PMC:7247521 / 29019-31631 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7247521","sourcedb":"PMC","sourceid":"7247521","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7247521","text":"The application of COVID-19 docking server and Discovery Studio software elucidated the interactions between the 20 lead-likeness compounds (S1, W5, MX17, MX16, W11, M5, XO1, MXO1, SO1, WO1, X4, MX8, M3, S5, SX1, O1, X2, X1, O2, MS1) and the 10 nonstructural and 2 structural proteins (Mpro, PLpro, nsp12 [RdRp with RNA], nsp12 [RdRp without RNA], nsp13 [Helicase ADP site], nsp13 [Helicase NCB site], nsp14 [ExoN], nsp14 [N7-MTase], nsp15 [endoribonuclease], nsp16 [2′-O-MTase], N protein NCB site, E protein [ion channel]). The docking scores were depicted in Table 3, Table 4 . The smaller of docking score, the lower of energy would be required, which means the binding between the compounds and the targets are stronger. There are 9 compounds presenting better bonding ability than other compounds.\nTable 3 Docking score between specific ingredients of QFPD and 2019-nCov proteins.\nMolecule M3 M5 S1 S5 W11 W5 X1 X2 X4 O1 O2\nMain Protease −7.7 −7.3 −6.8 −6.9 −7.2 −7.5 −7.1 −7.9 −7.3 −7.1 −7.4\nPapain-like protease −8.7 −8.5 −9.9 −7.7 −8 −8 −8.4 −8.7 −8.2 −8.6 −8.2\nRdRp with RNA −8.4 −8.5 −8.5 −8.3 −9.1 −9.1 −8.4 −8.2 −8.2 −8.3 −8.6\nRdRp without RNA −6.8 −6.8 −6.9 −6.8 −6.7 −6.9 −7.1 −7.2 −6.5 −7.3 −7.1\nHelicase ADP site −6.3 −6.3 −7.3 −6.5 −6 −6 −6.3 −6.5 −6.2 −6.1 −6.5\nHelicase NCB site −7.9 −6.9 −7.2 −7.1 −7.2 −7.2 −7.4 −7.5 −7.3 −7.4 −7.4\nNsp14(ExoN) −6.8 −6.6 −6.3 −6.4 −6.9 −6.8 −6.7 −6.9 −6.4 −6.6 −6.9\nNsp14(N7-MTase) −8.8 −8.1 −8.5 −7.5 −8.4 −8.4 −8.3 −8.5 −8 −8.3 −8.5\nNsp15(endoribonuclease) −6.6 −6.3 −6.3 −5.9 −6.2 −6.2 −6.2 −6.3 −6.2 −6.4 −6.4\nNsp16(2′-O-MTase) −7.5 −7.4 −7.5 −7.2 −8.2 −8.2 −7.7 −7.9 −7.7 −7.9 −8.4\nN protein NCB site −7.6 −7.5 −7.8 −7.6 −7.6 −7.6 −8 −8 −7.5 −7.6 −7.6\nE protein(ion channel) −8.1 −7 −7.8 −6.7 −6.4 −6.4 −7.2 −7.3 −7.2 −7.1 −6.8\nM: MXSG, S: SGMH, X: XCH, O: Others.\nTable 4 Evaluation of the effect of QFPD on the robustness disturbance of COVID-19 network.\nTopology MXSG SGMH XCH WLS Others BXTM YDBF\nDTS 25.66 26.71 21.02 17.64 23.16 14.52 22.71\nAC −4.63 −5.21 −3.02 −3.49 −5.38 −2.32 −3.78\nAPL 13.35 13.40 9.96 6.49 10.66 4.59 11.17\nCoC −1.44 −1.64 −1.59 −1.30 −1.23 −1.15 −1.25\nClC −6.24 −6.46 −6.45 −6.36 −5.88 −6.46 −6.52\nAverage connectivity (AC), Connection centrality (CoC), Closeness centrality (ClC): the larger the quotient is, the more stable the network and, the less the influence made by the drug. Disturbance total score (DTS), Average length of shortest path (APL), : the larger the quotient is, the less stable the network and, the larger the influence made by the drug. Negative control formula: BXTM. Positive control formula: YDBF.","divisions":[{"label":"table-wrap","span":{"begin":804,"end":1824}},{"label":"label","span":{"begin":804,"end":811}},{"label":"caption","span":{"begin":812,"end":886}},{"label":"p","span":{"begin":812,"end":886}},{"label":"table","span":{"begin":887,"end":1787}},{"label":"tr","span":{"begin":887,"end":929}},{"label":"th","span":{"begin":887,"end":895}},{"label":"th","span":{"begin":896,"end":898}},{"label":"th","span":{"begin":899,"end":901}},{"label":"th","span":{"begin":902,"end":904}},{"label":"th","span":{"begin":905,"end":907}},{"label":"th","span":{"begin":908,"end":911}},{"label":"th","span":{"begin":912,"end":914}},{"label":"th","span":{"begin":915,"end":917}},{"label":"th","span":{"begin":918,"end":920}},{"label":"th","span":{"begin":921,"end":923}},{"label":"th","span":{"begin":924,"end":926}},{"label":"th","span":{"begin":927,"end":929}},{"label":"tr","span":{"begin":930,"end":998}},{"label":"td","span":{"begin":930,"end":943}},{"label":"td","span":{"begin":944,"end":948}},{"label":"td","span":{"begin":949,"end":953}},{"label":"td","span":{"begin":954,"end":958}},{"label":"td","span":{"begin":959,"end":963}},{"label":"td","span":{"begin":964,"end":968}},{"label":"td","span":{"begin":969,"end":973}},{"label":"td","span":{"begin":974,"end":978}},{"label":"td","span":{"begin":979,"end":983}},{"label":"td","span":{"begin":984,"end":988}},{"label":"td","span":{"begin":989,"end":993}},{"label":"td","span":{"begin":994,"end":998}},{"label":