PMC:7264098 / 14565-16505 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7264098","sourcedb":"PMC","sourceid":"7264098","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7264098","text":"Table 1 Selected clinical studies using stem cells for the treatment of SARS-CoV-2 infection.\nCell type Dosage Number of patients Outcome Stage of study Reference or NCT numbers#\nMSCs (tissue source unspecified) Single dose of 1 × 106 cells per kg, IV 7 patients with severe COVID-19 pneumonia Regulation of inflammatory response (Decreased plasma C-reaction protein, reduced cytokine-secreting immune cells, reduced TNF-α, increased IL-10 and VEGF) Complete Leng et al., 2020\nAdipose tissue-derived MSCs Two serial doses of 1.5 × 106 cells per kg, IV Estimated: 100 patients N/A Phase 2; Not yet recruiting NCT04348461\nDental pulp stem cells 3 × 107 cells IV on day 1, 4, and 7 Estimated: 20 patients N/A Phase 1 clinical trial; recruiting NCT04336254\nDental pulp stem cells 1 × 106 cells per kg IV on day 1, 3, and 7 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