PMC:7243778 / 13856-14673
Annnotations
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 326 | 306-310 | Gene | denotes | ACE2 | Gene:59272 |
| 327 | 384-385 | Gene | denotes | N | Gene:43740575 |
| 328 | 550-551 | Gene | denotes | S | Gene:43740568 |
| 329 | 28-33 | Species | denotes | mouse | Tax:10090 |
| 330 | 72-77 | Species | denotes | human | Tax:9606 |
| 331 | 594-602 | Species | denotes | SARS-CoV | Tax:694009 |
| 332 | 180-183 | CellLine | denotes | H12 | CVCL:G696 |
| 333 | 760-763 | CellLine | denotes | H12 | CVCL:G696 |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T60 | 34-48 | Body_part | denotes | immunoglobulin | http://purl.org/sig/ont/fma/fma62871 |
| T61 | 78-92 | Body_part | denotes | immunoglobulin | http://purl.org/sig/ont/fma/fma62871 |
| T62 | 488-499 | Body_part | denotes | amino acids | http://purl.org/sig/ont/fma/fma82739 |
| T63 | 552-559 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T64 | 653-661 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T49 | 594-602 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T157 | 28-33 | http://purl.obolibrary.org/obo/CLO_0007836 | denotes | mouse |
| T158 | 49-54 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | genes |
| T159 | 69-77 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | by human |
| T160 | 93-98 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | genes |
| T161 | 127-129 | http://purl.obolibrary.org/obo/CLO_0050050 | denotes | S1 |
| T162 | 142-144 | http://purl.obolibrary.org/obo/CLO_0050510 | denotes | 18 |
| T163 | 221-224 | http://purl.obolibrary.org/obo/CLO_0001435 | denotes | 5E4 |
| T164 | 264-266 | http://purl.obolibrary.org/obo/CLO_0001627 | denotes | aa |
| T165 | 285-290 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T166 | 358-360 | http://purl.obolibrary.org/obo/CLO_0001627 | denotes | aa |
| T167 | 503-505 | http://purl.obolibrary.org/obo/CLO_0050050 | denotes | S1 |
| T168 | 644-646 | http://purl.obolibrary.org/obo/CLO_0050050 | denotes | S1 |
| T169 | 650-652 | http://purl.obolibrary.org/obo/CLO_0008922 | denotes | S2 |
| T170 | 650-652 | http://purl.obolibrary.org/obo/CLO_0050052 | denotes | S2 |
| T171 | 675-677 | http://purl.obolibrary.org/obo/CLO_0050050 | denotes | S1 |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T71 | 349-356 | Chemical | denotes | epitope | http://purl.obolibrary.org/obo/CHEBI_53000 |
| T72 | 488-499 | Chemical | denotes | amino acids | http://purl.obolibrary.org/obo/CHEBI_33709 |
| T73 | 488-493 | Chemical | denotes | amino | http://purl.obolibrary.org/obo/CHEBI_46882 |
| T74 | 494-499 | Chemical | denotes | acids | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T75 | 552-559 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T76 | 650-652 | Chemical | denotes | S2 | http://purl.obolibrary.org/obo/CHEBI_29387 |
| T77 | 653-661 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
LitCovid-PD-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glyco_epitope_db_id |
|---|---|---|---|---|---|
| T1 | 164-167 | GlycoEpitope | denotes | 3A7 | http://www.glycoepitope.jp/epitopes/AN0057 |
| T2 | 191-194 | GlycoEpitope | denotes | 4E2 | http://www.glycoepitope.jp/epitopes/AN0611 |
| T3 | 201-204 | GlycoEpitope | denotes | 5A5 | http://www.glycoepitope.jp/epitopes/AN0206 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T107 | 0-141 | Sentence | denotes | By using Xenomouse in which mouse immunoglobulin genes were replaced by human immunoglobulin genes, 19 neutralizing mAbs bound S1 were found. |
| T108 | 142-320 | Sentence | denotes | 18 of them, 1B5 [38], 3A7, 3C7, 3F3, 3H12, 4A10, 4E2, 4G2, 5A5, 5A7, 5D3, 5D6, 5E4, 6B1, 6B5, 6B8, 6C1 and 6C2 bound RBD (aa 318–510) to avoid virus binding to the ACE2 receptor. |
| T109 | 321-459 | Sentence | denotes | The last one, 4D4, bound an epitope (aa 12–261) located on the N-terminal of RBD and inhibited post-binding event but not the RBD binding. |
| T110 | 460-565 | Sentence | denotes | Truncation of the first 300 amino acids of S1 blocked the trimerization and the fusion of S protein [39]. |
| T111 | 566-730 | Sentence | denotes | Synergistic effects in some SARS-CoV strains of 4D4 with other mAbs targeting S1 or S2 proteins such as 3C7 (S1), 1F8 (HR1) or 5E9 (HR2) were also reported [38,40]. |
| T112 | 731-817 | Sentence | denotes | The tri-combination of 3C7, 3H12 and 4D4 could effectively neutralize escape variants. |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32450171-19748648-66454463 | 159-161 | 19748648 | denotes | 38 |
| 32450171-15313178-66454464 | 561-563 | 15313178 | denotes | 39 |
| 32450171-19748648-66454465 | 723-725 | 19748648 | denotes | 38 |
| 32450171-17161858-66454466 | 726-728 | 17161858 | denotes | 40 |