"tr","span":{"begin":999,"end":1070}},{"label":"td","span":{"begin":999,"end":1019}},{"label":"td","span":{"begin":1020,"end":1024}},{"label":"td","span":{"begin":1025,"end":1029}},{"label":"td","span":{"begin":1030,"end":1034}},{"label":"td","span":{"begin":1035,"end":1039}},{"label":"td","span":{"begin":1040,"end":1042}},{"label":"td","span":{"begin":1043,"end":1045}},{"label":"td","span":{"begin":1046,"end":1050}},{"label":"td","span":{"begin":1051,"end":1055}},{"label":"td","span":{"begin":1056,"end":1060}},{"label":"td","span":{"begin":1061,"end":1065}},{"label":"td","span":{"begin":1066,"end":1070}},{"label":"tr","span":{"begin":1071,"end":1139}},{"label":"td","span":{"begin":1071,"end":1084}},{"label":"td","span":{"begin":1085,"end":1089}},{"label":"td","span":{"begin":1090,"end":1094}},{"label":"td","span":{"begin":1095,"end":1099}},{"label":"td","span":{"begin":1100,"end":1104}},{"label":"td","span":{"begin":1105,"end":1109}},{"label":"td","span":{"begin":1110,"end":1114}},{"label":"td","span":{"begin":1115,"end":1119}},{"label":"td","span":{"begin":1120,"end":1124}},{"label":"td","span":{"begin":1125,"end":1129}},{"label":"td","span":{"begin":1130,"end":1134}},{"label":"td","span":{"begin":1135,"end":1139}},{"label":"tr","span":{"begin":1140,"end":1211}},{"label":"td","span":{"begin":1140,"end":1156}},{"label":"td","span":{"begin":1157,"end":1161}},{"label":"td","span":{"begin":1162,"end":1166}},{"label":"td","span":{"begin":1167,"end":1171}},{"label":"td","span":{"begin":1172,"end":1176}},{"label":"td","span":{"begin":1177,"end":1181}},{"label":"td","span":{"begin":1182,"end":1186}},{"label":"td","span":{"begin":1187,"end":1191}},{"label":"td","span":{"begin":1192,"end":1196}},{"label":"td","span":{"begin":1197,"end":1201}},{"label":"td","span":{"begin":1202,"end":1206}},{"label":"td","span":{"begin":1207,"end":1211}},{"label":"tr","span":{"begin":1212,"end":1280}},{"label":"td","span":{"begin":1212,"end":1229}},{"label":"td","span":{"begin":1230,"end":1234}},{"label":"td","span":{"begin":1235,"end":1239}},{"label":"td","span":{"begin":1240,"end":1244}},{"label":"td","span":{"begin":1245,"end":1249}},{"label":"td","span":{"begin":1250,"end":1252}},{"label":"td","span":{"begin":1253,"end":1255}},{"label":"td","span":{"begin":1256,"end":1260}},{"label":"td","span":{"begin":1261,"end":1265}},{"label":"td","span":{"begin":1266,"end":1270}},{"label":"td","span":{"begin":1271,"end":1275}},{"label":"td","span":{"begin":1276,"end":1280}},{"label":"tr","span":{"begin":1281,"end":1353}},{"label":"td","span":{"begin":1281,"end":1298}},{"label":"td","span":{"begin":1299,"end":1303}},{"label":"td","span":{"begin":1304,"end":1308}},{"label":"td","span":{"begin":1309,"end":1313}},{"label":"td","span":{"begin":1314,"end":1318}},{"label":"td","span":{"begin":1319,"end":1323}},{"label":"td","span":{"begin":1324,"end":1328}},{"label":"td","span":{"begin":1329,"end":1333}},{"label":"td","span":{"begin":1334,"end":1338}},{"label":"td","span":{"begin":1339,"end":1343}},{"label":"td","span":{"begin":1344,"end":1348}},{"label":"td","span":{"begin":1349,"end":1353}},{"label":"tr","span":{"begin":1354,"end":1420}},{"label":"td","span":{"begin":1354,"end":1365}},{"label":"td","span":{"begin":1366,"end":1370}},{"label":"td","span":{"begin":1371,"end":1375}},{"label":"td","span":{"begin":1376,"end":1380}},{"label":"td","span":{"begin":1381,"end":1385}},{"label":"td","span":{"begin":1386,"end":1390}},{"label":"td","span":{"begin":1391,"end":1395}},{"label":"td","span":{"begin":1396,"end":1400}},{"label":"td","span":{"begin":1401,"end":1405}},{"label":"td","span":{"begin":1406,"end":1410}},{"label":"td","span":{"begin":1411,"end":1415}},{"label":"td","span":{"begin":1416,"end":1420}},{"label":"tr","span":{"begin":1421,"end":1489}},{"label":"td","span":{"begin":1421,"end":1436}},{"label":"td","span":{"begin":1437,"end":1441}},{"label":"td","span":{"begin":1442,"end":1446}},{"label":"td","span":{"begin":1447,"end":1451}},{"label":"td","span":{"begin":1452,"end":1456}},{"label":"td","span":{"begin":1457,"end":1461}},{"label":"td","span":{"begin":1462,"end":1466}},{"label":"td","span":{"begin":1467,"end":1471}},{"label":"td","span":{"begin":1472,"end":1476}},{"label":"td","span":{"begin":1477,"end":1479}},{"label":"td","span":{"begin":1480,"end":1