PMC:7247521 / 45480-46732 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"818","span":{"begin":292,"end":298},"obj":"Gene"},{"id":"819","span":{"begin":303,"end":316},"obj":"Gene"},{"id":"820","span":{"begin":450,"end":454},"obj":"Gene"},{"id":"821","span":{"begin":694,"end":698},"obj":"Gene"},{"id":"822","span":{"begin":817,"end":821},"obj":"Gene"},{"id":"823","span":{"begin":201,"end":207},"obj":"Gene"},{"id":"824","span":{"begin":227,"end":231},"obj":"Species"},{"id":"825","span":{"begin":232,"end":240},"obj":"Species"},{"id":"826","span":{"begin":533,"end":538},"obj":"Species"},{"id":"827","span":{"begin":564,"end":585},"obj":"Species"},{"id":"828","span":{"begin":632,"end":637},"obj":"Species"},{"id":"829","span":{"begin":1021,"end":1025},"obj":"Species"},{"id":"830","span":{"begin":587,"end":591},"obj":"Species"},{"id":"831","span":{"begin":940,"end":951},"obj":"Chemical"},{"id":"832","span":{"begin":93,"end":108},"obj":"Disease"},{"id":"833","span":{"begin":405,"end":413},"obj":"Disease"},{"id":"834","span":{"begin":539,"end":562},"obj":"Disease"},{"id":"835","span":{"begin":796,"end":804},"obj":"Disease"},{"id":"836","span":{"begin":971,"end":983},"obj":"Disease"},{"id":"837","span":{"begin":1036,"end":1051},"obj":"Disease"},{"id":"838","span":{"begin":1120,"end":1123},"obj":"Disease"},{"id":"839","span":{"begin":1236,"end":1251},"obj":"Disease"}],"attributes":[{"id":"A818","pred":"tao:has_database_id","subj":"818","obj":"Gene:406959"},{"id":"A819","pred":"tao:has_database_id","subj":"819","obj":"Gene:406919"},{"id":"A820","pred":"tao:has_database_id","subj":"820","obj":"Gene:1022"},{"id":"A821","pred":"tao:has_database_id","subj":"821","obj":"Gene:1022"},{"id":"A822","pred":"tao:has_database_id","subj":"822","obj":"Gene:1022"},{"id":"A823","pred":"tao:has_database_id","subj":"823","obj":"Gene:406959"},{"id":"A824","pred":"tao:has_database_id","subj":"824","obj":"Tax:114727"},{"id":"A825","pred":"tao:has_database_id","subj":"825","obj":"Tax:9606"},{"id":"A826","pred":"tao:has_database_id","subj":"826","obj":"Tax:9606"},{"id":"A827","pred":"tao:has_database_id","subj":"827","obj":"Tax:10359"},{"id":"A828","pred":"tao:has_database_id","subj":"828","obj":"Tax:10310"},{"id":"A829","pred":"tao:has_database_id","subj":"829","obj":"Tax:114727"},{"id":"A830","pred":"tao:has_database_id","subj":"830","obj":"Tax:10359"},{"id":"A831","pred":"tao:has_database_id","subj":"831","obj":"MESH:D002784"},{"id":"A832","pred":"tao:has_database_id","subj":"832","obj":"MESH:D001102"},{"id":"A833","pred":"tao:has_database_id","subj":"833","obj":"MESH:C000657245"},{"id":"A834","pred":"tao:has_database_id","subj":"834","obj":"MESH:D015658"},{"id":"A835","pred":"tao:has_database_id","subj":"835","obj":"MESH:C000657245"},{"id":"A836","pred":"tao:has_database_id","subj":"836","obj":"MESH:D007249"},{"id":"A837","pred":"tao:has_database_id","subj":"837","obj":"MESH:D001102"},{"id":"A839","pred":"tao:has_database_id","subj":"839","obj":"MESH:D001102"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"It has been reported that host cellular microRNAs (miRNAs) are involved in the regulation of virus infection [41]. A previous study discovered that significantly up-regulated MIR301 and down-regulated MIR183/130B were found in H1N1 patients [42]. Consistent with these results, we found that MIR183 and MIR130A/B/301 are related to four functional units of QFPD, indicating these microRNAs may exert anti−COVID-19 activity through QFPD. In addition, CDKs have played a role in the efficient replication of various viruses, including human HIV-1, papillomaviruses, human cytomegalovirus (HCMV), herpes simplex virus (HSV) type 1 and HSV-2 [43,44]. In agreement with these results, we found that CDK7 was predicted to enriched in the five formulae, suggesting that QFPD may regulate replication of COVID-19 viruses via CDK7 mediated cell cycle and RNA polymerase II transcription. Recently, a previous study showed that LXR known to regulate cholesterol homeostasis during inflammation were differentially regulated during H1N1 influenza virus infection [45]. Based on our results that LXR was associated with MSXG, SGMH, XCH, WLS targets, we speculated that QFPD can regulate metabolic and pro-inflammatory processes to counter COVID-19 virus infection."