PMC:7247521 / 45480-46732 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue	tao:has_database_id
818	292-298	Gene	denotes	MIR183	Gene:406959
819	303-316	Gene	denotes	MIR130A/B/301	Gene:406919
820	450-454	Gene	denotes	CDKs	Gene:1022
821	694-698	Gene	denotes	CDK7	Gene:1022
822	817-821	Gene	denotes	CDK7	Gene:1022
823	201-207	Gene	denotes	MIR183	Gene:406959
824	227-231	Species	denotes	H1N1	Tax:114727
825	232-240	Species	denotes	patients	Tax:9606
826	533-538	Species	denotes	human	Tax:9606
827	564-585	Species	denotes	human cytomegalovirus	Tax:10359
828	632-637	Species	denotes	HSV-2	Tax:10310
829	1021-1025	Species	denotes	H1N1	Tax:114727
830	587-591	Species	denotes	HCMV	Tax:10359
831	940-951	Chemical	denotes	cholesterol	MESH:D002784
832	93-108	Disease	denotes	virus infection	MESH:D001102
833	405-413	Disease	denotes	COVID-19	MESH:C000657245
834	539-562	Disease	denotes	HIV-1, papillomaviruses	MESH:D015658
835	796-804	Disease	denotes	COVID-19	MESH:C000657245
836	971-983	Disease	denotes	inflammation	MESH:D007249
837	1036-1051	Disease	denotes	virus infection	MESH:D001102
838	1120-1123	Disease	denotes	XCH
839	1236-1251	Disease	denotes	virus infection	MESH:D001102

Id	Subject	Object	Predicate	Lexical cue
T687	26-30	GO:0018995	denotes	host
T688	40-49	SO:0000276	denotes	microRNAs
T689	51-57	SO:0000276	denotes	miRNAs
T690	79-89	GO:0065007	denotes	regulation
T691	93-98	NCBITaxon:10239	denotes	virus
T692	175-181	PR:000010182	denotes	MIR301
T693	201-207	PR:000010182	denotes	MIR183
T694	380-389	SO:0000646	denotes	microRNAs
T695	405-413	SP_7	denotes	COVID-19
T696	491-502	GO:0006260	denotes	replication
T697	514-521	NCBITaxon:10239	denotes	viruses
T698	533-538	SP_6;NCBITaxon:9606	denotes	human
T699	542-543	NCBITaxon:10376	denotes	-
T700	546-562	NCBITaxon:9258	denotes	papillomaviruses
T701	564-569	SP_6;NCBITaxon:9606	denotes	human
T702	570-585	NCBITaxon:10358	denotes	cytomegalovirus
T703	587-591	NCBITaxon:10358	denotes	HCMV
T704	594-600	NCBITaxon:9606	denotes	herpes
T705	601-614	NCBITaxon:10376	denotes	simplex virus
T706	616-619	NCBITaxon:10298	denotes	HSV
T707	632-635	NCBITaxon:10298	denotes	HSV
T708	694-698	PR:000005265	denotes	CDK7
T709	772-780	GO:0065007	denotes	regulate
T710	781-792	GO:0006260	denotes	replication
T711	796-804	SP_7	denotes	COVID-19
T712	805-812	NCBITaxon:10239	denotes	viruses
T713	817-821	PR:000005265	denotes	CDK7
T714	831-841	GO:0007049	denotes	cell cycle
T715	931-939	GO:0065007	denotes	regulate
T716	940-951	CHEBI:16113;CHEBI:16113;GO:0042632	denotes	cholesterol
T717	952-963	GO:0042632	denotes	homeostasis
T718	1004-1013	GO:0065007	denotes	regulated
T719	1026-1035	NCBITaxon:7719	denotes	influenza
T720	1036-1041	NCBITaxon:10239	denotes	virus
T721	1166-1174	GO:0065007	denotes	regulate
T722	1175-1184	GO:0008152	denotes	metabolic
T723	1227-1235	SP_7	denotes	COVID-19
T724	1236-1241	NCBITaxon:10239	denotes	virus

Id	Subject	Object	Predicate	Lexical cue	fma_id
T188	539-542	Body_part	denotes	HIV	http://purl.org/sig/ont/fma/fma278683
T189	831-835	Body_part	denotes	cell	http://purl.org/sig/ont/fma/fma68646
T190	846-849	Body_part	denotes	RNA	http://purl.org/sig/ont/fma/fma67095

Id	Subject	Object	Predicate	Lexical cue	mondo_id
T104	93-108	Disease	denotes	virus infection	http://purl.obolibrary.org/obo/MONDO_0005108
T105	99-108	Disease	denotes	infection	http://purl.obolibrary.org/obo/MONDO_0005550
T106	405-413	Disease	denotes	COVID-19	http://purl.obolibrary.org/obo/MONDO_0100096
T107	594-608	Disease	denotes	herpes simplex	http://purl.obolibrary.org/obo/MONDO_0004609
T108	796-804	Disease	denotes	COVID-19	http://purl.obolibrary.org/obo/MONDO_0100096
T109	971-983	Disease	denotes	inflammation	http://purl.obolibrary.org/obo/MONDO_0021166
T110	1021-1035	Disease	denotes	H1N1 influenza	http://purl.obolibrary.org/obo/MONDO_0005460
T111	1026-1035	Disease	denotes	influenza	http://purl.obolibrary.org/obo/MONDO_0005812
T112	1036-1051	Disease	denotes	virus infection	http://purl.obolibrary.org/obo/MONDO_0005108
T113	1042-1051	Disease	denotes	infection	http://purl.obolibrary.org/obo/MONDO_0005550
T114	1227-1235	Disease	denotes	COVID-19	http://purl.obolibrary.org/obo/MONDO_0100096
T115	1236-1251	Disease	denotes	virus infection	http://purl.obolibrary.org/obo/MONDO_0005108
T116	1242-1251	Disease	denotes	infection	http://purl.obolibrary.org/obo/MONDO_0005550

