At last, the potential 221 target genes of XCH were analyzed by PPI network, and the results showed that there were 166 nodes and 643 edges. 5 modules scores were > 2.5 (Fig. 5E). Module 1 (score: 5.769) consisted of 13 nodes and the seed gene was COX7A1; Module 2 (score: 2.769) consisted of 13 nodes and the seed gene was RRM1; module 3 (score: 5.5) consisted of 12 nodes and the seed gene was CNR2; module 4 (score: 2.909) consisted of 11 nodes and the seed gene was ACSS1; module 5 (score: 3.0) consisted of 7 nodes and the seed gene was FFAR1. KEGG pathway enrichment analysis showed that XCH modules were enriched in calcium signaling pathway, cGMP-PKG signaling pathway, neuroactive ligand-receptor interaction, et.al.