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PMC:7247521 / 29019-31631 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
418 1071-1075 Gene denotes RdRp Gene:43740578
419 1140-1144 Gene denotes RdRp Gene:43740578
420 1212-1220 Gene denotes Helicase Gene:164045
421 1281-1289 Gene denotes Helicase Gene:164045
423 867-876 Species denotes 2019-nCov Tax:2697049
425 1809-1812 Disease denotes XCH
429 2141-2147 Gene denotes ClC −6 Gene:1185
430 1931-1943 Disease denotes SGMH XCH WLS
431 2052-2055 Disease denotes APL MESH:D015473
433 1899-1907 Disease denotes COVID-19 MESH:C000657245
436 2575-2579 Chemical denotes BXTM
437 2437-2440 Disease denotes APL MESH:D015473
446 208-223 Gene denotes SX1, O1, X2, X1
447 286-290 Gene denotes Mpro Gene:8673700
448 306-310 Gene denotes RdRp Gene:43740578
449 329-333 Gene denotes RdRp Gene:43740578
450 355-363 Gene denotes Helicase Gene:164045
451 382-390 Gene denotes Helicase Gene:164045
452 292-297 Gene denotes PLpro Gene:43740578
453 19-27 Disease denotes COVID-19 MESH:C000657245

LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T373 19-27 SP_7 denotes COVID-19
T374 130-139 CHEBI:36357;CHEBI:36357 denotes compounds
T375 299-304 PR:000000125 denotes nsp12
T376 322-327 PR:000000125 denotes nsp12
T377 348-353 PR:000000125 denotes nsp13
T378 364-372 SO:0000346 denotes ADP site
T379 375-380 PR:000000125 denotes nsp13
T380 402-407 PR:000000125 denotes nsp14
T381 416-421 PR:000000125 denotes nsp14
T382 434-439 PR:000000125 denotes nsp15
T383 460-465 PR:000000125 denotes nsp16
T384 480-489 PG_4 denotes N protein
T385 500-509 PG_2 denotes E protein
T386 511-514 CHEBI:24870;CHEBI:24870 denotes ion
T387 686-695 CHEBI:36357;CHEBI:36357 denotes compounds
T388 738-747 CHEBI:36357;CHEBI:36357 denotes compounds
T389 793-802 CHEBI:36357;CHEBI:36357 denotes compounds
T397 867-876 SP_7 denotes 2019-nCov
T398 1899-1907 SP_7 denotes COVID-19
T399 2367-2371 CHEBI:23888;CHEBI:23888 denotes drug
T400 2543-2547 CHEBI:23888;CHEBI:23888 denotes drug

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T95 276-284 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T96 316-319 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T97 342-345 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T98 409-413 Body_part denotes ExoN http://purl.org/sig/ont/fma/fma84120
T99 482-489 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T100 502-509 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T101 877-885 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T102 1081-1084 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T103 1153-1156 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T104 1360-1364 Body_part denotes ExoN http://purl.org/sig/ont/fma/fma84120
T105 1644-1651 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T106 1714-1721 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T60 19-27 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T61 1899-1907 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T247 141-143 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T248 204-206 http://purl.obolibrary.org/obo/CLO_0008933 denotes S5
T249 229-232 http://purl.obolibrary.org/obo/CLO_0007875 denotes MS1
T250 229-232 http://purl.obolibrary.org/obo/CLO_0052410 denotes MS1
T251 902-904 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T252 905-907 http://purl.obolibrary.org/obo/CLO_0008933 denotes S5
T253 2141-2144 http://purl.obolibrary.org/obo/CLO_0002494 denotes ClC
T254 2265-2268 http://purl.obolibrary.org/obo/CLO_0002494 denotes ClC

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T192 4-15 Chemical denotes application http://purl.obolibrary.org/obo/CHEBI_33232
T193 200-202 Chemical denotes M3 http://purl.obolibrary.org/obo/CHEBI_51083|http://purl.obolibrary.org/obo/CHEBI_53453
T195 204-206 Chemical denotes S5 http://purl.obolibrary.org/obo/CHEBI_29386
T196 225-227 Chemical denotes O2 http://purl.obolibrary.org/obo/CHEBI_15379
T197 276-284 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T198 364-367 Chemical denotes ADP http://purl.obolibrary.org/obo/CHEBI_16761|http://purl.obolibrary.org/obo/CHEBI_456216|http://purl.obolibrary.org/obo/CHEBI_73342
T201 482-489 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T202 502-509 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T203 511-514 Chemical denotes ion http://purl.obolibrary.org/obo/CHEBI_24870
T204 877-885 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T205 896-898 Chemical denotes M3 http://purl.obolibrary.org/obo/CHEBI_51083|http://purl.obolibrary.org/obo/CHEBI_53453
T207 905-907 Chemical denotes S5 http://purl.obolibrary.org/obo/CHEBI_29386
T208 927-929 Chemical denotes O2 http://purl.obolibrary.org/obo/CHEBI_15379
T209 1221-1224 Chemical denotes ADP http://purl.obolibrary.org/obo/CHEBI_16761|http://purl.obolibrary.org/obo/CHEBI_456216|http://purl.obolibrary.org/obo/CHEBI_73342
T212 1644-1651 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T213 1714-1721 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T214 1722-1725 Chemical denotes ion http://purl.obolibrary.org/obo/CHEBI_24870
T215 2367-2371 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T216 2543-2547 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T100 511-522 http://purl.obolibrary.org/obo/GO_0022831 denotes ion channel
T101 1722-1733 http://purl.obolibrary.org/obo/GO_0022831 denotes ion channel

