begin":140,"end":147},"obj":"Chemical"},{"id":"T188","span":{"begin":148,"end":156},"obj":"Chemical"},{"id":"T191","span":{"begin":273,"end":280},"obj":"Chemical"},{"id":"T192","span":{"begin":398,"end":405},"obj":"Chemical"}],"attributes":[{"id":"A187","pred":"chebi_id","subj":"T187","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A188","pred":"chebi_id","subj":"T188","obj":"http://purl.obolibrary.org/obo/CHEBI_16467"},{"id":"A189","pred":"chebi_id","subj":"T188","obj":"http://purl.obolibrary.org/obo/CHEBI_29016"},{"id":"A190","pred":"chebi_id","subj":"T188","obj":"http://purl.obolibrary.org/obo/CHEBI_32696"},{"id":"A191","pred":"chebi_id","subj":"T191","obj":"http://purl.obolibrary.org/obo/CHEBI_33252"},{"id":"A192","pred":"chebi_id","subj":"T192","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"subj":"T187","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T188","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T191","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T192","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T120","span":{"begin":0,"end":314},"obj":"Sentence"},{"id":"T121","span":{"begin":315,"end":349},"obj":"Sentence"},{"id":"T122","span":{"begin":350,"end":476},"obj":"Sentence"},{"id":"T123","span":{"begin":477,"end":535},"obj":"Sentence"},{"id":"T124","span":{"begin":536,"end":582},"obj":"Sentence"},{"id":"T125","span":{"begin":583,"end":639},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T120","pred":"source","obj":"LitCovid-sentences"},{"subj":"T121","pred":"source","obj":"LitCovid-sentences"},{"subj":"T122","pred":"source","obj":"LitCovid-sentences"},{"subj":"T123","pred":"source","obj":"LitCovid-sentences"},{"subj":"T124","pred":"source","obj":"LitCovid-sentences"},{"subj":"T125","pred":"source","obj":"LitCovid-sentences"}]},{"project":"MyTest","denotations":[{"id":"32574271-28267716-34514674","span":{"begin":507,"end":510},"obj":"28267716"},{"id":"32574271-29299029-34514675","span":{"begin":530,"end":533},"obj":"29299029"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"attributes":[{"subj":"32574271-28267716-34514674","pred":"source","obj":"MyTest"},{"subj":"32574271-29299029-34514675","pred":"source","obj":"MyTest"}]},{"project":"TEST0","denotations":[{"id":"32574271-30-37-2882266","span":{"begin":507,"end":510},"obj":"[\"28267716\"]"},{"id":"32574271-53-60-2882267","span":{"begin":530,"end":533},"obj":"[\"29299029\"]"}],"attributes":[{"subj":"32574271-30-37-2882266","pred":"source","obj":"TEST0"},{"subj":"32574271-53-60-2882267","pred":"source","obj":"TEST0"}]},{"project":"2_test","denotations":[{"id":"32574271-28267716-34514674","span":{"begin":507,"end":510},"obj":"28267716"},{"id":"32574271-29299029-34514675","span":{"begin":530,"end":533},"obj":"29299029"}],"attributes":[{"subj":"32574271-28267716-34514674","pred":"source","obj":"2_test"},{"subj":"32574271-29299029-34514675","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PMC-OGER-BB","color":"#aa93ec","default":true},{"id":"LitCovid-PubTator","color":"#95ec93"},{"id":"LitCovid-PD-FMA-UBERON","color":"#ec93af"},{"id":"LitCovid-PD-CLO","color":"#93c9ec"},{"id":"LitCovid-PD-CHEBI","color":"#e3ec93"},{"id":"LitCovid-sentences","color":"#da93ec"},{"id":"MyTest","color":"#93ecc0"},{"id":"TEST0","color":"#eca693"},{"id":"2_test","color":"#9399ec"}]}]}}