}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T687","span":{"begin":26,"end":30},"obj":"GO:0018995"},{"id":"T688","span":{"begin":40,"end":49},"obj":"SO:0000276"},{"id":"T689","span":{"begin":51,"end":57},"obj":"SO:0000276"},{"id":"T690","span":{"begin":79,"end":89},"obj":"GO:0065007"},{"id":"T691","span":{"begin":93,"end":98},"obj":"NCBITaxon:10239"},{"id":"T692","span":{"begin":175,"end":181},"obj":"PR:000010182"},{"id":"T693","span":{"begin":201,"end":207},"obj":"PR:000010182"},{"id":"T694","span":{"begin":380,"end":389},"obj":"SO:0000646"},{"id":"T695","span":{"begin":405,"end":413},"obj":"SP_7"},{"id":"T696","span":{"begin":491,"end":502},"obj":"GO:0006260"},{"id":"T697","span":{"begin":514,"end":521},"obj":"NCBITaxon:10239"},{"id":"T698","span":{"begin":533,"end":538},"obj":"SP_6;NCBITaxon:9606"},{"id":"T699","span":{"begin":542,"end":543},"obj":"NCBITaxon:10376"},{"id":"T700","span":{"begin":546,"end":562},"obj":"NCBITaxon:9258"},{"id":"T701","span":{"begin":564,"end":569},"obj":"SP_6;NCBITaxon:9606"},{"id":"T702","span":{"begin":570,"end":585},"obj":"NCBITaxon:10358"},{"id":"T703","span":{"begin":587,"end":591},"obj":"NCBITaxon:10358"},{"id":"T704","span":{"begin":594,"end":600},"obj":"NCBITaxon:9606"},{"id":"T705","span":{"begin":601,"end":614},"obj":"NCBITaxon:10376"},{"id":"T706","span":{"begin":616,"end":619},"obj":"NCBITaxon:10298"},{"id":"T707","span":{"begin":632,"end":635},"obj":"NCBITaxon:10298"},{"id":"T708","span":{"begin":694,"end":698},"obj":"PR:000005265"},{"id":"T709","span":{"begin":772,"end":780},"obj":"GO:0065007"},{"id":"T710","span":{"begin":781,"end":792},"obj":"GO:0006260"},{"id":"T711","span":{"begin":796,"end":804},"obj":"SP_7"},{"id":"T712","span":{"begin":805,"end":812},"obj":"NCBITaxon:10239"},{"id":"T713","span":{"begin":817,"end":821},"obj":"PR:000005265"},{"id":"T714","span":{"begin":831,"end":841},"obj":"GO:0007049"},{"id":"T715","span":{"begin":931,"end":939},"obj":"GO:0065007"},{"id":"T716","span":{"begin":940,"end":951},"obj":"CHEBI:16113;CHEBI:16113;GO:0042632"},{"id":"T717","span":{"begin":952,"end":963},"obj":"GO:0042632"},{"id":"T718","span":{"begin":1004,"end":1013},"obj":"GO:0065007"},{"id":"T719","span":{"begin":1026,"end":1035},"obj":"NCBITaxon:7719"},{"id":"T720","span":{"begin":1036,"end":1041},"obj":"NCBITaxon:10239"},{"id":"T721","span":{"begin":1166,"end":1174},"obj":"GO:0065007"},{"id":"T722","span":{"begin":1175,"end":1184},"obj":"GO:0008152"},{"id":"T723","span":{"begin":1227,"end":1235},"obj":"SP_7"},{"id":"T724","span":{"begin":1236,"end":1241},"obj":"NCBITaxon:10239"}],"text":"It has been reported that host cellular microRNAs (miRNAs) are involved in the regulation of virus infection [41]. A previous study discovered that significantly up-regulated MIR301 and down-regulated MIR183/130B were found in H1N1 patients [42]. Consistent with these results, we found that MIR183 and MIR130A/B/301 are related to four functional units of QFPD, indicating these microRNAs may exert anti−COVID-19 activity through QFPD. In addition, CDKs have played a role in the efficient replication of various viruses, including human HIV-1, papillomaviruses, human cytomegalovirus (HCMV), herpes simplex virus (HSV) type 1 and HSV-2 [43,44]. In agreement with these results, we found that CDK7 was predicted to enriched in the five formulae, suggesting that QFPD may regulate replication of COVID-19 viruses via CDK7 mediated cell cycle and RNA polymerase II transcription. Recently, a previous study showed that LXR known to regulate cholesterol homeostasis during inflammation were differentially regulated during H1N1 influenza virus infection [45]. Based on our results that LXR was associated with MSXG, SGMH, XCH, WLS targets, we speculated that QFPD can regulate metabolic and pro-inflammatory processes to counter COVID-19 virus infection."