PMC:7247521 / 23246-23971 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"323","span":{"begin":248,"end":254},"obj":"Gene"},{"id":"324","span":{"begin":324,"end":328},"obj":"Gene"},{"id":"325","span":{"begin":396,"end":400},"obj":"Gene"},{"id":"326","span":{"begin":470,"end":475},"obj":"Gene"},{"id":"327","span":{"begin":542,"end":547},"obj":"Gene"},{"id":"328","span":{"begin":623,"end":630},"obj":"Chemical"},{"id":"329","span":{"begin":650,"end":654},"obj":"Chemical"},{"id":"330","span":{"begin":43,"end":46},"obj":"Disease"},{"id":"331","span":{"begin":594,"end":597},"obj":"Disease"}],"attributes":[{"id":"A323","pred":"tao:has_database_id","subj":"323","obj":"Gene:1346"},{"id":"A324","pred":"tao:has_database_id","subj":"324","obj":"Gene:6240"},{"id":"A325","pred":"tao:has_database_id","subj":"325","obj":"Gene:1269"},{"id":"A326","pred":"tao:has_database_id","subj":"326","obj":"Gene:84532"},{"id":"A327","pred":"tao:has_database_id","subj":"327","obj":"Gene:2864"},{"id":"A328","pred":"tao:has_database_id","subj":"328","obj":"MESH:D002118"},{"id":"A329","pred":"tao:has_database_id","subj":"329","obj":"MESH:D006152"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"At last, the potential 221 target genes of XCH were analyzed by PPI network, and the results showed that there were 166 nodes and 643 edges. 5 modules scores were \u003e 2.5 (Fig. 5E). Module 1 (score: 5.769) consisted of 13 nodes and the seed gene was COX7A1; Module 2 (score: 2.769) consisted of 13 nodes and the seed gene was RRM1; module 3 (score: 5.5) consisted of 12 nodes and the seed gene was CNR2; module 4 (score: 2.909) consisted of 11 nodes and the seed gene was ACSS1; module 5 (score: 3.0) consisted of 7 nodes and the seed gene was FFAR1. KEGG pathway enrichment analysis showed that XCH modules were enriched in calcium signaling pathway, cGMP-PKG signaling pathway, neuroactive ligand-receptor interaction, et.al."}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T263","span":{"begin":34,"end":39},"obj":"SO:0001867"},{"id":"T264","span":{"begin":239,"end":243},"obj":"SO:0000704"},{"id":"T265","span":{"begin":248,"end":254},"obj":"PR:000005786"},{"id":"T266","span":{"begin":315,"end":319},"obj":"SO:0000704"},{"id":"T267","span":{"begin":324,"end":328},"obj":"PR:000014305"},{"id":"T268","span":{"begin":387,"end":391},"obj":"SO:0000704"},{"id":"T269","span":{"begin":396,"end":400},"obj":"PR:000001126"},{"id":"T270","span":{"begin":461,"end":465},"obj":"SO:0000704"},{"id":"T271","span":{"begin":470,"end":475},"obj":"PR:000003671"},{"id":"T272","span":{"begin":533,"end":537},"obj":"SO:0000704"},{"id":"T273","span":{"begin":542,"end":547},"obj":"PR:000001582"},{"id":"T274","span":{"begin":598,"end":605},"obj":"SO:0000417"},{"id":"T275","span":{"begin":623,"end":648},"obj":"GO:0019722"}],"text":"At last, the potential 221 target genes of XCH were analyzed by PPI network, and the results showed that there were 166 nodes and 643 edges. 5 modules scores were \u003e 2.5 (Fig. 5E). Module 1 (score: 5.769) consisted of 13 nodes and the seed gene was COX7A1; Module 2 (score: 2.769) consisted of 13 nodes and the seed gene was RRM1; module 3 (score: 5.5) consisted of 12 nodes and the seed gene was CNR2; module 4 (score: 2.909) consisted of 11 nodes and the seed gene was ACSS1; module 5 (score: 3.0) consisted of 7 nodes and the seed gene was FFAR1. KEGG pathway enrichment analysis showed that XCH modules were enriched in calcium signaling pathway, cGMP-PKG signaling pathway, neuroactive ligand-receptor interaction, et.al."