Id	Subject	Object	Predicate	Lexical cue
T407	3-6	http://purl.obolibrary.org/obo/CLO_0051582	denotes	has
T408	93-98	http://purl.obolibrary.org/obo/NCBITaxon_10239	denotes	virus
T409	110-112	http://purl.obolibrary.org/obo/CLO_0053794	denotes	41
T410	115-116	http://purl.obolibrary.org/obo/CLO_0001020	denotes	A
T411	311-312	http://purl.obolibrary.org/obo/CLO_0001021	denotes	B
T412	414-422	http://purl.obolibrary.org/obo/CLO_0001658	denotes	activity
T413	467-468	http://purl.obolibrary.org/obo/CLO_0001020	denotes	a
T414	514-521	http://purl.obolibrary.org/obo/NCBITaxon_10239	denotes	viruses
T415	533-538	http://purl.obolibrary.org/obo/NCBITaxon_9606	denotes	human
T416	564-569	http://purl.obolibrary.org/obo/NCBITaxon_9606	denotes	human
T417	609-614	http://purl.obolibrary.org/obo/NCBITaxon_10239	denotes	virus
T418	805-812	http://purl.obolibrary.org/obo/NCBITaxon_10239	denotes	viruses
T419	831-835	http://purl.obolibrary.org/obo/GO_0005623	denotes	cell
T420	889-890	http://purl.obolibrary.org/obo/CLO_0001020	denotes	a
T421	1036-1041	http://purl.obolibrary.org/obo/NCBITaxon_10239	denotes	virus
T422	1053-1055	http://purl.obolibrary.org/obo/CLO_0053799	denotes	45
T423	1236-1241	http://purl.obolibrary.org/obo/NCBITaxon_10239	denotes	virus

Id	Subject	Object	Predicate	Lexical cue	chebi_id
T359	861-863	Chemical	denotes	II	http://purl.obolibrary.org/obo/CHEBI_74067
T360	940-951	Chemical	denotes	cholesterol	http://purl.obolibrary.org/obo/CHEBI_16113

Id	Subject	Object	Predicate	Lexical cue
T143	79-89	http://purl.obolibrary.org/obo/GO_0065007	denotes	regulation
T144	831-841	http://purl.obolibrary.org/obo/GO_0007049	denotes	cell cycle
T145	864-877	http://purl.obolibrary.org/obo/GO_0006351	denotes	transcription
T146	940-963	http://purl.obolibrary.org/obo/GO_0042632	denotes	cholesterol homeostasis
T147	952-963	http://purl.obolibrary.org/obo/GO_0042592	denotes	homeostasis
T148	971-983	http://purl.obolibrary.org/obo/GO_0006954	denotes	inflammation

Id	Subject	Object	Predicate	Lexical cue
T336	0-114	Sentence	denotes	It has been reported that host cellular microRNAs (miRNAs) are involved in the regulation of virus infection [41].
T337	115-246	Sentence	denotes	A previous study discovered that significantly up-regulated MIR301 and down-regulated MIR183/130B were found in H1N1 patients [42].
T338	247-436	Sentence	denotes	Consistent with these results, we found that MIR183 and MIR130A/B/301 are related to four functional units of QFPD, indicating these microRNAs may exert anti−COVID-19 activity through QFPD.
T339	437-646	Sentence	denotes	In addition, CDKs have played a role in the efficient replication of various viruses, including human HIV-1, papillomaviruses, human cytomegalovirus (HCMV), herpes simplex virus (HSV) type 1 and HSV-2 [43,44].
T340	647-878	Sentence	denotes	In agreement with these results, we found that CDK7 was predicted to enriched in the five formulae, suggesting that QFPD may regulate replication of COVID-19 viruses via CDK7 mediated cell cycle and RNA polymerase II transcription.
T341	879-1057	Sentence	denotes	Recently, a previous study showed that LXR known to regulate cholesterol homeostasis during inflammation were differentially regulated during H1N1 influenza virus infection [45].
T342	1058-1252	Sentence	denotes	Based on our results that LXR was associated with MSXG, SGMH, XCH, WLS targets, we speculated that QFPD can regulate metabolic and pro-inflammatory processes to counter COVID-19 virus infection.

Id	Subject	Object	Predicate	Lexical cue
32554251-23962477-6393510	110-112	23962477	denotes	41
32554251-12097601-6393511	639-641	12097601	denotes	43
32554251-23153050-6393512	1053-1055	23153050	denotes	45