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T188","span":{"begin":539,"end":542},"obj":"Body_part"},{"id":"T189","span":{"begin":831,"end":835},"obj":"Body_part"},{"id":"T190","span":{"begin":846,"end":849},"obj":"Body_part"}],"attributes":[{"id":"A188","pred":"fma_id","subj":"T188","obj":"http://purl.org/sig/ont/fma/fma278683"},{"id":"A189","pred":"fma_id","subj":"T189","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A190","pred":"fma_id","subj":"T190","obj":"http://purl.org/sig/ont/fma/fma67095"}],"text":"It has been reported that host cellular microRNAs (miRNAs) are involved in the regulation of virus infection [41]. A previous study discovered that significantly up-regulated MIR301 and down-regulated MIR183/130B were found in H1N1 patients [42]. Consistent with these results, we found that MIR183 and MIR130A/B/301 are related to four functional units of QFPD, indicating these microRNAs may exert anti−COVID-19 activity through QFPD. In addition, CDKs have played a role in the efficient replication of various viruses, including human HIV-1, papillomaviruses, human cytomegalovirus (HCMV), herpes simplex virus (HSV) type 1 and HSV-2 [43,44]. In agreement with these results, we found that CDK7 was predicted to enriched in the five formulae, suggesting that QFPD may regulate replication of COVID-19 viruses via CDK7 mediated cell cycle and RNA polymerase II transcription. Recently, a previous study showed that LXR known to regulate cholesterol homeostasis during inflammation were differentially regulated during H1N1 influenza virus infection [45]. Based on our results that LXR was associated with MSXG, SGMH, XCH, WLS targets, we speculated that QFPD can regulate metabolic and pro-inflammatory processes to counter COVID-19 virus infection."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T104","span":{"begin":93,"end":108},"obj":"Disease"},{"id":"T105","span":{"begin":99,"end":108},"obj":"Disease"},{"id":"T106","span":{"begin":405,"end":413},"obj":"Disease"},{"id":"T107","span":{"begin":594,"end":608},"obj":"Disease"},{"id":"T108","span":{"begin":796,"end":804},"obj":"Disease"},{"id":"T109","span":{"begin":971,"end":983},"obj":"Disease"},{"id":"T110","span":{"begin":1021,"end":1035},"obj":"Disease"},{"id":"T111","span":{"begin":1026,"end":1035},"obj":"Disease"},{"id":"T112","span":{"begin":1036,"end":1051},"obj":"Disease"},{"id":"T113","span":{"begin":1042,"end":1051},"obj":"Disease"},{"id":"T114","span":{"begin":1227,"end":1235},"obj":"Disease"},{"id":"T115","span":{"begin":1236,"end":1251},"obj":"Disease"},{"id":"T116","span":{"begin":1242,"end":1251},"obj":"Disease"}],"attributes":[{"id":"A104","pred":"mondo_id","subj":"T104","obj":"http://purl.obolibrary.org/obo/MONDO_0005108"},{"id":"A105","pred":"mondo_id","subj":"T105","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A106","pred":"mondo_id","subj":"T106","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A107","pred":"mondo_id","subj":"T107","obj":"http://purl.obolibrary.org/obo/MONDO_0004609"},{"id":"A108","pred":"mondo_id","subj":"T108","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A109","pred":"mondo_id","subj":"T109","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"},{"id":"A110","pred":"mondo_id","subj":"T110","obj":"http://purl.obolibrary.org/obo/MONDO_0005460"},{"id":"A111","pred":"mondo_id","subj":"T111","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"},{"id":"A112","pred":"mondo_id","subj":"T112","obj":"http://purl.obolibrary.org/obo/MONDO_0005108"},{"id":"A113","pred":"mondo_id","subj":"T113","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A114","pred":"mondo_id","subj":"T114","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A115","pred":"mondo_id","subj":"T115","obj":"http://purl.obolibrary.org/obo/MONDO_0005108"},{"id":"A116","pred":"mondo_id","subj":"T116","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"}],"text":"It