484}},{"label":"td","span":{"begin":1485,"end":1489}},{"label":"tr","span":{"begin":1490,"end":1568}},{"label":"td","span":{"begin":1490,"end":1513}},{"label":"td","span":{"begin":1514,"end":1518}},{"label":"td","span":{"begin":1519,"end":1523}},{"label":"td","span":{"begin":1524,"end":1528}},{"label":"td","span":{"begin":1529,"end":1533}},{"label":"td","span":{"begin":1534,"end":1538}},{"label":"td","span":{"begin":1539,"end":1543}},{"label":"td","span":{"begin":1544,"end":1548}},{"label":"td","span":{"begin":1549,"end":1553}},{"label":"td","span":{"begin":1554,"end":1558}},{"label":"td","span":{"begin":1559,"end":1563}},{"label":"td","span":{"begin":1564,"end":1568}},{"label":"tr","span":{"begin":1569,"end":1641}},{"label":"td","span":{"begin":1569,"end":1586}},{"label":"td","span":{"begin":1587,"end":1591}},{"label":"td","span":{"begin":1592,"end":1596}},{"label":"td","span":{"begin":1597,"end":1601}},{"label":"td","span":{"begin":1602,"end":1606}},{"label":"td","span":{"begin":1607,"end":1611}},{"label":"td","span":{"begin":1612,"end":1616}},{"label":"td","span":{"begin":1617,"end":1621}},{"label":"td","span":{"begin":1622,"end":1626}},{"label":"td","span":{"begin":1627,"end":1631}},{"label":"td","span":{"begin":1632,"end":1636}},{"label":"td","span":{"begin":1637,"end":1641}},{"label":"tr","span":{"begin":1642,"end":1711}},{"label":"td","span":{"begin":1642,"end":1660}},{"label":"td","span":{"begin":1661,"end":1665}},{"label":"td","span":{"begin":1666,"end":1670}},{"label":"td","span":{"begin":1671,"end":1675}},{"label":"td","span":{"begin":1676,"end":1680}},{"label":"td","span":{"begin":1681,"end":1685}},{"label":"td","span":{"begin":1686,"end":1690}},{"label":"td","span":{"begin":1691,"end":1693}},{"label":"td","span":{"begin":1694,"end":1696}},{"label":"td","span":{"begin":1697,"end":1701}},{"label":"td","span":{"begin":1702,"end":1706}},{"label":"td","span":{"begin":1707,"end":1711}},{"label":"tr","span":{"begin":1712,"end":1787}},{"label":"td","span":{"begin":1712,"end":1734}},{"label":"td","span":{"begin":1735,"end":1739}},{"label":"td","span":{"begin":1740,"end":1742}},{"label":"td","span":{"begin":1743,"end":1747}},{"label":"td","span":{"begin":1748,"end":1752}},{"label":"td","span":{"begin":1753,"end":1757}},{"label":"td","span":{"begin":1758,"end":1762}},{"label":"td","span":{"begin":1763,"end":1767}},{"label":"td","span":{"begin":1768,"end":1772}},{"label":"td","span":{"begin":1773,"end":1777}},{"label":"td","span":{"begin":1778,"end":1782}},{"label":"td","span":{"begin":1783,"end":1787}},{"label":"table-wrap-foot","span":{"begin":1788,"end":1824}},{"label":"footnote","span":{"begin":1788,"end":1824}},{"label":"p","span":{"begin":1788,"end":1824}},{"label":"label","span":{"begin":1825,"end":1832}},{"label":"caption","span":{"begin":1833,"end":1916}},{"label":"p","span":{"begin":1833,"end":1916}},{"label":"table","span":{"begin":1917,"end":2186}},{"label":"tr","span":{"begin":1917,"end":1960}},{"label":"th","span":{"begin":1917,"end":1925}},{"label":"th","span":{"begin":1926,"end":1930}},{"label":"th","span":{"begin":1931,"end":1935}},{"label":"th","span":{"begin":1936,"end":1939}},{"label":"th","span":{"begin":1940,"end":1943}},{"label":"th","span":{"begin":1944,"end":1950}},{"label":"th","span":{"begin":1951,"end":1955}},{"label":"th","span":{"begin":1956,"end":1960}},{"label":"tr","span":{"begin":1961,"end":2006}},{"label":"td","span":{"begin":1961,"end":1964}},{"label":"td","span":{"begin":1965,"end":1970}},{"label":"td","span":{"begin":1971,"end":1976}},{"label":"td","span":{"begin":1977,"end":1982}},{"label":"td","span":{"begin":1983,"end":1988}},{"label":"td","span":{"begin":1989,"end":1994}},{"label":"td","span":{"begin":1995,"end":2000}},{"label":"td","span":{"begin":2001,"end":2006}},{"label":"tr","span":{"begin":2007,"end":2051}},{"label":"td","span":{"begin":2007,"end":2009}},{"label":"td","span":{"begin":2010,"end":2015}},{"label":"td","span":{"begin":2016,"end":2021}},{"label":"td","span":{"begin":2022,"end":2027}},{"label":"td","span":{"begin":2028,"end":2033}},{"label":"td","span":{"begin":2034,"end":2039}},{"label":"td","span":{"begin":2040,"end":2045}},{"label":"td","span":{"begin":2046,"end":2051}},{"label":"tr","span":{"begin":2052,"end":2094}},{"label":"td","span":{"begin":2052,"end":2055