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T216 0-525 Sentence denotes The application of COVID-19 docking server and Discovery Studio software elucidated the interactions between the 20 lead-likeness compounds (S1, W5, MX17, MX16, W11, M5, XO1, MXO1, SO1, WO1, X4, MX8, M3, S5, SX1, O1, X2, X1, O2, MS1) and the 10 nonstructural and 2 structural proteins (Mpro, PLpro, nsp12 [RdRp with RNA], nsp12 [RdRp without RNA], nsp13 [Helicase ADP site], nsp13 [Helicase NCB site], nsp14 [ExoN], nsp14 [N7-MTase], nsp15 [endoribonuclease], nsp16 [2′-O-MTase], N protein NCB site, E protein [ion channel]).
T217 526-580 Sentence denotes The docking scores were depicted in Table 3, Table 4 .
T218 581-725 Sentence denotes The smaller of docking score, the lower of energy would be required, which means the binding between the compounds and the targets are stronger.
T219 726-803 Sentence denotes There are 9 compounds presenting better bonding ability than other compounds.
T220 804-886 Sentence denotes Table 3 Docking score between specific ingredients of QFPD and 2019-nCov proteins.
T221 887-929 Sentence denotes Molecule M3 M5 S1 S5 W11 W5 X1 X2 X4 O1 O2
T222 930-998 Sentence denotes Main Protease −7.7 −7.3 −6.8 −6.9 −7.2 −7.5 −7.1 −7.9 −7.3 −7.1 −7.4
T223 999-1070 Sentence denotes Papain-like protease −8.7 −8.5 −9.9 −7.7 −8 −8 −8.4 −8.7 −8.2 −8.6 −8.2
T224 1071-1139 Sentence denotes RdRp with RNA −8.4 −8.5 −8.5 −8.3 −9.1 −9.1 −8.4 −8.2 −8.2 −8.3 −8.6
T225 1140-1211 Sentence denotes RdRp without RNA −6.8 −6.8 −6.9 −6.8 −6.7 −6.9 −7.1 −7.2 −6.5 −7.3 −7.1
T226 1212-1280 Sentence denotes Helicase ADP site −6.3 −6.3 −7.3 −6.5 −6 −6 −6.3 −6.5 −6.2 −6.1 −6.5
T227 1281-1353 Sentence denotes Helicase NCB site −7.9 −6.9 −7.2 −7.1 −7.2 −7.2 −7.4 −7.5 −7.3 −7.4 −7.4
T228 1354-1420 Sentence denotes Nsp14(ExoN) −6.8 −6.6 −6.3 −6.4 −6.9 −6.8 −6.7 −6.9 −6.4 −6.6 −6.9
T229 1421-1489 Sentence denotes Nsp14(N7-MTase) −8.8 −8.1 −8.5 −7.5 −8.4 −8.4 −8.3 −8.5 −8 −8.3 −8.5
T230 1490-1568 Sentence denotes Nsp15(endoribonuclease) −6.6 −6.3 −6.3 −5.9 −6.2 −6.2 −6.2 −6.3 −6.2 −6.4 −6.4
T231 1569-1641 Sentence denotes Nsp16(2′-O-MTase) −7.5 −7.4 −7.5 −7.2 −8.2 −8.2 −7.7 −7.9 −7.7 −7.9 −8.4
T232 1642-1711 Sentence denotes N protein NCB site −7.6 −7.5 −7.8 −7.6 −7.6 −7.6 −8 −8 −7.5 −7.6 −7.6
T233 1712-1787 Sentence denotes E protein(ion channel) −8.1 −7 −7.8 −6.7 −6.4 −6.4 −7.2 −7.3 −7.2 −7.1 −6.8
T234 1788-1816 Sentence denotes M: MXSG, S: SGMH, X: XCH, O:
T235 1817-1824 Sentence denotes Others.
T236 1825-1916 Sentence denotes Table 4 Evaluation of the effect of QFPD on the robustness disturbance of COVID-19 network.
T237 1917-1960 Sentence denotes Topology MXSG SGMH XCH WLS Others BXTM YDBF
T238 1961-2006 Sentence denotes DTS 25.66 26.71 21.02 17.64 23.16 14.52 22.71
T239 2007-2051 Sentence denotes AC −4.63 −5.21 −3.02 −3.49 −5.38 −2.32 −3.78
T240 2052-2094 Sentence denotes APL 13.35 13.40 9.96 6.49 10.66 4.59 11.17
T241 2095-2140 Sentence denotes CoC −1.44 −1.64 −1.59 −1.30 −1.23 −1.15 −1.25
T242 2141-2186 Sentence denotes ClC −6.24 −6.46 −6.45 −6.36 −5.88 −6.46 −6.52
T243 2187-2372 Sentence denotes Average connectivity (AC), Connection centrality (CoC), Closeness centrality (ClC): the larger the quotient is, the more stable the network and, the less the influence made by the drug.
T244 2373-2548 Sentence denotes Disturbance total score (DTS), Average length of shortest path (APL), : the larger the quotient is, the less stable the network and, the larger the influence made by the drug.
T245 2549-2580 Sentence denotes Negative control formula: BXTM.
T246 2581-2612 Sentence denotes Positive control formula: YDBF.

LitCovid-PD-GlycoEpitope

Id Subject Object Predicate Lexical cue glyco_epitope_db_id
T3 186-189 GlycoEpitope denotes WO1 http://www.glycoepitope.jp/epitopes/AN0690