has been reported that host cellular microRNAs (miRNAs) are involved in the regulation of virus infection [41]. A previous study discovered that significantly up-regulated MIR301 and down-regulated MIR183/130B were found in H1N1 patients [42]. Consistent with these results, we found that MIR183 and MIR130A/B/301 are related to four functional units of QFPD, indicating these microRNAs may exert anti−COVID-19 activity through QFPD. In addition, CDKs have played a role in the efficient replication of various viruses, including human HIV-1, papillomaviruses, human cytomegalovirus (HCMV), herpes simplex virus (HSV) type 1 and HSV-2 [43,44]. In agreement with these results, we found that CDK7 was predicted to enriched in the five formulae, suggesting that QFPD may regulate replication of COVID-19 viruses via CDK7 mediated cell cycle and RNA polymerase II transcription. Recently, a previous study showed that LXR known to regulate cholesterol homeostasis during inflammation were differentially regulated during H1N1 influenza virus infection [45]. Based on our results that LXR was associated with MSXG, SGMH, XCH, WLS targets, we speculated that QFPD can regulate metabolic and pro-inflammatory processes to counter COVID-19 virus infection."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T407","span":{"begin":3,"end":6},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T408","span":{"begin":93,"end":98},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T409","span":{"begin":110,"end":112},"obj":"http://purl.obolibrary.org/obo/CLO_0053794"},{"id":"T410","span":{"begin":115,"end":116},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T411","span":{"begin":311,"end":312},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T412","span":{"begin":414,"end":422},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T413","span":{"begin":467,"end":468},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T414","span":{"begin":514,"end":521},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T415","span":{"begin":533,"end":538},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T416","span":{"begin":564,"end":569},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T417","span":{"begin":609,"end":614},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T418","span":{"begin":805,"end":812},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T419","span":{"begin":831,"end":835},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T420","span":{"begin":889,"end":890},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T421","span":{"begin":1036,"end":1041},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T422","span":{"begin":1053,"end":1055},"obj":"http://purl.obolibrary.org/obo/CLO_0053799"},{"id":"T423","span":{"begin":1236,"end":1241},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"}],"text":"It has been reported that host cellular microRNAs (miRNAs) are involved in the regulation of virus infection [41]. A previous study discovered that significantly up-regulated MIR301 and down-regulated MIR183/130B were found in H1N1 patients [42]. Consistent with these results, we found that MIR183 and MIR130A/B/301 are related to four functional units of QFPD, indicating these microRNAs may exert anti−COVID-19 activity