}},{"label":"td","span":{"begin":2056,"end":2061}},{"label":"td","span":{"begin":2062,"end":2067}},{"label":"td","span":{"begin":2068,"end":2072}},{"label":"td","span":{"begin":2073,"end":2077}},{"label":"td","span":{"begin":2078,"end":2083}},{"label":"td","span":{"begin":2084,"end":2088}},{"label":"td","span":{"begin":2089,"end":2094}},{"label":"tr","span":{"begin":2095,"end":2140}},{"label":"td","span":{"begin":2095,"end":2098}},{"label":"td","span":{"begin":2099,"end":2104}},{"label":"td","span":{"begin":2105,"end":2110}},{"label":"td","span":{"begin":2111,"end":2116}},{"label":"td","span":{"begin":2117,"end":2122}},{"label":"td","span":{"begin":2123,"end":2128}},{"label":"td","span":{"begin":2129,"end":2134}},{"label":"td","span":{"begin":2135,"end":2140}},{"label":"tr","span":{"begin":2141,"end":2186}},{"label":"td","span":{"begin":2141,"end":2144}},{"label":"td","span":{"begin":2145,"end":2150}},{"label":"td","span":{"begin":2151,"end":2156}},{"label":"td","span":{"begin":2157,"end":2162}},{"label":"td","span":{"begin":2163,"end":2168}},{"label":"td","span":{"begin":2169,"end":2174}},{"label":"td","span":{"begin":2175,"end":2180}},{"label":"td","span":{"begin":2181,"end":2186}}],"tracks":[{"project":"LitCovid-PubTator","denotations":[{"id":"418","span":{"begin":1071,"end":1075},"obj":"Gene"},{"id":"419","span":{"begin":1140,"end":1144},"obj":"Gene"},{"id":"420","span":{"begin":1212,"end":1220},"obj":"Gene"},{"id":"421","span":{"begin":1281,"end":1289},"obj":"Gene"},{"id":"423","span":{"begin":867,"end":876},"obj":"Species"},{"id":"425","span":{"begin":1809,"end":1812},"obj":"Disease"},{"id":"429","span":{"begin":2141,"end":2147},"obj":"Gene"},{"id":"430","span":{"begin":1931,"end":1943},"obj":"Disease"},{"id":"431","span":{"begin":2052,"end":2055},"obj":"Disease"},{"id":"433","span":{"begin":1899,"end":1907},"obj":"Disease"},{"id":"436","span":{"begin":2575,"end":2579},"obj":"Chemical"},{"id":"437","span":{"begin":2437,"end":2440},"obj":"Disease"},{"id":"446","span":{"begin":208,"end":223},"obj":"Gene"},{"id":"447","span":{"begin":286,"end":290},"obj":"Gene"},{"id":"448","span":{"begin":306,"end":310},"obj":"Gene"},{"id":"449","span":{"begin":329,"end":333},"obj":"Gene"},{"id":"450","span":{"begin":355,"end":363},"obj":"Gene"},{"id":"451","span":{"begin":382,"end":390},"obj":"Gene"},{"id":"452","span":{"begin":292,"end":297},"obj":"Gene"},{"id":"453","span":{"begin":19,"end":27},"obj":"Disease"}],"attributes":[{"id":"A418","pred":"tao:has_database_id","subj":"418","obj":"Gene:43740578"},{"id":"A419","pred":"tao:has_database_id","subj":"419","obj":"Gene:43740578"},{"id":"A420","pred":"tao:has_database_id","subj":"420","obj":"Gene:164045"},{"id":"A421","pred":"tao:has_database_id","subj":"421","obj":"Gene:164045"},{"id":"A423","pred":"tao:has_database_id","subj":"423","obj":"Tax:2697049"},{"id":"A429","pred":"tao:has_database_id","subj":"429","obj":"Gene:1185"},{"id":"A431","pred":"tao:has_database_id","subj":"431","obj":"MESH:D015473"},{"id":"A433","pred":"tao:has_database_id","subj":"433","obj":"MESH:C000657245"},{"id":"A437","pred":"tao:has_database_id","subj":"437","obj":"MESH:D015473"},{"id":"A447","pred":"tao:has_database_id","subj":"447","obj":"Gene:8673700"},{"id":"A448","pred":"tao:has_database_id","subj":"448","obj":"Gene:43740578"},{"id":"A449","pred":"tao:has_database_id","subj":"449","obj":"Gene:43740578"},{"id":"A450","pred":"tao:has_database_id","subj":"450","obj":"Gene:164045"},{"id":"A451","pred":"tao:has_database_id","subj":"451","obj":"Gene:164045"},{"id":"A452","pred":"tao:has_database_id","subj":"452","obj":"Gene:43740578"},{"id":"A453","pred":"tao:has_database_id","subj":"453","obj":"MESH:C000657245"},{"subj":"418","pred":"source","obj":"LitCovid-PubTator"},{"subj":"419","pred":"source","obj":"LitCovid-PubTator"},{"subj":"420","pred":"source","obj":"LitCovid-PubTator"},{"subj":"421","pred":"source","obj":"LitCovid-PubTator"},{"subj":"423","pred":"source","obj":"LitCovid-PubTator"},{"subj":"425","pred":"source","obj":"LitCovid-PubTator"},{"subj":"429","pred":"source","obj":"LitCovid-PubTator"},{"subj":"430","pred":"source","obj":"LitCovid-PubTator"},{"subj":"431","pred":"source","obj":"LitCovid-PubTator"},{"subj":"433","pred":"source","obj":"LitCovid-PubTator"},{"subj":"436","pred":"source","obj":"