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T64","span":{"begin":239,"end":243},"obj":"Body_part"},{"id":"T65","span":{"begin":315,"end":319},"obj":"Body_part"},{"id":"T66","span":{"begin":387,"end":391},"obj":"Body_part"},{"id":"T67","span":{"begin":461,"end":465},"obj":"Body_part"},{"id":"T68","span":{"begin":533,"end":537},"obj":"Body_part"}],"attributes":[{"id":"A64","pred":"fma_id","subj":"T64","obj":"http://purl.org/sig/ont/fma/fma74402"},{"id":"A65","pred":"fma_id","subj":"T65","obj":"http://purl.org/sig/ont/fma/fma74402"},{"id":"A66","pred":"fma_id","subj":"T66","obj":"http://purl.org/sig/ont/fma/fma74402"},{"id":"A67","pred":"fma_id","subj":"T67","obj":"http://purl.org/sig/ont/fma/fma74402"},{"id":"A68","pred":"fma_id","subj":"T68","obj":"http://purl.org/sig/ont/fma/fma74402"}],"text":"At last, the potential 221 target genes of XCH were analyzed by PPI network, and the results showed that there were 166 nodes and 643 edges. 5 modules scores were \u003e 2.5 (Fig. 5E). Module 1 (score: 5.769) consisted of 13 nodes and the seed gene was COX7A1; Module 2 (score: 2.769) consisted of 13 nodes and the seed gene was RRM1; module 3 (score: 5.5) consisted of 12 nodes and the seed gene was CNR2; module 4 (score: 2.909) consisted of 11 nodes and the seed gene was ACSS1; module 5 (score: 3.0) consisted of 7 nodes and the seed gene was FFAR1. KEGG pathway enrichment analysis showed that XCH modules were enriched in calcium signaling pathway, cGMP-PKG signaling pathway, neuroactive ligand-receptor interaction, et.al."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T153","span":{"begin":34,"end":39},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"},{"id":"T154","span":{"begin":239,"end":243},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"},{"id":"T155","span":{"begin":315,"end":319},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"},{"id":"T156","span":{"begin":387,"end":391},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"},{"id":"T157","span":{"begin":439,"end":441},"obj":"http://purl.obolibrary.org/obo/CLO_0053733"},{"id":"T158","span":{"begin":461,"end":465},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"},{"id":"T159","span":{"begin":533,"end":537},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"},{"id":"T160","span":{"begin":631,"end":640},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T161","span":{"begin":659,"end":668},"obj":"http://purl.obolibrary.org/obo/SO_0000418"}],"text":"At last, the potential 221 target genes of XCH were analyzed by PPI network, and the results showed that there were 166 nodes and 643 edges. 5 modules scores were \u003e 2.5 (Fig. 5E). Module 1 (score: 5.769) consisted of 13 nodes and the seed gene was COX7A1; Module 2 (score: 2.769) consisted of 13 nodes and the seed gene was RRM1; module 3 (score: 5.5) consisted of 12 nodes and the seed gene was CNR2; module 4 (score: 2.909) consisted of 11 nodes and the seed gene was ACSS1; module 5 (score: 3.0) consisted of 7 nodes and the seed gene was FFAR1. KEGG pathway enrichment analysis showed that XCH modules were enriched in calcium signaling pathway, cGMP-PKG signaling pathway, neuroactive ligand-receptor interaction, et.al."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T131","span":{"begin":64,"end":67},"obj":"Chemical"},{"id":"T133","span":{"begin":623,"end":630},"obj":"Chemical"},{"id":"T135","span":{"begin":650,"end":654},"obj":"Chemical"},{"id":"T136","span":{"begin":690,"end":696},"obj":"Chemical"}],"attributes":[{"id":"A131","pred":"chebi_id","subj":"T131","obj":"http://purl.obolibrary.org/obo/CHEBI_53266"},{"id":"A132","pred":"chebi_id","subj":"T131","obj":"http://purl.obolibrary.org/obo/CHEBI_60614"},{"id":"A133","pred":"chebi_id","subj":"T133","obj":"http://purl.obolibrary.org/obo/CHEBI_22984"},{"id":"A134","pred":"chebi_id","subj":"T133","obj":"http://purl.obolibrary.org/obo/CHEBI_29320"},{"id":"A135","pred":"chebi_id","subj":"T135","obj":"http://purl.obolibrary.org/obo/CHEBI_16356"},{"id":"A136","pred":"chebi_id","subj":"T136","obj":"http://purl.obolibrary.org/obo/CHEBI_52214"}],"text":"At last, the potential 221 target genes of XCH were analyzed by PPI network, and the results showed that there were 166 nodes and 643 edges. 