through QFPD. In addition, CDKs have played a role in the efficient replication of various viruses, including human HIV-1, papillomaviruses, human cytomegalovirus (HCMV), herpes simplex virus (HSV) type 1 and HSV-2 [43,44]. In agreement with these results, we found that CDK7 was predicted to enriched in the five formulae, suggesting that QFPD may regulate replication of COVID-19 viruses via CDK7 mediated cell cycle and RNA polymerase II transcription. Recently, a previous study showed that LXR known to regulate cholesterol homeostasis during inflammation were differentially regulated during H1N1 influenza virus infection [45]. Based on our results that LXR was associated with MSXG, SGMH, XCH, WLS targets, we speculated that QFPD can regulate metabolic and pro-inflammatory processes to counter COVID-19 virus infection."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T359","span":{"begin":861,"end":863},"obj":"Chemical"},{"id":"T360","span":{"begin":940,"end":951},"obj":"Chemical"}],"attributes":[{"id":"A359","pred":"chebi_id","subj":"T359","obj":"http://purl.obolibrary.org/obo/CHEBI_74067"},{"id":"A360","pred":"chebi_id","subj":"T360","obj":"http://purl.obolibrary.org/obo/CHEBI_16113"}],"text":"It has been reported that host cellular microRNAs (miRNAs) are involved in the regulation of virus infection [41]. A previous study discovered that significantly up-regulated MIR301 and down-regulated MIR183/130B were found in H1N1 patients [42]. Consistent with these results, we found that MIR183 and MIR130A/B/301 are related to four functional units of QFPD, indicating these microRNAs may exert anti−COVID-19 activity through QFPD. In addition, CDKs have played a role in the efficient replication of various viruses, including human HIV-1, papillomaviruses, human cytomegalovirus (HCMV), herpes simplex virus (HSV) type 1 and HSV-2 [43,44]. In agreement with these results, we found that CDK7 was predicted to enriched in the five formulae, suggesting that QFPD may regulate replication of COVID-19 viruses via CDK7 mediated cell cycle and RNA polymerase II transcription. Recently, a previous study showed that LXR known to regulate cholesterol homeostasis during inflammation were differentially regulated during H1N1 influenza virus infection [45]. Based on our results that LXR was associated with MSXG, SGMH, XCH, WLS targets, we speculated that QFPD can regulate metabolic and pro-inflammatory processes to counter COVID-19 virus infection."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T143","span":{"begin":79,"end":89},"obj":"http://purl.obolibrary.org/obo/GO_0065007"},{"id":"T144","span":{"begin":831,"end":841},"obj":"http://purl.obolibrary.org/obo/GO_0007049"},{"id":"T145","span":{"begin":864,"end":877},"obj":"http://purl.obolibrary.org/obo/GO_0006351"},{"id":"T146","span":{"begin":940,"end":963},"obj":"http://purl.obolibrary.org/obo/GO_0042632"},{"id":"T147","span":{"begin":952,"end":963},"obj":"http://purl.obolibrary.org/obo/GO_0042592"},{"id":"T148","span":{"begin":971,"end":983},"obj":"http://purl.obolibrary.org/obo/GO_0006954"}],"text":"It has been reported that host cellular microRNAs (miRNAs) are involved in the regulation of virus infection [41]. A previous study discovered that significantly up-regulated MIR301 and down-regulated MIR183/130B were found in H1N1 patients [42]. Consistent with these results, we found that MIR183 and MIR130A/B/301 are related to four functional units of QFPD, indicating these microRNAs may exert anti−COVID-19 activity through QFPD. In addition, CDKs have played a role in the efficient replication of various viruses, including human HIV-1, papillomaviruses, human cytomegalovirus (HCMV), herpes simplex virus (HSV) type 1 and HSV-2 [43,44]. In agreement with these results, we found that CDK7 was predicted to enriched in the five formulae, suggesting that QFPD may regulate replication of COVID-19 viruses via CDK7 mediated cell cycle and RNA polymerase II transcription. Recently, a previous study showed that LXR known to regulate cholesterol homeostasis during inflammation were differentially regulated during H1N1 influenza virus infection [45]. Based on our results that LXR was associated with MSXG, SGMH, XCH, WLS targets, we speculated that QFPD can regulate metabolic and pro-inflammatory processes to counter COVID-19 virus infection."}