LitCovid-PubTator"},{"subj":"437","pred":"source","obj":"LitCovid-PubTator"},{"subj":"446","pred":"source","obj":"LitCovid-PubTator"},{"subj":"447","pred":"source","obj":"LitCovid-PubTator"},{"subj":"448","pred":"source","obj":"LitCovid-PubTator"},{"subj":"449","pred":"source","obj":"LitCovid-PubTator"},{"subj":"450","pred":"source","obj":"LitCovid-PubTator"},{"subj":"451","pred":"source","obj":"LitCovid-PubTator"},{"subj":"452","pred":"source","obj":"LitCovid-PubTator"},{"subj":"453","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T373","span":{"begin":19,"end":27},"obj":"SP_7"},{"id":"T374","span":{"begin":130,"end":139},"obj":"CHEBI:36357;CHEBI:36357"},{"id":"T375","span":{"begin":299,"end":304},"obj":"PR:000000125"},{"id":"T376","span":{"begin":322,"end":327},"obj":"PR:000000125"},{"id":"T377","span":{"begin":348,"end":353},"obj":"PR:000000125"},{"id":"T378","span":{"begin":364,"end":372},"obj":"SO:0000346"},{"id":"T379","span":{"begin":375,"end":380},"obj":"PR:000000125"},{"id":"T380","span":{"begin":402,"end":407},"obj":"PR:000000125"},{"id":"T381","span":{"begin":416,"end":421},"obj":"PR:000000125"},{"id":"T382","span":{"begin":434,"end":439},"obj":"PR:000000125"},{"id":"T383","span":{"begin":460,"end":465},"obj":"PR:000000125"},{"id":"T384","span":{"begin":480,"end":489},"obj":"PG_4"},{"id":"T385","span":{"begin":500,"end":509},"obj":"PG_2"},{"id":"T386","span":{"begin":511,"end":514},"obj":"CHEBI:24870;CHEBI:24870"},{"id":"T387","span":{"begin":686,"end":695},"obj":"CHEBI:36357;CHEBI:36357"},{"id":"T388","span":{"begin":738,"end":747},"obj":"CHEBI:36357;CHEBI:36357"},{"id":"T389","span":{"begin":793,"end":802},"obj":"CHEBI:36357;CHEBI:36357"},{"id":"T397","span":{"begin":867,"end":876},"obj":"SP_7"},{"id":"T398","span":{"begin":1899,"end":1907},"obj":"SP_7"},{"id":"T399","span":{"begin":2367,"end":2371},"obj":"CHEBI:23888;CHEBI:23888"},{"id":"T400","span":{"begin":2543,"end":2547},"obj":"CHEBI:23888;CHEBI:23888"}],"attributes":[{"subj":"T373","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T374","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T375","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T376","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T377","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T378","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T379","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T380","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T381","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T382","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T383","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T384","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T385","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T386","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T387","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T388","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T389","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T397","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T398","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T399","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T400","pred":"source","obj":"LitCovid-PMC-OGER-BB"}]},{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T95","span":{"begin":276,"end":284},"obj":"Body_part"},{"id":"T96","span":{"begin":316,"end":319},"obj":"Body_part"},{"id":"T97","span":{"begin":342,"end":345},"obj":"Body_part"},{"id":"T98","span":{"begin":409,"end":413},"obj":"Body_part"},{"id":"T99","span":{"begin":482,"end":489},"obj":"Body_part"},{"id":"T100","span":{"begin":502,"end":509},"obj":"Body_part"},{"id":"T101","span":{"begin":877,"end":885},"obj":"Body_part"},{"id":"T102","span":{"begin":1081,"end":1084},"obj":"Body_part"},{"id":"T103","span":{"begin":1153,"end":1156},"obj":"Body_part"},{"id":"T104","span":{"begin":1360,"end":1364},"obj":"Body_part"},{"id":"T105","span":{"begin":1644,"end":1651},"obj":"Body_part"},{"id":"T106","span":{"begin":1714,"end":1721},"obj":"Body_part"}],"attributes":[{"id":"A95","pred":"fma_id","subj":"T95","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A96","pred":"fma_id","subj":"T96","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A97","pred":"fma_id","subj":"T97","