5 modules scores were \u003e 2.5 (Fig. 5E). Module 1 (score: 5.769) consisted of 13 nodes and the seed gene was COX7A1; Module 2 (score: 2.769) consisted of 13 nodes and the seed gene was RRM1; module 3 (score: 5.5) consisted of 12 nodes and the seed gene was CNR2; module 4 (score: 2.909) consisted of 11 nodes and the seed gene was ACSS1; module 5 (score: 3.0) consisted of 7 nodes and the seed gene was FFAR1. KEGG pathway enrichment analysis showed that XCH modules were enriched in calcium signaling pathway, cGMP-PKG signaling pathway, neuroactive ligand-receptor interaction, et.al."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T92","span":{"begin":623,"end":640},"obj":"http://purl.obolibrary.org/obo/GO_0019722"},{"id":"T93","span":{"begin":631,"end":640},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T94","span":{"begin":659,"end":676},"obj":"http://purl.obolibrary.org/obo/GO_0007165"},{"id":"T95","span":{"begin":659,"end":668},"obj":"http://purl.obolibrary.org/obo/GO_0023052"}],"text":"At last, the potential 221 target genes of XCH were analyzed by PPI network, and the results showed that there were 166 nodes and 643 edges. 5 modules scores were \u003e 2.5 (Fig. 5E). Module 1 (score: 5.769) consisted of 13 nodes and the seed gene was COX7A1; Module 2 (score: 2.769) consisted of 13 nodes and the seed gene was RRM1; module 3 (score: 5.5) consisted of 12 nodes and the seed gene was CNR2; module 4 (score: 2.909) consisted of 11 nodes and the seed gene was ACSS1; module 5 (score: 3.0) consisted of 7 nodes and the seed gene was FFAR1. KEGG pathway enrichment analysis showed that XCH modules were enriched in calcium signaling pathway, cGMP-PKG signaling pathway, neuroactive ligand-receptor interaction, et.al."}

{"project":"LitCovid-sentences","denotations":[{"id":"T149","span":{"begin":0,"end":140},"obj":"Sentence"},{"id":"T150","span":{"begin":141,"end":179},"obj":"Sentence"},{"id":"T151","span":{"begin":180,"end":196},"obj":"Sentence"},{"id":"T152","span":{"begin":197,"end":272},"obj":"Sentence"},{"id":"T153","span":{"begin":273,"end":346},"obj":"Sentence"},{"id":"T154","span":{"begin":347,"end":418},"obj":"Sentence"},{"id":"T155","span":{"begin":419,"end":493},"obj":"Sentence"},{"id":"T156","span":{"begin":494,"end":548},"obj":"Sentence"},{"id":"T157","span":{"begin":549,"end":725},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"At last, the potential 221 target genes of XCH were analyzed by PPI network, and the results showed that there were 166 nodes and 643 edges. 5 modules scores were \u003e 2.5 (Fig. 5E). Module 1 (score: 5.769) consisted of 13 nodes and the seed gene was COX7A1; Module 2 (score: 2.769) consisted of 13 nodes and the seed gene was RRM1; module 3 (score: 5.5) consisted of 12 nodes and the seed gene was CNR2; module 4 (score: 2.909) consisted of 11 nodes and the seed gene was ACSS1; module 5 (score: 3.0) consisted of 7 nodes and the seed gene was FFAR1. KEGG pathway enrichment analysis showed that XCH modules were enriched in calcium signaling pathway, cGMP-PKG signaling pathway, neuroactive ligand-receptor interaction, et.al."}