{"project":"LitCovid-sentences","denotations":[{"id":"T336","span":{"begin":0,"end":114},"obj":"Sentence"},{"id":"T337","span":{"begin":115,"end":246},"obj":"Sentence"},{"id":"T338","span":{"begin":247,"end":436},"obj":"Sentence"},{"id":"T339","span":{"begin":437,"end":646},"obj":"Sentence"},{"id":"T340","span":{"begin":647,"end":878},"obj":"Sentence"},{"id":"T341","span":{"begin":879,"end":1057},"obj":"Sentence"},{"id":"T342","span":{"begin":1058,"end":1252},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"It has been reported that host cellular microRNAs (miRNAs) are involved in the regulation of virus infection [41]. A previous study discovered that significantly up-regulated MIR301 and down-regulated MIR183/130B were found in H1N1 patients [42]. Consistent with these results, we found that MIR183 and MIR130A/B/301 are related to four functional units of QFPD, indicating these microRNAs may exert anti−COVID-19 activity through QFPD. In addition, CDKs have played a role in the efficient replication of various viruses, including human HIV-1, papillomaviruses, human cytomegalovirus (HCMV), herpes simplex virus (HSV) type 1 and HSV-2 [43,44]. In agreement with these results, we found that CDK7 was predicted to enriched in the five formulae, suggesting that QFPD may regulate replication of COVID-19 viruses via CDK7 mediated cell cycle and RNA polymerase II transcription. Recently, a previous study showed that LXR known to regulate cholesterol homeostasis during inflammation were differentially regulated during H1N1 influenza virus infection [45]. Based on our results that LXR was associated with MSXG, SGMH, XCH, WLS targets, we speculated that QFPD can regulate metabolic and pro-inflammatory processes to counter COVID-19 virus infection."}

{"project":"2_test","denotations":[{"id":"32554251-23962477-6393510","span":{"begin":110,"end":112},"obj":"23962477"},{"id":"32554251-12097601-6393511","span":{"begin":639,"end":641},"obj":"12097601"},{"id":"32554251-23153050-6393512","span":{"begin":1053,"end":1055},"obj":"23153050"}],"text":"It has been reported that host cellular microRNAs (miRNAs) are involved in the regulation of virus infection [41]. A previous study discovered that significantly up-regulated MIR301 and down-regulated MIR183/130B were found in H1N1 patients [42]. Consistent with these results, we found that MIR183 and MIR130A/B/301 are related to four functional units of QFPD, indicating these microRNAs may exert anti−COVID-19 activity through QFPD. In addition, CDKs have played a role in the efficient replication of various viruses, including human HIV-1, papillomaviruses, human cytomegalovirus (HCMV), herpes simplex virus (HSV) type 1 and HSV-2 [43,44]. In agreement with these results, we found that CDK7 was predicted to enriched in the five formulae, suggesting that QFPD may regulate replication of COVID-19 viruses via CDK7 mediated cell cycle and RNA polymerase II transcription. Recently, a previous study showed that LXR known to regulate cholesterol homeostasis during inflammation were differentially regulated during H1N1 influenza virus infection [45]. Based on our results that LXR was associated with MSXG, SGMH, XCH, WLS targets, we speculated that QFPD can regulate metabolic and pro-inflammatory processes to counter COVID-19 virus infection."}