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A98","pred":"fma_id","subj":"T98","obj":"http://purl.org/sig/ont/fma/fma84120"},{"id":"A99","pred":"fma_id","subj":"T99","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A100","pred":"fma_id","subj":"T100","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A101","pred":"fma_id","subj":"T101","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A102","pred":"fma_id","subj":"T102","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A103","pred":"fma_id","subj":"T103","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A104","pred":"fma_id","subj":"T104","obj":"http://purl.org/sig/ont/fma/fma84120"},{"id":"A105","pred":"fma_id","subj":"T105","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A106","pred":"fma_id","subj":"T106","obj":"http://purl.org/sig/ont/fma/fma67257"},{"subj":"T95","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T96","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T97","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T98","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T99","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T100","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T101","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T102","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T103","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T104","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T105","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T106","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T60","span":{"begin":19,"end":27},"obj":"Disease"},{"id":"T61","span":{"begin":1899,"end":1907},"obj":"Disease"}],"attributes":[{"id":"A60","pred":"mondo_id","subj":"T60","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A61","pred":"mondo_id","subj":"T61","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"subj":"T60","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T61","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T247","span":{"begin":141,"end":143},"obj":"http://purl.obolibrary.org/obo/CLO_0050050"},{"id":"T248","span":{"begin":204,"end":206},"obj":"http://purl.obolibrary.org/obo/CLO_0008933"},{"id":"T249","span":{"begin":229,"end":232},"obj":"http://purl.obolibrary.org/obo/CLO_0007875"},{"id":"T250","span":{"begin":229,"end":232},"obj":"http://purl.obolibrary.org/obo/CLO_0052410"},{"id":"T251","span":{"begin":902,"end":904},"obj":"http://purl.obolibrary.org/obo/CLO_0050050"},{"id":"T252","span":{"begin":905,"end":907},"obj":"http://purl.obolibrary.org/obo/CLO_0008933"},{"id":"T253","span":{"begin":2141,"end":2144},"obj":"http://purl.obolibrary.org/obo/CLO_0002494"},{"id":"T254","span":{"begin":2265,"end":2268},"obj":"http://purl.obolibrary.org/obo/CLO_0002494"}],"attributes":[{"subj":"T247","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T248","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T249","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T250","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T251","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T252","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T253","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T254","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T192","span":{"begin":4,"end":15},"obj":"Chemical"},{"id":"T193","span":{"begin":200,"end":202},"obj":"Chemical"},{"id":"T195","span":{"begin":204,"end":206},"obj":"Chemical"},{"id":"T196","span":{"begin":225,"end":227},"obj":"Chemical"},{"id":"T197","span":{"begin":276,"end":284},"obj":"Chemical"},{"id":"T198","span":{"begin":364,"end":367},"obj":"Chemical"},{"id":"T201","span":{"begin":482,"end":489},"obj":"Chemical"},{"id":"T202","span":{"begin":502,"end":509},"obj":"Chemical"},{"id":"T203","span":{"begin":511,"end":514},"obj":"Chemical"},{"id":"T204","span":{"begin":877,"end":885},"obj":"Chemical"},{"id":"T205","span":{"begin":896,"end":898},"obj":"Chemical"},{"id":"T207","span":{"begin":905,"end":907},"obj":"Chemical"},{"id":"T208","span":{"begin":927,"end":929},"obj":"Chemical"},{"id":"T209","span":{"begin":1221,"end":1224},"obj":"Chemical"},{"id":"T212","span":{"begin":1644,"end":1651},"obj":"Chemical"},{"id":"T213","span":{"begin":1714,"end":1721},"obj":"Chemical"},{"id":"T214","span":{"begin":1722,"end":1725},"obj":"Chemical"},{"id":"T215","span":{"begin":2367,"end":2371},"obj":"Chemical"},{"id":"T216","span":{"begin":2543,"end":2547},"obj":"Chemical"}],"attributes":[{"id":"A192","pred":"chebi_id","subj":"T192","obj":"http://purl.obolibrary.org/obo/CHEBI_33232"},{"id":"A193","pred":"chebi_id","subj":"T193","obj":"http://purl.obolibrary.org/obo/CHEBI_51083"},{"id":"A194","pred":"chebi_id","subj":"T193","obj":"http://purl.obolibrary.org/obo/CHEBI_53453"},{"id":"A195","pred":"chebi_id","subj":"T195","obj":"http://purl.obolibrary.org/obo/CHEBI_29386"},{"id":"A196","pred":"chebi_id","subj":"T196","obj":"http://purl.obolibrary.org/obo/CHEBI_15379"},{"id":"A197","pred":"chebi_id","subj":"T197","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A198","pred":"chebi_id","subj":"T198","obj":"http://purl.obolibrary.org/obo/CHEBI_16761"},{"id":"A199","pred":"chebi_id","subj":"T198","obj":"http://purl.obolibrary.org/obo/CHEBI_456216"},{"id":"A200","pred":"chebi_id","subj":"T198","obj":"http://purl.obolibrary.org/obo/CHEBI_73342"},{"id":"A201","pred":"chebi_id","subj":"T201","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A202","pred":"chebi_id","subj":"T202","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A203","pred":"chebi_id","subj":"T203","obj":"http://purl.obolibrary.org/obo/CHEBI_24870"},{"id":"A204","pred":"chebi_id","subj":"T204","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A205","pred":"chebi_id","subj":"T205","obj":"http://purl.obolibrary.org/obo/CHEBI_51083"},{"id":"A206","pred":"chebi_id","subj":"T205","obj":"http://purl.obolibrary.org/obo/CHEBI_53453"},{"id":"A207","pred":"chebi_id","subj":"T207","obj":"http://purl.obolibrary.org/obo/CHEBI_29386"},{"id":"A208","pred":"chebi_id","subj":"T208","obj":"http://purl.obolibrary.org/obo/CHEBI_15379"},{"id":"A209","pred":"chebi_id","subj":"T209","obj":"http://purl.obolibrary.org/obo/CHEBI_16761"},{"id":"A210","pred":"chebi_id","subj":"T209","obj":"http://purl.obolibrary.org/obo/CHEBI_456216"},{"id":"A211","pred":"chebi_id","subj":"T209","obj":"http://purl.obolibrary.org/obo/CHEBI_73342"},{"id":"A212","pred":"chebi_id","subj":"T212","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A213","pred":"chebi_id","subj":"T213","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A214","pred":"chebi_id","subj":"T214","obj":"http://purl.obolibrary.org/obo/CHEBI_24870"},{"id":"A215","pred":"chebi_id","subj":"T215","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A216","pred":"chebi_id","subj":"T216","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"subj":"T192","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T193","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T195","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T196","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T197","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T198","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T201","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T202","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T203","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T204","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T205","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T207","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T208","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T209","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T212","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T213","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T214","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T215","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T216","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T100","span":{"begin":511,"end":522},"obj":"http://purl.obolibrary.org/obo/GO_0022831"},{"id":"T101","span":{"begin":1722,"end":1733},"obj":"http://purl.obolibrary.org/obo/GO_0022831"}],"attributes":[{"subj":"T100","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T101","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T216","span":{"begin":0,"end":525},"obj":"Sentence"},{"id":"T217","span":{"begin":526,"end":580},"obj":"Sentence"},{"id":"T218","span":{"begin":581,"end":725},"obj":"Sentence"},{"id":"T219","span":{"begin":726,"end":803},"obj":"Sentence"},{"id":"T220","span":{"begin":804,"end":886},"obj":"Sentence"},{"id":"T221","span":{"begin":887,"end":929},"obj":"Sentence"},{"id":"T222","span":{"begin":930,"end":998},"obj":"Sentence"},{"id":"T223","span":{"begin":999,"end":1070},"obj":"Sentence"},{"id":"T224","span":{"begin":1071,"end":1139},"obj":"Sentence"},{"id":"T225","span":{"begin":1140,"end":1211},"obj":"Sentence"},{"id":"T226","span":{"begin":1212,"end":1280},"obj":"Sentence"},{"id":"T227","span":{"begin":1281,"end":1353},"obj":"Sentence"},{"id":"T228","span":{"begin":1354,"end":1420},"obj":"Sentence"},{"id":"T229","span":{"begin":1421,"end":1489},"obj":"Sentence"},{"id":"T230","span":{"begin":1490,"end":1568},"obj":"Sentence"},{"id":"T231","span":{"begin":1569,"end":1641},"obj":"Sentence"},{"id":"T232","span":{"begin":1642,"end":1711},"obj":"Sentence"},{"id":"T233","span":{"begin":1712,"end":1787},"obj":"Sentence"},{"id":"T234","span":{"begin":1788,"end":1816},"obj":"Sentence"},{"id":"T235","span":{"begin":1817,"end":1824},"obj":"Sentence"},{"id":"T236","span":{"begin":1825,"end":1916},"obj":"Sentence"},{"id":"T237","span":{"begin":1917,"end":1960},"obj":"Sentence"},{"id":"T238","span":{"begin":1961,"end":2006},"obj":"Sentence"},{"id":"T239","span":{"begin":2007,"end":2051},"obj":"Sentence"},{"id":"T240","span":{"begin":2052,"end":2094},"obj":"Sentence"},{"id":"T241","span":{"begin":2095,"end":2140},"obj":"Sentence"},{"id":"T242","span":{"begin":2141,"end":2186},"obj":"Sentence"},{"id":"T243","span":{"begin":2187,"end":2372},"obj":"Sentence"},{"id":"T244","span":{"begin":2373,"end":2548},"obj":"Sentence"},{"id":"T245","span":{"begin":2549,"end":2580},"obj":"Sentence"},{"id":"T246","span":{"begin":2581,"end":2612},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T216","pred":"source","obj":"LitCovid-sentences"},{"subj":"T217","pred":"source","obj":"LitCovid-sentences"},{"subj":"T218","pred":"source","obj":"LitCovid-sentences"},{"subj":"T219","pred":"source","obj":"LitCovid-sentences"},{"subj":"T220","pred":"source","obj":"LitCovid-sentences"},{"subj":"T221","pred":"source","obj":"LitCovid-sentences"},{"subj":"T222","pred":"source","obj":"LitCovid-sentences"},{"subj":"T223","pred":"source","obj":"LitCovid-sentences"},{"subj":"T224","pred":"source","obj":"LitCovid-sentences"},{"subj":"T225","pred":"source","obj":"LitCovid-sentences"},{"subj":"T226","pred":"source","obj":"LitCovid-sentences"},{"subj":"T227","pred":"source","obj":"LitCovid-sentences"},{"subj":"T228","pred":"source","obj":"LitCovid-sentences"},{"subj":"T229","pred":"source","obj":"LitCovid-sentences"},{"subj":"T230","pred":"source","obj":"LitCovid-sentences"},{"subj":"T231","pred":"source","obj":"LitCovid-sentences"},{"subj":"T232","pred":"source","obj":"LitCovid-sentences"},{"subj":"T233","pred":"source","obj":"LitCovid-sentences"},{"subj":"T234","pred":"source","obj":"LitCovid-sentences"},{"subj":"T235","pred":"source","obj":"LitCovid-sentences"},{"subj":"T236","pred":"source","obj":"LitCovid-sentences"},{"subj":"T237","pred":"source","obj":"LitCovid-sentences"},{"subj":"T238","pred":"source","obj":"LitCovid-sentences"},{"subj":"T239","pred":"source","obj":"LitCovid-sentences"},{"subj":"T240","pred":"source","obj":"LitCovid-sentences"},{"subj":"T241","pred":"source","obj":"LitCovid-sentences"},{"subj":"T242","pred":"source","obj":"LitCovid-sentences"},{"subj":"T243","pred":"source","obj":"LitCovid-sentences"},{"subj":"T244","pred":"source","obj":"LitCovid-sentences"},{"subj":"T245","pred":"source","obj":"LitCovid-sentences"},{"subj":"T246","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PD-GlycoEpitope","denotations":[{"id":"T3","span":{"begin":186,"end":189},"obj":"GlycoEpitope"}],"attributes":[{"id":"A3","pred":"glyco_epitope_db_id","subj":"T3","obj":"http://www.glycoepitope.jp/epitopes/AN0690"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-GlycoEpitope"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PubTator","color":"#ecda93","default":true},{"id":"LitCovid-PMC-OGER-BB","color":"#c093ec"},{"id":"LitCovid-PD-FMA-UBERON","color":"#93eca6"},{"id":"LitCovid-PD-MONDO","color":"#ec939a"},{"id":"LitCovid-PD-CLO","color":"#93b4ec"},{"id":"LitCovid-PD-CHEBI","color":"#ceec93"},{"id":"LitCovid-PD-GO-BP","color":"#ec93e8"},{"id":"LitCovid-sentences","color":"#93ecd6"},{"id":"LitCovid-PD-GlycoEpitope","color":"#ecbc93"}]}]}}